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1. 发明申请

WO01027588A1 SCANNING TUNNELING MICROSCOPE LIGHT EMITTING/CONDENSING DEVICE 审中-公开
标题翻译：扫描隧道显微镜发光/冷凝装置
公开(公告)号：WO01027588A1
公开(公告)日：2001-04-19
申请号：PCT/JP2000/005498
申请日：2000-08-17
IPC分类号： G01Q60/12 , G01Q30/02 , G01Q60/10 , G01N13/12
CPC分类号： G01Q60/12 , Y10S362/804 , Y10S977/861 , Y10S977/868
摘要： A scanning tunneling microscope light emitting/condensing device having a higher condensing efficiency in vacuum without sacrifice in a high spatial resolution provided by the STM. The scanning tunneling microscope light emitting/condensing device comprises a scanning tunneling microscope, and a plurality of optical fibers (2) radially disposed around a scanning tunneling microscope probe (1) with the tip end of the probe (1) as the center so as to condense light emission in operating this microscope.
摘要翻译：扫描隧道显微镜发光/冷凝装置，其在真空中具有较高的冷凝效率，而不牺牲由STM提供的高空间分辨率。扫描隧道显微镜发光/冷凝装置包括扫描隧道显微镜和以探针（1）的顶端为中心径向设置在扫描隧道显微镜探针（1）周围的多个光纤（2），以便在操作该显微镜时凝结发光。

2. 发明申请

WO03028037A2 DEVICE AND METHOD FOR SCANNING PROBE MICROSCOPE 审中-公开
标题翻译： DEVICE AND METHOD FOR的扫描探针显微镜
公开(公告)号：WO03028037A2
公开(公告)日：2003-04-03
申请号：PCT/DE0203688
申请日：2002-09-24
申请人： JPK INSTRUMENTS AG , KNEBEL DETLEF , JAEHNKE TORSTEN , SUENWOLDT OLAF
发明人： KNEBEL DETLEF , JAEHNKE TORSTEN , SUENWOLDT OLAF
IPC分类号： G01B21/00 , G01B21/30 , G01Q20/02 , G01Q60/06 , G12B21/08 , G12B21/22
CPC分类号： G01Q20/02 , Y10S977/868
摘要： The invention concerns a device and a method for a scanning probe microscope, in particular, an atomic force scanning microscope. The invention is characterized in that it comprises a measuring device (100) including a lateral displacement mechanism (1) for displacing a measuring probe (5) in a plane, a vertical displacement mechanism (4) for displacing the measuring probe in a plane perpendicular to said plane, and sample-holder (11) for receiving a sample to be measured (6). An optical path (10) of the condenser is formed through the measuring device (100), so that the sample-holder (11) is arranged in the region of one end of the optical path (10) of the condenser.
摘要翻译：本发明涉及一种用于扫描探针显微镜的装置和方法，特别是具有用于在一个平面上，用于移动（5）的垂直移动装置（4）发布的测量探头的测量装置（100），横向位移装置（1）的扫描力显微镜包括垂直于该平面和用于接收测试样品（6）的样品载体（11）的方向上的测量探头（5）。由通过冷凝器的测量装置（100）（10）形成，使得样品载体（11）被布置在所述冷凝器的光路（10）的一个端部的区域中。

3. 发明申请

WO1994025888A1 OPTICALLY GUIDED MACROSCOPIC-SCAN-RANGE/NANOMETER RESOLUTION PROBING SYSTEM 审中-公开
标题翻译：光学引导光栅扫描范围/纳米光束分辨率探测系统
公开(公告)号：WO1994025888A1
公开(公告)日：1994-11-10
申请号：PCT/US1994004624
申请日：1994-04-26
申请人： BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM
发明人： BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM , MARCHMAN, Herschel , WETSEL, Grover, C.
IPC分类号： G02B21/00
CPC分类号： G01Q60/22 , Y10S977/868
摘要： A large-nanostructure probe with optically guided macroscopic scanning is disclosed for high-resolution imaging and characterization of nanostructures. The invention contemplates the use of a coarse positioning system, which comprises one or more quadratic index fiber optic lenses (11) in conjunction with an optical microscope (12). A magnifying probe (37) is placed in close proximity to a sample under inspection. The fiber optic lenses (11) of the coarse positoning system are used to noninvasively carry the image of a sample-to-probe junction to the optical microscope (12). The optical microscope further magnifies the image, allowing for precise positioning of the probe tip to within 1 mu m of a desired feature on the sample surface. For ease to viewing, the magnified image from the microscope may be displayed on a monitor using a charge coupled device ("CCD") camera (13), if so desired. Also disclosed is a long-range probing system wherein the probe tip may be one of a variety of measurement or probing apparatus. For example, a particularly effective configuration of the long-range probing system is one in which the optical viewing system of the present invention serves as part of a coarse approach system for a scanning tunneling microscope probe.
摘要翻译：公开了具有光学引导的宏观扫描的大型纳米结构探针用于纳米结构的高分辨率成像和表征。本发明考虑使用粗定位系统，其包括与光学显微镜（12）结合的一个或多个二次折射率光纤透镜（11）。放大探头（37）放置在靠近被检样品的位置。粗定位系统的光纤透镜（11）被用来将样品 - 探针结的图像无侵入地携带到光学显微镜（12）。光学显微镜进一步放大图像，允许将探针尖端精确定位在样品表面上所需特征的1微米以内。为了便于查看，如果需要，可以使用电荷耦合器件（“CCD”）相机（13）将显微镜的放大图像显示在监视器上。还公开了一种远程探测系统，其中探针尖端可以是各种测量或探测装置之一。例如，长距离探测系统的特别有效的构造是其中本发明的光学观察系统用作扫描隧道显微镜探针的粗略方法系统的一部分。

