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1. 发明申请

WO2016077333A1 DOUBLE IDENTIFICATION FOR SAMPLE TRACKING ON A DIAGNOSTIC DEVICE 审中-公开
标题翻译：用于诊断设备上的样本跟踪的双重标识
公开(公告)号：WO2016077333A1
公开(公告)日：2016-05-19
申请号：PCT/US2015/059938
申请日：2015-11-10
申请人： GENMARK DIAGNOSTICS, INC.
发明人： TIEMAN, Brad Frederick , COREY, Scott
IPC分类号： G01N35/00
CPC分类号： B01L3/502 , B01L3/54 , B01L3/545 , B01L2200/026 , B01L2300/021 , B01L2300/022 , B01L2300/042 , B01L2300/087 , B01L2400/0481 , G01N35/00732 , G01N2035/00742 , G01N2035/00752 , G01N2035/00762 , G01N2035/00772 , G01N2035/00782 , G01N2035/00801 , G01N2035/00811 , G01N2035/00831 , G01N2035/00851
摘要： A sample-containing device configured to be placed into a sample processing instrument for performing a process on a sample contained in the device includes redundant identification features, such as machine-readable tags. A first machine-readable information tag is read before the device is placed in the instrument, and a second machine-readable information tag is read after the device is in the instrument. Information read from the two tags is compared to determine if there is proper correspondence between the information read from the tags to ensure that the correct sample processing device was placed in the instrument.
摘要翻译：被配置为放置在用于对包含在该设备中的样品进行处理的样品处理仪器中的样品含有装置包括冗余识别特征，诸如机器可读标签。在将设备放置在仪器中之前，先读取第一个机器可读信息标签，并在设备进入仪器后读取第二机器可读信息标签。比较从两个标签读取的信息，以确定从标签读取的信息之间是否存在正确的对应关系，以确保将正确的样品处理装置放置在仪器中。

2. 发明申请

WO2010147895A1 SYSTEM FOR MANAGING INVENTORIES OF REAGENTS 审中-公开
标题翻译：管理试剂库存的系统
公开(公告)号：WO2010147895A1
公开(公告)日：2010-12-23
申请号：PCT/US2010/038519
申请日：2010-06-14
申请人： ABBOTT LABORATORIES , FRITCHIE, Patrick, P. , JONES, John, C. , SCHWARTZ, Oscar, F.
发明人： FRITCHIE, Patrick, P. , JONES, John, C. , SCHWARTZ, Oscar, F.
IPC分类号： G01N35/00
CPC分类号： G01N35/00663 , G01N35/00584 , G01N35/00732 , G01N35/0099 , G01N35/04 , G01N2035/00435 , G01N2035/00673 , G01N2035/00762 , G01N2035/00811 , G01N2035/00821 , G01N2035/0091 , G06Q10/087 , Y10T436/11 , Y10T436/13
摘要： A system for managing the inventory of reagents for a laboratory automation system is disclosed. The system for managing the inventory of reagents comprises a controller, software for the controller, and a refrigerator capable of refrigerating reagents, detecting the presence or absence of reagents in the refrigerator, and detecting the location of reagents in the refrigerator. The system for managing the inventory of reagents is connected to a laboratory automation system. The laboratory automation system comprises at least one clinical analyzer. A typical system for managing inventories of reagents includes an operator interface for the loading of boxes of reagents and other supplies, radio frequency identification system for identification of inventory and tracking, robotic mechanisms for loading containers onto the track system and removing containers from the track system, de-capping equipment, refrigeration equipment, and information technology connections to laboratory analyzers and vendors.
摘要翻译：公开了一种用于管理实验室自动化系统的试剂库存的系统。用于管理试剂库存的系统包括控制器，用于控制器的软件和能够冷藏试剂的冰箱，检测冰箱中试剂的存在或不存在以及检测冰箱中试剂的位置。用于管理试剂库存的系统连接到实验室自动化系统。实验室自动化系统至少包括一个临床分析仪。用于管理试剂库存的典型系统包括用于装载试剂盒和其他用品的操作者界面，用于识别库存和跟踪的射频识别系统，用于将容器装载到轨道系统上的机器人机构以及从轨道系统中移出容器，脱帽设备，制冷设备以及与实验室分析仪和供应商的信息技术连接。

