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1. 发明申请

WO2021191228A1 POLYMER 审中-公开
公开(公告)号：WO2021191228A1
公开(公告)日：2021-09-30
申请号：PCT/EP2021/057481
申请日：2021-03-23
申请人： CAMBRIDGE DISPLAY TECHNOLOGY LIMITED , SUMITOMO CHEMICAL CO., LTD
发明人： KAMTEKAR, Kiran
IPC分类号： C08G61/12 , H01L51/00 , H01L51/42 , C07D333/32 , C07D495/14 , C07D519/00 , C08G2261/12 , C08G2261/1412 , C08G2261/146 , C08G2261/3246 , C08G2261/3247 , C08G2261/411 , C08G2261/52 , C08G2261/95 , C08G61/122 , C08G61/126 , C08L65/00 , H01L51/0043 , H01L51/4253
摘要： A polymer comprising an electron-donating repeat unit of formula (I) and an electron-accepting repeat unit: -(A)n- (I) wherein A in each occurrence is independently a group of formula (II): Y in each occurrence is independently O or S. Z is O, S or NR3 wherein R3 is H or a substituent. R1 in each occurrence is independently H or a substituent. R2 in each occurrence is independently a substituent, n is at least 2. The polymer may be used as an electron-donating polymer in combination with an electron- accepting material in a bulk heterojunction layer of an organic photodetector.

2. 发明申请

WO2009047568A3 IN VITRO PRESERVATION OF LIVING ANIMAL CELLS AND COMPOUNDS SUITABLE FOR USE IN THE PRESERVATION OF LIVING ANIMAL CELLS 审中-公开
标题翻译：活体动物细胞保存及适用于保存生命动物细胞的化合物
公开(公告)号：WO2009047568A3
公开(公告)日：2009-07-23
申请号：PCT/GB2008050931
申请日：2008-10-10
申请人： ANTOXIS LTD , MCPHAIL DONALD BARTON , COOK GRAEME JAMES , JOHNSTONE ANDREW SCOTT
发明人： MCPHAIL DONALD BARTON , COOK GRAEME JAMES , JOHNSTONE ANDREW SCOTT
IPC分类号： A01N1/02 , C07D207/36 , C07D213/69 , C07D215/22 , C07D307/32 , C07D307/58 , C07D307/60 , C07D309/32 , C07D309/40 , C07D311/16 , C07D311/30 , C07D311/62 , C07D333/32 , C07D335/06
CPC分类号： C07D311/62 , A01N1/02 , A01N1/0226 , C07D207/36 , C07D215/22 , C07D307/58 , C07D311/30 , C07D333/32 , C07D335/06 , C12N5/0606 , C12N2501/999
摘要： Certain compounds of Formula (I) or salts thereof are suitable for use in the in vitro preservation of living animal cells. The living animal cells may be isolated cells, such as stem cells, or groups of cells such as tissue or an organ.
摘要翻译：某些式（I）化合物或其盐适用于活体动物细胞的体外保存。活的动物细胞可以是分离的细胞，诸如干细胞，或者诸如组织或器官的细胞组。

