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1. 发明申请

WO2017087811A1 ENGINEERED BACTEROIDES OUTER MEMBRANE VESICLES 审中-公开
标题翻译：工程菌噬菌体外膜微生物
公开(公告)号：WO2017087811A1
公开(公告)日：2017-05-26
申请号：PCT/US2016/062790
申请日：2016-11-18
申请人： MASSACHUSETTS INSTITUTE OF TECHNOLOGY , RIPKA, Juliane, Florentine
发明人： RIPKA, Juliane, Florentine , LU, Timothy, Kuan-Ta , MIMEE, Mark, K.
IPC分类号： C12N15/03 , A61K39/02 , C07K14/195
CPC分类号： C07K14/195 , A61K35/74 , A61K38/164 , A61K38/2066 , A61K39/0216 , A61K2035/11 , C07K14/5428 , C07K2319/00 , C07K2319/035 , C07K2319/50 , C12N15/03 , C12N15/62 , C12N15/74
摘要： The present disclosure provides, in some aspects, versatile intestinal protein delivery systems deploying engineered human gut commensals of the Bacteroides species to secrete heterologous, therapeutic proteins via outer membrane vesicles (OMVs).
摘要翻译：在一些方面，本公开内容提供了通用肠蛋白递送系统，其部署了拟杆菌属物种的工程化人肠道共生物以经由外膜囊泡（OMV）分泌异源治疗性蛋白质。

2. 发明申请

WO1997021806A1 METHOD OF RECOVERING A BIOLOGICAL MOLECULE FROM A RECOMBINANT MICROORGANISM 审中-公开
标题翻译：从重组微生物恢复生物分子的方法
公开(公告)号：WO1997021806A1
公开(公告)日：1997-06-19
申请号：PCT/US1996019890
申请日：1996-12-16
申请人： OCEANIX BIOSCIENCES CORPORATION
发明人： OCEANIX BIOSCIENCES CORPORATION , CARLSON, Peter, S. , QUINTERO, Ernesto, J. , MANYAK, David, M. , CHMURNY, Alan, B.
IPC分类号： C12N15/02
CPC分类号： C12N15/10 , C12N15/03 , C12N15/1093 , C12N15/52 , C12N15/75 , C12N15/76 , C12N15/88
摘要： The present invention is directed to a method of recovering a biological molecule from a recombinant microorganism produced using a method based on either protoplast fusion or lipofection. The present invention further provides a method of identifying, isolating, or making a biological molecule from a recombinant microorganism and also encompasses the biological molecule produced by a recombinant microorganism. Moreover, the present invention relates to a method of making a recombinant microorganism containing the nucleic acid of a microorganism in an environmental sample, as well as the recombinant microorganisms themselves. Finally, the present invention is directed to a method of making a recombinant library, as well as the recombinant library itself.
摘要翻译：本发明涉及从使用基于原生质体融合或脂质转染的方法产生的重组微生物中回收生物分子的方法。本发明还提供从重组微生物鉴定，分离或制备生物分子的方法，还包括由重组微生物产生的生物分子。此外，本发明涉及在环境样品中含有微生物核酸的重组微生物以及重组微生物本身的方法。最后，本发明涉及制备重组文库以及重组文库本身的方法。