3. 发明申请

WO0198765A9 MULTIANALYTE MOLECULAR ANALYSIS 审中-公开
标题翻译：多元分子分析
公开(公告)号：WO0198765A9
公开(公告)日：2003-09-04
申请号：PCT/US0120179
申请日：2001-06-21
申请人： BIOARRAY SOLUTIONS LTD , XIANG LI ALICE , BANERJEE SUKANTA , CHAU WO CHIU , PODUAL KAIRALI
发明人： XIANG LI ALICE , BANERJEE SUKANTA , CHAU WO CHIU , PODUAL KAIRALI
IPC分类号： G01N21/64 , B01J19/00 , C12M1/34 , C12Q1/68 , G01N33/53 , G01N33/543 , G01N33/553 , G01N33/58 , G01N35/00 , G01N27/26 , C12P19/34 , G01N21/00
CPC分类号： C12Q1/6813 , B01J19/0046 , B01J2219/00286 , B01J2219/00315 , B01J2219/00497 , B01J2219/005 , B01J2219/00527 , B01J2219/00545 , B01J2219/00576 , B01J2219/00585 , B01J2219/00596 , B01J2219/00644 , B01J2219/00648 , B01J2219/00653 , B01J2219/00722 , B01J2219/00725 , C12Q1/6837 , C12Q1/6876 , G01N27/745 , G01N33/5434 , G01N33/54346 , G01N33/587 , G01N2035/00564 , G01N2035/00762 , G01N2446/20 , G01N2446/64 , Y10T436/11 , C12Q2565/513 , C12Q2563/143 , C12Q2563/107 , C12Q2563/155
摘要： The present invention provides methods and apparatus for the application of a particle array in bioassay format to perform qualitative and/or quantitative molecular interaction analysis between two classes of molecules (an analyte and a binding agent). The methods and apparatus disclosed herein permit the determination of the presence or absence of association, the strength of association, and/or the rate of association and dissociation governing the binding interactions between the binding agents and the analyte molecules. The present invention is especially useful for performing multiplexed (parallel) assays for qualitative and/or quantitative analysis of binding interactions of a number of analyte molecules in a sample.
摘要翻译：本发明提供了用于以生物测定形式应用颗粒阵列以在两类分子（分析物和结合剂）之间进行定性和/或定量分子相互作用分析的方法和装置。本文公开的方法和装置允许确定结合剂和分析物分子之间的结合相互作用的存在或不存在，缔合的强度，和/或缔合速率和解离速率。本发明特别可用于进行多个（并行）测定以定性和/或定量分析样品中许多分析物分子的结合相互作用。

