专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

WO2010029317A2 TREATING INFLAMMATORY CONDITIONS 审中-公开
标题翻译：处理危害条件
公开(公告)号：WO2010029317A2
公开(公告)日：2010-03-18
申请号：PCT/GB2009/002196
申请日：2009-09-10
申请人： IBD COLUMN THERAPIES INTERNATIONAL AB , WINQVIST, Ola , COTTON, Graham
发明人： WINQVIST, Ola , COTTON, Graham
IPC分类号： C07K14/52 , A61M1/36 , B01J20/32
CPC分类号： A61M1/3679 , A61M1/3618 , B01J20/262 , B01J20/267 , B01J20/28004 , B01J20/28009 , B01J20/28016 , B01J20/3085 , B01J20/3212 , B01J20/3219 , B01J20/3242 , B01J20/3272 , B01J20/3274 , B01J2220/58 , C07K14/52 , C07K14/521 , C07K17/06 , C07K17/10
摘要： An apheresis column loaded with a solid support comprises one or more chemokines, in particular biotinylated chemokines, immobilized directly or indirectly on the support, in particular on a support carrying streptavidin. Also disclosed are uses of the column and the support and a method of depleting cells, in particular leukocytes, from the peripheral blood of a person suffering from an inflammatory condition such as Inflammatory Bowel Disease (IBD).
摘要翻译：负载有固体支持物的单采血液柱包含一个或多个趋化因子，特别是生物素化的趋化因子，其直接或间接地固定在载体上，特别是在携带链霉亲和素的载体上。还公开了柱和载体的使用以及从患有炎症性肠炎（IBD）的人的外周血中消耗细胞，特别是白细胞的方法。

2. 发明申请

WO2007133147A1 METHOD AND MEANS FOR TREATING INFLAMMATORY BOWEL DISEASE 审中-公开
标题翻译：治疗炎症性皮肤病的方法和手段
公开(公告)号：WO2007133147A1
公开(公告)日：2007-11-22
申请号：PCT/SE2007/000459
申请日：2007-05-14
申请人： IBD COLUMN THERAPIES INTERNATIONAL AB , THÖRN, Magnus , WINQVIST, Ola
发明人： THÖRN, Magnus , WINQVIST, Ola
IPC分类号： A61K39/395 , A61M1/36 , A61P1/04
CPC分类号： C07K16/28 , A61M1/3679
摘要： A method of treating inflammatory bowel disease (IBD) comprises providing an intestinal biopsy sample obtained from inflamed tissue of a patient; mechanically treating the sample to obtain a cell suspension; identifying cell surface markers of activated leukocytes selected from T lymphocytes, neutrophil granulocytes, and eosinophil granulocytes in the suspension; raising antibodies against one of more of the activated cells and immobilizing them on a support; providing a column loaded with the support; diverting a portion of the patient's peripheral blood to make it pass through the column before re-infusing it to the patient to make the activated leukocytes couple with antibodies on the support, thereby eliminating them from the blood stream. Also disclosed are corresponding columns and supports, and their use in the method.
摘要翻译：治疗炎性肠病（IBD）的方法包括提供从患者的发炎组织获得的肠活检样品; 机械处理样品以获得细胞悬浮液; 鉴定悬浮液中选自T淋巴细胞，嗜中性粒细胞和嗜酸粒细胞粒细胞的活化白细胞的细胞表面标志物; 提高针对一种或多种活化细胞的抗体并将其固定在载体上; 提供装载有支撑件的柱子; 转移患者外周血的一部分使其通过柱，然后将其再次注入患者，使活化的白细胞与载体上的抗体偶联，从而从血液中除去它们。还公开了相应的列和支持，以及它们在该方法中的使用。

