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1. 发明申请

WO2021000248A1 环丙烷类化合物连续合成的方法及装置审中-公开
公开(公告)号：WO2021000248A1
公开(公告)日：2021-01-07
申请号：PCT/CN2019/094345
申请日：2019-07-02
申请人：凯莱英医药集团(天津)股份有限公司
发明人：洪浩 , 卢江平 , 丰惜春 , 孙兴芳 , 张峰
IPC分类号： C07C2/86 , C07C13/04 , C07C245/16 , C07B37/02
摘要：本发明公开了一种环丙烷类化合物连续合成的方法及装置。该方法包括以下步骤：在第一反应器中连续进行重氮甲烷前体的合成反应，第一反应器的反应产物流入分离器中进行分层，分层得到的有机相溢流进入第二反应器，在第二反应器中连续消耗重氮甲烷前体制备重氮甲烷并原位进行富电子单烯烃环丙烷化反应得到环丙烷类化合物。应用本发明的技术方案，可以实现自动化控制，减少高风险物料的转移，避免进行重氮甲烷溶液的管路转移风险，有效提高生产安全性；而且设备简单，可以节省设备投资，能够安全定量的实现重氮甲烷生成以及烯烃环丙烷化反应的同时进行。

2. 发明申请

WO2019060998A1 CATALYST-FREE AND REDOX-NEUTRAL INNATE TRIFLUOROMETHYLATION AND ALKYLATION OF (HETERO)AROMATICS ENABLED BY LIGHT 审中-公开
公开(公告)号：WO2019060998A1
公开(公告)日：2019-04-04
申请号：PCT/CA2018/051223
申请日：2018-09-28
申请人： THE ROYAL INSTITUTION FOR THE ADVANCEMENT OF LEARNING/MCGILL UNIVERSITY
发明人： LI, Chao-Jun , LIU, Wenbo , LIU, Peng
IPC分类号： C07C317/24 , C07B37/02 , C07B45/04
摘要： The present disclosure relates to reagents and method for performing trifluoromethylation, difluoromethylation or alkylation of aromatic or heteroaromatic rings in a redox-neutral manner without any catalyst which are enabled by light. In addition, there are methods for synthesizing the starting reagents used in the trifluoromethylation, difluoromethylation or alkylation reactions.

3. 发明申请

WO2009045156A1 NOVEL CATALYST FOR ALDOL CONDENSATION REACTIONS 审中-公开
标题翻译：新型催化剂用于ALDOL冷凝反应
公开(公告)号：WO2009045156A1
公开(公告)日：2009-04-09
申请号：PCT/SE2008/051091
申请日：2008-09-29
申请人： NOZIÉRE, Barbara , CÓRDOVA, Armando
发明人： NOZIÉRE, Barbara , CÓRDOVA, Armando
IPC分类号： C07C45/72 , C07B37/02 , C07C49/203
CPC分类号： C07B37/02 , C07C45/73 , C07C49/04
摘要： The present invention presents catalytic systems for aldol condensation reactions, comprising the step of reacting at least one aldehyde or one ketone starting material in the presence of an inorganic ammonium salt, or an aqueous or organic solution prepared from such salt. The efficiency of the catalytic system of the present invention is comparable to those of the classical strong acid and strong base catalysts.
摘要翻译：本发明提出了用于醛醇缩合反应的催化体系，包括在无机铵盐存在下使至少一种醛或一种酮原料反应的步骤，或由该盐制备的水或有机溶液。本发明的催化体系的效率与经典的强酸和强碱催化剂的效率相当。

4. 发明申请

WO2005005345A3 USE OF FUNCTIONALIZED ONIUM SALTS AS A SOLUBLE SUPPORT FOR ORGANIC SYNTHESIS 审中-公开
标题翻译：作为有机合成的可溶性支持使用功能性的盐水
公开(公告)号：WO2005005345A3
公开(公告)日：2005-03-31
申请号：PCT/FR2004001724
申请日：2004-07-02
申请人： CENTRE NAT RECH SCIENT , UNIV RENNES , VAULTIER MICHEL , GMOUH SAID , HASSINE FATIMA
发明人： VAULTIER MICHEL , GMOUH SAID , HASSINE FATIMA
IPC分类号： C07B37/02 , C07B37/04 , C07B37/12 , C07B61/00 , C07C67/03 , C07D211/16 , C07C209/08 , C07C211/63 , C07C213/02 , C07C213/08 , C07C215/44 , C07C219/10 , C07C219/12
CPC分类号： C07D211/16 , C07B37/02 , C07B37/04 , C07B37/12 , C07B61/00 , C07C67/03 , C07C2602/42 , C07C69/76 , C07C69/618 , C07C69/753 , C07C69/92
摘要： The invention relates to the use of a onium salt functionalized by at least one organic function, as a soluble support, in the presence of at least one organic solvent, for organic synthesis of a molecule, in a homogenous phase, by at least one transformation of said organic function. The onium salt enables the synthesized molecule to be released. The onium salt is present in liquid or solid form at room temperature and corresponds to formula Al , X1 , wherein A1 represents a cation and X1 représents an anion.
摘要翻译：本发明涉及在至少一种有机功能上作为可溶性载体在至少一种有机溶剂的存在下官能化的鎓盐的用途，用于通过至少一种转化在均相中有机合成分子的有机功能。鎓盐使得合成的分子被释放。鎓盐在室温下以液体或固体形式存在，对应于式A1 + X1，其中A1 +表示阳离子，X1'代表阴离子。