4. 发明申请

WO01051207A1 LINEAR PROBE CARRIER 审中-公开
标题翻译：线性探测器
公开(公告)号：WO01051207A1
公开(公告)日：2001-07-19
申请号：PCT/US2001/001026
申请日：2001-01-10
IPC分类号： G01N21/64 , B01L3/00 , C12M1/00 , C12M1/34 , C12Q1/00 , C12Q1/68 , C40B40/06 , C40B60/14 , G01N33/53 , G01N33/543 , G01N33/58 , G01N35/00 , G01N37/00 , G01N33/52
CPC分类号： B01L3/545 , B01J2219/00317 , B01J2219/00369 , B01J2219/00378 , B01J2219/00385 , B01J2219/0043 , B01J2219/00513 , B01J2219/00515 , B01J2219/00518 , B01J2219/0052 , B01J2219/00536 , B01J2219/00538 , B01J2219/0054 , B01J2219/00542 , B01J2219/00545 , B01J2219/00547 , B01J2219/00554 , B01J2219/00563 , B01J2219/00576 , B01J2219/00585 , B01J2219/00596 , B01J2219/00605 , B01J2219/0061 , B01J2219/00612 , B01J2219/00619 , B01J2219/00621 , B01J2219/00626 , B01J2219/00637 , B01J2219/00657 , B01J2219/00673 , B01J2219/00707 , B01J2219/0072 , B01J2219/00722 , B01L3/505 , C40B40/06 , C40B60/14 , G01N35/00009 , G01N35/00732 , G01N2035/00118 , G01N2035/00752 , G01N2035/00762
摘要： The invention relates to a probe carrier in which a flexible substrate carries a one-dimensiona P configuration of probes wherein each different type of probe is attached to its own discrete portion of the substrate. The invention also relates to a probe carrier in which a flexible substrate such as a tape or fiber carries a two-dimensional configuration of probes. Furthermore, systems for fabricating and packaging flexible probe carrier threads are presented. Flexible probe carrier threads are packaged in forms of pins, rods, coils and spools to increase efficiency of hybridization and generate compact formats for transportation and use of probe carriers. Novel methods for hybridization of packaged probe carriers are disclosed. Methods for reading results of hybridization to packaged probe carriers are also disclosed.
摘要翻译：本发明涉及一种探针载体，其中柔性基底承载一维P型探针，其中每种不同类型的探针连接到其自身离散部分的基底。本发明还涉及一种探针载体，其中诸如带或纤维之类的柔性基底承载探针的二维构型。此外，提出了用于制造和封装柔性探针载体线的系统。灵活的探针载体螺纹以引脚，棒，线圈和线轴的形式封装，以提高杂交效率，并产生用于运输和使用探针载体的紧凑格式。公开了用于封装的探针载体的杂交的新方法。还公开了读取与包装的探针载体杂交结果的方法。

5. 发明申请

WO1989011641A1 PROCESS AND DEVICE FOR NON-INTRUSIVELY, CONTINUOUSLY AND AUTOMATICALLY TAKING, STORING AND SUPPLYING ANALYSIS SAMPLES AND DATA FOR FUTURE EVALUATION 审中-公开
标题翻译：非侵入性，连续和自动获取，存储和提供分析样本和数据进行未来评估的过程和设备
公开(公告)号：WO1989011641A1
公开(公告)日：1989-11-30
申请号：PCT/DE1989000330
申请日：1989-05-24
申请人： BRUKER-FRANZEN ANALYTIK GMBH , ODERNHEIMER, Bernhard
发明人： BRUKER-FRANZEN ANALYTIK GMBH
IPC分类号： G01N01/22
CPC分类号： G01N35/00732 , G01D15/12 , G01D15/14 , G01N1/2214 , G01N1/405 , G01N30/00 , G01N35/00009 , G01N2001/282 , G01N2001/2826 , G01N2035/00762 , G11B5/62 , G11B7/24
摘要： A process and device are useful to take and store samples (9) and correlated data (11) in a continuous and automatic manner, and if necessary for later evaluating the samples and data in a simple manner. Sample and data storage bodies are used, as well as specially developed heads for storing samples and for recording data and specially developed heads for taking samples and for reading sample data. This allow chemical processes to be continuously monitored, during production processes as well as when undesirable and/or toxic liquid or gaseous chemical substances and/or compounds may otherwise be generated.
摘要翻译：过程和设备有用于以连续和自动的方式采集和存储样本（9）和相关数据（11），并且如果需要，以简单的方式稍后评估样本和数据是有用的。使用样品和数据存储体，以及专门开发的用于存储样品和记录数据的头，以及特别开发的用于取样和读取样品数据的头。这允许在生产过程期间以及当可能产生不期望的和/或有毒的液体或气体化学物质和/或化合物时，连续地监测化学过程。

