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1. 发明申请

WO2010136360A2 BENZYLIDENE MALONATES 审中-公开
标题翻译：苯并噻唑啉酮
公开(公告)号：WO2010136360A2
公开(公告)日：2010-12-02
申请号：PCT/EP2010/056843
申请日：2010-05-19
申请人： BASF SE , HANSCH, Markus , EHLIS, Thomas , WALLQUIST, Olof , WAGNER, Barbara , HERZOG, Bernd , GIESINGER, Jochen
发明人： HANSCH, Markus , EHLIS, Thomas , WALLQUIST, Olof , WAGNER, Barbara , HERZOG, Bernd , GIESINGER, Jochen
IPC分类号： A61K8/37 , A61Q17/04 , C07C69/73
CPC分类号： A61K8/37 , A61Q17/04 , C07C69/73
摘要： Disclosed is the use of benzylidene malonates of formula (1), wherein R 1 is methyl; ethyl; propyl; or n-butyl; if R 1 is methyl, then R is tert. butyl; formula (A); a radical of formula (1a); or a radical of formula (1b); wherein R 2 and R 3 , independently from each other are hydrogen; or methyl; R 4 is methyl; ethyl; or n-propyl; R 5 and R 6 independently from each other are hydrogen; or C 1 -C 3 alkyl; if R 1 is ethyl; propyl; or n-butyl, then R is isopropyl; for the protection of human and animal hair and skin against UV radiation.
摘要翻译：公开了式（1）的亚苄基丙二酸酯的用途，其中R 1是甲基; 乙基; 丙基; 或正丁基; 如果R1是甲基，那么R是叔丁基。丁基; 式（A）; 式（1a）的基团; 或式（1b）的基团; 其中R2和R3彼此独立地是氢; 或甲基; R4是甲基; 乙基; 或正丙基; R5和R6彼此独立地是氢; 或C 1 -C 3烷基; 如果R1是乙基; 丙基; 或正丁基，那么R是异丙基; 用于保护人和动物的头发和皮肤免受紫外线辐射。

2. 发明申请

WO2006003094A2 MEROCYANINE DERIVATIVES 审中-公开
公开(公告)号：WO2006003094A2
公开(公告)日：2006-01-12
申请号：PCT/EP2005/052850
申请日：2005-06-20
申请人： CIBA SPECIALTY CHEMICALS HOLDING INC. , WAGNER, Barbara , BIENEWALD, Frank , WOLLEB, Heinz , WALLQUIST, Olof , HERZOG, Bernd , EHLIS, Thomas , HAASE, Jürg
发明人： WAGNER, Barbara , BIENEWALD, Frank , WOLLEB, Heinz , WALLQUIST, Olof , HERZOG, Bernd , EHLIS, Thomas , HAASE, Jürg
IPC分类号： A61K7/42
CPC分类号： A61K8/498 , A61K8/4913 , A61K8/494 , A61Q17/04
摘要： Disclosed is the use of merocyanine derivatives of formula (I), wherein Q is hydrogen; C 1 -C 22 alkyl; -OH; -OR 7 ; -NR 7 R 8 ; or -N=R 9 ; R 1 is hydrogen; C 1 -C 22 alkyl; -OR 7 , -SR 7 ; -NR 7 R 8 ; C 1 -C 22 alkyl; C 2 -C 12 alkenyl; C 2 -C 12 alkinyl; C 3 -C 12 cycloalkyl; C 3 -C 12 cycloalkenyl; C 7 -C 12 aralkyl; C 1 -C 12 heteroalkyl, C 2 -C 11 heteroaralkyl; C 6 -C 10 aryl; or C 1 -C 9 heteroaryl; R 4 is cyano; COR 7 , COOR 7 ; CONR 7 R 8 ; SO 2 (C 6 -C 12 )aryl; C 2 -C 12 alk-1-enyl; C 3 -C 12 cycloalk-1-enyl; C 2 -C 12 alk-1-inyl; C 2 -C 12 heteroalkyl; C 3 -C 5 heterocycloalkyl; C 6 -C 10 aryl; or C 1 -C 9 heteroaryl; R 5 is -COR 7 ; -COOR 7 ; -OR 7 ; -SR 7 , -NHR 7 , -NR 7 R 8 ; C 1 -C 22 alkyl; C 2 -C 12 alkenyl; C 2 -C 12 alkinyl; C 3 -C 12 cycloalkyl; C 3 -C 12 cycloalkenyl; C 7 -C 12 aralkyl; C 1 -C 12 alkylphenyl; C 1 -C 12 alkoxy-C 6 -C 10 aryl; C 1 -C 12 heteroalkyl; C 2 -C 11 heteroaralkyl; C 3 -C 12 cycloheteroalkyl; C 6 -C 10 aryl; C 1 - C 12 alkoxy-C 6 -C 10 aryl; or C 1 -C 9 heteroaryl; R 6 is hydrogen; C 1 -C 22 alkyl; C 1 -C 22 alkoxy; or COR 7 ; R 7 and R 8 independently from each other are hydrogen; C 1 -C 22 alkyl; C 2 -C 12 alkenyl; C 2 -C 12 alkinyl; C 3 -C 12 cycloalkyl; C 3 -C 12 cycloalkenyl; -(CH 2 ) t COOH; C 7 -C 12 aralkyl; C 1 -C 12 heteroalkyl; C 2 -C 11 heteroaralkyl; C 6 -C 10 aryl; C 1 -C 9 heteroaryl; Si-R 10 R 11 R 12 ; Si(OR 10 )(OR 11 )(OR 12 ); SiR 10 (OR 11 )(OR 12 ); SiR 10 R 11 (OR 12 ); -(CH 2 ) u -O-(CH 2 ) v -SiR 10 R 11 R 12 ; or a radical X-Sil; t, u and v, independently from each other are a number from 1 to 5; R 9 is a (C 1 -C 6 )alkylidene radical; R 10 , R 11 , R 12 independently form each other are C 1 -C 22 alkyl; X is a linker; Sil is a silane-, oligosiloxane- or polysiloxane radical; R 1 and R 2 , R 1 and Q, R 1 and R 6 , R 1 and T, R 2 and R 3 , R 2 and R 4 , R 2 and R 6 , R 2 and Q, R 4 and R 6 , R 4 and T, R 6 and Q, T and Q, each independently, are linked together, so that 1, 2, 3 or 4 carbocyclic or N, O and/or S-heterocyclic rings are formed, wherein each of them, independently from each other, may be condensed with an aromatic or heteroaromatic ring, and/or more N-, O- and/or S-heterocyclic rings, and each N atom in a N-heterocyclic ring may be substituted by C 1 -C 22 alkyl; n is a number from 1 to 4; wherein at least one of the radicals R 1 , R 6 or Q is different from hydrogen; if n = 1 T is -COR 5 ; -CN; C 6 -C 10 aryl; -NHR 5 ; or -SO 2 -(C 6 -C 12 )aryl; R 2 and R 3 independently from each other are C 1 -C 22 alkyl; hydroxy-C 1 -C 22 alkyl; C 2 -C 12 alkenyl; C 2 -C 12 alkinyl; C 3 -C 12 cycloalkyl, C 3 -C 12 cycloalkenyl; C 7 -C 12 aralkyl; C 1 -C 12 heteroalkyl; C 3 -C 12 cycloheteroalkyl; C 6 -C 10 aryl; C 1 -C 9 heteroaryl; or a radical of formula (II); p is a number from 5 to 100; q is a number from 1 to 5; s is a number from 0 to 4; if n = 2 R 2 and R 3 are each C 1 -C 5 alkylene; and simultaneously T is defined as for n = 1; or T is a bivalent radical of formula -NR 7 -V-NR 7 -, wherin V is phenylene; or C 1 -C 5 alkylene; R 7 is hydrogen; or C 1 -C 5 alkyl; and R 2 and R 3 simultaneously are defined as for n = 1; if n = 3 one of R 2 , R 3 or T is a trivalent radical; if n = 4 one of R 2 , R 3 or T is a tetravalent radical; for protecting of human hair and skin against the damaging effect of UV radiation.