3. 发明申请

WO2007098597A1 GLYCOSIDASE INHIBITORS AND METHODS OF SYNTHESIZING SAME 审中-公开
标题翻译：糖苷酶抑制剂及其合成方法
公开(公告)号：WO2007098597A1
公开(公告)日：2007-09-07
申请号：PCT/CA2007/000330
申请日：2007-03-02
申请人： SIMON FRASER UNIVERSITY , PINTO, Brian Mario , JOHNSTON, Blair, D. , GHAVAMI, Ahmad , SZCZEPINA, Monica Gabriela , LIU, Hui , SADALAPURE, Kashinath , JENSEN, Henrik H. , NASI, Ravindranath , KUMAR, Nag Sharwan
发明人： PINTO, Brian Mario , JOHNSTON, Blair, D. , GHAVAMI, Ahmad , SZCZEPINA, Monica Gabriela , LIU, Hui , SADALAPURE, Kashinath , JENSEN, Henrik H. , NASI, Ravindranath , KUMAR, Nag Sharwan
IPC分类号： C07D333/32 , A61K31/095 , A61K31/381 , A61K31/40 , C07C391/00 , C07D207/12
CPC分类号： C07D207/12 , C07D333/32 , C07D335/02 , C07D345/00 , C07D495/04
摘要： Methods for synthesizing Salacinol, its stereoisomers, and analogues, homologues and other derivatives thereof potentially useful as glycosidase inhibitors are described. In some embodiments the compounds of the invention may have the general formula (I) or (II). The synthetic schemes may comprise reacting a cyclic sulfate with a 5-membered ring sugar containing a heteroatom (X). The heteroatom preferably comprises sulfur, selenium, or nitrogen. The cyclic sulfate and ring sugar reagents may be readily prepared from carbohydrate precursors, such as D-glucose, L-glucose, D-xylose and L-xylose. The target compounds are prepared by opening of the cyclic sulfates by nucleophilic attack of the heteroatoms on the 5-membered ring sugars. The resulting heterocyclic compounds have a stable, inner salt structure comprising a heteroatom cation and a sulfate anion. The synthetic schemes yield various stereoisomers of the target compounds in moderate to good yields with limited side-reactions. Chain-extended analogues of Salacinol are also described.
摘要翻译：描述了可能用作糖苷酶抑制剂的Salacinol，其立体异构体和类似物，同系物和其它衍生物的合成方法。在一些实施方案中，本发明的化合物可以具有通式（I）或（II）。合成方案可以包括使环硫酸盐与含有杂原子（X）的5元环糖反应。杂原子优选包含硫，硒或氮。环状硫酸盐和环糖试剂可以容易地从碳水化合物前体如D-葡萄糖，L-葡萄糖，D-木糖和L-木糖制备。通过在5元环糖上的杂原子的亲核攻击来打开环状硫酸盐来制备目标化合物。所得的杂环化合物具有包含杂原子阳离子和硫酸根阴离子的稳定的内盐结构。合成方案以有限的副反应以中等到良好的产率产生目标化合物的各种立体异构体。还描述了Salacinol的链延长类似物。

4. 发明申请

WO2007014249A3 NOVEL COMPOUNDS, PHARMACEUTICAL COMPOSITIONS CONTAINING SAME, AND METHODS OF USE FOR SAME 审中-公开
标题翻译：新化合物，含有它们的药物组合物及其使用方法
公开(公告)号：WO2007014249A3
公开(公告)日：2007-05-31
申请号：PCT/US2006028981
申请日：2006-07-26
申请人： UNIV JOHNS HOPKINS , FASGEN INC , KUHAJDA FRANCIS P , TOWNSEND CRAIG A , MEDGHALCHI SUSAN M , MCFADDEN JILL M
发明人： KUHAJDA FRANCIS P , TOWNSEND CRAIG A , MEDGHALCHI SUSAN M , MCFADDEN JILL M
IPC分类号： C07D333/02 , C07D333/32 , C07D333/34
CPC分类号： C07D333/38 , C07D409/12
摘要： A pharmaceutical composition containing a pharmaceutical diluent and a compound of formula II: wherein: R 8 = H, C 1 -C 20 alkyl, cycloalkyl, alkenyl, aryl, arylalkyl, or alkylaryl, -C(O)R 4 , where R 4 is H, C 1 -C 20 alkyl, cycloalkyl, alkenyl, aryl, arylalkyl, or alkylaryl, optionally containing halogen atoms, or -OH, -OR 7 or -NR 7 , where R 7 is H, C 1 -C 20 alkyl, cycloalkyl, alkenyl, aryl, arylalkyl, or alkylaryl, optionally containing halogen atoms; R 9 = -OR 5 , -NR 5 , -NH-NH-R 5 where R 5 is H, C 1 -C 20 alkyl, cycloalkyl, alkenyl, aryl, arylalkyl, allyl, or alkylaryl, optionally containing halogen atoms; R 10 = H, C 1 -C 20 alkyl, cycloalkyl, alkenyl, aryl, arylalkyl, or alkylaryl, or- CH 2 C(O)R 6 , where R 6 is OR 7 and NR 7 , where R 7 = H, C 1 -C 20 alkyl, cycloalkyl, alkenyl, aryl, arylalkyl, allyl, or alkylaryl and can optionally contain halogen atoms. Also included in the invention are methods of using the pharmaceutical compositions and the chemical compounds used in the compositions.
摘要翻译：含有药物稀释剂和式II化合物的药物组合物：其中：R 8 = H，C 1 -C 20烷基，环烷基，烯基，芳基，芳基烷基或烷基芳基，-C（O）R 4，其中R 4是H，C 1 -C 3烷基，或任选地含有卤素原子的烷基，芳基，芳基烷基或烷基芳基，或-OH，-OR 7或-NR 7，其中R 7为H，C 1 -C 20烷基，环烷基，烯基，芳基，芳基烷基或烷基芳基，任选地含有卤素原子 ; R 9 = -OR 5，-NR 5，-NH-NH-R 5，其中R 0 任选地含有卤素原子的烷基，环烷基，链烯基，芳基，芳基烷基，烯丙基或烷基芳基; R 10 = H，C 1 -C 20烷基，环烷基，烯基，芳基，芳烷基或烷基芳基，或 - 2 C（O）R 6，其中R 6为OR 7和NR 7，其中R 7 = H，C 1 -C 20烷基，环烷基，烯基，芳基，芳基烷基，烯丙基或烷基芳基，并且可任选地含有卤原子。本发明还包括使用组合物中使用的药物组合物和化合物的方法。

