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1. 发明授权

US07107997B1 Method and apparatus for increasing angiogenic, growth factor in heart muscle 失效
标题翻译：用于增加心肌中血管生成，生长因子的方法和装置
公开(公告)号：US07107997B1
公开(公告)日：2006-09-19
申请号：US10383785
申请日：2002-09-09
申请人： Jeffrey Warren Moses , Nicholas N. Kipshidze , Martin B. Leon , Ran Kornowski
发明人： Jeffrey Warren Moses , Nicholas N. Kipshidze , Martin B. Leon , Ran Kornowski
IPC分类号： A61B19/00
CPC分类号： A61B17/2202 , A61B2017/00247 , A61B2018/00392
摘要： The present invention relates to methods and apparatuses for use in revascularization of damaged areas of myocardium through application of one or more radiation type treatment modalities.
摘要翻译：本发明涉及通过应用一种或多种辐射型治疗方式用于心肌损伤区血运重建的方法和装置。

2. 发明授权

US06962584B1 Electromagnetic photonic catheter for reducing restenosis 失效
标题翻译：用于减少再狭窄的电磁光导管
公开(公告)号：US06962584B1
公开(公告)日：2005-11-08
申请号：US10234443
申请日：2002-09-04
申请人： Gregg W. Stone , Jeffrey W. Moses , Martin B. Leon , Nicholas N. Kipshidze , Harvinder Sahota , Bandula Wijay
发明人： Gregg W. Stone , Jeffrey W. Moses , Martin B. Leon , Nicholas N. Kipshidze , Harvinder Sahota , Bandula Wijay
IPC分类号： A61B17/22 , A61B18/18 , A61B18/22 , A61B18/24
CPC分类号： A61B18/245 , A61B2017/22002 , A61B2018/2261
摘要： The method of vascular treatment for restenosis or vulnerable plaque after an invasive procedure, such as for example angioplasty, stenting with or without drug coating, or drug delivery, comprises: inserting a catheter or hollow guide wire to the treatment location; delivering light through the catheter in the wavelength range of about 700–2500 nm; and moving the light to treat the affected region.
摘要翻译：在侵入性手术（例如血管成形术，有或没有药物包被的支架置入或药物递送）之后的再狭窄或易损斑块的血管治疗方法包括：将导管或空心导丝插入治疗位置; 在约700-2500nm的波长范围内通过导管传送光; 并移动光线对付受影响的地区。

3. 发明授权

US07918884B2 Stent for treatment of bifurcated lesions 有权
标题翻译：支架治疗分叉病变
公开(公告)号：US07918884B2
公开(公告)日：2011-04-05
申请号：US10863192
申请日：2004-06-08
申请人： David C. Majercak , Matthew Krever , Jin S. Park , Robert S. Burgermeister , Hikmat Hojeibane , Martin B. Leon
发明人： David C. Majercak , Matthew Krever , Jin S. Park , Robert S. Burgermeister , Hikmat Hojeibane , Martin B. Leon
IPC分类号： A61F2/01
CPC分类号： A61F2/856 , A61F2/91 , A61F2/915 , A61F2002/821 , A61F2002/91533 , A61F2002/91558 , A61F2210/0004 , A61F2250/0067
摘要： A stent includes a lattice defining a substantially cylindrical configuration having a proximal end portion and a distal end portion, and a middle portion between the proximal end and the distal end. The lattice being moveable from a crimped state to an expanded state, and a plurality of adjacent hoops. Each hoop has a plurality of adjacent loops. Additionally, the stent further includes a plurality of bridges connecting adjacent hoops and a plurality of extensions on the lattice. Each of the hoops and bridges define a cell. The proximal end portion and the distal end portion of the lattice have at least one cell respectively and the middle portion of the lattice has at least one cell. The plurality of extensions are on the middle portion of the lattice. The plurality of extensions are cantilevered projections from the bridges and/or hoops of the lattice. The plurality of extensions are movably deformable in a direction away from the lattice, for example, at least some of the extensions are movably deformable in a direction away from the bridges and at least some of the extensions are movably deformable in a direction away from the hoops.
摘要翻译：支架包括限定具有近端部分和远端部分的基本上圆柱形构造的格子，以及近端和远端之间的中间部分。格子可以从卷曲状态移动到展开状态，并且多个相邻的环。每个箍具有多个相邻的环。此外，支架还包括连接相邻环的多个桥和在晶格上的多个延伸部。每个环和桥定义一个单元格。晶格的近端部分和远端部分分别具有至少一个电池，并且晶格的中间部分具有至少一个电池。多个延伸部位于格子的中间部分。多个延伸部是从网格的桥和/或环的悬臂突起。所述多个延伸部在远离格子的方向上可移动地变形，例如，至少一些延伸部在远离桥梁的方向上可移动地变形，并且至少一些延伸部分沿着远离网格的方向可移动地变形箍