3. 发明申请

WO2006114381A1 USE OF BENZOTRIAZOLE DERIVATIVES FOR PHOTOSTABILISATION 审中-公开
标题翻译：苯并噻唑衍生物用于光化学的用途
公开(公告)号：WO2006114381A1
公开(公告)日：2006-11-02
申请号：PCT/EP2006/061686
申请日：2006-04-20
申请人： CIBA SPECIALTY CHEMICALS HOLDING INC. , MÜLLER, Stefan , GIESINGER, Jochen , EHLIS, Thomas , HERZOG, Bernd , KÖNIG, Peter , KREYER, Gilbert , QUASS, Katja
发明人： MÜLLER, Stefan , GIESINGER, Jochen , EHLIS, Thomas , HERZOG, Bernd , KÖNIG, Peter , KREYER, Gilbert , QUASS, Katja
IPC分类号： A61K8/49 , A61Q17/04
CPC分类号： A61Q17/04 , A61K8/496 , A61K2800/52
摘要： Use of benzotriazole derivatives of formula (1), wherein R 1 is C 1 -C 30 alkyl; C 1 C 5 alkoxy; C 1 -C 5 alkoxycarbonyl; C 5 -C 7 cycloalkyl; C 6 -C 10 aryl; aralkyl; -SO 3 M; a radical of formula (1a) R 3 is hydrogen; C 1 C 5 alkyl; C 1 C 5 alkoxy; halogen, preferably Cl; or hydroxy; R 4 and R 5 are each independently of the other hydrogen; or d-C 5 alkyl; m is 1 or 2; n is O or 1 ; if m = 1 , R 2 is hydrogen; unsubstituted or phenyl-substituted d-C 1 -C 12 alkyl; or C 6 -C 10 aryl; if m = 2, R2 is the direct bond; or -(CH 2 ) P -; and p is 1 to 3; for enhancing the photostability of cosmetic or dermatologic compositons comprising at least one further organic UV absorber.
摘要翻译：式（1）的苯并三唑衍生物的用途，其中R 1是C 1 -C 30烷基; ç_{1 C _{5 烷氧基; ç_{1 -C _{5 烷氧基羰基; ç_{5 -C _{7 环烷基; ç_{6 -C _{10 芳基; 芳; -SO _{3 米; 式（1a）R 3的基团是氢; ç_{1 C _{5 烷基; ç_{1 C _{5 烷氧基; 卤素，优选Cl; 或羟基; R 4和R 5各自独立地为氢; 或C 1 -C 5烷基; m为1或2; n为0或1; 如果m = 1，R 2是氢; 未取代或苯基取代的C 1 -C 12烷基; 或C 6 -C 10芳基; 如果m = 2，则R2是直接键; 或 - （CH 2）2 - 。 p为1〜3; 用于增强包含至少一种其它有机UV吸收剂的化妆品或皮肤病学组合物的光稳定性。}}}}}}}}}}}}}