5. 发明申请

WO2007014273A2 SULFONAMIDES AS SELECTIVE ESTROGEN RECEPTOR MODULATORS 审中-公开
标题翻译：磺酰胺作为选择性雌激素受体调节剂
公开(公告)号：WO2007014273A2
公开(公告)日：2007-02-01
申请号：PCT/US2006029025
申请日：2006-07-25
申请人： UNIV ILLINOIS , KATZENELLENBOGEN JOHN A , KATZENELLENBOGEN BENITA S , COMPTON DENNIS R
发明人： KATZENELLENBOGEN JOHN A , KATZENELLENBOGEN BENITA S , COMPTON DENNIS R
IPC分类号： A61K31/381 , A61K31/18 , A61K31/195 , A61K31/34 , C07C303/00 , C07D307/02 , C07D333/32
CPC分类号： C07C311/29 , C07D307/64 , C07D333/34
摘要： Compounds, pharmaceutically acceptable salts, stereoisomers and prodrugs thereof, that are ER ligands and particularly to such compounds that are ER beta-selective and/or ER beta-specific ligands. Compounds herein include certain compounds which are ER beta-selective agonists. Compounds herein include ER beta- selective agonists which exhibit minimal agonist or antagonist effect on ER alpha. Compounds of the invention include those of Formula (I) and any pharmaceutically acceptable salts, stereoisomers and prodrugs thereof wherein AR, R 1 , R 3 , and X 1 -X 4 are as defined hereinabove.
摘要翻译：化合物，药学上可接受的盐，立体异构体和前药，其为ER配体，特别是ERβ选择性和/或ERβ特异性配体的这些化合物。本文中的化合物包括某些化合物，其为ERβ-选择性激动剂。本文的化合物包括对ERα表现出最小激动剂或拮抗剂作用的ERβ-选择性激动剂。本发明的化合物包括式（I）化合物及其任何药学上可接受的盐，立体异构体和前药，其中AR，R 1，R 3和X 1 -X 4是如上所定义的。

