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1. 发明申请

WO2015003622A1 A COMPOSITE CARRIER FOR IMMOBILIZATION OF PROTEINS, POLYPEPTIDES OR OLIGOPEPTIDES, PREPARATION METHODS AND APPLICATION THEREOF 审中-公开
标题翻译：用于蛋白质，多肽或寡核苷酸固定的复合载体，其制备方法及其应用
公开(公告)号：WO2015003622A1
公开(公告)日：2015-01-15
申请号：PCT/CN2014/081843
申请日：2014-07-08
申请人： BIORIGHT WORLDWIDE COMPANY LIMITED. , CHEUNG, Chung Hong
发明人： CHEUNG, Chung Hong , WANG, Jun
IPC分类号： C12N11/08 , B01D15/08 , C12N11/06 , C07K17/06 , C07K17/08 , B01J20/26
CPC分类号： C08J9/0061 , A01N43/68 , B01D15/3809 , B01J20/24 , B01J20/267 , B01J20/286 , B01J20/3212 , B01J20/3219 , B01J20/3274 , B01J31/0234 , B01J31/06 , C07K1/22 , C07K5/0806 , C07K7/62 , C07K14/31 , C07K17/04 , C07K17/06 , C07K17/08 , C08J2201/026 , C08J2361/28 , C08J2403/10 , C08J2405/08 , C12N9/1051 , C12N11/02 , C12N11/06 , C12N11/08 , C12N11/10
摘要： Provided are a composite carrier for immobilization of a protein, polypeptide or oligopeptide, a preparation method and an application thereof. The composite carrier is a porous material which comprises: (1) a porous organic foam material containing open pores; and (2) a crosslinked product having aldehyde groups and immobilized on the surface of the walls of one or more pores of the porous organic foam material, wherein the aldehyde groups are able to react with the protein, polypeptide or oligopeptide, and the crosslinked product are formed by chitosan via a crosslinking reaction with a polyaldehyde compound.
摘要翻译：提供用于固定蛋白质，多肽或寡肽的复合载体，其制备方法和应用。复合载体是多孔材料，其包括：（1）含有开孔的多孔有机泡沫材料; 和（2）具有醛基并且固定在多孔有机泡沫材料的一个或多个孔的壁的表面上的交联产物，其中醛基能够与蛋白质，多肽或寡肽反应，并且交联产物由壳聚糖通过与多醛化合物的交联反应形成。

2. 发明申请

WO2013102684A1 AFFINITY TAG SYSTEM 审中-公开
标题翻译： AFFINITY标签系统
公开(公告)号：WO2013102684A1
公开(公告)日：2013-07-11
申请号：PCT/EP2013/050169
申请日：2013-01-07
申请人： UNIVERSITY COLLEGE DUBLIN
发明人： O'CONNELL, David , LINSE, Sara Snogerup , THULIN, Eva , MERINO, Alejandro
IPC分类号： C07K1/20 , C07K1/22 , C07K14/47
CPC分类号： C07K17/06 , C07K1/22 , C07K14/4728 , C07K2319/00 , C07K2319/50
摘要： The present invention pertains to an affinity tag system for the immobilisation and/or purification of molecules such as biological or organic molecules. The invention provides EF-hand subdomains of calcium binding proteins, such as calbindin D9k, as affinity tags and affinity ligands for immobilising, detecting and/or purifying molecules, particularly proteins. Also provided are methods utilising the affinity tag system of the invention, affinity matrices comprising EF-hand subdomain affinity ligands and fusion proteins comprising EF-hand subdomain affinity tags.
摘要翻译：本发明涉及用于固定和/或纯化分子例如生物或有机分子的亲和标签系统。本发明提供钙结合蛋白（例如钙结合蛋白D9k）的EF-手亚结构域作为用于固定，检测和/或纯化分子，特别是蛋白质的亲和标签和亲和配体。还提供了利用本发明的亲和标签系统的方法，包含EF-手子域亲和配体的亲和基质和包含EF-手子域亲和标签的融合蛋白。