5. 发明申请

WO01046096A1 METATHESIS PROCESS FOR CONVERTING SHORT CHAIN OLEFINS TO LONGER CHAIN OLEFINS 审中-公开
标题翻译：将短链烯烃转化成链长链烯烃的方法
公开(公告)号：WO01046096A1
公开(公告)日：2001-06-28
申请号：PCT/ZA2000/000258
申请日：2000-12-21
IPC分类号： B01J31/24 , C07B37/02 , C07B61/00 , C07C1/04 , C07C2/36 , C07C6/04 , C07C11/02 , C07C11/107 , C09K8/34 , C09K7/06
CPC分类号： C09K8/34 , C07C1/0485 , C07C6/04 , C07C11/02 , C07C2531/22
摘要： The invention provides a homogeneous metathesis process for converting C4 to C10 olefins in a Fischer-Tropsch derived feedstock to C6 to C18 olefins, wherein a higher transitions group metal catalyst is used to metathesize a double bond on a linear portion of the olefin, provided that the double bond is at least three carbons away from a branch if the olefin is branched. The catalyst may include a metal-alkylidene complex and the metal may be ruthenium, osmium, tungsten, or iridium. A suitable catalyst is a Grubbs catalyst. The metathesis process includes a recycle process to maintain the reaction equilibrium, although ethylene can be extracted from the process if a recycle process is not used. A co-solvent is used to increase the product yield. The C6 to C18 olefins produced by the above process may be suitable for use as drilling fluids.
摘要翻译：本发明提供了用于将费 - 托衍生的原料中的C 4 -C 10烯烃转化为C 6至C 18烯烃的均相复分解方法，其中使用较高的过渡基团金属催化剂使烯烃的线性部分上的双键偏析，条件是如果烯烃是分支的，双键是离开支链的至少三个碳。催化剂可以包括金属 - 亚烷基络合物，金属可以是钌，锇，钨或铱。合适的催化剂是Grubbs催化剂。复分解过程包括维持反应平衡的循环过程，尽管如果不使用再循环过程，则可以从该方法中提取乙烯。共溶剂用于提高产品产率。通过上述方法生产的C6至C18烯烃可适用于钻井液。

6. 发明申请

WO00035835A1 PROCESS FOR THE PREPARATION OF ORGANIC COMPOUNDS WITH IMIDE CATALYSTS 审中-公开
标题翻译：用于催化剂制备有机化合物的方法
公开(公告)号：WO00035835A1
公开(公告)日：2000-06-22
申请号：PCT/JP1999/006891
申请日：1999-12-09
IPC分类号： B01J31/02 , C07C2/76 , C07C29/36 , C07C45/33 , C07C45/34 , C07C45/39 , C07C49/323 , C07C49/345 , C07C67/347 , C07D307/33 , C07D315/00 , C07D317/30 , C08F20/30 , C07B37/02 , C07B37/04 , C07B41/00 , C07C2/82 , C07C13/615 , C07C29/32 , C07C31/137 , C07C67/333 , C07C69/675 , C07C69/716 , C07C69/732 , C07D307/32 , C08F20/28 , C08L33/14
CPC分类号： C07D307/33 , B01J31/0247 , C07B2200/09 , C07C2/76 , C07C29/36 , C07C45/33 , C07C45/34 , C07C45/39 , C07C49/323 , C07C49/345 , C07C67/347 , C07C2603/28 , C07C2603/68 , C07C2603/74 , C07D315/00 , C07D317/30 , C08F20/30 , C07C13/615 , C07C69/716 , C07C69/608 , C07C69/675 , C07C69/732 , C07C31/137 , C07C35/36 , C07C35/37
摘要： A process of reacting (A) a compound capable of forming a stable radical which is selected from among (A1) oxygen compounds having carbon-hydrogen bonds at the position adjacent to the oxygen atom, (A2) carbonyl compounds and (A3) compounds having hydrocarbon groups bearing methyne carbon with (B) a radical-scavenging compound selected from among (B1) unsaturated compounds, (B2) compounds having hydrocarbon groups bearing methyne carbon, and so on in the presence of molecular oxygen by the use of an imide catalyst represented by general formula (1) or the like to thereby obtain an adduct of the compound (B) with the compound (A), a product of substitution of the compound (B) with the compound (A), or oxides of both. In said formula, R and R are each hydrogen or the like, or alternatively R and R may be united to form a double bond or an aromatic or nonaromatic ring; and X is oxygen or hydroxyl. This process makes it possible to efficiently produce various organic compounds under mild conditions through addition or substitution by the use of molecular oxygen.
摘要翻译：（A）能够形成稳定基团的化合物的方法，其选自（A1）在与氧原子相邻的位置具有碳氢键的氧化合物，（A2）羰基化合物和（A3）化合物，其具有具有甲炔碳的烃基与（B）选自（B1）不饱和化合物的自由基清除化合物，（B2）具有带有甲炔碳的烃基的化合物等，在分子氧存在下通过使用酰亚胺催化剂由通式（1）表示，由此得到化合物（B）与化合物（A）的加成物，化合物（B）与化合物（A）的取代或二者的氧化物的加合物。在所述式中，R 1和R 2各自为氢等，或者R 1和R 2可以一起形成双键或芳族或非芳香环; X是氧或羟基。该方法可以通过使用分子氧进行加成或取代而在温和条件下有效地生产各种有机化合物。