3. 发明申请

WO2012172344A2 TREATING CONDITIONS ASSOCIATED WITH SEPSIS 审中-公开
标题翻译：处理与SEPSIS相关的条件
公开(公告)号：WO2012172344A2
公开(公告)日：2012-12-20
申请号：PCT/GB2012/051354
申请日：2012-06-13
申请人： ITH IMMUNE THERAPY HOLDINGS , COTTON, Graham , WINQVIST, Ola
发明人： COTTON, Graham , WINQVIST, Ola
IPC分类号： C07K14/52 , A61M1/36 , B01J20/32 , C07K17/02 , G01N33/68
CPC分类号： C07K14/522 , A61M1/3679 , C07K14/523 , G01N33/56911 , G01N33/6893 , G01N2333/715 , G01N2800/125 , G01N2800/26 , G01N2800/52 , G01N2800/56 , G01N2800/60
摘要： A method for treating sepsis and/or respiratory distress syndrome (RDS) comprises applying peripheral blood from a patient or subject to an apheresis column loaded with a solid support comprising one or more binding reagents capable of specifically binding to a chemokine receptor, optionally the chemokine receptor CCR5, CXCR1, CXCR2, and/or CCR2 immobilized directly or indirectly on the support thus removing one or more chemokine receptor, optionally CCR5, CXCR1, CXCR2, and/or CCR2 expressing cells from the peripheral blood of the patient or subject. Various companion therapeutic methods and useful binding reagents are also described.
摘要翻译：用于治疗败血症和/或呼吸窘迫综合征（RDS）的方法包括将来自患者或受试者的外周血应用于装有固体支持物的单采血管柱，所述固体支持物包含一种或多种能够特异性结合趋化因子受体的结合试剂，任选的趋化因子受体CCR5，CXCR1，CXCR2和/或CCR2直接或间接固定在载体上，从而从患者或受试者的外周血中除去一种或多种趋化因子受体，任选CCR5，CXCR1，CXCR2和/或CCR2表达细胞。还描述了各种伴侣治疗方法和有用的结合试剂。

4. 发明申请

WO2013041833A1 TREATING CONDITIONS ASSOCIATED WITH METABOLIC SYNDROME 审中-公开
标题翻译：治疗与代谢综合征相关的病症
公开(公告)号：WO2013041833A1
公开(公告)日：2013-03-28
申请号：PCT/GB2012/051349
申请日：2012-06-13
申请人： COTTON, Graham , WINQVIST, Ola , ITH IMMUNE THERAPY HOLDINGS AB
发明人： COTTON, Graham , WINQVIST, Ola
IPC分类号： A61M1/36 , B01J20/32
CPC分类号： B01J20/3202 , A61M1/3679 , B01J20/3219 , B01J20/3274 , C07K14/521
摘要： A method for treating a condition associated with metabolic syndrome or for treating adiposis dolorosa (AD) comprises applying peripheral blood from a patient or subject to an apheresis column loaded with a solid support comprising one or more binding reagents capable of specifically binding to a chemokine receptor, optionally the chemokine receptor CCR2, CCR1, CCR3, CCR4 or CCR5 immobilized directly or indirectly on the support thus removing one or more chemokine receptor, optionally CCR2, CCR1, CCR3, CCR4 and CCR5 expressing cells from the peripheral blood of the patient or subject. Various companion diagnostic methods and useful binding reagents are also described.
摘要翻译：用于治疗与代谢综合征有关的病症或用于治疗肥胖症（AD）的病症的方法包括将来自患者或受试者的外周血应用于装载有能够特异性结合趋化因子受体的一种或多种结合试剂的固体支持物的单采血液柱，任选地直接或间接固定在载体上的趋化因子受体CCR2，CCR1，CCR3，CCR4或CCR5，从而从患者或受试者的外周血中除去一种或多种趋化因子受体，任选CCR2，CCR1，CCR3，CCR4和CCR5表达细胞。还描述了各种伴侣诊断方法和有用的结合试剂。

5. 发明申请

WO2012172341A2 TREATING CANCER 审中-公开
标题翻译：治疗癌症
公开(公告)号：WO2012172341A2
公开(公告)日：2012-12-20
申请号：PCT/GB2012/051351
申请日：2012-06-13
申请人： COTTON, Graham , WINQVIST, Ola , ITH IMMUNE THERAPY HOLDINGS
发明人： COTTON, Graham , WINQVIST, Ola
IPC分类号： A61M1/36
CPC分类号： C07K14/521 , A61M1/3679
摘要： A method for treating cancer comprising applying peripheral blood from a patient or subject to an apheresis column loaded with a solid support comprising one or more binding reagents capable of specifically binding to a chemokine receptor, optionally the chemokine receptor CCR7, CCR5, CCR6, CCR8, CXCR4, CXCR7, CCR4, CCR9, CCR10, CXCR3 or CXCR5 or to a Treg receptor immobilized directly or indirectly on the support thus removing one or more chemokine receptor, optionally CCR7, CCR5, CCR6, CCR8, CXCR4, CXCR7, CCR4, CCR9, CCR10, CXCR3 or CXCR5 or Treg receptor expressing cells from the peripheral blood of the patient or subject. Various companion diagnostic methods and useful binding reagents are also described.
摘要翻译：一种治疗癌症的方法，包括将来自患者或受试者的外周血加载于装有固体支持物的单采血管柱，所述固体支持物包含一种或多种能够特异性结合趋化因子受体的结合试剂，任选的趋化因子受体CCR7，CCR5，CCR6，CCR8， CXCR4，CXCR7，CCR4，CCR9，CCR10，CXCR3或CXCR5或直接或间接固定在载体上的Treg受体，从而除去一种或多种趋化因子受体，任选CCR7，CCR5，CCR6，CCR8，CXCR4，CXCR7，CCR4，CCR9， CCR10，CXCR3或CXCR5或来自患者或受试者的外周血的Treg受体表达细胞。还描述了各种伴侣诊断方法和有用的结合试剂。

