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1. 发明申请

WO2008030865A1 ASSAY FOR ANTIBODIES TO MYCOBACTERIUM PARATUBERCULOSIS 审中-公开
标题翻译：抗体对MYCOBACTERIUM PARATUBERCULOSIS的测定
公开(公告)号：WO2008030865A1
公开(公告)日：2008-03-13
申请号：PCT/US2007/077625
申请日：2007-09-05
申请人： WISCONSIN ALUMNI RESEARCH FOUNDATION , COLLINS, Michael, T. , SHIN, Sung, Jae , CHO, Donghee
发明人： COLLINS, Michael, T. , SHIN, Sung, Jae , CHO, Donghee
IPC分类号： C12N1/20 , C07K14/35 , G01N33/569 , C12R1/32
CPC分类号： C12R1/32 , C07K14/35 , G01N33/5695
摘要： A method of detecting an immune response to a paratuberculosis- specific antigen, comprising incubating a sample from a subject with the paratuberculosis-specific antigen and detecting the presence of an antibody in the sample as an indication of an immune response to the paratuberculosis- specific antigen. The antigen may be obtained from a novel M. paratυbercυlosis strain JTC303. The antigen may be obtained from the JTC303 culture filtrate. Also provided are antibodies to the paratuberculosis- specific antigen, and a diagnostic kit for the detection of an immune response to a paratuberculosis-specific antigen in a mammal.
摘要翻译：检测对副结核特异性抗原的免疫应答的方法，包括将来自受试者的样品与副结核病特异性抗原孵育并检测样品中抗体的存在，作为对副结核特异性抗原的免疫应答的指示。抗原可以从新型的副伤寒杆菌菌株JTC303获得。抗原可以从JTC303培养滤液中获得。还提供了针对副结核病特异性抗原的抗体，以及用于检测哺乳动物中对结核分枝杆菌特异性抗原的免疫应答的诊断试剂盒。

2. 发明申请

WO01003731A1 DIM MUTANTS OF MYCOBACTERIA AND USES THEREOF 审中-公开
标题翻译： MYCOBACTERIA的DIM MUTANT和它们的用途
公开(公告)号：WO01003731A1
公开(公告)日：2001-01-18
申请号：PCT/US2000/040312
申请日：2000-07-06
IPC分类号： A61P31/04 , C07K14/35 , C12N1/21 , A61K39/02 , A61K39/04 , C12N1/12 , C12N1/20 , C12N9/00 , C12P21/06 , G01N33/53 , G01N33/573
CPC分类号： C12R1/32 , A61K2039/52 , C07K14/35
摘要： Disclosed are novel recombinant mutant strains of mycobacteria that are deficient for the synthesis or transport of dimycoserosalphthiocerol ("DIM"). The present invention also provides a method of producing a recombinant mutant mycobacterium that is deficient for the synthesis or transport of DIM, comprising mutating a nucleic acid responsible for the synthesis or transport of dimycoserosalphthiocerol, including a nucleic acid comprising the promoter for the pps operon, fadD28 or mmpL7. The present invention also provides a vaccine comprising a DIM mutant mycobacterium of the present invention, as well as a method for the treatment or prevention of tuberculosis in a subject using the vaccine.
摘要翻译：公开了分子细菌的新型重组突变菌株，其用于合成或转运二环神经鞘硫醇（“DIM”）。本发明还提供了一种缺乏合成或转运DIM的重组突变型分枝杆菌的方法，其包括突变负责合成或转运二环神经节硫蛋白的核酸，包括包含pps操纵子启动子的核酸， fadD28或mmpL7。本发明还提供了包含本发明的DIM突变型分枝杆菌的疫苗，以及使用疫苗治疗或预防受试者的结核病的方法。