3. 发明申请

WO2011161017A1 NEW MEDIUM, DEVICES AND METHODS 审中-公开
标题翻译：新媒体，设备和方法
公开(公告)号：WO2011161017A1
公开(公告)日：2011-12-29
申请号：PCT/EP2011/060130
申请日：2011-06-17
申请人： JJK MEDICAL LTD. , AXELSSON, Jonas
发明人： AXELSSON, Jonas
IPC分类号： C07K17/02 , C07K14/705 , A61M1/14
CPC分类号： C07K14/705 , A61M1/16 , A61M1/1698 , A61M1/34 , A61M1/3403 , A61M1/36 , A61M1/3679 , B01J20/3274 , C07K17/02 , C07K17/06 , C07K17/14
摘要： A separation medium is provided, comprising at least one megalin polypeptide and/or at least one cubilin polypeptide immobilized on a support. Also provided are devices comprising the separation medium, as well as methods and uses employing the separation medium for extracorporeal removal of low molecular weight proteins,or fragments or derivatives thereof, from complex biological fluids.
摘要翻译：提供了分离介质，其包含固定在载体上的至少一种巨蛋白多肽和/或至少一种立克氏素多肽。还提供了包括分离介质的装置，以及使用分离介质从复杂生物流体体外去除低分子量蛋白质或其片段或衍生物的方法和用途。

4. 发明申请

WO2011070573A1 ANTIMICROBIAL WATER TREATMENT MEMBRANES AND PRODUCTION THEREOF 审中-公开
标题翻译：抗微生物水处理膜及其生产
公开(公告)号：WO2011070573A1
公开(公告)日：2011-06-16
申请号：PCT/IL2010/001034
申请日：2010-12-07
申请人： BEN-GURION UNIVERSITY OF THE NEGEV RESEARCH AND DEVELOPMENT AUTHORITY , KASHER, Roni , RONEN, Ze'ev , BENIN, Ehud , BAR-ILAN UNIVERSITY
发明人： KASHER, Roni , RONEN, Ze'ev , BENIN, Ehud
IPC分类号： A61K38/00 , C07K5/00
CPC分类号： C07K5/1019 , B01D61/025 , B01D61/027 , B01D61/145 , B01D65/08 , B01D67/0093 , B01D69/144 , B01D2321/168 , B01D2323/38 , B01D2325/48 , C07K17/06 , C07K17/08
摘要： The present invention discloses antimicrobial water treatment membranes, comprising a water treatment membrane, covalently attached to one or more antimicrobial peptides or derivatives thereof, either directly or via one or more tether molecules. There are also provided a process for preparing these antimicrobial membranes, and uses thereof in water treatment applications.
摘要翻译：本发明公开了直接或通过一个或多个系链分子共价连接到一种或多种抗微生物肽或其衍生物上的抗菌水处理膜。还提供了制备这些抗微生物膜的方法及其在水处理应用中的用途。

5. 发明申请

WO2010029317A8 TREATING INFLAMMATORY CONDITIONS 审中-公开
标题翻译：处理危害条件
公开(公告)号：WO2010029317A8
公开(公告)日：2011-05-05
申请号：PCT/GB2009002196
申请日：2009-09-10
申请人： ITH IMMUNE THERAPY HOLDINGS AB , WINQVIST OLA , COTTON GRAHAM
发明人： WINQVIST OLA , COTTON GRAHAM
IPC分类号： C07K14/52 , A61M1/36 , B01J20/32
CPC分类号： A61M1/3679 , A61M1/3618 , B01J20/262 , B01J20/267 , B01J20/28004 , B01J20/28009 , B01J20/28016 , B01J20/3085 , B01J20/3212 , B01J20/3219 , B01J20/3242 , B01J20/3272 , B01J20/3274 , B01J2220/58 , C07K14/52 , C07K14/521 , C07K17/06 , C07K17/10
摘要： An apheresis column loaded with a solid support comprises one or more chemokines, in particular biotinylated chemokines, immobilized directly or indirectly on the support, in particular on a support carrying streptavidin. Also disclosed are uses of the column and the support and a method of depleting cells, in particular leukocytes, from the peripheral blood of a person suffering from an inflammatory condition such as Inflammatory Bowel Disease (IBD).
摘要翻译：负载有固体支持物的单采血浆柱包含一种或多种趋化因子，特别是生物素化的趋化因子，其直接或间接地固定在载体上，特别是在携带链霉亲和素的载体上。还公开了柱和支持物的使用以及从患有炎症性肠炎（IBD）的人的外周血中消耗细胞，特别是白细胞的方法。

