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1. 发明授权

US06833143B1 Process for the preparation of a extract rich in bacosides from the herb Bacopa monniera 失效
标题翻译：从草药Bacopa monniera制备富含芽孢杆菌的提取物的方法
公开(公告)号：US06833143B1
公开(公告)日：2004-12-21
申请号：US10400192
申请日：2003-03-26
申请人： Atul Prakash Kahol , Tarun Singh , Sudeep Tandon , Madan Mohan Gupta , Suman Preet Singh Khanuja
发明人： Atul Prakash Kahol , Tarun Singh , Sudeep Tandon , Madan Mohan Gupta , Suman Preet Singh Khanuja
IPC分类号： A61K3578
CPC分类号： A61K36/80
摘要： The present invention provides a novel process for the preparation of bacosides enriched fraction in a non-hygroscopic form the extract of Bacopa monniera, the said process comprising the steps of drying freshly harvested herb in a hot air oven at 37-42° C., powdering and sieving the dried herb to obtain powder of 30-40 mesh size, defatting the powdered herb with hexane in a modified soxhlet extractor, extracting the defatted powdered herb with acetone, again extracting the same herb with methanol to obtain an extract containing bacosides, concentrating the extract to one twentieth of its original volume under reduced pressure, gradually adding the concentrated extract to acetone for precipitating the bacosides, filtering the bacosides in a Nutsche type vacuum filter, dissolving the crude bacoside mass into 2-10 parts water, extracting the bacoside solution with n-butanol to selectively transfer the bacosides to the solvent phase, separating and concentrating the solvent phase under vacuum to obtain semi-dry mass, dissolving the semi dried mass into 2-10 parts water, adding and stirring 1-5% of &bgr;-cyclodextrin to stabilize the bacosides, spray drying the stabilized bacoside solution by maintaining hot air temperature at 90-110° C., to obtain a stable free flowing fraction of Bacopa monniera rich in bacosides.
摘要翻译：本发明提供了一种用于制备以非吸湿形式的Bacopa monniera提取物富集杆菌的部分的新方法，所述方法包括以下步骤：在37-42℃的热空气烘箱中干燥新鲜收获的草本植物，粉碎和筛分干草，得到30-40目尺寸的粉末，用改性索氏提取器用己烷脱脂粉末，用丙酮提取脱脂粉末草药，再次用甲醇提取相同的草本，得到含有药剂的提取物，将提取物在减压下浓缩至其原始体积的二十分之一，逐渐将浓缩提取物加入到丙酮中沉淀芽孢杆菌，过滤Nutsche型真空过滤器中的芽孢杆菌，将粗制药物块溶解在2-10份水中，使用正丁醇选择性转移杆菌苷至溶剂相，分离和浓缩溶剂相获得半干质量，将半干质量溶解在2-10份水中，加入并搅拌1-5％的β-环糊精以稳定芽孢杆菌，通过将热空气温度保持在90℃喷雾干燥稳定的bacoside溶液， 110℃，以获得富含芽孢杆菌的Bacopa monniera的稳定的自由流动分数。

2. 发明授权

US06830765B2 Green tea extract for treating obesity 有权
标题翻译：用于治疗肥胖症的绿茶提取物
公开(公告)号：US06830765B2
公开(公告)日：2004-12-14
申请号：US10274888
申请日：2002-10-22
申请人： Max Rombi
发明人： Max Rombi
IPC分类号： A61K3578
CPC分类号： A61K36/82 , A23F3/18 , A23F3/28 , A61K2300/00
摘要： The invention relates to a composition for the treatment of obesity, comprising a catechol-rich extract of green tea, in particular containing from 20% to 50% by mass of catechols expressed as epigallocatechol gallate (EGCG).
摘要翻译：本发明涉及一种用于治疗肥胖症的组合物，其包含富含儿茶酚的富茶提取物，特别是含有20％至50质量％的表没食子儿茶素没食子酸酯（EGCG）的邻苯二酚。

3. 发明授权

US06827951B2 Composition and method for smoke detoxification 有权
标题翻译：烟雾排毒的组成和方法
公开(公告)号：US06827951B2
公开(公告)日：2004-12-07
申请号：US10058299
申请日：2002-01-30
申请人： Thomas Newmark , Paul Schulick
发明人： Thomas Newmark , Paul Schulick
IPC分类号： A61K3578
CPC分类号： A61K36/61 , A61K36/23 , A61K36/53 , A61K36/534 , A61K36/82 , A61K36/9066 , A61K36/9068 , A61K2300/00
摘要： A method is provided for effecting smoke detoxification in a human by using a composition that is made of effective amounts of supercritical extract and hydroalcoholic extract of turmeric.
摘要翻译：提供了一种通过使用由有效量的超临界萃取物和姜黄的醇醇提取物制成的组合物来实现人体中烟雾解毒的方法。