7. 发明申请

WO1994014732A1 THE CATALYTIC ALKYLATION OF AROMATIC COMPOUNDS WITH ALKENES 审中-公开
标题翻译：具有碱性的芳族化合物的催化烷基化
公开(公告)号：WO1994014732A1
公开(公告)日：1994-07-07
申请号：PCT/US1993012572
申请日：1993-12-22
申请人： MALLINCKRODT SPECIALTY CHEMICALS COMPANY
发明人： MALLINCKRODT SPECIALTY CHEMICALS COMPANY , KUHN, Deborah, K.
IPC分类号： C07B37/02
CPC分类号： C07B37/02 , B01J21/066 , B01J23/30 , C07C2/66 , C07C2521/06 , C07C2523/30 , C07C15/02
摘要： An aromatic compound (such as benzene) is alkylated with an alkene (such as propylene) by contacting the two compounds together in the presence of a tungsten on zirconia catalyst. The reaction preferably takes place at elevated temperature and elevated pressure. The process of the invention has very high selectivity and conversion, and produces no or only very low amounts of undesirable oligomers (as measured by bromine number).
摘要翻译：通过在氧化锆催化剂上的钨存在下将两种化合物接触在一起，使烯烃（例如丙烯）烷基化。反应优选在升高的温度和升高的压力下进行。本发明的方法具有非常高的选择性和转化率，并且不产生或仅产生非常少量的不需要的低聚物（通过溴值测量）。

8. 发明申请

WO2018214044A1 PROCESS FOR PREPARING BRANCHED SKIPPED DIENES 审中-公开
公开(公告)号：WO2018214044A1
公开(公告)日：2018-11-29
申请号：PCT/CN2017/085650
申请日：2017-05-24
申请人： SOUTHERN UNIVERSITY OF SCIENCE AND TECHNOLOGY
发明人： HO, Chun Yu , LIAN, Xiaoyan , CHEN, Weihao
IPC分类号： C07B37/02 , C07C37/14 , C07C13/20
CPC分类号： C07C41/30 , C07C2601/16 , C07C43/188 , C07C43/168
摘要： The present invention is a process for preparing skipped dienes from simple endocyclic dienes and simple olefins by a transition metal catalyst.