4. 发明申请

WO2008090066A2 STABILIZATION OF UV-SENSITIVE ACTIVE INGREDIENTS 审中-公开
标题翻译：紫外线敏感活性成分的稳定性
公开(公告)号：WO2008090066A2
公开(公告)日：2008-07-31
申请号：PCT/EP2008/050440
申请日：2008-01-16
申请人： CIBA HOLDING INC. , WAGNER, Barbara , HERZOG, Bernd , MÜLLER, Stefan , EHLIS, Thomas
发明人： WAGNER, Barbara , HERZOG, Bernd , MÜLLER, Stefan , EHLIS, Thomas
IPC分类号： A61K8/41 , A61K8/44 , A61K8/49 , A61Q17/04
CPC分类号： A61K8/41 , A61K8/35 , A61K8/44 , A61K2800/52 , A61Q5/00 , A61Q5/02 , A61Q5/04 , A61Q5/06 , A61Q5/12 , A61Q17/04 , A61Q19/004 , A61Q19/04
摘要： Disclosed is the use of merocyanine derivatives of formula (1) for stabilizing UV-sensitive active ingredients like dibenzoylmethane derivatives.
摘要翻译：公开了式（1）的部花青衍生物用于稳定紫外线敏感活性成分如二苯甲酰甲烷衍生物的用途。

5. 发明申请

WO2012052499A1 USE OF SILANE AND SILOXANE BIS(BIPHENYL)TRIAZINE DERIVATIVES AS UV ABSORBERS 审中-公开
标题翻译：使用硅烷和硅氧烷双（BIPHENYL）TRIAZINE衍生物作为紫外线吸收剂
公开(公告)号：WO2012052499A1
公开(公告)日：2012-04-26
申请号：PCT/EP2011/068303
申请日：2011-10-20
申请人： BASF SE , WAGNER, Barbara , HERZOG, Bernd
发明人： WAGNER, Barbara , HERZOG, Bernd
IPC分类号： A61K8/58 , A61K8/898 , A61Q17/04
CPC分类号： A61K8/585 , A61K8/898 , A61Q17/04 , C07F7/0854
摘要： Disclosed is the use of silane and siloxane bis(biphenyl)triazine derivatives of formula (1), wherein n is a number from 1 to 4; if n = 1, X is * -L-Sil; or a radical of formula (11'), L is a linker selected from a radical of formula (2); R1, R2, R3 independently from each other are C1-C 22 alkyl; C 6 -C 20 aryl; C 1 -C 22 alkoxy; or O-C 6 -C 20 aryl; R4, R5, R6 and R7 independently from each other are hydrogen; C 1 -C 22 alkyl; C 6 -C 20 aryl; C 1 - C 22 alkoxy; or O-C 6 -C 20 aryl; b is a number from 0 to 30; c is a number from 0 to 6; and d is a number from 0 to 1; p is a number from 1 to 250; q is a number from 0 to 250; and Sil, Sil 1 and Sil 2 independently from each other are a a silane-, oligosiloxane or polysiloxane moiety; if n = 2, X is a bivalent radical of formula (1a); or (1b); x is a number from 2 to 250; y is a number from 0 to 250; and z is a number from 1 to 50; if n = 3, X is a trivalent radical containing a silane-, oligosiloxane or polysiloxane moiety; If n = 4, X is a tetravalent radical of formula (1c); and A is a radical of formula (111') as UV absorbers.
摘要翻译：公开了式（1）的硅烷和硅氧烷双（联苯）三嗪衍生物的用途，其中n为1至4的数; 如果n = 1，X为* -L-Sil; 或式（11'）的基团，L是选自式（2）的基团的连接基团; R 1，R 2，R 3彼此独立地为C 1 -C 22烷基; C6-C20芳基; C1-C22alkoxy; 或O-C6-C20芳基; R4，R5，R6和R7彼此独立地是氢; C1-C22烷基; C6-C20芳基; C 1 -C 22烷氧基; 或O-C6-C20芳基; b是从0到30的数字; c是从0到6的数字; d为0〜1的数; p是从1到250的数字; q是从0到250的数字; 和Sil，Sil1和Sil2彼此独立地是硅烷，低聚硅氧烷或聚硅氧烷部分; 如果n = 2，X是式（1a）的二价基团; 或（1b）; x是从2到250的数字; y是从0到250的数字; z为1〜50的数; 如果n = 3，X是含有硅烷，低聚硅氧烷或聚硅氧烷部分的三价基团; 如果n = 4，X是式（1c）的四价基团; 并且A是作为UV吸收剂的式（111'）基团。