3. 发明申请

WO2018019656A1 BACTERIAL STRAIN PRODUCING 2,3-BUTANEDIOL AND OTHER METABOLITES 审中-公开
标题翻译：产生2,3-丁二醇和其他代谢物的细菌菌株
公开(公告)号：WO2018019656A1
公开(公告)日：2018-02-01
申请号：PCT/EP2017/068117
申请日：2017-07-18
申请人： FUNDACION TECNALIA RESEARCH & INNOVATION
发明人： RONCAL MARTÍNEZ, Tomás , CABALLERO ROMÁN, Susana , DÍAZ DE GUEREÑU ZABARTE, María Del Mar , RINCÓN ARROYO, Inés , PRIETO FERNÁNDEZ, Soraya , OCHOA GÓMEZ, José Ramón
IPC分类号： C12R1/46 , C12N1/20 , C12N15/01
CPC分类号： C12R1/46 , C12N1/20 , C12N15/01 , C12N15/03 , C12P7/16 , C12P7/18 , C12P7/26 , C12P7/56
摘要： The present invention provides a modified strain of the bacterium Lactococcus lactis obtainable by a method that comprises a step of fusion of two protoplasts from two Lactococcus lactis parental strains which, compared to the wild type strain of Lactococcus lactis from which they derive, show: (a) an increased ability to produce acetoin and/or 2,3- butanediol (2,3-BDO), and (b) a decreased ability to produce lactic acid, when cultured under aerobic conditions, and wherein the modified strain of Lactococcus lactis has an increased ability to produce 2,3-BDO of at least 20 times the amount produced by the wild type strain, an increased ability to produce acetoin of at least 20 times the amount produced by the wild type strain and a decreased ability to produce lactic acid of at least 10 times the amount produced by the wild type strain, when cultured under aerobic conditions. Also provided are methods to produce acetoin and 2,3- BDO..
摘要翻译：本发明提供了一种可通过包括将来自两种乳酸乳球菌的两种原生质体融合的步骤的方法获得的细菌乳酸乳球菌的经修饰的菌株它们衍生自乳酸乳球菌的野生型菌株显示出：（a）增加了产生3-羟基丁酮和/或2,3-丁二醇（2,3-丁二醇）的能力，（b）当在有氧条件下培养时，产生乳酸的能力降低，并且其中经修饰的乳酸乳球菌菌株具有提高的至少产生2,3-BDO的能力是野生型菌株产生的量的20倍，产生至少20倍于野生型菌株产生量的乙偶姻的能力，并且产生的乳酸产量至少是野生型产量的10倍当在有氧条件下培养时应变。还提供了生产乙偶姻和2,3-BDO的方法。

4. 发明申请

WO99049026A1 BACTERIA ATTENUATED BY A NON-REVERTING MUTATION IN EACH OF THE AROC, OMPF AND OMPC GENES, USEFUL AS VACCINES 审中-公开
标题翻译：通过AROC，OMPF和OMPC基因的非反转突变减毒细菌，有用的疫苗
公开(公告)号：WO99049026A1
公开(公告)日：1999-09-30
申请号：PCT/GB1999/000935
申请日：1999-03-25
IPC分类号： G01N33/543 , A61K39/02 , A61K39/095 , A61K39/10 , A61K39/102 , A61K39/106 , A61K39/108 , A61K39/112 , A61P31/04 , C12N1/20 , C12N1/21 , C12N15/01 , C12N15/03 , C12N15/31 , C12R1/19 , G01N33/74
CPC分类号： G01N33/74 , A61K39/0258 , A61K2039/522 , C12N15/03 , G01N2333/65 , G01N2800/52 , Y02A50/474 , Y02A50/484 , Y10S435/975
摘要： The invention provides a bacterium attenuated by a non-reverting mutation in each of the aroC gene, the ompF gene and the ompC gene. The bacterium is useful as a vaccine. The bacterium may, for example, be an attenuated strain of E.coli useful in vaccination against diarrhoea.
摘要翻译：本发明提供在aroC基因，ompF基因和ompC基因各自中通过非回复突变减毒的细菌。该细菌可用作疫苗。细菌可以是例如用于预防腹泻的疫苗的大肠杆菌的减毒菌株。

5. 发明申请

WO2017055932A2 IMPROVED PROPIONIBACTERIUM STRAINS FOR THE PRODUCTION OF PROPIONIC ACID 审中-公开
标题翻译：改良丙酸菌的生产应用
公开(公告)号：WO2017055932A2
公开(公告)日：2017-04-06
申请号：PCT/IB2016/001658
申请日：2016-09-29
申请人： THE UNIVERSITY OF QUEENSLAND
发明人： LUNA-FLORES, Carlos, H. , NIELSEN, Lars, K. , MARCELLIN, Esteban , STOWERS, Christopher, C. , MARTINS, Bianca, F. , COX, Brad, M.
IPC分类号： C12N1/20 , C12N9/14 , C12N9/78 , C12N9/00 , C07K14/195 , C12P7/52 , C12R1/01
CPC分类号： C07K14/195 , C12N9/93 , C12N15/03 , C12P7/52 , C12R1/01
摘要： Disclosed herein are new strains of Propionibacterium and methods for the biosynthetic production of propionic acid.
摘要翻译：本文公开了丙酸杆菌的新菌株和丙酸生物合成生产的方法。

