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1. 发明申请

WO2004088324A3 PROTEOMIC ANALYSIS OF BIOLOGICAL FLUIDS 审中-公开
标题翻译：生物流体的保护性分析
公开(公告)号：WO2004088324A3
公开(公告)日：2005-06-02
申请号：PCT/US2004008954
申请日：2004-03-23
申请人： PROTEOGENIX INC , ROSENFELD RON , NAGALLA SRI , GRAVETT MIKE
发明人： ROSENFELD RON , NAGALLA SRI , GRAVETT MIKE
IPC分类号： G01N33/68 , B01J19/00 , C07K16/00 , G01N33/543
CPC分类号： G01N33/6803 , G01N33/6893
摘要： The invention concerns the identification of proteomes of biological fluids and their use in determining the state of maternal/fetal conditions, including maternal conditions of fetal origin, chromosomal aneuploidies, and fetal diseases associated with fetal growth and maturation. In particular, the invention concerns the identification of the proteome of amniotic fluid (multiple proteins representing the composition of amniotic fluid) and the correlation of characteristic changes in the normal, proteome with various pathologic maternal/fetal conditions, such as intra-amniotic infection, or chromosomal defects.
摘要翻译：本发明涉及生物流体蛋白质组学的鉴定及其在确定母体/胎儿状态的用途，包括胎儿起源的母亲条件，染色体非整倍体以及与胎儿生长和成熟相关的胎儿疾病。特别地，本发明涉及羊水蛋白质组（代表羊水组成的多种蛋白质）的鉴定以及正常蛋白质组与各种病理性母亲/胎儿病症如羊膜内感染之间的特征变化的相关性，或染色体缺陷。

2. 发明申请

WO2009097584A1 MATERNAL SERUM BIOMARKERS FOR DETECTION OF PRE-ECLAMPSIA 审中-公开
标题翻译：用于检测前体血清的大肠杆菌生物标志物
公开(公告)号：WO2009097584A1
公开(公告)日：2009-08-06
申请号：PCT/US2009/032739
申请日：2009-01-30
申请人： PROTEOGENIX, INC. , NAGALLA, Srinivasa , RASANEN, Juha , GRAVETT, Michael
发明人： NAGALLA, Srinivasa , RASANEN, Juha , GRAVETT, Michael
IPC分类号： G01N33/68
CPC分类号： G01N33/689 , G01N2800/368
摘要： The present invention concerns the identification and detection of maternal serum biomarkers of pre-eclampsia and associated complications, gestational hypertension and placental insufficiency using global proteomic approaches. The invention further concerns the identification of maternal serum biomarkers for detection of pre-eclampsia and associated complications, gestational hypertension and placental insufficiency during early gestation.
摘要翻译：本发明涉及使用全球蛋白质组学方法识别和检测孕妇血清生化标志物的先兆子痫及相关并发症，妊娠高血压和胎盘功能不全。本发明还涉及鉴定用于检测先兆子痫及相关并发症的母体血清生物标志物，妊娠早期妊娠期高血压和胎盘功能不全。

3. 发明申请

WO2009097579A1 GESTATIONAL AGE DEPENDENT PROTEOMIC CHANGES OF HUMAN MATERNAL SERUM FOR MONITORING MATERNAL AND FETAL HEALTH 审中-公开
标题翻译：人体年龄依赖于人类血清中监测母体和健康的主要血清的保护性变化
公开(公告)号：WO2009097579A1
公开(公告)日：2009-08-06
申请号：PCT/US2009/032731
申请日：2009-01-30
申请人： PROTEOGENIX, INC. , NAGALLA, Srinivasa , RASANEN, Juha , GRAVETT, Michael
发明人： NAGALLA, Srinivasa , RASANEN, Juha , GRAVETT, Michael
IPC分类号： G01N33/68
CPC分类号： G01N33/689 , G01N33/6803
摘要： The present invention concerns a global maternal serum proteome map and its changes during healthy gestation. Accordingly, the present invention provides an important tool for plasma-based maternal-fetal diagnostics.
摘要翻译：本发明涉及全球母体血清蛋白质组图及其在健康妊娠期间的变化。因此，本发明提供了基于血浆的母胎诊断的重要工具。