6. 发明申请

WO2009156324A2 USE OF BENZOTROPOLONE DERIVATIVES AS UV ABSORBERS AND ANTIOXIDANTS AND THEIR USE IN SUNSCREENS AND/OR COSMETIC COMPOSITIONS 审中-公开
标题翻译：作为紫外线吸收剂和抗氧化剂的苯并吡喃酮衍生物的使用及其在SUNSCREENS和/或化妆品组合物中的应用
公开(公告)号：WO2009156324A2
公开(公告)日：2009-12-30
申请号：PCT/EP2009/057587
申请日：2009-06-18
申请人： BASF SE , WAGNER, Barbara , ÖHRLEIN, Reinhold , HERZOG, Bernd , EICHIN, Kai , BAISCH, Gabriele , PORTMANN, Stephanie
发明人： WAGNER, Barbara , ÖHRLEIN, Reinhold , HERZOG, Bernd , EICHIN, Kai , BAISCH, Gabriele , PORTMANN, Stephanie
IPC分类号： A61Q17/00 , A61Q17/04 , A61K8/35 , C07C49/717 , C07H15/203 , C07D311/02
CPC分类号： A61Q17/04 , A61K8/35 , A61Q19/08 , C07C49/747 , C07C62/38 , C07C69/712 , C07C69/757 , C07C305/18 , C07C2602/12 , C07F9/4006 , C07H15/18 , C07H15/203 , C07H15/26
摘要： Described is the use of benzotropolone and their derivatives, especially the compounds of formula (1); wherein R 2 , R 3 , R 4 , R 5 and R 6 independently of one another are hydrogen; OH; C 1 -C 30 alkyl, C 2 -C 30 al- kenyl, C 1 -C 30 alkoxy, C 3 -C 12 cycloalkyl or C 1 C 30 hydroxyalkyl, which may be substituted by one or more E and/or interrupted by one or more D; C 6 -C 20 aryl, which may be substitu¬ ted by one or more G; C 4 -C 20 heteroaryl, which may be substituted by one or more G, C 2 - C 18 alkenyl, C 2 -C 18 alkynyl, C 7 -C 25 aralkyl, CN, or -CO-R 17 ; C 1 -C 30 mono- or dialkylamino; COR 9 ; COOR 9 ; CONR 9 R 10 ; CN; SO 2 R 9 ; OCOOR 9 ; OCOR 9 ; NHCOOR 9 ; NR 9 COR 10 ; NH 2 ; *-(CO)-NH-(CH 2 ) n1 -(PO)-(OR 11 ) 2 ; -(CO)-O-(CH 2 ) n1 -(PO)-(OR 11 ) 2 ; sulphate; sulphonate; phosphate; phosphonate; -(CH 2 ) n2 -[O-(SO 2 )] n3 -OR 11 ; -O-(CH 2 ) n4 (CO) n5 -R 11 ; -(O) n6 -(CH 2 ) n7 -(PO)-(OR 9 ) 2 ; -(O) n6 -(CH 2 ) n7 -SO 2 -OR 9 ; halogen; organosilanyl; organo- siloxanyl; or a sugar residue linked directly in an α- or β-mode via the anomeric oxygen to the benzotropolone system or via a linear or branched alkylene, alkenylene, alkadiene or alkatriene spacer (sugar- (CH 2 ) n -(X 1 ) 1 or 0 -benzotropolone system, wherein n = 1 -10 and X 1 = -0-; -(CO)-; -0-C0-; -COO-, -NH-; -S-; -SO 2 -); R 1 , R 7 and R 8 independently of one another are hydrogen; C 1 C 12 alkyl or C 3 -C 12 -cycloalkyl, which may be substituted by one or more E and/or interrupted by one or more D; C 6 - C 20 aryl, which may be substituted by one or more G; C 4 -C 20 heteroaryl, which may be substituted by one or more G, C 2 -C 18 alkenyl, C 2 -C 18 alkynyl, C 7 -C 25 aralkyl, or COOR 9 ; COR 9 ; CONR 9 R 10 ; SO 3 R 9 ; SO 2 R 9 ; PO 3 (R 9 ) 2 ; PO 2 (R 9 ) 2 ; organosilanyl; organosiloxanyl; or a sugar residue linked directly in an α- or β-mode via the anomeric oxygen to the benzotropolone system or via a linear or branched alkylene, alkenylene, alkadiene or alkatriene spacer (sugar-(CH 2 ) n -(X 2 ) 1 or 0 -*, wherein n = 1 -10 and X 2 = -C(=0)-; -0-C0-*); R 9 and R 10 independently from each other are hydrogen; C 1 C 18 alkyl or C 3 -C 12 -cycloalkyl which may be substituted by one or more E and/or interrupted by one or more D; C 6 - C 20 aryl, which may be substituted by one or more G; C 4 -C 20 heteroaryl, which may be substituted by one or more G; organosilanyl; organosiloxanyl; or a sugar residue linked directly in an α- or β-mode via the anomeric oxygen or via a linear or branched alkylene, alkenylene, alkadiene or alkatriene spacer (sugar- (CH 2 ) n -*, wherein n = 1 -10); or R 9 and R 10 together form a five or six membered ring, R 11 is hydrogen; or C 1 -C 5 alkyl; n 1 , n 2 , n 4 and n 7 independently from each other are a number from 1 to 5; n 3 , n 5 and n 6 independently from each other are a 0; or 1; D is -CO-; -COO-; -S-; -SO-; -SO2-; -O-; -NR 14 -; -S 1 R 19 R 20 -; -POR 11 -; -CR 12 =CR 13 -; or -C≡C-; and E is -0R 18 ; -SR 18 ; -NR 14 R 15 ; -NR 14 COR 15 ; -C0R 17 ; -COOR 16 ; -CONR 14 R 15 ; -CN; halogen; Or SO 3 R 18 ; SO 2 R 18 ; PO 3 (R 18 ) 2 ; PO 2 (R 18 ) 2 ; organosilanyl; organosiloxanyl; or a sugar residue linked directly in an α- or β-mode via the anomeric oxygen or via a linear or branched alkylene, alkenylene, alkadiene or alkatriene spacer (sugar- (CH 2 )n-(X 1 ) 1 or 0 -*, wherein n = 1 -10 and X1 = -0-; -C(=0)-; -0-C0-; -COO-; -NH-; -S-; -SO 2 -); G is E; C 1 -C 18 alkyl, which is optionally interrupted by D; C 1 -C 18 perfluoroalkyl; C 1 -C 18 alkoxy, which is optionally substituted by E and/or interrupted by D; wherein R 12 , R 13 , R 14 and R 15 independently of each other are hydrogen; C 6 -C 18 aryl which is optionally substituted by OH, C 1 -C 18 alkyl or C 1 -C 18 alkoxy; C 1 -C 18 alkyl, which is optionally interrupted by -O-; or Ri4 and Ri5 together form a five or six membered ring, Ri6 is hydrogen; C6-Ci8aryl which is optionally substituted by OH, C 1 -C 18 alkyl or d- C 18 alkoxy; C 1 -C 18 alkyl which is optionally interrupted by -O-; R 17 is H; C 6 -C 18 aryl which is optionally substituted by OH, C 1 -C 18 alkyl or C 1 -C 18 alkoxy; or d- C 18 alkyl which is optionally interrupted by -O-; R 18 is hydrogen; C 6 -C 18 aryl, which is optionally substituted by OH, C 1 -C 18 alkyl or d- C 18 alkoxy; C 1 -C 18 alkyl, which is optionally interrupted by -O-; R 19 and R 20 independently of each other are hydrogen; C 1 -C 18 alkyl; C 6 -C 18 aryl which is optionally substituted by C 1 -C 18 alkyl; and R 21 is C 1 -C 18 alkyl; or C 6 -C 18 aryl, which is substituted by C 1 -C 18 alkyl; * means, that this radical is directed to the benzotropolone moiety; for the protection of human and animal hair and skin against UV radiation.
摘要翻译：描述了苯佐龙醇及其衍生物，特别是式（1）的化合物的用途; 其中R2，R3，R4，R5和R6彼此独立地是氢; 哦; C 1 -C 30烷基，C 2 -C 30亚烯基，C 1 -C 30烷氧基，C 3 -C 12环烷基或C 1 -C 30羟烷基，其可以被一个或多个E取代和/或被一个或多个D中断; 可以被一个或多个G取代的C 6 -C 20芳基; 可以被一个或多个G，C 2 -C 18烯基，C 2 -C 18炔基，C 7 -C 25芳烷基，CN或-CO-R 17取代的C 4 -C 20杂芳基; C 1 -C 30单 - 或二烷基氨基; COR 9; COOR9; CONR9R10; CN; SO 2 R 9; OCOOR9; OCOR9; NHCOOR9; NR9COR10; NH2; * - （CO）-NH-（CH 2）N 1 - （PO） - （OR 11）2; - （CO）-O-（CH 2）N 1 - （PO） - （OR 11）2; 硫酸盐; 磺酸盐; 磷酸盐; 膦酸盐; - （CH 2）N 2 - [O-（SO2）] N3-OR11; -O-（CH2）N4（CO）N5-R11; - （O）N 6 - （CH 2）N 7 - （PO） - （OR 9）2; - （O）N 6 - （CH 2）N7-SO2-OR 9; 卤素; organosilanyl; 有机硅氧烷基或通过异头氧直接连接到苯佐洛酮系统或通过直链或支链亚烷基，亚烯基，链二烯或烷基三烯间隔物（糖 - （CH 2）n - （X1）1或O - 苯并异噻唑酮系统，其中n = 1-10且X1 = -0-; - （CO） - ; -O-C0-; -COO-，-NH-; -S-; -SO2-）; R 1，R 7和R 8彼此独立地是氢; C 1 -C 12烷基或C 3 -C 12环烷基，其可以被一个或多个E取代和/或被一个或多个D中断; 可以被一个或多个G取代的C 6 -C 20芳基; 可以被一个或多个G，C 2 -C 18烯基，C 2 -C 18炔基，C 7 -C 25芳烷基或COOR 9取代的C 1 -C 20杂芳基; COR 9; CONR9R10; SO3R9; SO 2 R 9; PO3（R 9）2; PO2（R 9）2; organosilanyl; 有机硅氧烷; 或直链或α-支链的亚烷基，链烯二烯或三亚胺间隔基（糖 - （CH 2）n - （X 2）1或O - *，其中n = 1-10，X2 = -C（= O） - ; - O-C0- *）; R9和R10彼此独立地是氢; 可以被一个或多个E取代和/或被一个或多个D中断的C 1 -C 18烷基或C 3 -C 12 - 环烷基; 可以被一个或多个G取代的C 6 -C 20芳基; 可以被一个或多个G取代的C 4 -C 20杂芳基; organosilanyl; 有机硅氧烷; 或通过端基异构体氧或经由直链或支链的亚烷基，亚烯基，链二烯或烷基三烯间隔物（糖 - （CH 2）n - ），其中n = 1-10）直接连接在α-或β-模式中的糖残基; 或R 9和R 10一起形成五元或六元环，R 11为氢; 或C 1 -C 5烷基; n1，n2，n4和n7彼此独立地为1至5的数; n3，n5和n6彼此独立地为0; 或1; D是-CO-; -COO-; -S-; -所以-; -SO2-; -O-; NR 14; -S1R19R20-; -POR11-; -CR12 = CR13-; 或-C = C-; E为-0R18; -SR18; -NR14R15; -NR14COR15; -C0R17; -COOR16; -CONR14R15; -CN; 卤素; 或SO3R18; SO2R18; PO3（R18）2; PO2（R18）2; organosilanyl; 有机硅氧烷; 或通过异头氧直接或通过直链或支链亚烷基，亚烯基，链二烯或烷三胺间隔基（糖 - （CH 2）n - （X1）1或0- *）直接连接在α-或β-模式上的糖残基，其中 n = 1-10且X1 = -0-; -C（= O） - ; - O-O-COO-; -NH-; -S-; -SO2-）; G是E 任选地被D中断的C 1 -C 18烷基; C1-C18perfluoroalkyl; 任选被E取代和/或被D中断的C1-C18烷氧基; 其中R 12，R 13，R 14和R 15彼此独立地是氢; 任选被OH，C 1 -C 18烷基或C 1 -C 18烷氧基取代的C 6 -C 18芳基; 任选地被-O-间隔的C 1 -C 18烷基; 或R 14和R 15一起形成五或六元环，R 6是氢; 任选被OH，C 1 -C 18烷基或C 1 -C 18烷氧基取代的C 6 -C 18芳基; 任选被-O-间隔的C 1 -C 18烷基; R17为H; 任选被OH，C 1 -C 18烷基或C 1 -C 18烷氧基取代的C 6 -C 18芳基; 或任选被-O-中断的C 1 -C 18烷基; R18是氢; 任选被OH，C 1 -C 18烷基或C 1 -C 18烷氧基取代的C 6 -C 18芳基; 任选地被-O-间隔的C 1 -C 18烷基; R 19和R 20彼此独立地是氢; C1-C18烷基; 任选被C 1 -C 18烷基取代的C 6 -C 18芳基; 和R 21是C 1 -C 18烷基; 或被C 1 -C 18烷基取代的C 6 -C 18芳基; *表示该基团针对苯佐洛尔酮部分; 用于保护人和动物的头发和皮肤免受紫外线辐射。