4. 发明授权

US06825173B2 Preparation of fagopyritols and uses therefor 有权
标题翻译：吡唑并吡唑的制备及其用途
公开(公告)号：US06825173B2
公开(公告)日：2004-11-30
申请号：US10193456
申请日：2002-07-10
申请人： Ralph L. Obendorf , Marcin Horbowicz
发明人： Ralph L. Obendorf , Marcin Horbowicz
IPC分类号： A61K3578
CPC分类号： C07H15/207 , A61K31/70 , C07H1/08 , Y10S514/866 , A61K2300/00
摘要： The present invention describes isolated Fagopyritol A1, isolated Fagopyritol A3, and isolated Fagopyritol B3. Compositions which include two or more of Fagopyritol A1, Fagopyritol A2, Fagopyritol A3, Fagopyritol B1, Fagopyritol B2, Fagopyritol B3, and D-chiro-inositol, at least one of which is an isolated Fagopyritol A1, isolated Fagopyritol A3, or isolated Fagopyritol B3, are also disclosed. Methods for preparing substantially pure Fagopyritol A1, Fagopyritol A3, Fagopyritol B3, or mixtures thereof from buckwheat are also described. The fagopyritols can be used to prepare pharmaceutical compositions, the administration of which can be used to treat diabetes.
摘要翻译：本发明描述了分离的Fagopyritol A1，分离的Fagopyritol A3和分离的Fagopyritol B3。包含Fagopyritol A1，Fagopyritol A2，Fagopyritol A3，Fagopyritol B1，Fagopyritol B2，Fagopyritol B3和D-手性肌醇两种或更多种的组合物，其中至少一种是分离的Fagopyritol A1，分离的Fagopyritol A3或分离的Fagopyritol B3也被公开。还描述了从荞麦制备基本上纯的Fagopyritol A1，Fagopyritol A3，Fagopyritol B3或其混合物的方法。吡咯并吡喃可用于制备药物组合物，其施用可用于治疗糖尿病。

5. 发明授权

US06814986B1 Composition for treating obesity and esthetic treatment process 有权
标题翻译：用于治疗肥胖和美容治疗过程的组合物
公开(公告)号：US06814986B1
公开(公告)日：2004-11-09
申请号：US09601019
申请日：2000-10-17
申请人： Max Rombi
发明人： Max Rombi
IPC分类号： A61K3578
CPC分类号： A61K36/82 , A23F3/18 , A23F3/28 , A61K2300/00
摘要： The invention relates to a composition for the curative and prophylactic treatment of obesity, comprising a catechol-rich extract of green tea, in particular containing from 20% to 50% by mass of catechols expressed as epigallocatechol gallate (EGCG).

6. 发明授权

US06793943B2 Health food products 有权
标题翻译：保健食品
公开(公告)号：US06793943B2
公开(公告)日：2004-09-21
申请号：US09828798
申请日：2001-04-10
申请人： Takao Daicho
发明人： Takao Daicho
IPC分类号： A61K3578
CPC分类号： A61K31/575 , A23L33/105 , A23V2002/00 , A61K36/23 , A61K36/258 , A61K36/284 , A61K36/31 , A61K36/344 , A61K36/36 , A61K36/48 , A61K36/481 , A61K36/484 , A61K36/725 , A61K36/734 , A61K36/8945 , A61K36/8969 , A61K36/899 , A61K31/35 , A61K2300/00 , A23V2250/304 , A23V2250/2116 , A23V2250/21 , A23V2250/70
摘要： An object of the present invention is to provide a very effective health food exhibiting the effect near that which has been already achieved by the traditional Chinese medical science. The present invention relates to a health food product comprising cholic acid, especially to a health food product comprising cholic acid and isoflavone and/or isoflavone glycoside.
摘要翻译：本发明的目的是提供一种非常有效的保健食品，其表现出接近中国传统医学已经实现的效果。本发明涉及包含胆酸的保健食品，特别涉及包含胆酸和异黄酮和/或异黄酮糖苷的保健食品。