6. 发明申请

WO2007010954A1 THIOPHENE COMPOUNDS AND THROMBOPOIETIN RECEPTOR ACTIVATORS 审中-公开
标题翻译：噻吩类化合物和血栓素受体激活剂
公开(公告)号：WO2007010954A1
公开(公告)日：2007-01-25
申请号：PCT/JP2006/314317
申请日：2006-07-13
申请人： NISSAN CHEMICAL INDUSTRIES, LTD. , MIYAJI, Katsuaki , YANAGIHARA, Kazufumi , SHIGETA, Yukihiro , IWAMOTO, Shunsuke , HORIKAWA, Masato , HIROKAWA, Yutaka , OWADA, Shingo , NAKANO, Satoshi , OTA, Hirofumi , ISHIWATA, Norihisa
发明人： MIYAJI, Katsuaki , YANAGIHARA, Kazufumi , SHIGETA, Yukihiro , IWAMOTO, Shunsuke , HORIKAWA, Masato , HIROKAWA, Yutaka , OWADA, Shingo , NAKANO, Satoshi , OTA, Hirofumi , ISHIWATA, Norihisa
IPC分类号： C07D333/32 , C07D409/12
CPC分类号： C07D409/14 , C07D333/32 , C07D333/38 , C07D413/14
摘要： ABSTRACT A compound represented by the formula (I) (wherein R 1 , R 2 , R 3 and R 4 are as defined in the description), a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof.
摘要翻译：摘要一种由式（I）表示的化合物（其中R 1，R 2，R 3和R 4 如说明书中所定义），化合物或其溶剂合物的互变异构体，前药或药学上可接受的盐。

7. 发明申请

WO2006123020A1 PEPTIDOMIMETICS SELECTIVE FOR THE SOMATOSTATIN RECEPTOR SUBTYPES 1 AND/OR 4 审中-公开
标题翻译：选择SOMATOSTATIN受体亚型1和/或4的PEPTIDOMIMETICS
公开(公告)号：WO2006123020A1
公开(公告)日：2006-11-23
申请号：PCT/FI2006/050197
申请日：2006-05-16
申请人： OY JUVANTIA PHARMA LTD , TOMPERI, Jussi , SALO, Harri , KALLATSA, Oili , KNUUTTILA, Pia , LAAKSO, Päivi , HÖGLUND, Iisa , HOFFRÉN, Anna-Marja , KOKKO, Kurt , SAARENKETO, Pauli , ENGSTRÖM, Mia , WURSTER, Siegfried
发明人： TOMPERI, Jussi , SALO, Harri , KALLATSA, Oili , KNUUTTILA, Pia , LAAKSO, Päivi , HÖGLUND, Iisa , HOFFRÉN, Anna-Marja , KOKKO, Kurt , SAARENKETO, Pauli , ENGSTRÖM, Mia , WURSTER, Siegfried
IPC分类号： C07C311/18 , C07C311/13 , C07C311/19 , C07C323/25 , C07C323/60 , C07D207/09 , C07D207/50 , C07D211/28 , C07D211/58 , C07D217/02 , C07D233/48 , C07D233/64 , C07D295/13 , C07D295/185 , C07D333/32 , C07D333/62 , A61K31/18 , A61K31/38 , A61K31/40 , A61K31/415 , A61K31/445 , A61K31/47 , A61K31/495 , A61K31/535
CPC分类号： C07C323/49 , A61K31/18 , A61K31/38 , A61K31/40 , A61K31/415 , A61K31/445 , A61K31/47 , A61K31/495 , A61K31/535 , C07C311/13 , C07C311/18 , C07C311/19 , C07C323/58 , C07C323/60 , C07C2601/14 , C07C2602/10 , C07D207/09 , C07D217/02 , C07D233/32 , C07D233/48 , C07D233/64 , C07D295/13 , C07D295/185 , C07D333/62
摘要： The invention relates to (hetero)arylsulfonylamino based peptidomimetics of formula (I), wherein A, D, E, J, Q1 R1 , R2, R3, p and j are defined as disclosed, or a pharmaceutically acceptable salt or ester thereof. Compounds of formula (I) possess high affinity and selectivity for the somatostatin receptor subtypes sst 1 and/or sst 4 and can be used for the treatment or diagnosis of diseases or conditions wherein sst 1 and/or sst 4 agonists or antagonists are indicated to be useful.
摘要翻译：本发明涉及式（I）的（杂）芳基磺酰氨基基肽模拟物，其中A，D，E，J，Q1 R1，R2，R3，p和j如所公开的，或其药学上可接受的盐或酯。式（I）的化合物对生长抑素受体亚型和/或sst 4具有高亲和力和选择性，可用于治疗或诊断疾病或病症其中sst 1和/或sst 4激动剂或拮抗剂被认为是有用的。