3. 发明申请

WO1990010079A1 PROCESS AND MEANS FOR THE MICROBIOLOGICAL REMEDIATION OF POLLUTED SOIL AND MICROORGANISMS FOR USE IN SAID PROCESS 审中-公开
标题翻译：污染土壤微生物的微生物修复方法和使用手段
公开(公告)号：WO1990010079A1
公开(公告)日：1990-09-07
申请号：PCT/FI1990000055
申请日：1990-02-27
申请人： ALKO LTD. , VALO, Risto, Juhani , HÄGGBLOM, Max, Mikael , SALKINOJA-SALONEN, Mirja
发明人： ALKO LTD.
IPC分类号： C12P01/04
CPC分类号： C12R1/32 , B09C1/10 , C12N11/08 , C12R1/01
摘要： The invention relates to a process for the microbiological remediation of soil polluted by chlorophenols, the soil to be decontaminated being composted with the chlorophenol-degrading microorganisms and the conditions being adjusted so that they favour for the growth of the microorganisms. According to the invention such chlorophenol-degrading microorganisms of the genus Rhodococcus and Mycobacterium are preferably used which are capable of degrading the chlorophenols also in field conditions. According to the invention the microorganisms are preferably immobilized in a solid porous support.
摘要翻译：本发明涉及一种用氯酚污染的土壤进行微生物修复的方法，要被去污的土壤被氯酚降解微生物堆肥并调整条件使其有利于微生物的生长。根据本发明，优选使用能够在现场条件下降解氯酚的红球菌属和分枝杆菌属的氯酚降解微生物。根据本发明，微生物优选固定在固体多孔载体中。

4. 发明申请

WO2017041399A1 一种多环芳烃污染修复微囊材料及其制备方法和应用审中-公开
公开(公告)号：WO2017041399A1
公开(公告)日：2017-03-16
申请号：PCT/CN2015/100076
申请日：2015-12-31
申请人：华南理工大学 , 广东粤港供水有限公司
发明人：杨琛 , 党志 , 邓辅财 , 孙国胜 , 黄慧星 , 郭楚玲 , 卢桂宁 , 易筱筠
IPC分类号： C12N1/20 , C12N11/10 , B09C1/10 , C02F3/34 , C12R1/32 , C02F101/32
CPC分类号： B09C1/10 , C02F3/34 , C12N1/20 , C12N11/10 , C12R1/32
摘要：提供了一种多环芳烃污染修复微囊材料，其制备方法和应用。所述制备方法包括如下步骤：(1)将微黄分支杆菌(Mycobacterium gilvum)CP13在细菌培养液中培养得到菌液，所述微黄分支杆菌CP13保藏于中国普通微生物菌种保藏管理中心(CGMCC)，保藏编号为CGMCC NO.7963；(2)用海藻酸钙和壳聚糖将上述菌液包埋在微囊中，制得用于修复多环芳烃污染的微囊材料。该微囊材料可用于含多环芳烃工业废水的生物处理及多环芳烃污染土壤的生物修复。

5. 发明申请

WO2007071978A1 METHOD OF PRODUCING ROUGH STRAINS OF BACTERIA AND USES THEREOF 审中-公开
标题翻译：生产细菌粗糙菌的方法及其用途
公开(公告)号：WO2007071978A1
公开(公告)日：2007-06-28
申请号：PCT/GB2006/004780
申请日：2006-12-19
申请人： BIOEOS LIMITED , STANFORD, John, Lawson , STANFORD, Cynthia, Ann , MCINTYRE, Graham , BOTTASSO, Oscar, Adelmo
发明人： STANFORD, John, Lawson , STANFORD, Cynthia, Ann , MCINTYRE, Graham , BOTTASSO, Oscar, Adelmo
IPC分类号： C12N1/20 , A61K39/39 , A61K39/04 , A61P37/02
CPC分类号： A61K39/39 , A61K39/04 , A61K2039/52 , A61K2039/521 , C12N1/36 , C12N15/01 , C12R1/32 , Y02A50/466
摘要： The present invention relates to a method of producing rough strains of a bacterium, such as Mycobacterium obuense , said method comprising exposing said bacterium to a sulfone and/or sulfonamide (such as 4,4'-Diaminodiphenyl sulfone or an analogue thereof). A rough strain of Mycobacterium obuense producible by said method and uses thereof. In particular, uses of a rough strain of Mycobacterium obuense deposited under the Budapest Treaty at the NCTC with the accession number NCTC 13365.
摘要翻译：本发明涉及一种生产细菌如粗分枝杆菌的粗品菌株的方法，所述方法包括将所述细菌暴露于砜和/或磺酰胺（例如4,4'-二氨基二苯砜或其类似物）。通过所述方法和其用途可生产的粗糙型分枝杆菌菌株。特别是使用根据布达佩斯条约保藏在NCTC的登录号NCTC 13365的粗糙菌株的分枝杆菌。

