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1. 发明申请

WO2023014989A1 METHODS AND AGENTS FOR DECREASING INSULIN RESISTANCE 审中-公开
公开(公告)号：WO2023014989A1
公开(公告)日：2023-02-09
申请号：PCT/US2022/039602
申请日：2022-08-05
申请人： WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH
发明人： DALL'AGNESE, Alessandra , PLATT, Jesse , LEE, Tong, Ihn , YOUNG, Richard, A.
IPC分类号： C07K14/72 , C12N15/10 , C12N15/63 , A61K38/44
摘要： Disclosed herein are methods and agents for decreasing insulin resistance and metformin resistance by modulating insulin receptor condensates. Also disclosed are methods of screening for agents to decrease insulin resistance.

2. 发明申请

WO2011097522A3 COMBINATION METHODS FOR TREATMENT OF DISEASE 审中-公开
公开(公告)号：WO2011097522A3
公开(公告)日：2011-08-11
申请号：PCT/US2011/023804
申请日：2011-02-04
申请人： WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH , RAHL, Peter, B. , YOUNG, Richard, A.
发明人： RAHL, Peter, B. , YOUNG, Richard, A.
IPC分类号： A61K31/445 , A61K31/453 , A61K31/506 , A61P35/00
摘要： In some aspects, the invention provides compositions and methods of use for treating a variety of diseases. In some aspect, the compositions and methods involve combined modulation of transcriptional modulators.

3. 发明申请

WO2005088306A2 BIOLOGICALLY-ACTIVE DNA-BINDING SITES AND RELATED METHODS 审中-公开
标题翻译：生物活性DNA结合位点及相关方法
公开(公告)号：WO2005088306A2
公开(公告)日：2005-09-22
申请号：PCT/US2005/007249
申请日：2005-03-03
申请人： WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH , HARBISON, Christopher , YOUNG, Richard, A. , GORDON, David, B. , FRAENKEL, Ernest
发明人： HARBISON, Christopher , YOUNG, Richard, A. , GORDON, David, B. , FRAENKEL, Ernest
IPC分类号： G01N33/53
CPC分类号： G01N33/5308 , C12Q2522/00
摘要： The invention relates to the identification of biologically-active DNA-binding sites to which a protein of interest binds in a cell. The invention also relates to the identification of agents and conditions which alter the biologically-active DNA-binding sites to which a protein binds. One aspect of the invention also provides methods for identifying pathways that are regulated by transcriptional regulators and for modulating the activity of the pathways.
摘要翻译：本发明涉及鉴定目的蛋白质在细胞中结合的生物活性DNA结合位点。本发明还涉及改变蛋白质结合的生物活性DNA结合位点的试剂和条件的鉴定。本发明的一个方面还提供了鉴定通过转录调节因子调节并调节途径活性的途径的方法。

4. 发明申请

WO1995003417A2 HOMOLOGOUSLY RECOMBINANT SLOW GROWING MYCOBACTERIA AND USES THEREFOR 审中-公开
标题翻译：非常重要的重组慢性生长因子及其用途
公开(公告)号：WO1995003417A2
公开(公告)日：1995-02-02
申请号：PCT/US1994008267
申请日：1994-07-22
申请人： WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH
发明人： WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH , ALDOVINI, Anna , YOUNG, Richard, A.
IPC分类号： C12N15/74
CPC分类号： A61K39/04 , A61K38/00 , A61K39/00 , C07K14/005 , C07K14/35 , C07K14/52 , C07K14/55 , C12N9/88 , C12N13/00 , C12N15/74 , C12N15/87 , C12N2740/16022 , C12R1/32 , Y02A50/412
摘要： A method of transforming slow-growing mycobacteria, such as M. bovis BCG, M. leprae, M. tuberculosis, M. avium, M. intracellulare and M. africanum; a method of manipulating genomic DNA of slow-growing mycobacteria through homologous recombination; a method of producing homologously recombinant (HR) slow-growing mycobacteria in which heterologous DNA is integrated into the genomic DNA at a homologous locus; homologously recombinant (HR) slow-growing mycobacteria having heterologous DNA integrated into their genomic DNA at a homologous locus; and mycobacteria DNA useful as a genetic marker.
摘要翻译：转化缓慢生长的分枝杆菌的方法，例如牛分枝杆菌BCG，麻疯病，结核分枝杆菌，鸟分枝杆菌，胞内分枝杆菌和非洲雄蕊; 通过同源重组操纵慢生长分枝杆菌的基因组DNA的方法; 产生同源重组（HR）慢生长分枝杆菌的方法，其中异源DNA在同源基因座整合到基因组DNA中; 同源重组（HR）缓慢生长的分枝杆菌在同源基因座处整合到其基因组DNA中的异源DNA; 和分枝杆菌DNA可用作遗传标记。