7. 发明申请

WO2012034932A1 USE OF SPECIFIC BIS(BIPHENYL)TRIAZINE DERIVATIVES AND MIXTURES THEREOF AS UV ABSORBERS 审中-公开
标题翻译：特异性双（BIPHENYL）TRIAZINE衍生物及其作为紫外吸收剂的混合物的使用
公开(公告)号：WO2012034932A1
公开(公告)日：2012-03-22
申请号：PCT/EP2011/065604
申请日：2011-09-09
申请人： BASF SE , WAGNER, Barbara , HERZOG, Bernd
发明人： WAGNER, Barbara , HERZOG, Bernd
IPC分类号： A61K8/49 , A61Q17/04
CPC分类号： A61K8/4966 , A61K2800/5922 , A61Q17/04
摘要： Disclosed is the use of mixtures comprising at least 2 structurally different bis(biphenyl)triazine derivatives of formula (1) wherein X is hydrogen; C 1 -C 50 alkyl which may be uninterrupted or interrupted by one or more oxygen atoms and/or substituted by one or more R 8 groups; C 3 -C 12 -cycloalkyl which is substituted by R 8 ; -CH((CH 2 ) p -R 8 )-CO-0-(CH 2 ) m -R 9 ; -CH((CH 2 ) p -R 8 )-CO-(NR 10 )-(CH 2 ) m -R 9 ; (a); (b); -CO-(CH 2 ) p -R 8 ; -CO-O-(CH 2 ) p -R 8 ; -CH 2 -CH(-O(CO)-R 8 )-R 9 ; -CO-(NR 10 )-(CH 2 ) P -R 8 ; C 6 -C 20 aryl; allyl; C 4 -C 50 alkenyl which is uninterrupted or is interrupted by one or more oxygen atoms; C 3 -C 12 cycloalkyl which is uninterrupted or interrupted by one or more oxygen atoms; C 3 -C 20 alkynyl; C 6 -C 12 cycloalkynyl; R 1 is hydrogen; unsubstituted or substituted C 1 -C 12 alkyl; unsubstituted or substituted C 3 -C 12 cycloalkyl; unsubstituted or substituted C 6 -C 20 aryl; unsubstituted or substituted C 2 -C 20 alkenyl; OR 7 ; OH; SR 8 ; SOR 7 ; SO 2 R 7 ; SO 3 H; SO 3 M; or a radical of the formula (c); R 2 , R 3 , R 4 , R 5 and R 6 independently of one another are hydrogen; hydroxyl; -CN; substituted or unsubstituted C 1 -C 20 alkyl; unsubstituted or substituted C 3 -C 12 -cycloalkyl; unsubstituted or substituted C 1 -C 18 alkoxy; unsubstituted or substituted C 4 -C 20 cycloalkoxy; C 7 -C 20 phenylalkyl; halogen; halo-C 1 -C 5 alkyl; sulfonyl; carboxyl; acylamino; acyloxy; C 1 -C 12 alkoxycarbonyl; aminocarbonyl; R 7 is substituted or unsubstituted C 1 -C 18 alkyl; unsubstituted or substituted C 3 -C 12 - cycloalkyl; unsubstituted or substituted C 6 -C 20 aryl; unsubstituted or substituted C 2 -C 20 alkenyl; or C 7 -C 20 phenylalkyl; M is alkali metal; R 8 and R 9 independently of one another are R x if attached to a carbon atom and are R y if attached to an oxygen atom; p is 0 to 20; m is 0 to 20; R x is hydrogen; hydroxyl; C 1 -C 30 alkyl; C 3 -C 12 cycloalkyl; C 1 -C 30 alkoxy; C 3 -C 12 cycloalkoxy; C 3 -C 12 cycloalkyl or C 3 -C 12 cycloalkoxy which is interrupted by one or more oxygen atoms; C 6 -C 12 aryl; hetero-C 3 -C 12 aryl; -OR z ; NHR Z ; R z ; CONR 10 R 11 ; SO 3 H; SO 3 M; OSO 3 H 2 ; allyl, C 2 -C 30 alkenyl; C 4 -C 12 -cycloalkenyl which is uninterrupted or interrupted by one or more oxygen atoms; C 3 -C 20 -alkynyl; or C 6 -C 12 cycloalkynyl; R y is hydrogen; C 1 -C 30 alkyl; C 3 -C 12 cycloalkyl which is uninterrupted or interrupted by one or more oxygen atoms; C 6 -C 12 aryl; hetero-C 3 -C 12 aryl; R z ; allyl, C 2 -C 30 alkenyl; C 4 -C 12 -cycloalkenyl which is uninterrupted or interrupted by one or more oxygen atoms; C 3 -C 20 -alkynyl; or C 6 -C 12 cycloalkynyl; R z is -COR 10 ; -COOR 10 ; -CONR 10 R 11 ; -CO-CH=CH 2 ; -CO-C(CH 3 )=CH 2 ; R 10 and R 11 independently of one another are hydrogen; C 1 -C 30 alkyl; C 1 -C 50 alkyl which is interrupted by one or more oxygen atoms; C 3 -C 12 cycloalkyl which is uninterrupted or interrupted by one or more oxygen atoms; C 2 -C 20 alkenyl which is uninterrupted or is interrupted by one or more oxygen atoms; or C 6 -C 12 aryl; or R 10 and R 11 together form a five or six membered ring; as UV absorbers for increasing the UVA protection factor of cosmetic or dermatological compositions.
摘要翻译：公开了使用包含至少2种结构不同的式（1）的双（联苯）三嗪衍生物的混合物，其中X是氢; 可以不间断或被一个或多个氧原子中断和/或被一个或多个R 8基团取代的C 1 -C 50烷基; 由R8取代的C 3 -C 12 - 环烷基; -CH（（CH 2）p-R8）-CO-O-（CH 2）M-R9; -CH（（CH 2）p-R8）-CO-（NR10） - （CH 2）M-R9; （一个）; （B）; -CO-（CH 2）p-R8; -CO-O-（CH 2）p-R8; -CH 2 CH（-O（CO）-R 8）-R 9; -CO-（NR10） - （CH 2）p-R8; C6-C20芳基; 烯; 不间断或被一个或多个氧原子中断的C 4 -C 50烯基; 不间断或被一个或多个氧原子中断的C 3 -C 12环烷基; C3-C20alkynyl; C6-C12cycloalkynyl; R1是氢; 未取代或取代的C 1 -C 12烷基; 未取代或取代的C 3 -C 12环烷基; 未取代或取代的C6-C20芳基; 未取代或取代的C 2 -C 20烯基; OR7; 哦; SR8; SOR7; SO 2 R 7; SO3H; SO3M; 或式（c）的基团; R2，R3，R4，R5和R6彼此独立地是氢; 羟; -CN; 取代或未取代的C 1 -C 20烷基; 未取代或取代的C 3 -C 12 - 环烷基; 未取代或取代的C 1 -C 18烷氧基; 未取代或取代的C 4 -C 20环烷氧基; C7-C20phenylalkyl; 卤素; 卤代-C 1 -C 5烷基; 磺酰基; 羧基; 酰氨基; 酰氧基; C1-C12alkoxycarbonyl; 羰基; R7是取代或未取代的C1-C18烷基; 未取代或取代的C 3 -C 12 - 环烷基; 未取代或取代的C6-C20芳基; 未取代或取代的C 2 -C 20烯基; 或C7-C20苯基烷基; M是碱金属; R 8和R 9彼此独立地是Rx，如果连接到碳原子，并且如果连接到氧原子，则为R y; p为0〜20; m为0〜20; Rx是氢; 羟; C1-C30烷基; C3-C12环烷基; C1-C30alkoxy; C3-C12cycloalkoxy; 被一个或多个氧原子中断的C 3 -C 12环烷基或C 3 -C 12环烷氧基; C6-12芳基; 杂-C 3 -C 12芳基; -ORz; NHRZ; RZ; CONR10R11; SO3H; SO3M; OSO3H2; 烯丙基，C 2 -C 30烯基; 不间断或被一个或多个氧原子中断的C 4 -C 12 - 环烯基; C3-C20炔基; 或C6-C12环炔基; Ry是氢; C1-C30烷基; 不间断或被一个或多个氧原子中断的C 3 -C 12环烷基; C6-12芳基; 杂-C 3 -C 12芳基; RZ; 烯丙基，C 2 -C 30烯基; 不间断或被一个或多个氧原子中断的C 4 -C 12 - 环烯基; C3-C20炔基; 或C6-C12环炔基; Rz是-COR10; -COOR10; -CONR10R11; -CO-CH = CH 2; -CO-C（CH 3）= CH 2; R 10和R 11彼此独立地是氢; C1-C30烷基; 被一个或多个氧原子中断的C 1 -C 50烷基; 不间断或被一个或多个氧原子中断的C 3 -C 12环烷基; 不间断或被一个或多个氧原子中断的C 2 -C 20烯基; 或C6-C12芳基; 或R 10和R 11一起形成五元或六元环; 作为用于增加化妆品或皮肤病学组合物的UVA保护因子的UV吸收剂。