6. 发明申请

WO0103730A9 UNMARKED DELETION MUTANTS OF MYCOBACTERIA AND METHODS OF USING SAME 审中-公开
标题翻译： MYCOBACTERIA的无标记删除突变体及其使用方法
公开(公告)号：WO0103730A9
公开(公告)日：2002-07-25
申请号：PCT/US0018453
申请日：2000-07-06
申请人： EINSTEIN COLL MED
发明人： JACOBS WILLIAM R JR , PAVELKA MARTIN S JR
IPC分类号： A61K39/00 , A61P31/04 , C12N1/21 , C12N9/02 , C12N15/74 , A61K39/02 , A61K39/04 , C12N1/20 , C12N15/09 , C12Q1/68 , G01N33/569
CPC分类号： C12N9/0004 , A61K39/00 , C12N15/74 , C12R1/32
摘要： Disclosed is a recombinant slow-growing mycobacterium comprising at least one mycobacterial gene containing an unmarked mutation, wherein an "unmarked mutation" is a mutated nucleotide sequence introduced into a mycobacterium where the introduced mutated nucleotide sequence does not contain a selectable marker, such as a gene conferring antibiotic resistance to the recombinant mycobacterium incorporating the mutated nucleotide sequence. Also disclosed is a method for preparing a recombinant slow-growing mycobacterium comprising at least one mycobacterial gene containing an unmarked mutation, as well as a vaccine comprising a recombinant slow-growing mycobacterium having at least one mycobacterial gene containing an unmarked mutation dispersed in a physiologically acceptable carrier. Further disclosed is a method of treating or preventing tuberculosis in a subject comprising administering the vaccine of the present invention in an amount effective to treat or prevent tuberculosis in the subject.
摘要翻译：公开了包含至少一种含有未标记突变的分枝杆菌基因的重组慢生长分枝杆菌，其中“未标记突变”是引入分枝杆菌的突变核苷酸序列，其中所引入的突变核苷酸序列不含可选择标记，例如基因对赋予突变核苷酸序列的重组分枝杆菌赋予抗生素抗性。还公开了一种制备重组慢生长分枝杆菌的方法，其包含至少一种含有未标记突变的分枝杆菌基因，以及包含重组慢生长分枝杆菌的疫苗，其具有至少一种分散在生理学上的未标记突变的分枝杆菌基因可接受的载体进一步公开的是治疗或预防受试者结核病的方法，包括以有效治疗或预防受试者结核病的量施用本发明的疫苗。

7. 发明申请

WO99002670A1 METHOD OF ATTENUATING PATHOGENIC MYCOBACTERIA AND STRAINS OF MYCOBACTERIA SO ATTENUATED 审中-公开
标题翻译：杀死病原菌的病原菌和菌株的灭活方法
公开(公告)号：WO99002670A1
公开(公告)日：1999-01-21
申请号：PCT/US1998/014227
申请日：1998-07-09
IPC分类号： A61K39/04 , C07K14/35 , C12N15/01 , C12N1/36
CPC分类号： C12R1/32 , A61K39/04 , A61K2039/521 , C07K14/35 , Y10S435/863 , Y10S435/864 , Y10S435/865 , Y10S435/866
摘要： This invention provides for novel attenuated strains of Mycobacterium tuberculosis and M. bovis. Attenuation is achieved by eliminating or by downregulating the expression of the alpha -crystallin heat shock protein gene ("acr gene"). The invention provides for vaccines and methods of vaccinating mammals for protection against Mycobacterium sp. that cause tuberculosis.
摘要翻译：本发明提供了结核分枝杆菌和牛分枝杆菌的新的减毒菌株。通过消除或通过下调α-晶状蛋白热休克蛋白基因（“acr基因”）的表达来实现衰减。本发明提供疫苗和疫苗接种哺乳动物用于保护分枝杆菌的方法。导致结核病。