6. 发明申请

WO2017114955A2 SYSTEMS AND METHODS FOR AUTOMATED, CUSTOMIZABLE SAMPLE PREPARATION TOOL, SOFTWARE SCRIPT, AND CALIBRATION ROUTINE FOR DETECTION OF METABOLITES AND LIPIDS 审中-公开
标题翻译：用于自动化，可定制的样品制备工具，软件脚本和校准程序的系统和方法，用于检测代谢物和脂质
公开(公告)号：WO2017114955A2
公开(公告)日：2017-07-06
申请号：PCT/EP2016/082934
申请日：2016-12-30
申请人： UNIVERSAL DIAGNOSTICS, S.L.
发明人： BITENC, Marko , KRUUSMAA, Kristi , CASTILLO, Paola Hurtado , GIRON, Ana Maria Jimenez , MARTINEZ, Rosa Argamasilla , ROSSELL, Andreu Fabregat , GOMEZ, Antonio Jesus Adsuar , MARTINEZ-BAREA, Juan , HENSE, Christian , GOMEZ, Patricia Rodriguez
IPC分类号： G01N35/02 , G01N35/00 , G01N35/04 , G01N35/10
CPC分类号： G01N35/1074 , G01N33/48 , G01N35/00732 , G01N35/0099 , G01N35/028 , G01N35/04 , G01N35/1002 , G01N35/1065 , G01N2035/00326 , G01N2035/00356 , G01N2035/00445 , G01N2035/00495 , G01N2035/00524 , G01N2035/00752 , G01N2035/00762 , G01N2035/00772 , G01N2035/0449 , Y10T436/11 , Y10T436/111666 , Y10T436/25 , Y10T436/25125 , Y10T436/25375 , Y10T436/2575
摘要： Described herein are automated and customizable sample preparation and analysis systems for detection and quantification of biomarkers (e.g., metabolites and/or lipids) in biological samples (e.g., blood, serum, or plasma) in a clinical setting. The automated systems are controlled by scripts that integrate communication between the components of the sample preparation system. Also described herein are mass spectrometry-based analytical methods featuring efficient system calibration and sample analysis that provide for accurate quantification of a set of markers in biological samples. The methods are capable of automatic high sample throughput in a clinical setting for detection and quantification using a mass spectrometry system and high performance liquid chromatography column.
摘要翻译：本文描述了用于检测和量化临床中生物样品（例如血液，血清或血浆）中的生物标志物（例如，代谢物和/或脂质）的自动且可定制的样品制备和分析系统设置。自动化系统由集成了样本制备系统组件之间通信的脚本控制。本文还描述了基于质谱分析的分析方法，其特征在于有效的系统校准和样品分析，其提供对生物样品中一组标记物的精确定量。该方法能够在临床环境中自动进行高通量样品检测，并使用质谱系统和高效液相色谱柱进行定量分析。

7. 发明申请

WO2016012459A2 PARALLEL CELL PROCESSING METHOD AND FACILITY 审中-公开
标题翻译：并行单元处理方法与设备
公开(公告)号：WO2016012459A2
公开(公告)日：2016-01-28
申请号：PCT/EP2015066666
申请日：2015-07-21
申请人： GE HEALTHCARE BIO SCIENCES , GE HEALTHCARE UK LTD
发明人： GHOUZE FIRMAN , VANEK PHILIP
IPC分类号： G01N35/00
CPC分类号： G01N35/0099 , A61K35/12 , B01J2219/00587 , B01J2219/00743 , G01N35/00732 , G01N2035/00326 , G01N2035/00752 , G01N2035/00762 , G01N2035/00782 , G01N2035/00811 , G01N2035/00831
摘要： The present invention provides improved methods, facilities and systems for parallel processing of biological cellular samples in an efficient and scalable manner. The invention enables parallel processing of biological cellular samples, such as patient samples, in a space and time efficient fashion. The methods, facilities and systems of the invention find particular utility in processing patient samples for use in cell therapy.
摘要翻译：本发明提供了以有效和可扩展的方式并行处理生物细胞样品的改进方法，设备和系统。本发明能够以空间和时间有效的方式平行处理生物细胞样品，例如患者样品。本发明的方法，设备和系统在处理用于细胞治疗的患者样品中特别有用。

