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1. 发明申请

US20050288771A1 Novel stent for treatment of bifurcated lesions 有权
标题翻译：用于治疗分叉病变的新型支架
公开(公告)号：US20050288771A1
公开(公告)日：2005-12-29
申请号：US10863192
申请日：2004-06-08
申请人： David Majercak , Matthew Krever , Jin Park , Robert Burgermeister , Hikmat Hojeibane , Martin Leon
发明人： David Majercak , Matthew Krever , Jin Park , Robert Burgermeister , Hikmat Hojeibane , Martin Leon
IPC分类号： A61F2/00 , A61F2/02 , A61F2/82 , A61M29/02 , A61F2/06
CPC分类号： A61F2/856 , A61F2/91 , A61F2/915 , A61F2002/821 , A61F2002/91533 , A61F2002/91558 , A61F2210/0004 , A61F2250/0067
摘要： A stent includes a lattice defining a substantially cylindrical configuration having a proximal end portion and a distal end portion, and a middle portion between the proximal end and the distal end. The lattice being moveable from a crimped state to an expanded state, and a plurality of adjacent hoops. Each hoop has a plurality of adjacent loops. Additionally, the stent further includes a plurality of bridges connecting adjacent hoops and a plurality of extensions on the lattice. Each of the hoops and bridges define a cell. The proximal end portion and the distal end portion of the lattice have at least one cell respectively and the middle portion of the lattice has at least one cell. The plurality of extensions are on the middle portion of the lattice. The plurality of extensions are cantilevered projections from the bridges and/or hoops of the lattice. The plurality of extensions are movably deformable in a direction away from the lattice, for example, at least some of the extensions are movably deformable in a direction away from the bridges and at least some of the extensions are movably deformable in a direction away from the hoops.
摘要翻译：支架包括限定具有近端部分和远端部分的基本上圆柱形构造的格子，以及近端和远端之间的中间部分。格子可以从卷曲状态移动到展开状态，并且多个相邻的环。每个箍具有多个相邻的环。此外，支架还包括连接相邻环的多个桥和在晶格上的多个延伸部。每个环和桥定义一个单元格。晶格的近端部分和远端部分分别具有至少一个电池，并且晶格的中间部分具有至少一个电池。多个延伸部位于格子的中间部分。多个延伸部是从网格的桥和/或环的悬臂突起。所述多个延伸部在远离格子的方向上可移动地变形，例如，至少一些延伸部在远离桥梁的方向上可移动地变形，并且至少一些延伸部分沿着远离网格的方向可移动地变形箍

2. 发明申请

US20050131524A1 Method for treating a bifurcated vessel 审中-公开
标题翻译：治疗分叉血管的方法
公开(公告)号：US20050131524A1
公开(公告)日：2005-06-16
申请号：US10863142
申请日：2004-06-08
申请人： David Majercak , Matthew Krever , Jin Park , Robert Burgermeister , Hikmat Hojeibane , Martin Leon
发明人： David Majercak , Matthew Krever , Jin Park , Robert Burgermeister , Hikmat Hojeibane , Martin Leon
IPC分类号： A61M29/02 , A61F2/06 , A61F2/84 , A61F2/90
CPC分类号： A61F2/91 , A61F2/915 , A61F2002/91541 , A61F2002/91558 , A61F2230/0054
摘要： A method for treating a bifurcated vessel, wherein the bifurcated vessel has a main vessel and a side branch vessel extending from the main vessel. The method includes the steps of: identifying a site in the main vessel and placing a stent at the site in the main vessel. The stent includes a lattice defining a substantially cylindrical configuration having a proximal end portion and a distal end portion, and a middle portion between the proximal end portion and the distal end portion. The lattice is movable from a crimped state to an expanded state. The lattice has a plurality of adjacent hoops. Each hoop has a plurality of adjacent loops, a plurality of bridges connecting adjacent hoops, and a plurality of extensions on at least some portions of the lattice. Each of the hoops and bridges define a cell. The proximal end portion and the distal end portion of the lattice have at least one cell respectively and the middle portion of the lattice has at least one cell. The at least one cell of the middle portion has spacing between adjacent hoops that is greater than spacing between adjacent hoops of the at least one cell of the proximal end portion and the distal end portion respectively. The at least one cell of the middle portion is dilated adjacent the side branch vessel and a surface of the side branch vessel is supported with at least one of the plurality of the extensions by deformably moving the at least one of the plurality of extensions away from the lattice and into contact with the surface of the side branch vessel.
摘要翻译：一种治疗分叉血管的方法，其中分叉血管具有主血管和从主血管延伸的侧支血管。该方法包括以下步骤：识别主容器中的位置并将支架放置在主容器中的位置处。支架包括限定具有近端部分和远端部分的基本上圆柱形构造的格子，以及近端部分和远端部分之间的中间部分。格子可以从卷曲状态移动到展开状态。格子具有多个相邻的箍。每个箍具有多个相邻的环，连接相邻环的多个桥，以及在该格的至少某些部分上的多个延伸部。每个环和桥定义一个单元格。晶格的近端部分和远端部分分别具有至少一个电池，并且晶格的中间部分具有至少一个电池。中间部分的至少一个单元在相邻的箍之间具有分别大于近端部分的至少一个单元和远端部分的相邻环之间的间隔的间隔。中间部分的至少一个单元在侧分支容器附近扩张，并且侧分支容器的表面由多个延伸部中的至少一个支撑，多个延伸部中的至少一个延伸部可变形地将多个延伸部中的至少一个远离格子并与侧支血管的表面接触。