8. 发明申请

WO1995003417A2 HOMOLOGOUSLY RECOMBINANT SLOW GROWING MYCOBACTERIA AND USES THEREFOR 审中-公开
标题翻译：非常重要的重组慢性生长因子及其用途
公开(公告)号：WO1995003417A2
公开(公告)日：1995-02-02
申请号：PCT/US1994008267
申请日：1994-07-22
申请人： WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH
发明人： WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH , ALDOVINI, Anna , YOUNG, Richard, A.
IPC分类号： C12N15/74
CPC分类号： A61K39/04 , A61K38/00 , A61K39/00 , C07K14/005 , C07K14/35 , C07K14/52 , C07K14/55 , C12N9/88 , C12N13/00 , C12N15/74 , C12N15/87 , C12N2740/16022 , C12R1/32 , Y02A50/412
摘要： A method of transforming slow-growing mycobacteria, such as M. bovis BCG, M. leprae, M. tuberculosis, M. avium, M. intracellulare and M. africanum; a method of manipulating genomic DNA of slow-growing mycobacteria through homologous recombination; a method of producing homologously recombinant (HR) slow-growing mycobacteria in which heterologous DNA is integrated into the genomic DNA at a homologous locus; homologously recombinant (HR) slow-growing mycobacteria having heterologous DNA integrated into their genomic DNA at a homologous locus; and mycobacteria DNA useful as a genetic marker.
摘要翻译：转化缓慢生长的分枝杆菌的方法，例如牛分枝杆菌BCG，麻疯病，结核分枝杆菌，鸟分枝杆菌，胞内分枝杆菌和非洲雄蕊; 通过同源重组操纵慢生长分枝杆菌的基因组DNA的方法; 产生同源重组（HR）慢生长分枝杆菌的方法，其中异源DNA在同源基因座整合到基因组DNA中; 同源重组（HR）缓慢生长的分枝杆菌在同源基因座处整合到其基因组DNA中的异源DNA; 和分枝杆菌DNA可用作遗传标记。

9. 发明申请

WO2017011565A1 COMPOSITIONS AND METHODS FOR IDENTIFYING DRUG RESISTANT TUBERCULOSIS 审中-公开
标题翻译：用于鉴定耐药性TUBCCOSOS的组合物和方法
公开(公告)号：WO2017011565A1
公开(公告)日：2017-01-19
申请号：PCT/US2016/042108
申请日：2016-07-13
申请人： ABBOTT MOLECULAR INC.
发明人： WANG, Hong , LECKIE, Gregor W. , PAHALAWATTA, Vihanga , ABRAVAYA, Klara , KOSTERA, Joshua , TANG, Ning , FRANK, Andrea
IPC分类号： A61P31/06 , C12Q1/68 , C12R1/32
CPC分类号： C12Q1/689 , C12Q2600/106 , C12Q2600/156 , C12R1/32
摘要： Provided herein are compositions and methods for diagnosing and characterizing tuberculosis infection. In particular, provided herein are compositions and methods for identifying drug resistant tuberculosis.
摘要翻译：本文提供了用于诊断和表征结核病感染的组合物和方法。特别地，本文提供了用于鉴定耐药性结核病的组合物和方法。

10. 发明申请

WO2016090622A1 羟酰辅酶A脱氢酶基因和酰基辅酶A硫解酶基因，及其基因工程菌和应用审中-公开
公开(公告)号：WO2016090622A1
公开(公告)日：2016-06-16
申请号：PCT/CN2014/093667
申请日：2014-12-12
申请人：华东理工大学
发明人：王风清 , 魏东芝 , 徐丽琴 , 刘浩浩 , 刘心斌 , 陈能辉
IPC分类号： C12N15/53 , C12N15/54 , C12N1/21 , C12N9/02 , C12N9/10 , C12P33/00 , C12P33/02 , C12R1/32
CPC分类号： C12P33/02 , C12N9/0006 , C12N9/10 , C12N9/1029 , C12P33/00 , C12R1/32 , C12Y101/01035 , C12Y203/01009
摘要：提供一种羟酰辅酶A脱氢酶基因和一种酰基辅酶A硫解酶基因，及其基因工程菌和应用。所述羟酰辅酶A脱氢酶基因编码如下蛋白质(ⅰ)或(ⅱ)：(ⅰ)具有SEQ ID NO:2所示的氨基酸序列；(ⅱ)在(ⅰ)限定的氨基酸序列中经过取代，缺失或者叠加一个或几个氨基酸衍生的蛋白质且与(ⅰ)的蛋白质具有相同的功能。构建缺失羟酰辅酶A脱氢酶基因或酰基辅酶A硫解酶基因的分枝杆菌基因工程菌，并将其用于制备1，4-BNA、4-BNA、9-OH-BNA等甾体化合物。

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