8. 发明申请

WO2007097267A1 液体移送装置审中-公开
标题翻译：液体运输装置
公开(公告)号：WO2007097267A1
公开(公告)日：2007-08-30
申请号：PCT/JP2007/052917
申请日：2007-02-19
申请人：武蔵エンジニアリング株式会社 , 生島和正
发明人：生島和正
IPC分类号： G01N35/10 , B01J4/02 , G01N37/00
CPC分类号： G01N35/1011 , B01J2219/00315 , B01J2219/00364 , B01J2219/00387 , B01J2219/00691 , B01J2219/00698 , B01L3/0248 , G01N35/028 , G01N2035/00752 , G01N2035/00762 , G01N2035/00801 , G01N2035/00851
摘要：　テーブル上に載置可能なマイクロプレート数を超えた量のマイクロプレートを対象として分注・分配等の液体移送を可能とする液体移送装置の提供。　貯留部材および排出部材を上面に着脱可能であるテーブルと、吸排出手段と、吸排出手段とテーブルとを相対移動させながら、予め組み込まれたプログラムに基づい液体移送を行う制御部と、入力手段と、警告信号通知手段とを具備する液体移送装置であって、前記制御部は、前記プログラムの作業対象となる貯留部材および／または排出部材の識別情報と、テーブル上に装着された貯留部材および／または排出部材との識別情報が同一であるかを判定する機能を有し、両者が同位置である場合には移送作業を継続し、両者が異なる場合にはエラー信号を発すると共に前記警告信号通知手段により前記プログラムの作業対象となる貯留部材および／または排出部材の識別情報を通知することを特徴とする液体移送装置。
摘要翻译：一种液体输送装置，其能够将诸如分配和分配液体的液体输送到可安装在桌子上的数量大于微板的微板中。液体输送装置包括从顶面到其上的工作台，可以安装/拆卸存储构件和排出构件，吸入/排出装置，用于基于内置程序执行液体转移的控制单元，移动吸入/排出装置和工作台，输入装置和警告信号报告装置，其特征在于，上述控制单元具有判断存储部件和/或排出部件的识别信息是否受到程序的工作与安装在工作台上的存储部件和/或排出部件的识别信息相同，并且当两者处于相同位置时，继续传送工作，并且当两者不同时，发出错误信号，并通过上述警告信号报告经过程序工作的存储部件和/或卸载部件的识别信息正式报告方式。

