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1. 发明申请

WO2022250553A1 METHOD OF OBTAINING HIGH-PURITY MYXOXANTHOPHYLIS FROM PIGMENT EXTRACTS OF CYANOBACTERIA 审中-公开
公开(公告)号：WO2022250553A1
公开(公告)日：2022-12-01
申请号：PCT/PL2022/050030
申请日：2022-05-23
申请人： UNIWERSYTET JAGIELLOŃSKI
发明人： MALEC, Przemysław , ŻBIK, Paweł
IPC分类号： B01D15/32 , B01D11/02 , C07C403/24 , A61K31/047
摘要： The subject of the invention is a method of obtaining high-purity myxoxanthophylls, consisting of solvent extraction using sonication, centrifugation, decantation of the supernatant, obtaining the extract by evaporating the solvent or solvent mixture, purifying the dissolved extract on a chromatographic column, all steps being carried out in the absence of light.

2. 发明申请

WO2022058857A1 METHODS FOR THE EVALUATION OF SYSTEM INERTNESS 审中-公开
公开(公告)号：WO2022058857A1
公开(公告)日：2022-03-24
申请号：PCT/IB2021/058258
申请日：2021-09-10
申请人： WATERS TECHNOLOGIES CORPORATION
发明人： PATEL, Amit , JUNG, Moon Chul , WALTER, Thomas H. , LAUBER, Matthew A. , WYNDHAM, Kevin , DELANO, Mathew , SIMEONE, Jennifer
IPC分类号： B01D15/32 , B01D15/36 , C07F7/08 , G01N30/56 , G01N30/88
摘要： The present disclosure is directed to methods for evaluating system inertness, such as the inertness of a LC or other fluidic system. Some methods are directed to tests wherein the column has been removed prior to injecting a sample including a positive (e.g., metal reacting moiety) control into the system. Some methods can include: (1) repeatedly injecting the sample into a system, the system comprising: fluidic paths wherein interior surfaces of the fluidic paths define wetted surfaces, and wherein at least a portion of the wetted surfaces of the fluidic flow path are coated with an inert coating, wherein the inert coating is inert to at least one analyte in the sample; (2) detecting a value associated with the positive control; and (3) analyzing values associated with the detected positive control to determine system inertness.

3. 发明申请

WO2020254483A1 HPLC-BASED DETECTION OF FLOCCULATION AGENTS IN A PROTEIN SAMPLE 审中-公开
公开(公告)号：WO2020254483A1
公开(公告)日：2020-12-24
申请号：PCT/EP2020/066922
申请日：2020-06-18
申请人： UCB BIOPHARMA SRL
发明人： GERVAIS, Annick , DUBISY, Joel
IPC分类号： B01D15/32 , G01N30/84 , G01N30/88 , G01N30/34 , B01D15/16
摘要： The current application provides a rapid and simple method for measuring residual pDADMAC in a sample containing a recombinant protein of interest based on the combination of use of reversed-phase hydrophobic interaction HPLC and charged aerosol detection.

4. 发明申请

WO2019152970A1 CHANNELED FIBERS IN SEPARATION OF BIOLOGICALLY ACTIVE NANOPARTICLES 审中-公开
公开(公告)号：WO2019152970A1
公开(公告)日：2019-08-08
申请号：PCT/US2019/016591
申请日：2019-02-05
申请人： CLEMSON UNIVERSITY RESEARCH FOUNDATION
发明人： MARCUS, R. Kenneth , BRUCE, Terri , WANG, Lei , HUANG, Sisi , SLONECKI, Tyler , POWELL, Rhonda Reigers
IPC分类号： B01D15/32 , A61K35/12 , C07K14/47
CPC分类号： B01D15/327 , A61K35/68 , B01J20/262 , B01J20/28023 , B01J20/285 , B01J20/286 , B01J2220/54 , C07K14/47 , G01N1/405 , G01N33/5005
摘要： A relatively fast, inexpensive, and non-destructive method for separation and isolation of biologically active nanoparticles is described. Methods include the use of solid phase separation medis such as channeled fibers in a hydrophobic interaction chromatography (HIC) protocol to isolate biologically active nanoparticles from other components of a mixture. Biologically active nanoparticles can include natural nanoparticles (e.g., exosomes, lysosomes, virus particles) as well as synthetic nanoparticles (liposomes, genetically modified virus particles, etc.)