5. 发明申请

WO2010033920A3 COMPOSITIONS AND METHODS FOR ENHANCING CELL REPROGRAMMING 审中-公开
公开(公告)号：WO2010033920A3
公开(公告)日：2010-03-25
申请号：PCT/US2009/057692
申请日：2009-09-21
申请人： WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH , YOUNG, Richard, A. , BILODEAU, Steven , KAGEY, Michael
发明人： YOUNG, Richard, A. , BILODEAU, Steven , KAGEY, Michael
IPC分类号： C12N5/0735 , C12N5/02 , C12N15/11 , C12Q1/68
摘要： The invention provides compositions and methods of use to enhance reprogramming of mammalian cells. Certain compositions and methods of the invention are of use to enhance generation of induced pluripotent stem cells by reprogramming somatic cells. Certain compositions and methods of the invention are of use to enhance reprogramming of pluripotent mammalian cells to a differentiated cell type. Certain compositions and methods of the invention are of use to enhance reprogramming of differentiated mammalian cells of a first cell type to differentiated mammalian cells of a second differentiated cell type. The reprogrammed somatic cells are useful for a number of purposes, including treating or preventing a medical condition in an individual. The invention further provides methods for identifying an agent that enhances or contributes to reprogramming mammalian cells. Certain of the inventive compositions and methods relate to inhibiting histone methylation.

6. 发明申请

WO2006028565A2 NOVEL METHODS FOR HIGH-THROUGHPUT GENOME-WIDE LOCATION ANALYSIS 审中-公开
标题翻译：用于高通量基因型位置分析的新方法
公开(公告)号：WO2006028565A2
公开(公告)日：2006-03-16
申请号：PCT/US2005/023481
申请日：2005-06-30
申请人： WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH , YOUNG, Richard, A. , LEE, Tong, Ihn , REYNOLDS, David , VOLKERT, Tom
发明人： YOUNG, Richard, A. , LEE, Tong, Ihn , REYNOLDS, David , VOLKERT, Tom
IPC分类号： C12Q1/68 , G01N33/68
CPC分类号： C12Q1/68 , C12Q1/6813 , C12Q2522/101
摘要： The invention relates to improved methods of identifying the genomic regions to which a protein of interest binds, and in particular, to methods that are highly-sensitive and/or high throughput. The invention also provides methods of identifying agents which modulate the binding of a protein to the genome of a cell and methods of identifying variant proteins, such as transcription factors, with altered genome-binding properties. The invention also provides kits related to the methods described herein.
摘要翻译：本发明涉及鉴定目的蛋白质所结合的基因组区域的改进方法，特别涉及高度敏感和/或高通量的方法。本发明还提供了鉴定调节蛋白质与细胞基因组的结合的试剂的方法以及鉴定具有改变的基因组结合特性的变体蛋白质（例如转录因子）的方法。本发明还提供了与本文所述方法相关的试剂盒。

7. 发明申请

WO2002059371A3 GENOME-WIDE LOCATION AND FUNCTION OF DNA BINDING PROTEINS 审中-公开
公开(公告)号：WO2002059371A3
公开(公告)日：2002-08-01
申请号：PCT/US2001/050396
申请日：2001-12-21
申请人： WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH , WYRICK, John , YOUNG, Richard, A. , REN, Bing , ROBERT, François , SIMON, Itamar
发明人： WYRICK, John , YOUNG, Richard, A. , REN, Bing , ROBERT, François , SIMON, Itamar
IPC分类号： C12Q1/68
摘要： The present invention relates to a method of identifying a region (one or more) of a genome of a cell to which a protein of interest binds. In the methods described herein, DNA binding protein of a cell is linked (e.g., covalently crosslinked) to genomic DNA of a cell. The genomic DNA to which the DNA binding protein is linked is removed and combined or contacted with DNA comprising a sequence complementary to genomic DNA of the cell under conditions in which hybridization between the identified genomic DNA and the sequence complementary to genomic DNA occurs. Region(s) of hybridization are region(s) of the genome of the cell to which the protein of binds. A method of identifying a set of genes where cell cycle regulator binding correlates with gene expression and of identifying genomic targets of cell cycle transcription activators in living cells is also encompassed.