6. 发明申请

WO2010079464A1 CNA_B DOMAIN ANTIGENS IN VACCINES AGAINST GRAM POSITIVE BACTERIA 审中-公开
标题翻译： CNA_B抗真菌细菌疫苗中的抗体
公开(公告)号：WO2010079464A1
公开(公告)日：2010-07-15
申请号：PCT/IB2010/050110
申请日：2010-01-12
申请人： NOVARTIS AG , MANETTI, Andrea , MARGARIT Y ROS, Immaculada
发明人： MANETTI, Andrea , MARGARIT Y ROS, Immaculada
IPC分类号： A61K39/02 , A61K39/085 , C07K14/31 , C07K14/315 , A61K39/09
CPC分类号： C07K14/315 , A61K39/085 , A61K39/092 , A61K2039/55566 , C07K16/44 , C12N15/03 , C12N15/63
摘要： The invention provides protective antigens which are useful in vaccine compositions to induce protection against gram positive bacteria, particularly against S. agalactiae, S. pyogenes, S. pneumoniae, S. aureus, S. suis, and S. equi.
摘要翻译：本发明提供了可用于疫苗组合物中的保护性抗原，以诱导针对革兰氏阳性细菌的保护，特别是针对无乳链球菌，化脓性链球菌，肺炎链球菌，金黄色葡萄球菌，猪链球菌和马赛克氏菌。

7. 发明申请

WO1991010363A1 AGRICULTURAL-CHEMICAL-PRODUCING ENDOSYMBIOTIC MICROORGANISMS 审中-公开
标题翻译：农业化学生产内生微生物
公开(公告)号：WO1991010363A1
公开(公告)日：1991-07-25
申请号：PCT/US1991000045
申请日：1991-01-11
申请人： CROP GENETICS INTERNATIONAL
发明人： CROP GENETICS INTERNATIONAL , CARLSON, Peter, S.
IPC分类号： A01N63/00
CPC分类号： C05F11/08 , C07K14/325 , C12N15/03 , C12N15/74 , C12N15/75
摘要： Hybrid agricultural-chemical producing microorganisms capable of entering into endosymbiotic relationships with plants are disclosed. The microorganisms are prepared by combining genetic material form an agricultural-chemical-producing microorganism and a plant infecting microorganism to form hybrid microorganisms and selecting from the hybrid microorganisms those hybrid microorganisms which are capable of producing an agricultural chemical, which do not create manifestations of disease in the plant host, and which are capable of entering into an endosymbiotic relationship with the plant host. Methods of use are also disclosed.
摘要翻译：公开了能够与植物进行内共生关系的混合农业化学生产微生物。微生物通过将遗传物质与农药生产微生物和植物感染微生物组合形成杂交微生物并从混合微生物中选出能够产生不产生疾病表现的农业化学品的杂交微生物来制备微生物在植物宿主中，其能够与植物宿主进入内共生关系。还公开了使用方法。

8. 发明申请

WO2014151279A1 VACCINES HAVING AN ANTIGEN AND INTERLEUKIN-23 AS AN ADJUVANT 审中-公开
标题翻译：具有抗原和白细胞介素-23的疫苗作为ADJUVANT
公开(公告)号：WO2014151279A1
公开(公告)日：2014-09-25
申请号：PCT/US2014/025348
申请日：2014-03-13
申请人： THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA , WEINER, David , MORROW, Matthew , YAN, Jian , FERRARO, Bernadette , HOKEY, David
发明人： WEINER, David , MORROW, Matthew , YAN, Jian , FERRARO, Bernadette , HOKEY, David
IPC分类号： A61K39/00
CPC分类号： A61K39/39 , A61K9/0009 , A61K39/015 , A61K39/12 , A61K2039/53 , A61K2039/54 , A61K2039/55527 , C07K14/54 , C12N7/00 , C12N15/03 , C12N2710/20033 , C12N2710/20034 , C12P21/02 , Y02A50/412
摘要： Disclosed herein is a vaccine comprising an antigen and IL-23. Also disclosed herein are methods for increasing an immune response in a subject. The methods may comprise administering the vaccine to the subject in need thereof. Vaccines are used to stimulate an immune response in an individual to provide protection against and/or treatment for a particular disease. Some vaccines include an antigen to induce the immune response.
摘要翻译：本文公开了包含抗原和IL-23的疫苗。本文还公开了增加受试者的免疫应答的方法。所述方法可以包括向有需要的受试者施用疫苗。疫苗用于刺激个体中的免疫应答以提供针对特定疾病和/或治疗特定疾病的保护。一些疫苗包括诱导免疫应答的抗原。

