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    • 5. 发明申请
    • SUNSCREEN COMPOSITIONS
    • SUNSCREEN组合物
    • WO1997003642A1
    • 1997-02-06
    • PCT/EP1996003043
    • 1996-07-11
    • CIBA SC HOLDING AGSTEHLIN, AlbertKREYER, GilbertLUTHER, Helmut
    • CIBA SC HOLDING AG
    • A61K07/42
    • A61Q17/04A61K8/4966
    • The present invention provides a solution, suitable for use in pharmaceutical or cosmetic compositions, comprising a) 1-40 % by weight of a compound having formula (1), in which R1, R2 and R3, independently, are H, OH, C1-C18alkoxy, NH2, NH-R4 or N(R4)2 in which R4 is C1-C18alkyl, OR4 in which R4 has its previous significance, phenyl, phenoxy or anilino, or pyrrolo, in which the respective phenyl or pyrrolo moieties are optionally substituted by one, two or three substituents selected from OH, carboxy, C1-C18alkyl or -alkoxy, C1-C18carboxyalkyl, C5-C8cycloalkyl, a methylidenecamphor group, a group -(CH=CH)nC(=O)-OR4 in which n is 0 or 1 and R4 has its previous significance or a group (a) or the corresponding alkali metal, ammonium, mono-, di- or tri-C1-C4alkylammonium, mono-, di- or tri-C2-C4alkanolammonium salts, or the C1-C18alkyl esters thereof; dissolved in b) a solvent selected from i) a C1-C8alkyl ester of a (hydroxy)polycarboxylic acid, with the exclusion of dioctyl malate; ii) a butylether; iii) an ester of a butyl ether; iv) an alcohol; v) a Guerbet alcohol; and vi) a di-(C1-C4alkyl)amide of an arylcarboxylic acid.
    • 本发明提供一种适用于药物或化妆品组合物的溶液,其包含a)1-40重量%的具有式(1)的化合物,其中R 1,R 2和R 3独立地是H,OH,C 1 -C 1-4烷氧基,NH 2,NH-R 4或其中R 4为C 1 -C 18烷基的N(R 4)2,其中R 4具有其先前含义的OR 4,苯基,苯氧基或苯胺基或吡咯基,其中各自的苯基或吡咯基部分是任选的 被一个,两个或三个选自OH,羧基,C 1 -C 18烷基或烷氧基,C 1 -C 18烃基烷基,C 5 -C 8环烷基,亚甲基or基, - (CH = CH)nC(= O)-OR 4的取代基取代,其中 n为0或1,R4为其先前的含义或基团(a)或相应的碱金属,铵,一,二或三-C 1 -C 4烷基铵,单 - ,二 - 或三-C2-链烷醇铵盐, 或其C1-C18烷基酯; 溶于b)选自i)(羟基)多元羧酸的C 1 -C 8烷基酯,除去苹果酸二辛酯的溶剂; ii)丁醚; iii)丁基醚的酯; iv)酒精; v)一个Guerbet酒; 和vi)芳基羧酸的二 - (C 1 -C 4烷基)酰胺。