8. 发明申请

WO2005117590A3 NOVEL COMPOUNDS, PHARMACEUTICAL COMPOSITIONS CONTAINING SAME, AND METHODS OF USE FOR SAME 审中-公开
公开(公告)号：WO2005117590A3
公开(公告)日：2005-12-15
申请号：PCT/US2005/018443
申请日：2005-05-25
申请人： FASGEN, LLC , THE JOHNS HOPKINS UNIVERSITY , MCFADDEN, Jill, M. , TOWNSEND, Craig, A. , MEDGHALCHI, Susan, M.
发明人： MCFADDEN, Jill, M. , TOWNSEND, Craig, A. , MEDGHALCHI, Susan, M.
IPC分类号： A61K31/381 , C07D333/32
摘要： A pharmaceutical composition comprising a pharmaceutical diluent and a compound of formula (II), wherein R 1 and R 2 , the same or different from each other, are H, C 1 -C 20 alkyl, cycloalkyl, alkenyl, aryl, arylalkyl, or alkylaryl, -CH 2 COR S , -CH 2 C(O)NR S , -C(O)R 5 , or -CH 2 OR 5 , and can optionally contain halogen atoms, where R 5 is a C 1 -C 12 alkyl group. R 3 and R 4 , the same or different from each other, are H, C 1 -C 20 alkyl, cycloalkyl, alkenyl, aryl, arylalkyl, or alkylaryl.

9. 发明申请

WO2004062601A3 ANTIBACTERIAL AGENTS 审中-公开
标题翻译：抗菌剂
公开(公告)号：WO2004062601A3
公开(公告)日：2005-04-21
申请号：PCT/US2004000433
申请日：2004-01-08
申请人： CHIRON CORP , ANDERSON NEILS H , BOWMAN JASON , ERWIN ALICE , HARWOOD ERIC , KLINE TONI , MDLULI KHISIMUZI , NG SIMON , PFISTER KEITH B , SHAWAR RIBHI , WAGMAN ALLAN , YABANNAVAR ASHA
发明人： ANDERSON NEILS H , BOWMAN JASON , ERWIN ALICE , HARWOOD ERIC , KLINE TONI , MDLULI KHISIMUZI , NG SIMON , PFISTER KEITH B , SHAWAR RIBHI , WAGMAN ALLAN , YABANNAVAR ASHA
IPC分类号： C07C233/83 , C07C239/16 , C07C251/40 , C07C255/24 , C07C255/25 , C07C255/44 , C07C255/57 , C07C259/06 , C07C275/14 , C07C275/16 , C07C275/26 , C07C279/14 , C07C311/06 , C07C311/08 , C07C311/19 , C07C311/21 , C07C317/32 , C07C323/25 , C07C323/41 , C07C323/60 , C07C323/62 , C07C335/08 , C07C337/08 , C07C381/00 , C07D207/08 , C07D207/09 , C07D207/14 , C07D207/16 , C07D207/26 , C07D207/27 , C07D207/32 , C07D207/327 , C07D211/26 , C07D211/42 , C07D211/56 , C07D211/58 , C07D211/62 , C07D213/38 , C07D213/40 , C07D213/54 , C07D213/56 , C07D213/61 , C07D213/74 , C07D213/80 , C07D213/81 , C07D213/82 , C07D215/48 , C07D217/26 , C07D231/12 , C07D233/54 , C07D235/10 , C07D235/14 , C07D239/26 , C07D239/42 , C07D241/04 , C07D241/12 , C07D241/18 , C07D263/34 , C07D285/00 , C07D285/01 , C07D295/13 , C07D295/135 , C07D295/155 , C07D295/192 , C07D295/215 , C07D307/68 , C07D311/24 , C07D317/60 , C07D317/68 , C07D333/20 , C07D333/24 , C07D333/32 , C07D333/36 , C07D333/58 , C07D453/00 , C07C233/00 , A61K31/16 , A61K31/165
CPC分类号： C07D453/00 , C07C233/83 , C07C239/16 , C07C251/40 , C07C255/24 , C07C255/25 , C07C255/44 , C07C255/57 , C07C259/06 , C07C275/14 , C07C275/16 , C07C275/26 , C07C279/14 , C07C311/06 , C07C311/08 , C07C311/19 , C07C311/21 , C07C317/32 , C07C323/25 , C07C323/41 , C07C323/60 , C07C323/62 , C07C335/08 , C07C337/08 , C07C381/00 , C07C2601/02 , C07C2601/04 , C07C2601/14 , C07C2601/18 , C07C2602/42 , C07C2603/74 , C07D207/08 , C07D207/09 , C07D207/14 , C07D207/16 , C07D207/27 , C07D207/327 , C07D211/26 , C07D211/42 , C07D211/56 , C07D211/58 , C07D211/62 , C07D213/38 , C07D213/40 , C07D213/54 , C07D213/56 , C07D213/61 , C07D213/74 , C07D213/80 , C07D213/81 , C07D213/82 , C07D215/48 , C07D217/26 , C07D231/12 , C07D233/56 , C07D233/64 , C07D235/14 , C07D239/26 , C07D239/42 , C07D241/04 , C07D241/12 , C07D241/18 , C07D263/34 , C07D285/01 , C07D295/13 , C07D295/135 , C07D295/155 , C07D295/192 , C07D295/215 , C07D307/68 , C07D311/24 , C07D317/60 , C07D317/68 , C07D333/20 , C07D333/24 , C07D333/32 , C07D333/36 , C07D333/58
摘要： Antibacterial compounds of formula (I) are provided: As well as stereoisomers, pharmaceutically acceptable salts, esters, and prodrugs thereof; pharmaceutical compositions comprising such compounds; methods of treating bacterial infections by the administration of such compounds; and processes for the preparation of the compounds.
摘要翻译：提供了式（I）的抗菌化合物：以及立体异构体，其药学上可接受的盐，酯和前药; 包含这些化合物的药物组合物; 通过施用这些化合物治疗细菌感染的方法; 和化合物的制备方法。