4. 发明申请

WO2006034427A3 DIAGNOSIS OF FETAL ANEUPLOIDY 审中-公开
公开(公告)号：WO2006034427A3
公开(公告)日：2006-03-30
申请号：PCT/US2005/034083
申请日：2005-09-20
申请人： PROTEOGENIX, INC. , ROSENFELD, Ron , NAGALLA, Srinivasa, R.
发明人： ROSENFELD, Ron , NAGALLA, Srinivasa, R.
IPC分类号： C12Q1/68 , A61K35/50 , A61K35/16
摘要： The invention relates to a method for the early non-invasive diagnosis of fetal aneuploidy. In particular, the invention concerns the diagnosis of fetal aneuploidy by identifying protein expression patterns characteristics of fetal aneuploidy in a maternal biological fluid, such as maternal serum or amniotic fluid.

5. 发明申请

WO2005088302A1 METHODS AND SYSTEMS FOR IDENTIFICATION OF MACROMOLECULES 审中-公开
标题翻译：用于鉴定大分子的方法和系统
公开(公告)号：WO2005088302A1
公开(公告)日：2005-09-22
申请号：PCT/US2005/005524
申请日：2005-02-22
申请人： PROTEOGENIX, INC. , NAGALLA, Srinivasa , SEARLE, Brian , DASARI, Surendra , TURNER, Mark, A.
发明人： NAGALLA, Srinivasa , SEARLE, Brian , DASARI, Surendra , TURNER, Mark, A.
IPC分类号： G01N33/48
CPC分类号： G06F19/22 , G06F19/28 , H01J49/0036
摘要： A method is provided for identifying sequences of molecules and sequence modifications form mass spectrometry data. At least one de novo sequence is produced from mass spectrometry data of sequences of molecules. A least one mass-based alignment is calculated between each de novo sequence and sequences in a sequence database. The molecular masses of molecules in the de novo sequence are compared to molecular masses of molecules in each sequence in the sequence database. Mass differences of modification sites are interpreted between the sequence in the sequence database and the novo sequence that have been identified by the mass-based alignment as modifications identified in a modification catalog. At least one match score for the mass-based alignment is calculated that provides an indication of matching between the sequence in the sequence database and the novo sequence. Sequences in the sequence database are identified from mass-based alignments in response to the match scores. Identifications of the sequence database are grouped from at least one de novo sequence into an identified macromolecule list that agrees with the novo sequencing results.
摘要翻译：提供了用于鉴定分子序列和形成质谱数据的序列修饰的方法。由分子序列的质谱数据产生至少一个从头序列。在序列数据库中的每个从头序列和序列之间计算至少一个基于质量的比对。将从头序列中的分子的分子质量与序列数据库中的每个序列中的分子的分子量进行比较。修饰位点的质量差异在序列数据库中的序列和通过基于质量的校准被鉴定为在修改目录中确定的修饰的新离子序列之间进行了解释。计算用于基于质量的比对的至少一个匹配得分，其提供序列数据库中的序列和新诗序列之间的匹配的指示。序列数据库中的序列根据匹配分数从基于质量的比对中确定。序列数据库的识别从至少一个从头序列分组到与新呼号测序结果一致的识别的大分子列表中。