6. 发明申请

WO2010029317A2 TREATING INFLAMMATORY CONDITIONS 审中-公开
标题翻译：处理危害条件
公开(公告)号：WO2010029317A2
公开(公告)日：2010-03-18
申请号：PCT/GB2009/002196
申请日：2009-09-10
申请人： IBD COLUMN THERAPIES INTERNATIONAL AB , WINQVIST, Ola , COTTON, Graham
发明人： WINQVIST, Ola , COTTON, Graham
IPC分类号： C07K14/52 , A61M1/36 , B01J20/32
CPC分类号： A61M1/3679 , A61M1/3618 , B01J20/262 , B01J20/267 , B01J20/28004 , B01J20/28009 , B01J20/28016 , B01J20/3085 , B01J20/3212 , B01J20/3219 , B01J20/3242 , B01J20/3272 , B01J20/3274 , B01J2220/58 , C07K14/52 , C07K14/521 , C07K17/06 , C07K17/10
摘要： An apheresis column loaded with a solid support comprises one or more chemokines, in particular biotinylated chemokines, immobilized directly or indirectly on the support, in particular on a support carrying streptavidin. Also disclosed are uses of the column and the support and a method of depleting cells, in particular leukocytes, from the peripheral blood of a person suffering from an inflammatory condition such as Inflammatory Bowel Disease (IBD).
摘要翻译：负载有固体支持物的单采血液柱包含一个或多个趋化因子，特别是生物素化的趋化因子，其直接或间接地固定在载体上，特别是在携带链霉亲和素的载体上。还公开了柱和载体的使用以及从患有炎症性肠炎（IBD）的人的外周血中消耗细胞，特别是白细胞的方法。

7. 发明申请

WO2008058302A1 S-LAYER PROTEIN COVERED SURFACES 审中-公开
标题翻译： S层蛋白覆盖表面
公开(公告)号：WO2008058302A1
公开(公告)日：2008-05-22
申请号：PCT/AT2007/000509
申请日：2007-11-13
申请人： NANO S BIOTECHNOLOGIE GMBH , MATIS, Alexander , RANINGER, Alexander , SLEYTR, Uwe
发明人： MATIS, Alexander , RANINGER, Alexander , SLEYTR, Uwe
IPC分类号： C07K17/00 , C07K14/195 , B01D71/74
CPC分类号： C07K14/195 , B01D65/08 , B01D67/0088 , B01D69/02 , B01D2321/168 , B82Y5/00 , C07K17/06
摘要： The present invention relates to S-layer protein covered surfaces, wherein the uncovered surface has a biomolecule binding capacity of less than 150 μg/cm 2 as measured by the BSA binding test and in that the surface is covered at least partially with an S-layer protein lattice.
摘要翻译：本发明涉及S层蛋白质覆盖的表面，其中未覆盖的表面具有通过BSA结合试验测量的小于150μg/ cm 2的生物分子结合能力，并且表面被覆盖至少部分地具有S层蛋白质晶格。