4. 发明申请

WO2006123967A2 FLUORESCENT NANOSCOPY METHOD 审中-公开
标题翻译：荧光纳米科技
公开(公告)号：WO2006123967A2
公开(公告)日：2006-11-23
申请号：PCT/RU2006000231
申请日：2006-05-05
申请人： KLIMOV ANDREY ALEXEEVICH , KLIMOV DMITRY ANDREEVICH , KLIMOV EVGENIY ANDREEVICH , KLIMOVA TATIANA VITALYEVNA
发明人： KLIMOV ANDREY ALEXEEVICH , KLIMOV DMITRY ANDREEVICH , KLIMOV EVGENIY ANDREEVICH , KLIMOVA TATIANA VITALYEVNA
CPC分类号： G01N21/6428 , G01N21/6458 , G01N21/6486 , H04N7/18 , H04N13/0275 , Y10S977/84 , Y10S977/868 , Y10S977/869 , Y10S977/881 , Y10T436/143333 , Y10T436/25
摘要： The invention relates to analysis of object dyed with fluorescent colouring agents carried out with the aid of a fluorescent microscope which is modified in terms of improved resolving power and called a nanoscope thereafter. The inventive method is carried out with the aid of a microscope comprising an optical system for visualising and projecting a sample image to a video camera which records and digitises images of individual fluorescence molecules and nanoparticles at a low noise, a computer for recording and processing images, a sample holder arranged in front of an object lens, a fluorescent radiation exciting source and a set of replaceable suppression filter for separating the sample fluorescent light. The invention is characterised in that the separately fluorescing visible molecules and nanoparticles are periodically formed in different object parts, the laser produces the oscillation thereof which is sufficient for recording the non-overlapping images of said molecules and nanoparticles and for decolouring already recorded fluorescent molecules, wherein tens of thousands of pictures of recorded individual molecule and nanoparticle images (in the form of stains whose diameter is of the order of a fluorescent light wavelength multiplied by a microscope amplification) are processed by a computer for searching the co-ordinates of the stain centres and building the object image according to millions of calculated stain center co-ordinates corresponding to the co-ordinates of the individual fluorescent molecules and nanoparticles. Said invention makes it possible to obtain a two- and three-dimensional image with a resoling power better than 20 nm and to record a colour image by dyeing proteins, nucleic acids and lipids with different colouring agents.
摘要翻译：本发明涉及使用荧光显色剂进行荧光着色剂染色的物体的分析，所述荧光显微镜在分辨能力提高方面被修改，此后称为纳米镜。本发明的方法借助于包括用于将样本图像可视化并投影到以低噪声记录和数字化各个荧光分子和纳米颗粒的图像的摄像机的光学系统的显微镜进行，用于记录和处理图像的计算机，配置在物镜前面的样品架，荧光放射线激励源和用于分离样品荧光的一组可更换抑制滤光片。本发明的特征在于，在不同的对象部分中周期性地形成分开的荧光可见分子和纳米颗粒，激光产生其足以记录所述分子和纳米颗粒的非重叠图像并且用于脱色已经记录的荧光分子的振荡，其中记录的单个分子和纳米颗粒图像（其直径为荧光波长乘以显微镜放大的污渍的形式）的数万张照片由计算机处理，用于搜索染色体的坐标根据与各个荧光分子和纳米颗粒的坐标相对应的数百万计算的染色中心坐标来建立对象图像。本发明使得可以获得具有优于20nm的分辨率的二维和三维图像，并通过用不同着色剂对蛋白质，核酸和脂质进行染色来记录彩色图像。