6. 发明申请

WO2004088324A2 PROTEOMIC ANALYSIS OF BIOLOGICAL FLUIDS 审中-公开
标题翻译：生物流体的保护性分析
公开(公告)号：WO2004088324A2
公开(公告)日：2004-10-14
申请号：PCT/US2004/008954
申请日：2004-03-23
申请人： PROTEOGENIX, INC. , ROSENFELD, Ron , NAGALLA, Sri , GRAVETT, Mike
发明人： ROSENFELD, Ron , NAGALLA, Sri , GRAVETT, Mike
IPC分类号： G01N33/68
CPC分类号： G01N33/6803 , G01N33/6893
摘要： The invention concerns the identification of proteomes of biological fluids and their use in determining the state of maternal/fetal conditions, including maternal conditions of fetal origin, chromosomal aneuploidies, and fetal diseases associated with fetal growth and maturation. In particular, the invention concerns the identification of the proteome of amniotic fluid (multiple proteins representing the composition of amniotic fluid) and the correlation of characteristic changes in the normal, proteome with various pathologic maternal/fetal conditions, such as intra-amniotic infection, or chromosomal defects.
摘要翻译：本发明涉及生物流体蛋白质组学的鉴定及其在确定母体/胎儿状况的用途，包括胎儿来源的母亲条件，染色体非整倍体和与胎儿生长和成熟相关的胎儿疾病。特别地，本发明涉及羊水蛋白质组（代表羊水组成的多种蛋白质）的鉴定以及正常蛋白质组学与各种病理性母体/胎儿病症如羊膜内感染之间的特征变化的相关性，或染色体缺陷。

7. 发明申请

WO2010088187A1 BIOMARKERS FOR DETECTION OF NEONATAL SEPSIS IN BIOLOGICAL FLUID 审中-公开
标题翻译：生物标志物检测生物流体中的新生儿食欲
公开(公告)号：WO2010088187A1
公开(公告)日：2010-08-05
申请号：PCT/US2010/022017
申请日：2010-01-25
申请人： PROTEOGENIX, INC. , NAGALLA, Srinivasa , GRAVETT, Mike
发明人： NAGALLA, Srinivasa , GRAVETT, Mike
IPC分类号： G01N33/68
CPC分类号： G01N33/6893 , G01N2550/00 , G01N2800/26 , G01N2800/60
摘要： The present invention concerns the identification and detection of biological fluid biomarkers of neonatal sepsis using global proteomic approaches.
摘要翻译：本发明涉及使用全球蛋白质组学方法识别和检测新生儿败血症的生物流体生物标志物。

8. 发明申请

WO2008063928A3 PROTEOMIC ANALYSIS OF CERVICAL-VAGINAL FLUIDS FOR DETECTING INTRA-UTERINE INFECTION OR DETERMINING PRE-TERM DELIVERY RISK IN A PREGNANT FEMALE 审中-公开
标题翻译：用于检测子宫内膜感染或确定孕妇预先传递风险的血管内皮细胞的保护性分析
公开(公告)号：WO2008063928A3
公开(公告)日：2008-09-12
申请号：PCT/US2007084311
申请日：2007-11-09
申请人： PROTEOGENIX INC , ROSENFELD RON , NAGALLA SRINIVASA , GRAVETT MIKE
发明人： ROSENFELD RON , NAGALLA SRINIVASA , GRAVETT MIKE
IPC分类号： G01N33/68
CPC分类号： G01N33/689 , G01N2800/368 , Y02A90/26
摘要： The invention concerns the identification of proteomes of biological fluids and their use in determining the state of maternal/fetal conditions, including maternal conditions of fetal origin, chromosomal aneuploidies, and fetal diseases associated with fetal growth and maturation. In particular, the invention concerns a comprehensive proteomic analysis of human amniotic fluid (AF) and cervical vaginal fluid (CVF), and the correlation of characteristic changes in the normal proteome with various pathologic maternal/fetal conditions, such as intra-amniotic infection, pre-term labor, and/or chromosomal defects. The invention further concerns the identification of biomarkers and groups of biomarkers that can be used for non-invasive diagnosis of various pregnancy-related disorders, and diagnostic assays using such biomarkers.
摘要翻译：本发明涉及生物流体蛋白质组学的鉴定及其在确定母体/胎儿状态的用途，包括胎儿起源的母亲条件，染色体非整倍体以及与胎儿生长和成熟相关的胎儿疾病。特别地，本发明涉及人类羊水（AF）和子宫颈阴道液（CVF）的综合蛋白质组学分析，以及正常蛋白质组特征变化与各种病理性母亲/胎儿病症如羊膜内感染，早期劳动和/或染色体缺陷。本发明还涉及可用于各种妊娠相关疾病的非侵入性诊断的生物标志物和生物标志物组的鉴定，以及使用此类生物标志物的诊断测定。