9. 发明申请

WO2017114955A3 SYSTEMS AND METHODS FOR AUTOMATED, CUSTOMIZABLE SAMPLE PREPARATION TOOL, SOFTWARE SCRIPT, AND CALIBRATION ROUTINE FOR DETECTION OF METABOLITES AND LIPIDS 审中-公开
标题翻译：用于自动化，可定制的样品制备工具，软件脚本和校准程序的系统和方法，用于检测代谢物和脂质
公开(公告)号：WO2017114955A3
公开(公告)日：2017-08-10
申请号：PCT/EP2016082934
申请日：2016-12-30
申请人： UNIVERSAL DIAGNOSTICS S L
发明人： BITENC MARKO , KRUUSMAA KRISTI , CASTILLO PAOLA HURTADO , GIRON ANA MARIA JIMENEZ , MARTINEZ ROSA ARGAMASILLA , ROSSELL ANDREU FABREGAT , GOMEZ ANTONIO JESUS ADSUAR , MARTINEZ-BAREA JUAN , HENSE CHRISTIAN , GOMEZ PATRICIA RODRIGUEZ
IPC分类号： G01N35/02 , G01N35/00 , G01N35/04 , G01N35/10
CPC分类号： G01N35/1074 , G01N35/00732 , G01N35/0099 , G01N35/028 , G01N35/04 , G01N35/1002 , G01N35/1065 , G01N2035/00326 , G01N2035/00356 , G01N2035/00445 , G01N2035/00495 , G01N2035/00524 , G01N2035/00752 , G01N2035/00762 , G01N2035/00772 , G01N2035/0449
摘要： Described herein are automated and customizable sample preparation and analysis systems for detection and quantification of biomarkers (e.g., metabolites and/or lipids) in biological samples (e.g., blood, serum, or plasma) in a clinical setting. The automated systems are controlled by scripts that integrate communication between the components of the sample preparation system. Also described herein are mass spectrometry-based analytical methods featuring efficient system calibration and sample analysis that provide for accurate quantification of a set of markers in biological samples. The methods are capable of automatic high sample throughput in a clinical setting for detection and quantification using a mass spectrometry system and high performance liquid chromatography column.
摘要翻译：本文描述了用于检测和量化临床环境中生物样品（例如血液，血清或血浆）中的生物标志物（例如，代谢物和/或脂质）的自动化且可定制的样品制备和分析系统。自动化系统由集成了样本制备系统组件之间通信的脚本控制。本文还描述了基于质谱分析的分析方法，其特征在于有效的系统校准和样品分析，其提供对生物样品中一组标记物的精确定量。该方法能够在临床环境中自动进行高样品通量，以便使用质谱系统和高效液相色谱柱进行检测和定量。

10. 发明申请

WO2004092743A1 SAMPLE ELEMENT QUALIFICATION 审中-公开
标题翻译：样品元素认证
公开(公告)号：WO2004092743A1
公开(公告)日：2004-10-28
申请号：PCT/US2004/011412
申请日：2004-04-14
申请人： OPTISCAN BIOMEDICAL CORPORATION , BRAIG, James, R. , LI, Ken, I. , WITTE, Kenneth, G. , RULE, Peter , HARTSTEIN, Philip, C.
发明人： BRAIG, James, R. , LI, Ken, I. , WITTE, Kenneth, G. , RULE, Peter , HARTSTEIN, Philip, C.
IPC分类号： G01N35/00
CPC分类号： G01N35/00732 , G01N21/03 , G01N21/5907 , G01N21/8483 , G01N2035/00752 , G01N2035/00762 , G01N2035/00772 , G01N2035/00782
摘要： A sample element (1305) includes first and second substantially parallel faces separated by an intermediate member. The parallel faces and the intermediate member at least partially define a sample chamber (1310) configured to hold a volume of fluid. The sample element further includes an optical path extending through the parallel faces and the intermediate member, such that electromagnetic radiation can propagate through the sample chamber. The sample element further includes an identifying compound disposed within or on at least one of the parallel faces. The identifying compound has at least one indexed optical absorbance feature, such that spectral analysis of electromagnetic radiation propagated through the sample chamber yields the indexed optical absorbance feature. Detection of the indexed optical absorbance feature in electromagnetic radiation propagated through the sample chamber indicates to an analyte detection system whether the sample element is configured for use with the analyte detection system.
摘要翻译：样品元件（1305）包括由中间构件分开的第一和第二基本上平行的面。平行面和中间构件至少部分地限定了构造成容纳一定体积的流体的样品室（1310）。样本元件还包括延伸穿过平行面和中间构件的光路，使得电磁辐射可以传播通过样品室。样本元件还包括设置在至少一个平行面内或之中的识别化合物。识别化合物具有至少一个索引的光吸收特征，使得通过样品室传播的电磁辐射的光谱分析产生索引的光吸收特征。通过样品室传播的电磁辐射中的指示光吸收特征的检测表明分析物检测系统是否将样品元件配置为与分析物检测系统一起使用。

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