10. 发明申请

WO02074726A3 ANILINE DERIVATIVES USEFUL AS PHOSPHODIESTERASE 4 INHIBITORS 审中-公开
标题翻译：苯胺衍生物作为磷酸二酯酶4抑制剂有用
公开(公告)号：WO02074726A3
公开(公告)日：2003-03-13
申请号：PCT/US0201508
申请日：2002-01-22
申请人： MEMORY PHARM CORP , HOPPER ALLEN , SCHUMACHER RICHARD A , TEHIM ASHOK , DE VIVO MICHAEL , BRUBAKER WILLIAM FREDERICK JR , LIU RUIPING , HESS HANS-JUERGEN ERNST , UNTERBECK AXEL
发明人： HOPPER ALLEN , SCHUMACHER RICHARD A , TEHIM ASHOK , DE VIVO MICHAEL , BRUBAKER WILLIAM FREDERICK JR , LIU RUIPING , HESS HANS-JUERGEN ERNST , UNTERBECK AXEL
IPC分类号： C07D213/36 , A61K31/136 , A61K31/4402 , A61K31/4406 , A61K31/4439 , A61K31/4545 , A61K31/496 , A61P9/00 , A61P9/10 , A61P11/00 , A61P25/00 , A61P25/14 , A61P25/16 , A61P25/24 , A61P25/28 , A61P29/00 , A61P31/18 , A61P37/08 , A61P43/00 , C07C217/84 , C07C217/88 , C07C217/92 , C07D213/38 , C07D213/73 , C07D213/74 , C07D215/12 , C07D333/16 , C07D333/32 , C07D401/12 , C07D405/12 , C07F7/18 , A61K31/44
CPC分类号： C07D213/73 , C07C217/84 , C07C217/88 , C07C217/92 , C07C2601/02 , C07C2601/08 , C07C2601/16 , C07C2602/08 , C07D213/38 , C07D215/12 , C07D333/16 , C07D333/32 , C07D401/12 , C07D405/12 , C07F7/1852 , C07F7/1856
摘要： PDE4 inhibition is achieved by novel compounds, e.g., N-substituted aniline and diphenylamine analogs. The compounds of the present invention are of Formula (I): wherein R , R , R and R are as defined herein.
摘要翻译：通过新化合物，例如N-取代的苯胺和二苯胺类似物来实现PDE4的抑制。本发明的化合物具有式（I）：其中R 1，R 2，R 3和R 4如本文所定义。

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