9. 发明申请

WO2008063928A9 PROTEOMIC ANALYSIS OF BIOLOGICAL FLUIDS 审中-公开
标题翻译：生物流体的保护性分析
公开(公告)号：WO2008063928A9
公开(公告)日：2008-07-17
申请号：PCT/US2007084311
申请日：2007-11-09
申请人： PROTEOGENIX INC , ROSENFELD RON , NAGALLA SRINIVASA , GRAVETT MIKE
发明人： ROSENFELD RON , NAGALLA SRINIVASA , GRAVETT MIKE
IPC分类号： G01N33/50 , G01N33/68
CPC分类号： G01N33/689 , G01N2800/368 , Y02A90/26
摘要： The invention concerns the identification of proteomes of biological fluids and their use in determining the state of maternal/fetal conditions, including maternal conditions of fetal origin, chromosomal aneuploidies, and fetal diseases associated with fetal growth and maturation. In particular, the invention concerns a comprehensive proteomic analysis of human amniotic fluid (AF) and cervical vaginal fluid (CVF), and the correlation of characteristic changes in the normal proteome with various pathologic maternal/fetal conditions, such as intra-amniotic infection, pre-term labor, and/or chromosomal defects. The invention further concerns the identification of biomarkers and groups of biomarkers that can be used for non-invasive diagnosis of various pregnancy-related disorders, and diagnostic assays using such biomarkers.
摘要翻译：本发明涉及生物流体蛋白质组学的鉴定及其在确定母体/胎儿状况的用途，包括胎儿来源的母亲条件，染色体非整倍体和与胎儿生长和成熟相关的胎儿疾病。特别地，本发明涉及人类羊水（AF）和子宫颈阴道液（CVF）的综合蛋白质组学分析，以及正常蛋白质组特征变化与各种病理性母体/胎儿状况的相关性，例如羊膜内感染，前期劳动和/或染色体缺陷。本发明还涉及可用于各种妊娠相关疾病的非侵入性诊断的生物标志物和生物标志物组的鉴定，以及使用这种生物标志物的诊断测定。

10. 发明申请

WO2008063928A2 PROTEOMIC ANALYSIS OF BIOLOGICAL FLUIDS 审中-公开
标题翻译：生物流体的蛋白质组学分析
公开(公告)号：WO2008063928A2
公开(公告)日：2008-05-29
申请号：PCT/US2007/084311
申请日：2007-11-09
申请人： PROTEOGENIX, INC. , ROSENFELD, Ron , NAGALLA, Srinivasa , GRAVETT, Mike
发明人： ROSENFELD, Ron , NAGALLA, Srinivasa , GRAVETT, Mike
IPC分类号： G01N33/50
CPC分类号： G01N33/689 , G01N2800/368 , Y02A90/26
摘要： The invention concerns the identification of proteomes of biological fluids and their use in determining the state of maternal/fetal conditions, including maternal conditions of fetal origin, chromosomal aneuploidies, and fetal diseases associated with fetal growth and maturation. In particular, the invention concerns a comprehensive proteomic analysis of human amniotic fluid (AF) and cervical vaginal fluid (CVF), and the correlation of characteristic changes in the normal proteome with various pathologic maternal/fetal conditions, such as intra-amniotic infection, pre-term labor, and/or chromosomal defects. The invention further concerns the identification of biomarkers and groups of biomarkers that can be used for non-invasive diagnosis of various pregnancy-related disorders, and diagnostic assays using such biomarkers.
摘要翻译：本发明涉及生物流体的蛋白质组的鉴定和它们在确定母体/胎儿状况（包括胎儿起源的母体状况，染色体非整倍体和与胎儿生长和成熟有关的胎儿疾病）中的用途。具体而言，本发明涉及人羊水（AF）和宫颈阴道液（CVF）的全面蛋白质组学分析，并且正常蛋白质组中的特征变化与各种病理性母/胎状况（例如羊膜内感染）早产，和/或染色体缺陷。本发明进一步涉及可用于非侵入性诊断各种妊娠相关病症的生物标志物和生物标志物组的鉴定，以及使用此类生物标志物的诊断测定。

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