发明申请
WO2015166491A3 FLUORESCENT MOLECULAR SENSOR FOR TARGETING CHANGES IN PROTEIN SURFACES, AND METHODS OF USE THEREOF
审中-公开
基本信息:
- 专利标题： FLUORESCENT MOLECULAR SENSOR FOR TARGETING CHANGES IN PROTEIN SURFACES, AND METHODS OF USE THEREOF
- 专利标题（中）：用于蛋白质表面变化的荧光分子传感器及其使用方法
- 申请号：PCT/IL2015050441 申请日：2015-04-28
- 公开(公告)号：WO2015166491A3 公开(公告)日：2015-12-23
- 发明人： MARGULIES DAVID , MOTIEI LEILA , MANKOVSKI NAAMA , NISSINKORN YAEL
- 申请人： YEDA RES & DEV
- 专利权人： YEDA RES & DEV
- 当前专利权人： YEDA RES & DEV
- 优先权： US201461985555 2014-04-29
- 主分类号： G01N33/50
- IPC分类号： G01N33/50 ; C07C229/76 ; C07D249/04 ; C07K1/13 ; C07K14/47 ; G01N33/533
摘要：
This invention is directed to monomolecular sensors, comprising a selective binder, a non-selective binder and a fluorophore, which can track changes that occur on the surface of labeled proteins. This invention is further directed to the use of such sensors for identifying binding partners of specific proteins. This invention is further directed to His-tag binding compounds and uses thereof in the preparation of genetically targeted detectable molecules and sensors which can specifically bind tag-labeled proteins.
摘要（中）：
本发明涉及单分子传感器，其包括选择性粘合剂，非选择性粘合剂和荧光团，其可以跟踪标记蛋白质表面上发生的变化。 本发明还涉及这种传感器用于鉴定特定蛋白质的结合伴侣的用途。 本发明进一步涉及His-标签结合化合物及其在制备可特异性结合标签标记的蛋白质的遗传可靶向可检测分子和传感器的用途。