7. 发明授权

US06793942B2 Composition and method for treating the effects of diseases and maladies 失效
标题翻译：治疗疾病和疾病影响的组合物和方法
公开(公告)号：US06793942B2
公开(公告)日：2004-09-21
申请号：US09754205
申请日：2001-01-05
申请人： Daniel Gelber , Richard Kleinberger
发明人： Daniel Gelber , Richard Kleinberger
IPC分类号： A61K3578
CPC分类号： A61K33/30 , A61K31/135 , A61K31/138 , A61K31/167 , A61K31/192 , A61K31/375 , A61K36/28 , A61K36/35 , A61K36/481 , A61K36/71 , A61K36/82 , A61K45/06 , A61K2300/00
摘要： An improved medicinal composition includes an effective amount of a pain relieving and anti-inflammatory pharmaceutical and an effective amount of a nutraceutical in a pharmaceutically acceptable base. At least one of the pharmaceutical and the nutraceutical treats a condition caused by an immune response of the respiratory system, particularly an immune response that triggers the cough reflex. The pharmaceutical is preferably a cough suppressant, an expectorant, or a decongestant. The nutraceutical is preferably an immune booster, an anti-oxidant, a liver protectant, a nutraceutical which sedates the cough reflex, or a combination thereof. Methods of using these compositions to treat conditions caused by a respiratory immune response are also disclosed.
摘要翻译：改进的药物组合物包括有效量的止痛和抗炎药物和有效量的药学上可接受的碱中的营养药物。药物和营养药物中的至少一种治疗由呼吸系统的免疫应答引起的病症，特别是触发咳嗽反射的免疫应答。药物优选为止咳剂，祛痰剂或减充血剂。营养药物优选是免疫增强剂，抗氧化剂，肝保护剂，镇静咳嗽反射的营养药物或其组合。还公开了使用这些组合物治疗由呼吸免疫应答引起的病症的方法。

8. 发明授权

US06790465B2 Composition and method for treating snoring 失效
标题翻译：打鼾的组合和方法
公开(公告)号：US06790465B2
公开(公告)日：2004-09-14
申请号：US09973185
申请日：2001-10-10
申请人： Glenn H. Weissman
发明人： Glenn H. Weissman
IPC分类号： A61K3578
CPC分类号： A61K45/06 , A61K9/006 , A61K9/007 , A61K31/00 , A61K36/185 , A61K36/28 , A61K36/484 , A61K36/534 , A61K36/61 , A61K36/736 , A61K36/752 , A61K36/758 , A61K36/899 , A61K2300/00
摘要： A composition and method are disclosed in which a anti-snoring solution comprising at least one homopolysaccharide is administered to pharyngeal mucous membranes, e.g., soft palate and uvula. The solution preferably includes oat beta glucan and a suitable delivery agent that will hold the active ingredients in solution, and optionally may be combined with essential oil compounds, vitamins, and/or flavoring agents. The solution is preferably administered in the form of a throat spray.
摘要翻译：公开了一种组合物和方法，其中将包含至少一种均聚糖的抗打鼾溶液施用于咽粘膜，例如软腭和小疣。该溶液优选包括燕麦β-葡聚糖和将活性成分保持在溶液中的合适的递送剂，并且任选地可与精油化合物，维生素和/或调味剂组合。溶液优选以喉部喷雾的形式施用。