8. 发明申请

WO2003075875A1 UV ABSORBER COMPOSITIONS COMPRISING A HYDROXYPHENYLTRIAZINE COMPOUND 审中-公开
标题翻译：含有羟基苯乙烯化合物的紫外线吸收剂组合物
公开(公告)号：WO2003075875A1
公开(公告)日：2003-09-18
申请号：PCT/EP2003/002200
申请日：2003-03-04
申请人： CIBA SPECIALTY CHEMICALS HOLDING INC. , HAASE, Jürg , EHLIS, Thomas , BORSOS, Elek , HÜGLIN, Dietmar , HERZOG, Bernd
发明人： HAASE, Jürg , EHLIS, Thomas , BORSOS, Elek , HÜGLIN, Dietmar , HERZOG, Bernd
IPC分类号： A61K7/42
CPC分类号： A61K8/4966 , A61Q17/04
摘要： UV absorber compositions are described, comprising (a) from 1 to 99 % by weight of a hydroxyphenyltriazine compound of formula (I) wherein R 1 , R 2 and R 3 are each independently of the others C 1 -C 18 alkyl; C 2 -C 10 ,alkenyl; or phenyl-C,-C 4 alkyl; R 4 is hydrogen; or C 1 -C 5 alkyl; and (b) from 99 to 1 % by weight of a further UV absorber selected from the group of (b) hydroxyphenyltriazines that are different from component (a), (b 2 ) benzotriazoles, (b 3 ) dibenzoylmethane derivatives and (b 4 ) camphor derivatives. The compositions are suitable as UV filters in cosmetic compositions.
摘要翻译：描述了紫外线吸收剂组合物，其包含（a）1至99重量％的式（I）的羟基苯基三嗪化合物，其中R 1，R 2和R 3各自独立地为C 1 -C 18烷基; C2-C10烯基; 或苯基-C 1 -C 4烷基; R4是氢; 或C 1 -C 5烷基; 和（b）99重量％至1重量％的另外的紫外线吸收剂，其选自（b）不同于组分（a），（b 2）苯并三唑，（b3）二苯甲酰甲烷衍生物和（b4）樟脑）的羟苯基三嗪衍生物。该组合物适用于化妆品组合物中的UV过滤器。