4. 发明授权

US07097832B1 Intramyocardial injection of autologous bone marrow 有权
标题翻译：心肌内注射自体骨髓
公开(公告)号：US07097832B1
公开(公告)日：2006-08-29
申请号：US09868411
申请日：2000-03-30
申请人： Ran Kornowski , Shmuel Fuchs , Stephen E. Epstein , Martin B. Leon
发明人： Ran Kornowski , Shmuel Fuchs , Stephen E. Epstein , Martin B. Leon
IPC分类号： A01N63/00 , C12N5/00 , C12N5/06
CPC分类号： A61K38/193 , A61K35/28 , A61K38/1709 , A61K2300/00
摘要： A method of treating cardiac or myocardial conditions comprises the administration of an effective amount of autologous bone marrow. The bone marrow may optionally be stimulated and/or administered in combination with a pharmaceutical drug, protein, gene or other factor or therapy that may enhance bone marrow production of angiogenic growth factors and/or promote endothelial cell proliferation or migration or blood vessel formation.
摘要翻译：治疗心脏或心肌病症的方法包括施用有效量的自体骨髓。骨髓可以任选地与可以增强血管生成生长因子的骨髓产生和/或促进内皮细胞增殖或迁移或血管形成的药物，蛋白质，基因或其他因子或治疗组合而被刺激和/或施用。

5. 发明授权

US06471979B2 Apparatus and method for delivering compounds to a living organism 失效
标题翻译：将化合物输送到生物体的装置和方法
公开(公告)号：US06471979B2
公开(公告)日：2002-10-29
申请号：US09943648
申请日：2001-08-30
申请人： Gishel New , Jeffrey W. Moses , Nicholas Kipshidze , Gary S. Roubin , Martin B. Leon
发明人： Gishel New , Jeffrey W. Moses , Nicholas Kipshidze , Gary S. Roubin , Martin B. Leon
IPC分类号： A61K31565
CPC分类号： A61K31/00 , A61F2/91 , A61F2/915 , A61F2002/91533 , A61F2002/91575 , A61F2230/0054 , A61F2250/0067 , A61K31/138 , A61K31/404 , A61K31/4196 , A61K31/451 , A61K31/4535 , A61K31/496 , A61K31/56 , A61K31/565 , A61K31/566 , A61K31/567 , A61K31/5685 , A61K31/57 , A61K31/685 , A61L29/16 , A61L31/16 , A61L2300/416 , A61L2300/43 , A61L2300/602 , A61M25/00 , A61M25/10 , A61M2025/0057 , A61M2025/105 , A61M2025/1072 , Y10S514/824
摘要： A method of treating or preventing vascular disease in a living organism. The method includes delivering an effective amount of a composition including a sex hormone, anti-hormone, sex-hormone agonist, steroid-hormone inhibitor/antagonist (partial or full), selective estrogen receptor modulator (SERM), or a combination thereof, to an affected area of a living organism.
摘要翻译：治疗或预防活体血管疾病的方法。该方法包括将有效量的包括性激素，抗激素，性激素激动剂，类固醇激素抑制剂/拮抗剂（部分或全部），选择性雌激素受体调节剂（SERM）或其组合物的组合物递送至受影响的生物体区域。

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