5. 发明申请

WO98038501A1 SCANNING PROBE MICROSCOPE PROVIDING UNOBSTRUCTED TOP DOWN AND BOTTOM UP VIEWS 审中-公开
标题翻译：扫描探针显微镜提供未设计的顶部和底部视图
公开(公告)号：WO98038501A1
公开(公告)日：1998-09-03
申请号：PCT/US1998/002729
申请日：1998-02-06
IPC分类号： G01Q30/02 , G01B7/34 , G01N21/01 , G01N27/00 , G01Q10/02 , G01Q10/04 , G01Q30/14 , G01Q30/20 , G01Q60/02 , G01Q70/02 , G02B21/18 , H01J37/20 , H01J37/26
CPC分类号： G01Q10/04 , G01Q30/025 , Y10S977/849 , Y10S977/86 , Y10S977/868 , Y10S977/869 , Y10S977/87 , Y10S977/872 , Y10S977/873
摘要： Scanning probe microscopes and scanning probe heads are provided having improved optical visualization and sample manipulation capabilities. The SPMs and SPM heads include at least one flexure stage for scanning in the x, y and/or z directions. In a preferred embodiment, the SPMs or SPM heads include flexure stages for scanning in the x, y and z directions. The z scanning stage is preferably positioned outside the lateral footprint of the x-y flexure stage so that a probe extending from the z scanning stage is outside the lateral footprint of the instrument. The SPMs and SPM heads are configured to provide top down and bottom up optical views of the sample and/or the probe and enable simultaneous scanning probe microscopy and optical imaging of a sample to be performed. The SPMs and SPM heads are designed to be readily combinable with existing upright and inverted optical microscopes currently available from various major manufacturers.
摘要翻译：提供扫描探针显微镜和扫描探头，具有改进的光学可视化和样品操作能力。 SPM和SPM头包括用于在x，y和/或z方向扫描的至少一个弯曲台。在优选实施例中，SPM或SPM头包括用于在x，y和z方向扫描的挠曲台。 z扫描台优选地定位在x-y弯曲台的横向覆盖区的外侧，使得从z扫描台延伸的探针位于仪器的横向覆盖区之外。 SPM和SPM头被配置为提供样品和/或探针的自顶向下和从底部的光学视图，并且能够执行样品的同时扫描探针显微镜和光学成像。 SPM和SPM头设计为可以与现有的各种主要制造商现有的直立和倒置光学显微镜组合。

6. 发明申请

WO1995008109A1 A MEASURING DEVICE FOR MEASURING THE INTENSITY AND/OR POLARIZATION OF ELECTROMAGNETIC RADIATION, FOR DETERMINING PHYSICAL PROPERTIES OF A PREPARATION, AND FOR READING INFORMATION FROM A STORAGE MEDIUM 审中-公开
标题翻译：用于测量电磁辐射的强度和/或极化的测量装置，用于确定制备的物理特性，以及用于从存储介质读取信息
公开(公告)号：WO1995008109A1
公开(公告)日：1995-03-23
申请号：PCT/NL1994000227
申请日：1994-09-16
申请人： STICHTING KATHOLIEKE UNIVERSITEIT NIJMEGEN , VAN KEMPEN, Herman , ABRAHAM, Daniël, Lee , PRINS, Menno, Willem, José , JANSEN, Ronald , VAN DER WIELEN, Maurice, Christienus, Martinus, Maria
发明人： STICHTING KATHOLIEKE UNIVERSITEIT NIJMEGEN
IPC分类号： G01N27/00
CPC分类号： G01Q60/16 , G01Q30/02 , G01Q60/02 , G01Q60/12 , G01Q60/14 , G01Q60/22 , G01R33/032 , G11B9/14 , G11B9/1463 , G11B11/007 , G11B11/10515 , G11B11/10545 , G11B13/045 , Y10S977/834 , Y10S977/852 , Y10S977/868 , Y10S977/95 , Y10S977/954 , Y10S977/96
摘要： A measuring device for measuring the intensity and/or polarization of electromagnetic radiation, more in particular of light. The measuring device is provided with a tunnel tip arranged facing a body at some distance, which tunnel tip at least partly consists of a semiconductor material. The measuring device further comprises a control unit for obtaining information about the intensity and/or polarization of the radiation by means of a tunnel current, generated under the influence of the radiation in the tunnel tip, between the tunnel tip and the body and/or a surface photovoltage of the tunnel tip, generated under the influence of the radiation. The device can be used as near field microscope, polarization selective near field detector. In one special embodiment the body forms an information storage medium.
摘要翻译：用于测量电磁辐射的强度和/或极化的测量装置，更特别是光。测量装置设置有一定的隧道末端，隧道末端以一定的距离面向身体，该隧道尖端至少部分地由半导体材料组成。测量装置还包括一个控制单元，用于通过在隧道尖端的辐射的影响下，在隧道末端和身体之间产生的隧道电流获得关于辐射的强度和/或极化的信息和/或隧道尖端的表面光电压，在辐射的影响下产生。该装置可用作近场显微镜，极化选择性近场探测器。在一个特殊实施例中，身体形成信息存储介质。

