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    • 3. 发明申请
    • SYSTEMS FOR SENSING PRESSURE/SHEAR FORCE
    • 感应压力/剪切力系统
    • WO2008042903A3
    • 2008-08-07
    • PCT/US2007080197
    • 2007-10-02
    • KLA TENCOR TECH CORPRENKEN WAYNE GSUN MEI HMASON ARON ABRAMOWKSIWIESE LYNN KARL
    • RENKEN WAYNE GSUN MEI HMASON ARON ABRAMOWKSIWIESE LYNN KARL
    • G01L5/00B24B37/04G01L1/14H01L21/00
    • G01L5/0047B24B37/04B24B49/16G01L1/142G01L5/008H01L21/67253
    • At least one pair of capacitively coupled electrodes contained in a structure is used to sense the deflection of a diaphragm in a pressure or force sensor for measuring the pressure or force exerted on the diaphragm. Preferably the structure has properties (such as one or more of the following: dimensions, hardness, area and flexibility) that are substantially the same as those of a real substrate, such as a semiconductor wafer or flat panel display panel. For measuring shear force, at least one shear force sensor is used to measure the shear force on a member, when the member is in contact with and pressed against a polishing or planarization surface and a lateral force is applied between the two surfaces. Preferably the structure and the surface of the structure have properties (such as one or more of the following: dimensions and coefficient of friction) that are substantially the same as those of a real substrate, such as a semiconductor wafer or flat panel display panel.
    • 使用包含在结构中的至少一对电容耦合电极来感测用于测量施加在隔膜上的压力或力的压力或力传感器中的隔膜的偏转。 优选地,结构具有与诸如半导体晶片或平板显示面板的实际基板的特性(例如尺寸,硬度,面积和柔性)相同的性质(诸如以下的一个或多个)。 为了测量剪切力,当构件与抛光或平坦化表面接触并压靠在抛光或平坦化表面上时,使用至少一个剪切力传感器来测量构件上的剪切力,并且在两个表面之间施加横向力。 优选地,结构和结构的表面具有与诸如半导体晶片或平板显示面板的实际基板基本上相同的性质(例如以下的一个或多个:尺寸和摩擦系数)。
    • 4. 发明申请
    • SYSTEMS FOR SENSING PRESSURE/SHEAR FORCE
    • 检测压力/剪切力的系统
    • WO2008042903A2
    • 2008-04-10
    • PCT/US2007/080197
    • 2007-10-02
    • KLA-TENCOR TECHNOLOGIES CORPORATIONRENKEN, Wayne, G.SUN, Mei, H.MASON, Aron, AbramowksiWIESE, Lynn, Karl
    • RENKEN, Wayne, G.SUN, Mei, H.MASON, Aron, AbramowksiWIESE, Lynn, Karl
    • B24B37/04
    • G01L5/0047B24B37/04B24B49/16G01L1/142G01L5/008H01L21/67253
    • At least one pair of capacitively coupled electrodes contained in a structure is used to sense the deflection of a diaphragm in a pressure or force sensor for measuring the pressure or force exerted on the diaphragm. Preferably the structure has properties (such as one or more of the following: dimensions, hardness, area and flexibility) that are substantially the same as those of a real substrate, such as a semiconductor wafer or flat panel display panel. For measuring shear force, at least one shear force sensor is used to measure the shear force on a member, when the member is in contact with and pressed against a polishing or planarization surface and a lateral force is applied between the two surfaces. Preferably the structure and the surface of the structure have properties (such as one or more of the following: dimensions and coefficient of friction) that are substantially the same as those of a real substrate, such as a semiconductor wafer or flat panel display panel.
    • 包含在结构中的至少一对电容耦合电极用于感测压力或力传感器中的膜片的偏转,以测量施加在膜片上的压力或力。 优选地,该结构具有与诸如半导体晶片或平板显示面板之类的真实基板的基本相同的性质(例如以下中的一个或多个:尺寸,硬度,面积和柔性)。 为了测量剪切力,当构件接触并压靠抛光或平坦化表面并在两个表面之间施加横向力时,使用至少一个剪切力传感器来测量构件上的剪切力。 优选地,结构和结构的表面具有与真实衬底(诸如半导体晶片或平板显示面板)的结构和表面基本相同的性质(例如以下中的一个或多个:尺寸和摩擦系数)。
    • 5. 发明申请
    • TUMOR SUPPRESSOR LOCUS IN PROSTATE CANCER
    • 肿瘤抑制剂位于前列腺癌中
    • WO2003097843A1
    • 2003-11-27
    • PCT/US2003/015208
    • 2003-05-14
    • HENRY M. JACKSON FOUNDATION FOR THE ADVANCEMENT OF MILITARY MEDICINEZOU, ChiqiangSUN, MeiSRIVASTAVA, ShivMOUL, Judd, W.
    • ZOU, ChiqiangSUN, MeiSRIVASTAVA, ShivMOUL, Judd, W.
    • C12N15/85
    • C07K14/4703A61K48/00
    • The long arm of chromosome 6 is frequently deleted in diverse human neoplasm. Studies showed a minimum deletion region between markers D6S1056 and D6S300 on chromosome 6q in primary CaP (prostate cancer). Significant association of LOH (loss of heterozygosity) of 6q16 with aging CaP patients and patients with seminal vesicle invasion was shown using LCM (laser capture microdissection)-derived DNA samples from 48 CaP patients. A novel contig designated as 6qTSG1 was generated within a minimal 200 kb region centered around D6S1013. The 6qTSG1 exhibited complex multiple splicing variants with low or absent expression in CaP cells. However, none of the transcripts identified contained a significant open reading frame. Expression of 6qTSG1 was induced in LNCaP cells that were cultured in charcoal-stripped serum medium suggesting an up-regulation of 6qTSG1 by androgen ablation. Induction of 6qTSGl expression in response to androgen ablation was abrogated in androgen independent derivatives of LNCaP cells. The 6qTSG1 inhibited tumor cell growth after transfection into PC3 cells. A candidate CaP suppressor locus was identified on chromosome 6q16.1, of which alteration linked to CaP progression.
    • 染色体6的长臂在不同的人类肿瘤中经常被删除。 研究显示原代CaP(前列腺癌)染色体6q上的标记D6S1056和D6S300之间的最小缺失区。 使用来自48名CaP患者的LCM(激光捕获显微切割)衍生的DNA样品,显示6q16的LOH(杂合性的丧失)与老化的CaP患者和精囊浸润患者的显着关联。 在以D6S1013为中心的最小200kb区域内产生了称为6qTSG1的新型重叠群体。 6qTSG1表现出在CaP细胞中具有低表达或缺失表达的复合多个剪接变体。 然而,没有一个确认的成绩单包含一个重要的开放阅读框架。 在用炭活化血清培养基培养的LNCaP细胞中诱导6qTSG1的表达,表明通过雄激素消融上调6qTSG1。 在雄激素消融中诱导6qTSG1表达在雄激素非依赖性LNCaP细胞衍生物中被消除。 转染PC3细胞后,6qTSG1抑制肿瘤细胞生长。 在染色体6q16.1上鉴定出候选CaP抑制基因座,其与CaP进展有关。