3. 发明申请

US20060051334A1 Injection of bone marrow-derived conditioned medium for angiogenesis 审中-公开
标题翻译：注射用于血管生成的骨髓来源的条件培养基
公开(公告)号：US20060051334A1
公开(公告)日：2006-03-09
申请号：US11117607
申请日：2005-04-27
申请人： Ran Kornowski , Shmuel Fuchs , Stephen Epstein , Martin Leon
发明人： Ran Kornowski , Shmuel Fuchs , Stephen Epstein , Martin Leon
IPC分类号： A61K48/00
CPC分类号： C12N5/0691 , A61K35/28 , A61K38/1825 , A61K38/1866 , A61K38/44 , A61K48/00 , C12N2502/1358 , C12Y114/13039 , A61K2300/00
摘要： Methods are provided for promoting formation of collateral blood supply at an ischemic site in tissue by culturing early attaching cells derived from growth of bone marrow aspirate in vitro, collecting early attaching cells produced by the bone marrow culture and injecting conditioned medium produced by culture of the early attaching cells into an ischemic site in heart or limb. The preferred early attaching cells for use in the invention methods are marrow-derived stromal cells. Any donor's bone marrow can be used in preparation of the conditioned medium. Optionally, the early attaching cells can be transfected with an angiogenesis promoting transgene encoding hypoxia inducing factor 1 alpha, a fibroblast growth factor and/or a nitric oxide synthase. Conditioned media containing angiogenic cytokines produced such cells are also provided for injection into tissue, such as heart or peripheral limb muscle, requiring formation of collateral blood supply.
摘要翻译：提供了通过体外培养早期粘附来自骨髓吸出物生长的细胞来促进组织缺血部位形成侧支血液供应的方法，收集由骨髓培养产生的早期附着细胞并注入通过培养产生的条件培养基早期将细胞附着到心脏或肢体的缺血部位。用于本发明方法的优选早期附着细胞是骨髓来源的基质细胞。任何供体的骨髓都可用于制备条件培养基。任选地，可以用编码缺氧诱导因子1α，成纤维细胞生长因子和/或一氧化氮合酶的血管生成促进转基因转染早期附着细胞。还提供了含有产生这种细胞的血管生成细胞因子的条件培养基用于注射到组织中，例如心脏或外周肢肌，需要形成侧支血液供应。

4. 发明申请

US20060094657A1 Inhibiting development of microvessels within coronary or peripheral vessel walls for restenosis/atherosclerosis prevention or therapy 审中-公开
标题翻译：抑制冠状动脉或外周血管壁内微血管的发展，用于再狭窄/动脉粥样硬化的预防或治疗
公开(公告)号：US20060094657A1
公开(公告)日：2006-05-04
申请号：US11295095
申请日：2005-12-06
申请人： Stephen Epstein , Ran Kornowski , Shmuel Fuchs , Martin Leon
发明人： Stephen Epstein , Ran Kornowski , Shmuel Fuchs , Martin Leon
IPC分类号： A61K38/17 , A61K48/00
CPC分类号： A61K45/06 , A61K38/179 , A61K38/1891
摘要： Disclosed and claimed are compositions and methods for therapy and/or prevention of restenosis and/or atherosclerosis. The compositions can include an agent for inhibiting VEGF and an agent for including vessel maturation; for instance, the soluble VEGF receptor and ang-1. Embodiments can include kits.
摘要翻译：公开并要求保护的是用于治疗和/或预防再狭窄和/或动脉粥样硬化的组合物和方法。组合物可以包括用于抑制VEGF的试剂和用于包括血管成熟的试剂; 例如，可溶性VEGF受体和ang-1。实施例可以包括套件。

5. 发明申请

US20060057722A1 Conditioned medium of autologous or allogenic progenitor cells for angiogenesis treatment 审中-公开
标题翻译：用于血管生成治疗的自体或同种异体祖细胞的条件培养基
公开(公告)号：US20060057722A1
公开(公告)日：2006-03-16
申请号：US11221469
申请日：2005-09-07
申请人： Ran Kornowski , Shmuel Fuchs , Stephen Epstein , Martin Leon
发明人： Ran Kornowski , Shmuel Fuchs , Stephen Epstein , Martin Leon
IPC分类号： C12N5/08
CPC分类号： A61K35/28 , A61K35/14 , A61K35/35 , A61K38/1709 , A61K38/1825 , A61K38/193 , A61K38/195 , A61K38/44 , A61K2300/00
摘要： A therapeutic composition is provided that comprises a cell-free conditioned medium containing mixed secretion products of isolated angiogenic progenitor cells obtained from bone marrow, peripheral blood, or adipose tissue. The composition may additionally contain angiogenesis-promoting proteins obtained by transfecting the progenitors cells in culture with an angiogenesis promoting transgene. The composition is useful to promote angiogenesis when introduced into or adjacent to an ischemic site in a patient, such as in myocardium or peripheral limb. Methods are also provided for utilizing such cell-free conditioned medium to deliver angiogenesis-promoting proteins to a patient. The cell-free conditioned medium can also be injected into the blood stream for delivery to the ischemic tissue. The cells can derive from either an autologous or allogenic source and can be lyophilized or frozen for storage.
摘要翻译：提供了一种治疗组合物，其包含含有从骨髓，外周血或脂肪组织获得的分离的血管生成祖细胞的混合分泌产物的无细胞条件培养基。该组合物可另外含有通过用促血管生成促进转基因在培养物中转染祖细胞获得的促血管生成蛋白。当将该组合物引入或邻近患者（例如心肌或外周肢体）中的缺血部位时，该组合物可用于促进血管生成。还提供了使用这种无细胞条件培养基将血管生成促进蛋白递送给患者的方法。无细胞条件培养基也可以注射到血流中以输送到缺血组织。细胞可来自自体或同种异体来源，并且可以冻干或冷冻储存。

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