9. 发明申请

WO2008110465A1 COUMESTAN-LIKE ANTIOXIDANTS AND UV ABSORBANTS 审中-公开
标题翻译：类似氧化物的抗氧化剂和紫外线吸收剂
公开(公告)号：WO2008110465A1
公开(公告)日：2008-09-18
申请号：PCT/EP2008/052463
申请日：2008-02-29
申请人： CIBA HOLDING INC. , WAGNER, Barbara , MONGIAT, Sébastien , HERZOG, Bernd , BASCHONG, Werner , BUTHE, Andreas , ÖHRLEIN, Reinhold
发明人： WAGNER, Barbara , MONGIAT, Sébastien , HERZOG, Bernd , BASCHONG, Werner , BUTHE, Andreas , ÖHRLEIN, Reinhold
IPC分类号： A61Q17/04
CPC分类号： C07D493/04 , A61K8/4973 , A61K8/498 , A61K2800/522 , A61Q17/04 , C07D491/04
摘要： The present invention relates toderivatives of the 1H-pyrano[4,3-b]benzofuran-1-one structure and their nitrogen analogueswhichpossess powerful antioxidant properties combined with a highly effective UV absorbing functionality in one molecule.These compounds are especially useful in cosmetical and dermatological formulations.
摘要翻译：本发明涉及1H-吡喃并[4,3-b]苯并呋喃-1-酮结构的衍生物及其具有强大抗氧化性能的氮类似物，其与一个分子中的高效紫外吸收功能相结合。这些化合物特别适用于化妆品和皮肤科配方。

10. 发明申请

WO2007071582A1 MEROCYANINE DERIVATIVES 审中-公开
标题翻译：月桂酰胺衍生物
公开(公告)号：WO2007071582A1
公开(公告)日：2007-06-28
申请号：PCT/EP2006/069516
申请日：2006-12-11
申请人： CIBA SPECIALTY CHEMICALS HOLDING INC. , WAGNER, Barbara , WALTHER, Astrid , HERZOG, Bernd
发明人： WAGNER, Barbara , WALTHER, Astrid , HERZOG, Bernd
IPC分类号： C07C255/31 , C07C317/32 , A61K8/41 , A61Q17/04
CPC分类号： C07C317/44 , C07C255/31 , C07C2601/16
摘要： Disclosed are merocyanine derivatives of formula (1), wherein R 1 and R 2 independently from each other are branched C 4 -C 22 alkyl; or branched C 4 -C 12 alkenyl; R 3 and R 4 independently from each other are cyano; COR 7 , COOR 7 ; CONR 7 R 8 ; SO 2 (C 6 - C 12 )aryl; C 2 -C 12 alk-1-enyl; C 3 -C 12 cycloalk-1-enyl; C 2 -C 12 alk-1-inyl; C 2 -C 12 heteroalkyl; C 3 - C 5 heterocycloalkyl; C 6 -C 10 aryl; or C 1 -C 9 heteroaryl; wherein at least one of R 3 and R 4 is cyano; R 5 and R 6 independently from each other are hydrogen; C 1 -C 6 alkyl; C 5 -C 8 cycloalkyl which may be substituted by one or more than one C 1 -C 4 alkyl; and R 7 and R 8 independently from each other are hydrogen; C 1 -C 22 alkyl; C 2 -C 12 alkenyl; C 2 - C 12 alkinyl; C 3 -C 12 cycloalkyl; C 3 -C 12 cycloalkenyl; -(CH 2 ) t COOH; C 7 -C 12 aralkyl; C 1 - C 12 heteroalkyl; C 2 -C 11 heteroaralkyl; C 6 -C 10 aryl; C 1 -C 9 heteroaryl. The compounds are useful as UV absorbers for protecting human hair and skin against the damaging effect of UV radiation.
摘要翻译：公开了式（1）的部花青衍生物，其中R 1和R 2彼此独立地为支链C 1-4 - 22 烷基; 或支化C 4 -C 12链烯基; R 3和R 4彼此独立地是氰基; COR 7 7，COOR 7; CONR _{7 - [R _{8 ; SO 2（C 6 -C 12）芳基; ç_{2 -C _{12 烷-1-烯基; ç_{3 -C _{12 环烷-1-烯基; ç_{2 -C _{12 烷-1-炔; ç_{2 -C _{12 杂烷基; C 3 -C 5杂环烷基; ç_{6 -C _{10 芳基; 或C 1 -C 9 - 杂芳基; 其中R 3和R 4中的至少一个是氰基; R 5和R 6彼此独立地是氢; ç_{1 -C _{6 烷基; 可以被一个或多于一个C 1 -C 4 - 亚烷基取代的C 5 -C 8环烷基 ; 和R 7和R 8彼此独立地是氢; ç_{1 -C _{22 烷基; ç_{2 -C _{12 烯基; C 2 -C 12炔基; ç_{3 -C _{12 环烷基; ç_{3 -C _{12 环烯基; - （CH _{2 ）_{吨 COOH; ç_{7 -C _{12 芳烷基; C 1 -C 12 - 杂烷基; ç_{2 -C _{11 杂芳烷基; ç_{6 -C _{10 芳基; ç_{1 -C _{9 杂芳基。这些化合物可用作紫外线吸收剂，用于保护人体毛发和皮肤免受紫外线辐射的破坏作用。}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}

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