8. 发明申请

WO2006113958A8 AFFINITY LIGANDS 审中-公开
标题翻译：亲和力配体
公开(公告)号：WO2006113958A8
公开(公告)日：2007-01-18
申请号：PCT/AT2006000167
申请日：2006-04-25
申请人： SANDOZ AG , BOEHRINGER INGELHEIM AUSTRIA , JUNGBAUER ALOIS , HAHN RAINER , KAAR WALTRAUD , SEIFERT MICHAEL , AUER BERNHARD , ACHMUELLER CLEMENS , WECHNER PHILIPP
发明人： JUNGBAUER ALOIS , HAHN RAINER , KAAR WALTRAUD , SEIFERT MICHAEL , AUER BERNHARD , ACHMUELLER CLEMENS , WECHNER PHILIPP
IPC分类号： C07K17/06 , C07K1/22
CPC分类号： C12P21/02 , C07K1/22 , C07K17/06 , C12N9/506 , C12N15/62
摘要： Disclosed is an affinity matrix comprising a solid phase and an affinity ligand comprising peptide bonds coupled to this solid phase, wherein the affinity ligand comprising peptide bond is selected from the following group of ligands: a) peptides comprising the formula X 1 X 2 X 3 X 4 , wherein X 1 to X 4 are amino acid residues and at least two of X 1 to X 4 is W, Y or F; b) peptides comprising the formula X 5 X 6 X 7 X 8 , wherein X 5 to X 8 are amino acid residues, at least one of X 5 to X 8 is W, and at least one of X 5 to X 8 is E or D; and c) poly-amino acids consisting of an amino acid monomer of the group consisting of R, K, E and D and an amino acid monomer of the group consisting of Y, F and W, preferably poly-KY, poly-KF, poly-KW, poly-RY, poly-RF, poly-RW, poly-EY, poly-DY, poly-EF, poly-EW, poly-DF and poly-DW, with the proviso that the peptides according to a) and b) have a maximum length of 35 amino acid residues and that the poly-amino acids according to c) have a minimum length of 20 amino acid residues.
摘要翻译：公开了包含固相和亲和配体的亲和基质，所述亲和配体包含与该固相偶联的肽键，其中所述包含肽键的亲和配体选自以下配体组：a）包含式X 1，其中X _{1 至X _{4 ，其中X _{2 3 >是氨基酸残基并且X 1至X 4中的至少两个是W，Y或F; b）包含下式的肽：其中X 5，X 5，X 5，X 5，X 5，其中X至X 8至少是氨基酸残基，X 5至X 8中至少一个是W，并且X _{5 至X _{8 是E或D; 和c）由选自R，K，E和D的氨基酸单体和选自Y，F和W的氨基酸单体组成的聚氨基酸，优选聚-KY，聚-KF， poly-KW，poly-RY，poly-RF，poly-RW，poly-EY，poly-DY，poly-EF，poly-EW，poly-DF和poly-DW，条件是a）和b）具有35个氨基酸残基的最大长度，并且根据c）的聚氨基酸具有20个氨基酸残基的最小长度。}}}}}

9. 发明申请

WO2004058946A3 PROTEIN ARRAYS 审中-公开
标题翻译：蛋白质阵列
公开(公告)号：WO2004058946A3
公开(公告)日：2005-07-28
申请号：PCT/US0341346
申请日：2003-12-22
申请人： SCRIPPS RESEARCH INST , SCHULTZ PETER G , WANG LEI
发明人： SCHULTZ PETER G , WANG LEI
IPC分类号： A61K38/03 , C07K1/04 , C07K1/107 , C07K17/06 , C12M3/00
CPC分类号： C07K17/06 , C07K1/047 , C07K1/1077 , Y10S435/97 , Y10S530/811
摘要： The invention provides proteins attached to solid supports, and methods of preparing such solid support-bound proteins are provided. The proteins are attached to solid supports by means of an unnatural amino acid incorporated into the protein, which unnatural amino acid includes a reactive group that can react with a second reactive group that is attached to a solid support.
摘要翻译：本发明提供了连接到固体支持物上的蛋白质，并且提供了制备这种固体支持结合蛋白质的方法。蛋白质通过并入蛋白质中的非天然氨基酸连接到固体支持物上，该非天然氨基酸包括可与附着于固体支持物上的第二反应性基团反应的反应性基团。

10. 发明申请

WO2005057462A1 A METHOD FOR DESIGNING SURFACES 审中-公开
标题翻译：一种设计表面的方法
公开(公告)号：WO2005057462A1
公开(公告)日：2005-06-23
申请号：PCT/AU2004/001747
申请日：2004-12-10
申请人： BIO-LAYER PTY LIMITED , GORSE, Alain-Dominique, Jean-Pierre
发明人： GORSE, Alain-Dominique, Jean-Pierre
IPC分类号： G06F19/00
CPC分类号： C07K1/22 , C07K17/02 , C07K17/06 , C07K2299/00 , G01N33/6803 , G01N33/6854 , G06F19/16 , G06F19/18 , G06F19/706
摘要： A method of producing a binding surface for a target molecule having a functional binding site, which method comprises: (i) identifying within the target molecule an anchor site which is remote from the functional binding site; (ii) generating a pharmacophore model for the anchor site; (iii) using the pharmacophore model to identify an anchor site binding ligand; and (iv) providing the anchor site binding ligand on a surface of a substrate such that the ability of the anchor site binding ligand to bind to the anchor site is preserved.
摘要翻译：一种制备具有功能性结合位点的靶分子的结合表面的方法，该方法包括：（i）在靶分子内鉴定远离功能性结合位点的锚定位点; （ii）为锚地点产生药效团模型; （iii）使用所述药效团模型来鉴定锚定位点结合配体; 和（iv）在底物的表面上提供锚定位点结合配体，使得锚定位点结合配体结合锚定位点的能力被保留。

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