7. 发明申请

WO1990010304A1 METHOD AND APPARATUS FOR SPECIFIC SPECTROSCOPIC ATOMIC IMAGING USING COMPLEMENTARY WAVELENGTH SPECIFIC PHOTON BIASING WITH ELECTRONIC AND TEMPERATURE BIASING ON A SCANNING TUNNELING MICROSCOPE 审中-公开
标题翻译：在扫描隧道显微镜上使用电子和温度偏移的补充波长特定光子偏转的特定光谱原子成像的方法和装置
公开(公告)号：WO1990010304A1
公开(公告)日：1990-09-07
申请号：PCT/US1990000098
申请日：1990-01-08
申请人： MIDWEST RESEARCH INSTITUTE , KAZMERSKI, Lawrence, L.
发明人： MIDWEST RESEARCH INSTITUTE
IPC分类号： H01J37/285
CPC分类号： G01Q60/12 , G01Q30/02 , G01Q30/10 , Y10S977/852 , Y10S977/861 , Y10S977/868
摘要： A method and apparatus (10) for specific spectroscopic atomic-imaging is disclosed for spatial resolution and imaging for display not only individual atoms on a sample (5) surface, but also bonding and the specific atomic species in such bond. The apparatus (10) includes a scanning tunneling microscope (STM) that is modified to include photon biasing, preferably a tuneable laser (54), modulating electronic surface biasing for the sample (5), and temperature biasing, preferably a vibration-free refrigerated sample mounting stage (12). Computer control (100) and data processing and visual display components (102) are also included. The method includes modulating the electronic bias voltage with and without selected photon wavelengths and frequency biasing under a stabilizing (usually cold) bias temperature to detect bonding and specific atomic species in the bonds as the STM rasters the sample (5). This data is processed along with atomic spatial topography data obtained from the STM raster scan to create a real-time visual image of the atoms on the sample (5) surface.
摘要翻译：公开了用于特定光谱原子成像的方法和装置（10）用于空间分辨率和成像，用于不仅显示样品（5）表面上的单个原子，而且还可以键合和这种键中的特定原子物质。该装置（10）包括扫描隧道显微镜（STM），其被修改为包括光子偏置，优选可调谐激光器（54），调制用于样品（5）的电子表面偏置，以及温度偏置，优选无振动的冷冻样品安装台（12）。还包括计算机控制（100）和数据处理和视觉显示组件（102）。该方法包括在稳定（通常为冷）偏压温度下调制具有和不具有所选择的光子波长和频率偏置的电子偏置电压，以在STM栅极对样品（5）进行栅格扫描时检测键中的键合和特定原子物质。将该数据与从STM光栅扫描获得的原子空间地形数据一起处理，以创建样品（5）表面上的原子的实时视觉图像。