9. 发明授权

US06790464B2 Herbal compositions for prostate conditions 失效
标题翻译：草药组合物用于前列腺病症
公开(公告)号：US06790464B2
公开(公告)日：2004-09-14
申请号：US10345158
申请日：2003-01-16
申请人： Koon Yong Kuok , Hien Ly
发明人： Koon Yong Kuok , Hien Ly
IPC分类号： A61K3578
CPC分类号： A61K36/899 , A23L33/105 , A61K36/07 , A61K36/074 , A61K36/076 , A61K36/11 , A61K36/185 , A61K36/232 , A61K36/233 , A61K36/237 , A61K36/25 , A61K36/268 , A61K36/324 , A61K36/328 , A61K36/36 , A61K36/428 , A61K36/46 , A61K36/48 , A61K36/481 , A61K36/484 , A61K36/539 , A61K36/54 , A61K36/62 , A61K36/64 , A61K36/65 , A61K36/68 , A61K36/708 , A61K36/71 , A61K36/714 , A61K36/716 , A61K36/744 , A61K36/756 , A61K36/804 , A61K36/882 , A61K36/884 , A61K36/8945 , A61K36/8964 , A61K36/8965 , A61K36/8994 , A61K38/09 , A61K2300/00
摘要： Methods and compositions are disclosed for prevention or treatment of prostate disorders and ameliorating symptoms thereof, including prostatitis, benign prostate hyperplasia and prostatic carcinoma. The methods comprise administering a composition of matter comprising the following herbal and other components: Radix Asparagi; Radix Angelicae Pubescentis; Radix Trichosanthis; Radix Scuttellariae; Radix Angelicae Sinensis; Radix Dipsaci; Cortex Eucommiae; Medulla Junci; Rhizoma Anemarrhenae; Caulis Akebiae; Herba Dianthi; Semen Plantaginis; Cortex Phellodendri (fried); Radix et Rhizoma Rhei; Rhizoma seu Radix Notopterygii; Olibanum; Fructus Gardeniae; Radix Astragali seu Hedysari; Rhizoma Cimicifugae; Radix Bupleuri; Myrrha; Gypsum Fibrosun; Radix Rehamanniae (crude); Folium Pyrrosiae; Rhizoma Acori Graminei; Rhizoma Dioscoreae Hypoglaucae; Radix Linderae; Herba Cistanche; Radix Paeoniae Rubra; Rhizoma Dioscoreae; Semen Euryales; Cortex Mouton; Polyporus Umbellatus; Radix Rehmanniae Praeparata; Medulla Tetrapanacis; Semen Coicis; Fructus Horedi Germinatus (Poria); Radix Aconiti Praeparata; Rhizoma Alismatis; Cortex Cinnamomi; Herba Asari; Radix Glycyrrhizae; Stigma Maydis; Phaseolus Radiatus L., and optionally, Ganoderma Lucidum.
摘要翻译：公开了用于预防或治疗前列腺疾病和改善其症状的方法和组合物，包括前列腺炎，良性前列腺增生和前列腺癌。所述方法包括施用包含以下草药和其它组分的物质组合物：天竺葵; 当归黄芪黄芪 e 当归; 甘草皮质杜仲; Medulla Junci; 根瘤菌 Caulis Akebiae; 草药精液植物皮质黄柏（油煎）; 枸杞子白芷根 Ol; 栀子花黄芪 ae 白芷没药石膏纤维素新西兰根（原油）; 叶子Pyrrosiae; 枸杞子枸杞子（Rhizoma Dioscoreae Hypoglaucae）枸杞子 Her肉白芍薯精液Euryales; 皮质木桐多孔菌地黄马杜拉精液Co is 枸杞（Poria）; 阿根廷阿利斯蒂斯 Cortex Cinnamomi; 草药Asari 甘草耻辱Maydis Phaseolus Radiatus L.，以及任选的灵芝（Ganoderma Lucidum）。

10. 发明授权

US06773708B1 Use of xanthophylls, astaxanthin e.g., for treatment of autoimmune diseases, chronic viral and intracellular bacterial infections 有权
标题翻译：使用叶黄素，虾青素例如用于治疗自身免疫性疾病，慢性病毒和细胞内细菌感染
公开(公告)号：US06773708B1
公开(公告)日：2004-08-10
申请号：US10088496
申请日：2002-03-28
申请人： Åke Lignell , Per Böttiger
发明人： Åke Lignell , Per Böttiger
IPC分类号： A61K3578
CPC分类号： A61K31/122 , A61K31/23
摘要： The use of at least one type of xanthophylls for the production of a medicament for suppression of excessive Th1 cell mediated immune responses and stimulation of Th2 cell mediated immune responses in a patient during ongoing infection and/or inflammation in said patient is disclosed. Excessive Th1 cell mediated immune responses are caused by such autoimmune diseases and chronic viral and intracellular bacterial infections as Psoriasis vulgaris, Multiple sclerosis (MS), Rheumatoid arthritis, Crohn's disease, insulin-dependent diabetes mellitus, Tuberculosis (TB), Acute graft-versus-host disease (transplant rejection) and HIV virus infection. The preferred type of xanthophyll is astaxanthin, particularly in a form esterified with fatty acids, obtainable by for example culturing the algae Haematococcus sp. Further, a method of suppressing excessive Th1 mediated immune responses and stimulating Th2 cell mediated immune responses in a patient during ongoing infection and/or inflammation in said patient is disclosed.
摘要翻译：公开了至少一种类型的叶黄素用于在所述患者的持续感染和/或炎症期间产生用于抑制过量Th1细胞介导的免疫应答和刺激Th2细胞介导的免疫应答的药物。过度的Th1细胞介导的免疫应答是由这种自身免疫疾病和寻常型银屑病，多发性硬化（MS），类风湿性关节炎，克罗恩病，胰岛素依赖型糖尿病，结核病（TB），急性移植物抗体宿主病（移植排斥）和HIV病毒感染。叶黄素的优选类型是虾青素，特别是以脂肪酸酯化的形式，可通过例如培养藻类Haematococcus sp。此外，公开了在所述患者的持续感染和/或炎症期间抑制过量的Th1介导的免疫应答和刺激患者中Th2细胞介导的免疫应答的方法。

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