5. 发明申请

WO2019067637A1 HIGH PURITY CHROMATOGRAPHIC MATERIALS COMPRISING AN IONIZABLE MODIFIER FOR RETENTION OF ACIDIC ANALYTES 审中-公开
公开(公告)号：WO2019067637A1
公开(公告)日：2019-04-04
申请号：PCT/US2018/052982
申请日：2018-09-26
申请人： WATERS TECHNOLOGIES CORPORATION
发明人： LAUBER, Matthew A. , RAINVILLE, Paul , FAIRCHILD, Jacob N. , OKANDEJI, Babajide , LAWRENCE, Nicole L. , SHAH, Dimple
IPC分类号： B01D15/32 , B01D15/36 , B01J20/283 , B01J20/287
CPC分类号： B01J20/288 , B01D15/327 , B01D15/36 , B01D15/3847 , B01J20/28061 , B01J20/28073 , B01J20/28076 , B01J20/283 , B01J20/287 , B01J2220/54 , B01J2220/80
摘要： The present invention provides the use of charged surface reversed phase chromatographic materials along with standard reversed-phase LC and mass spectrometry compatible conditions for the retention, separation, purification, and characterization of acidic, polar molecules, including, but not limited to, organic acids, α-amino acids, phosphate sugars, nucleotides, other acidic, polar biologically relevant molecules. The chromatographic materials of the invention are high purity chromatographic materials comprising a chromatographic surface wherein the chromatographic surface comprises a hydrophobic surface group and one or more ionizable modifier.

6. 发明申请

WO2017105127A1 정제된 형광 메티오닌 및 진핵세포 번역 시스템을 이용한 목적 단백질의 고효율 형광 표지 방법 审中-公开
标题翻译：使用纯化的荧光甲硫氨酸和真核翻译系统对靶蛋白进行高效荧光标记
公开(公告)号：WO2017105127A1
公开(公告)日：2017-06-22
申请号：PCT/KR2016/014794
申请日：2016-12-16
申请人： 연세대학교 산학협력단
发明人： 성백린 , 김정민
IPC分类号： C12N15/11 , G01N33/58 , G01N33/68 , C12P21/00 , B01D15/32 , B01D15/34
CPC分类号： B01D15/32 , B01D15/34 , C12N15/11 , C12P21/00 , G01N33/58 , G01N33/68
摘要： 본 발명은 정제된 형광 메티오닌 및 진핵세포 번역 시스템을 이용한 목적 단백질의 고효율 형광 표지 방법에 관한 것으로, 보다 상세하게는, 정제된 형광 메티오닌을 사용하여 진핵세포 내에서 목적 단백질 합성에 사용하여 인 비트로에서 목적 단백질의 합성 효율과 형광 표지 효율을 개선하는 효과를 제공한다. 또한, 본 발명은 형광 표지된 단일 아미노산의 유도체화 없이 단일 아미노산의 정량 곡선을 통해 형광 표지된 단일 아미노산을 정량할 수 있다.
摘要翻译：
本发明涉及使用荧光纯化蛋氨酸和真核系统中的靶蛋白，和更特别地是平移的高效荧光标记法，使用在真核细胞纯化的荧光甲硫氨酸目的它用于蛋白质合成以提供提高目标蛋白合成效率和体外荧光标记效率的效果。此外，本发明可以与通过单个氨基酸没有衍生化单一荧光标记的氨基酸的定量曲线荧光标记定量单个氨基酸。

7. 发明申请

WO2017052305A1 METHOD OF INSULIN PRODUCTION 审中-公开
标题翻译：胰岛素生产方法
公开(公告)号：WO2017052305A1
公开(公告)日：2017-03-30
申请号：PCT/KR2016/010713
申请日：2016-09-23
申请人： HANMI PHARM. CO., LTD.
发明人： CHOI, Seong Ho , KIM, Dae Jin , KIM, Jin Young , KIM, Sang Yun , CHOI, In Young , KWON, Se Chang
IPC分类号： C07K14/62 , C07K1/18 , B01D15/32 , B01D15/36
CPC分类号： B01D15/362 , B01D15/325 , C07K14/62
摘要： The present invention relates to a method of preparing insulin from proinsulin comprising converting high-concentration proinsulin into insulin by enzymatic cleavage, a method of purifying insulin, and insulin prepared therefrom.
摘要翻译：本发明涉及从胰岛素原制备胰岛素的方法，包括通过酶裂解将高浓度胰岛素原转化成胰岛素，由胰岛素制备的胰岛素和由其制备的胰岛素的方法。