8. 发明申请

WO2003028038A2 VERFAHREN UND VORRICHTUNG ZUM MESSEN EINER PROBE MIT HILFE EINES RASTERSONDENMIKROSKOPS 审中-公开
标题翻译：方法和装置用于测量样品用扫描型探针显微镜
公开(公告)号：WO2003028038A2
公开(公告)日：2003-04-03
申请号：PCT/DE2002/003690
申请日：2002-09-24
申请人： JPK INSTRUMENTS AG , KAMPS, Jörn
发明人： KAMPS, Jörn
IPC分类号： G12B21/08
CPC分类号： G01Q20/02 , Y10S977/868
摘要： Die Erfindung bezieht sich auf ein Verfahren und eine Vorrichtung zum Messen einer Messprobe mit Hilfe eines Rastersondenmikroskops, insbesondere eines Rasterkraftmikroskops, bei dem zum Messen einer Messprobe (6) eine Messsonde (5) mit Hilfe einer lateralen und einer vertikalen Verlagerungseinheit (1) relativ zu der Messprobe (6) verlagert wird; Messlichtstrahlen (21) mit Hilfe einer Lichtquelle (20) erzeugt und auf eine an der Messsonde angeordnete Reflexionseinrichtung (91) gelenkt werden; die Messlichtstrahlen (21) an der Reflexionseinrichtung (91) reflektiert werden, so dass reflektierte Messlichtstrahlen (21a) gebildet werden; und die reflektierten Messlichtstrahlen (21a) zum Erzeugen eines Messsignals mit Hilfe einer Korrekturlinse (47) auf eine Empfängerfläche (32) einer Empfängeeinrichtung (27) gelenkt werden, wobei die Korrekturlinse (47) in einem Abstand, welcher im wesentlichen gleich einer Fokuslänge der Korrekturlinse (47) ist, von der Empfängerfläche (32) angeordnet ist.
摘要翻译：本发明涉及一种方法和一种使用扫描探针显微镜，尤其是扫描力显微镜，测定测量样品的装置，其特征在于，用于测量测量样品（6），测量探头（5）通过横向和垂直位移单元的装置（1）相测量样品（6）的位移; 测量光线由光源（20）的装置产生（21）并引导到布置在所述反射装置（91）的测量探头; 测量的光线（21）反射的反射装置（91），使得反射光线（21A）形成测量; 和反射的测量光线（21A），用于通过校正透镜（47）的装置产生一测量信号的接收表面（32）的接收装置（27）被引导，所述的一个距离，该距离基本上等于所述校正透镜的焦距校正透镜（47）（47），从接收器表面（32）被布置。

9. 发明申请

WO2003014392A2 USE AND EVALUATION OF A [2+2] PHOTOADDITION IN IMMOBILIZATION OF OLIGONUCLEOTIDES ON A THREE-DIMENSIONAL HYDROGEL MATRIX 审中-公开
标题翻译：寡核苷酸在三维水凝胶基质中固定[2 + 2]光固化的应用与评价
公开(公告)号：WO2003014392A2
公开(公告)日：2003-02-20
申请号：PCT/IB2002/004038
申请日：2002-08-09
申请人： AMERSHAM BIOSCIENCES AB
发明人： ELGHANIAN, Robert , BRUSH, Charles, K. , XU, Yanzheng
IPC分类号： C12Q1/68
CPC分类号： B82Y30/00 , B01J19/0046 , B01J2219/00378 , B01J2219/00529 , B01J2219/00641 , B01J2219/00659 , B01J2219/00711 , B01J2219/00722 , C12Q1/6834 , C40B60/14 , Y10S977/86 , Y10S977/868 , C12Q2523/319
摘要： [2 + 2] photo-attachable functional groups were incorporated in polyacrylamide based hydrogels and synthetic oligonucleotide probes. The probes were photochemically attached by covalent bonding to the three dimensional surface of a hydrogel. The resultant hydrogel microarrays were used for detection of specific target oligonucleotides, including mRNA and DNA, as suitable for expression and single nucleotide polymorphism type microarray analyses.
摘要翻译：在聚丙烯酰胺基水凝胶和合成的寡核苷酸探针中引入了[2 + 2]光可附着的官能团。探针通过共价键结合到水凝胶的三维表面上而光化学附着。所得到的水凝胶微阵列用于检测适合于表达和单核苷酸多态性类型微阵列分析的特定靶寡核苷酸，包括mRNA和DNA。

10. 发明申请

WO01094784A1 SYNTHETIC MUSCLE BASED DIAPHRAGM PUMP APPARATUSES 审中-公开
标题翻译：基于合成肌肉的膜片泵设备
公开(公告)号：WO01094784A1
公开(公告)日：2001-12-13
申请号：PCT/US2001/017683
申请日：2001-06-01
IPC分类号： A61F9/007 , A61M1/00 , A61M5/142 , A61M5/145 , F04B43/04 , F04B17/00
CPC分类号： A61M5/14586 , A61F9/00781 , A61M1/0023 , A61M5/14276 , A61M5/14593 , F04B43/04 , F04B43/043 , Y10S977/868 , Y10S977/906
摘要： An implantable, pressure adjustable diaphragm pump assembly comprises a main body having an interior end (17), a posterior end (17') and an interior chamber (14). A first and second check valve (16, 18) are respectively disposed in the interior and posterior ends. A diaphragm (20) extends across the interior chamber whereby oscillating movement of the diaphragm causes fluid flow through the pump assembly. The diaphragm is powered by a source of electrical power.
摘要翻译：可植入的压力可调的隔膜泵组件包括具有内端（17），后端（17'）和内室（14）的主体。第一和第二止回阀（16,18）分别设置在内部和后端。隔膜（20）延伸穿过内部室，由此隔膜的振动运动使流体流过泵组件。隔膜由电源供电。

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