9. 发明申请

WO2008046918A3 ADDITION REACTIONS USING TRANSITION METAL CATALYSTS IN HALOGENATED SOLVENTS 审中-公开
标题翻译：在卤化溶剂中过渡金属化的额外反应
公开(公告)号：WO2008046918A3
公开(公告)日：2008-07-31
申请号：PCT/EP2007061229
申请日：2007-10-19
申请人： BASF SE , RUDOLPH JENS , PACIELLO ROCCO , JAEKEL CHRISTOPH , HETTCHE FRANK , BOERNER ARMIN , DUBROVINA NATALIA , BIRKHOLZ MANDY-NICOLE , BREIT BERNHARD
发明人： RUDOLPH JENS , PACIELLO ROCCO , JAEKEL CHRISTOPH , HETTCHE FRANK , BOERNER ARMIN , DUBROVINA NATALIA , BIRKHOLZ MANDY-NICOLE , BREIT BERNHARD
IPC分类号： C07B37/02 , B01J31/18 , C07C29/16 , C07C45/50 , C07D211/76
CPC分类号： C07C45/50 , B01J31/1845 , B01J31/2409 , B01J31/2438 , B01J31/2452 , B01J31/2466 , B01J31/2471 , B01J2231/32 , B01J2231/321 , B01J2231/323 , B01J2231/325 , B01J2231/326 , B01J2231/342 , B01J2231/44 , B01J2231/52 , B01J2231/543 , B01J2231/645 , B01J2531/0266 , B01J2531/0291 , B01J2531/821 , B01J2531/822 , B01J2531/842 , B01J2531/847 , B01J2531/94 , C07B53/00 , C07B2200/07 , C07C45/505 , C07C45/72 , C07C67/303 , C07C231/12 , C07F9/65683 , C07F15/0073 , C07C69/34 , C07C233/47
摘要： The present invention relates to a method for reacting compounds, comprising at least one carbon-carbon or carbon-heteroatom double bond, by 1,2-addition in the presence of a catalyst, comprising at least one transition metal complex having at least two ligands, which each have a pnicogen atom-containing group and at least one functional group enable to form intermolecular, non-covalent bonds, in the presence of a halogenated solvent, which has at least one heteroatom different from halogen. The present invention further relates to a method for producing chiral compounds in the presence of the above-described catalysts and solvents, and to the use of these catalysts in the presence of such solvents.
摘要翻译：本发明涉及一种用于反应包含至少一个碳 - 碳或碳 - 杂原子双键，由1,2-加成在催化剂的存在下的化合物包含至少一种过渡金属配合物具有至少两个配位体各自具有pnicogenatomhaltige的处理基团和至少一个能够形成分子间非共价键官能团的基团，并且在具有至少一个除卤素以外的杂原子的卤化溶剂存在下进行。本发明进一步涉及在上述催化剂和溶剂存在下制备手性化合物的方法以及这些催化剂在这些溶剂存在下的用途。

10. 发明申请

WO2008025673A1 NEW CYCLOPENTADIENYL, INDENYL OR FLUORENYL SUBSTITUTED PHOSPHINE COMPOUNDS AND THEIR USE IN CATALYTIC REACTIONS 审中-公开
标题翻译：新环戊二烯基，茚基或氟代替膦酸酯化合物及其在催化反应中的应用
公开(公告)号：WO2008025673A1
公开(公告)日：2008-03-06
申请号：PCT/EP2007/058417
申请日：2007-08-14
申请人： EVONIK DEGUSSA GMBH , PLENIO, Herbert , FLECKENSTEIN, Christoph , KADYROV, Renat , ALMENA, Juan , MONSEES, Axel , RIERMEIER, Thomas
发明人： PLENIO, Herbert , FLECKENSTEIN, Christoph , KADYROV, Renat , ALMENA, Juan , MONSEES, Axel , RIERMEIER, Thomas
IPC分类号： C07F9/54 , C07F9/50 , B01J27/185 , C07B37/02
CPC分类号： C07C2/88 , B01J31/2404 , B01J31/2447 , B01J2231/321 , B01J2231/4227 , B01J2231/4266 , B01J2231/4283 , B01J2531/824 , C07C17/26 , C07C41/30 , C07C45/62 , C07C201/12 , C07C209/68 , C07C253/30 , C07D213/16 , C07D213/22 , C07D213/73 , C07D265/30 , C07F9/5022 , C07F9/5442
摘要： The invention is directed to a phosphine compound represented by general formula (1) wherein R' and R" independently are selected from alkyl, cycloalkyl and 2-furyl radicals, or R' and R" are joined together to form with the phosphorous atom a carbon-phosphorous monocycle comprising at least 3 carbon atoms or a carbon- phosphorous bicycle; the alkyl radicals, cycloalkyl radicals, and carbon-phosphorous monocycle being unsubstituted or substituted by at least one radical selected from the group of alkyl, cycloalkyl, aryl, alkoxy, and aryloxy radicals; Cp s is a partially substituted or completely substituted cyclopentadien-1-yl group, including substitutions resulting in a fused ring system, and wherein a substitution at the 1- position of the cyclopentadien-1-yl group is mandatory when the cyclopentadien-1-yl group is not part of a fused ring system or is part of an indenyl group. Also claimed is the use of these phosphines as ligands in catalytic reactions and the preparation of these phosphines.
摘要翻译：本发明涉及由通式（1）表示的膦化合物，其中R'和R“独立地选自烷基，环烷基和2-呋喃基，或者R'和R”连接在一起形成磷原子a 包含至少3个碳原子的碳 - 磷单环或碳磷自行车; 烷基，环烷基和碳 - 磷单环未被取代或被至少一个选自烷基，环烷基，芳基，烷氧基和芳氧基的基团取代; Cp是部分取代或完全取代的环戊二烯-1-基，包括产生稠环体系的取代基，并且其中环戊二烯-1-基的1-位取代为当环戊二烯-1-基不是稠合环系的一部分或者是茚基的一部分时是强制性的。还要求保护的是在催化反应中使用这些膦作为配体并制备这些膦。

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