8. 发明申请

WO2016057715A1 GRAPHENE MEDIA FOR CHROMATOGRAPHY 审中-公开
标题翻译：用于色谱的石墨介质
公开(公告)号：WO2016057715A1
公开(公告)日：2016-04-14
申请号：PCT/US2015/054553
申请日：2015-10-07
申请人： NITTO DENKO CORPORATION , OZAIR, Siddiqui
发明人： OZAIR, Siddiqui
IPC分类号： B01D15/08 , B01D15/32 , B01J20/22 , B01J20/281 , B01J20/291
CPC分类号： B01D15/325 , B01D15/08 , B01D15/322 , B01J20/22 , B01J20/28061 , B01J20/282 , B01J20/291 , B01J20/3204 , B01J20/3208 , B01J20/3223 , B01J20/324
摘要： Described herein are methods separating mixtures of organic materials, the methods comprising retaining a graphene oxide; contacting the mixture with a graphene oxide; passing an organic eluent over the graphene oxide to concurrently elute the organic materials in the mixture at different rates; and selectively collecting the at least one organic material from the passed eluent, separating the at least one organic material from another. Also described herein are chromatographic materials, columns and systems incorporated in same methods.
摘要翻译：本文描述了分离有机材料的混合物的方法，所述方法包括保留氧化石墨烯; 使所述混合物与氧化石墨烯接触; 将有机洗脱液通过氧化石墨烯，同时以不同的速率洗脱混合物中的有机物质; 以及从所述经过的洗脱液中选择性收集所述至少一种有机材料，将所述至少一种有机材料与另一种分离。本文还描述了以相同方法并入的色谱材料，色谱柱和系统。

9. 发明申请

WO2015131994A1 IL-15/IL-15RALPHA BASED CONJUGATES PURIFICATION METHOD 审中-公开
标题翻译：基于IL-15 / IL-15RALPHA的凝血酶纯化方法
公开(公告)号：WO2015131994A1
公开(公告)日：2015-09-11
申请号：PCT/EP2015/000473
申请日：2015-03-03
申请人： CYTUNE PHARMA
发明人： BECHARD, David , DE MARTINOFF, Guy
IPC分类号： B01D15/32 , B01D15/36 , C07K1/18 , C07K1/20 , C07K1/36 , C07K14/435
CPC分类号： B01J41/20 , A61K38/00 , B01D15/14 , B01D15/327 , B01D15/363 , C07K1/18 , C07K1/20 , C07K14/5443 , C07K14/7155 , C07K2319/00
摘要： The present invention relates to a method for preparing a composition comprising monomeric conjugates from a sample, said conjugate comprising (a) a polypeptide comprising the amino acid sequence of interleukin 15 or derivatives thereof, and (b) a polypeptide comprising the amino acid sequence of the sushi domain of IL-15Rα or derivatives thereof; wherein said method comprises the use of anion-exchange chromatography followed by a hydrophobic interaction chromatography; and to a pharmaceutical composition which can be obtained by such a method.
摘要翻译：本发明涉及一种制备包含来自样品的单体缀合物的组合物的方法，所述缀合物包含（a）包含白介素15或其衍生物的氨基酸序列的多肽，和（b）包含氨基酸序列的多肽 IL-15Rα的寿司结构域或其衍生物; 其中所述方法包括使用阴离子交换层析，然后进行疏水相互作用层析; 以及可以通过这种方法获得的药物组合物。

10. 发明申请

WO2013052087A1 NEUTRAL ZWITTERIONIC DISPLACER MOLECULES FOR HYDROPHOBIC DISPLACEMENT CHROMATOGRAPHY 审中-公开
标题翻译：用于疏水性位移色谱法的中性ZWITTERIONIC位移分子
公开(公告)号：WO2013052087A1
公开(公告)日：2013-04-11
申请号：PCT/US2012/000433
申请日：2012-10-03
申请人： SACHEM, INC.
发明人： HAYMORE, Barry, L.
IPC分类号： B01D15/32 , B01D15/42
CPC分类号： C07K1/20 , B01D15/325 , B01D15/422
摘要： A process for separating organic compounds from a mixture by reverse- phase displacement chromatography, including providing a hydrophobic stationary phase; applying to the hydrophobic stationary phase a mixture comprising organic compounds to be separated; displacing the organic compounds from the hydrophobic stationary phase by applying thereto an aqueous composition comprising a non-surface active hydrophobic neutral zwitterionic displacer molecule and optionally an organic solvent; and collecting a plurality of fractions eluted from the hydrophobic stationary phase containing the separated organic compounds; in which the non-surface active hydrophobic neutral zwitterionic displacer molecule comprises a hydrophobic zwitterion having the general formula, as defined in the disclosure: [CM-R*-CM'].
摘要翻译：通过反相置换色谱从混合物中分离有机化合物的方法，包括提供疏水性固定相; 向疏水性固定相施加包含要分离的有机化合物的混合物; 通过向其施加包含非表面活性的疏水性中性两性离子置换剂分子和任选的有机溶剂的水性组合物来从疏水性固定相中移出有机化合物; 并收集从含有分离的有机化合物的疏水性固定相洗脱的多个级分; 其中非表面活性疏水性中性两性离子置换剂分子包含如本公开所定义的具有通式的疏水性两性离子：[CM-R * -CM']。

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