9. 发明申请

WO2014145785A1 HOST CELLS WITH ARTIFICIAL ENDOSYMBIONTS 审中-公开
标题翻译：具有人造内皮细胞的宿主细胞
公开(公告)号：WO2014145785A1
公开(公告)日：2014-09-18
申请号：PCT/US2014/030609
申请日：2014-03-17
申请人： BELL BIOSYSTEMS, LLC
发明人： BELL, Caleb, B., III , BAZAROV, Alexey
IPC分类号： A01N63/00 , A61B5/055 , G01N33/554 , G01N33/569
CPC分类号： A61K41/00 , A61K35/14 , A61K35/17 , A61K35/30 , A61K49/1896 , C12N1/20 , C12N15/03 , C12Q1/02 , G01N33/4833
摘要： The present invention is directed generally to eukaryotic cells comprising single-celled organisms that are introduced into the eukaryotic cell through human intervention and which transfer to daughter cells of the eukaryotic cell through at least five cell divisions, and methods of introducing such single-celled organisms into eukaryotic cells. The invention also provides methods of using such eukaryotic cells. The invention further provides single- celled organisms that introduce a phenotype to eukaryotic cells that is maintained in daughter cells. The invention additionally provides eukaryotic cells containing magnetotactic bacteria.
摘要翻译：本发明一般涉及包含单细胞生物的真核细胞，其通过人类干预被引入真核细胞，并通过至少五个细胞分裂转移到真核细胞的子细胞，以及引入这种单细胞生物的方法进入真核细胞。本发明还提供了使用这种真核细胞的方法。本发明进一步提供了将细胞表型引入保留在子细胞中的真核细胞的单细胞生物体。本发明另外提供含有磁力细菌的真核细胞。

10. 发明申请

WO2008131359A1 GENETICALLY MODIFIED BIOLOGICAL CELLS 审中-公开
标题翻译：遗传改良生物细胞
公开(公告)号：WO2008131359A1
公开(公告)日：2008-10-30
申请号：PCT/US2008/061060
申请日：2008-04-21
申请人： FAIN REAN INC. , O'KEEFE, Theresa L. , CURTISS, Timothy J.
发明人： O'KEEFE, Theresa L. , CURTISS, Timothy J.
IPC分类号： C12N15/00 , C12N1/20 , C12N15/85 , C07K1/00
CPC分类号： C12N15/03 , C07K14/195 , C12N15/70 , C12N15/74 , C12N15/902 , C12N2500/38 , C12P19/42
摘要： The present invention is based, in part, on our discovery of a way to configure expression cassettes so that the expression of a selectable marker protein, which is critical for the growth or survival of a cell, also results in the expression of a protein of interest in a biological cell. Accordingly, in one aspect, the invention features a genetically modified cell (e.g., a bacterial cell) that includes a chromosomally integrated or cytoplasmic expression cassette that includes a first nucleic acid sequence encoding a protein of interest and a second nucleic acid sequence encoding a selectable marker protein. The regulatory sequence (e.g., the sequence encoding a functional promoter) that drives expression of the required selectable marker protein also drives expression of the protein of interest. For that reason, we may refer to their expression as being "linked" or "functionally coupled."
摘要翻译：本发明部分地基于我们发现配置表达盒的方式，使得对细胞的生长或存活至关重要的选择性标记蛋白的表达也导致蛋白质的表达对生物细胞的兴趣。因此，一方面，本发明的特征在于遗传修饰的细胞（例如，细菌细胞），其包括染色体整合或细胞质表达盒，其包含编码目的蛋白的第一核酸序列和编码可选择的蛋白质的第二核酸序列标记蛋白。驱动所需选择标记蛋白表达的调节序列（例如，编码功能启动子的序列）也驱动目的蛋白质的表达。因此，我们可能将其表达称为“联系”或“功能耦合”。

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