8. 发明申请

WO1988005823A2 MYCOBACTERIUM TUBERCULOSIS GENES ENCODING PROTEIN ANTIGENS 审中-公开
标题翻译： MYCOBACTERIUM TUBERCULOSIS GENES编码蛋白抗原
公开(公告)号：WO1988005823A2
公开(公告)日：1988-08-11
申请号：PCT/US1988000281
申请日：1988-02-01
申请人： WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH
发明人： WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH , HUSSON, Robert, N. , YOUNG, Richard, A. , SHINNICK, Thomas, M.
IPC分类号： C12N15/00
CPC分类号： C07K14/35 , A61K39/00
摘要： Mycobacterium tuberculosis genes encoding five immunologically relevant proteins have been isolated by systematically screening a lambda gt11 recombinant DNA expression library with a collection of murine monoclonal antibodies directed against protein antigens of this pathogen. One of the M. tuberculosis antigens, a 65kD protein, has been shown to have determinants common to M. tuberculosis and M. leprae. In addition, genes encoding proteins of other mycobacteria (M. africanum, M. smegmatis, M. bovis BCG and M. avium) have been isolated. Isolation and characterization of genes encoding major protein antigens of M. tuberculosis make it possible to develop reagents useful in the diagnosis, prevention and treatment of tuberculosis. They can be used, for example, in the development of skin tests, serodiagnostic tests and vaccines specific for tuberculosis.
摘要翻译：已经通过用针对该病原体的蛋白质抗原的鼠单克隆抗体的集合系统地筛选λgt11重组DNA表达文库来分离编码五种免疫相关蛋白的结核分枝杆菌基因。结核分枝杆菌抗原（一种65kD蛋白）中的一种已被证明具有与结核分枝杆菌和麻疯病菌相似的决定因素。此外，已经分离了编码其他分枝杆菌蛋白质的基因（M. africanum，M.耻垢分枝杆菌，牛分枝杆菌BCG和鸟分枝杆菌）。编码结核分枝杆菌主要蛋白质抗原的基因的分离和表征使得开发可用于诊断，预防和治疗结核病的试剂成为可能。它们可以用于例如皮肤试验，血清诊断试验和特异性结核病疫苗的开发。

9. 发明申请

WO2017011710A2 CHROMOSOME NEIGHBORHOOD STRUCTURES AND METHODS RELATING THERETO 审中-公开
标题翻译：染色体邻近结构及其相关方法
公开(公告)号：WO2017011710A2
公开(公告)日：2017-01-19
申请号：PCT/US2016/042367
申请日：2016-07-14
申请人： WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH
发明人： HNISZ, Denes , YOUNG, Richard, A. , BORGES-RIVERA, Diego, R. , WEINTRAUB, Abraham, S. , JI, Xiong , DADON, Daniel, B. , FAN, Zi, Peng , LEE, Tong, Ihn
IPC分类号： C12Q1/68 , G06F19/18
CPC分类号： C12Q1/68 , C12Q1/6809 , C12Q1/6841 , G06F19/18 , C12Q2522/101 , C12Q2523/101 , C12Q2535/122 , C12Q2543/101
摘要： Work described herein reveals 3D regulatory landscapes of hESCs representative of early human development. This work also demonstrates that cohesin-associated CTCF loops, and the cohesin-associate enhancer-promoter loops within them, dominate the organization of TADs. The CTCF-CTCF loops form a chromosomal scaffold of insulated neighborhoods that are largely preserved in vertebrates, and enhancer-promoter interactions occur within these neighborhoods. Genes are regulated in the context of conserved insulated neighborhood structures. Loss of neighborhood structures occurs frequently in cancer cells, and proto- oncogenes can be activated by genetic alterations that disrupt specific 3D chromosome structures.
摘要翻译：本文描述的工作揭示了代表早期人类发展的hESCs的3D监管景观。这项工作还表明，凝聚素相关的CTCF环和它们内的内聚素相关增强子 - 启动子环主导了TAD的组织。 CTCF-CTCF环形成绝大多数的遗传染色体支架，其主要保存在脊椎动物中，增强子 - 启动子相互作用发生在这些邻域内。基因在保守的绝缘邻域结构的上下文中被调节。邻近结构的损失频繁发生在癌细胞中，原癌基因可以通过破坏特定3D染色体结构的遗传改变来激活。

10. 发明申请

WO2007030678A3 METHODS OF GENOME-WIDE LOCATION ANALYSIS IN STEM CELLS 审中-公开
公开(公告)号：WO2007030678A3
公开(公告)日：2007-03-15
申请号：PCT/US2006/034962
申请日：2006-09-07
申请人： WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH , YOUNG, Richard, A. , LEE, Tong, Ihn , GUENTHER, Matthew , BOYER, Laurie, A.
发明人： YOUNG, Richard, A. , LEE, Tong, Ihn , GUENTHER, Matthew , BOYER, Laurie, A.
IPC分类号： C12Q1/68
摘要： The invention relates to improved methods of identifying the genomic regions to which a protein of interest binds, and in particular, to methods that apply to stem cells such as but not limited to, embryonic stem cells and adult stem cells. The invention also provides methods of identifying agents which modulate differentiation of stem cells. The invention also provides methods of defining the differentiation potential of a cell and of designing array oligonucleotides.

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