6. 发明申请

WO2012172337A2 TREATING CARDIOVASCULAR DISEASE 审中-公开
标题翻译：治疗心血管疾病
公开(公告)号：WO2012172337A2
公开(公告)日：2012-12-20
申请号：PCT/GB2012/051346
申请日：2012-06-13
申请人： ITH IMMUNE THERAPY HOLDINGS , COTTON, Graham , WINQVIST, Ola
发明人： COTTON, Graham , WINQVIST, Ola
IPC分类号： C07K14/52 , C07K17/02 , A61M1/36 , B01J20/32 , G01N33/68
CPC分类号： C07K14/523 , A61M1/3679 , B01J20/3208 , B01J20/3219 , B01J20/3274 , G01N33/6863 , G01N2333/7158 , G01N2800/323 , G01N2800/52 , G01N2800/56
摘要： A method for treating cardiovascular disease comprises applying peripheral blood from a patient or subject to an apheresis column loaded with a solid support comprising one or more binding reagents capable of specifically binding to a chemokine receptor, optionally the chemokine receptor CCR2, CCR1 and/or CCR7 immobilized directly or indirectly on the support thus removing chemokine receptor, optionally CCR2, CCR1 and/or CCR7 expressing cells from the peripheral blood of the patient or subject. Various companion diagnostic methods and useful binding reagents are also described.
摘要翻译：治疗心血管疾病的方法包括将来自患者或受试者的外周血应用于装载有固体支持物的单采血管柱，所述固体支持物包含一种或多种能够特异性结合趋化因子受体，任选地趋化因子受体CCR2，CCR1和/或CCR7的结合试剂直接或间接地固定在载体上，从而从患者或受试者的外周血中除去趋化因子受体，任选CCR2，CCR1和/或CCR7表达细胞。还描述了各种伴侣诊断方法和有用的结合试剂。

7. 发明申请

WO2012172347A1 DIAGNOSING AND TREATING INFLAMMATORY BOWEL DISEASE AND IRRITABLE BOWEL SYNDROME 审中-公开
标题翻译：诊断和治疗炎症性皮肤疾病和可疑牙刷综合征
公开(公告)号：WO2012172347A1
公开(公告)日：2012-12-20
申请号：PCT/GB2012/051357
申请日：2012-06-13
申请人： WINQVIST, Ola , COTTON, Graham , ITH IMMUNE THERAPY HOLDINGS AB
发明人： WINQVIST, Ola , COTTON, Graham
IPC分类号： G01N33/68 , G01N33/50 , C07K14/52 , C07K17/00 , A61M1/36 , B01J20/32
CPC分类号： C07K14/52 , C07K17/00 , G01N33/6863 , G01N2333/7158 , G01N2800/065
摘要： A method of diagnosing, monitoring progression of, or monitoring treatment of inflammatory bowel disease comprises determining the levels of CD14 + HLA-DR hi monocytes or monocytes expressing CCR7 or CCR9 or both CCR7 and CCR9 in a sample obtained from a subject, wherein high levels of CD14 + HLA-DR hi monocytes or monocytes expressing CCR7 or CCR9 or both CCR7 and CCR9, or increased levels of CD14 + HLA-DR hi monocytes or monocytes expressing CCR7 or CCR9 or both CCR7 and CCR9 compared to control, indicate the presence or progression of inflammatory bowel disease. Similar methods for diagnosing irritable bowel syndrome are also described. Various companion therapeutic methods and useful binding reagents are also described.
摘要翻译：诊断，监测炎症性肠病的进展或监测治疗的方法包括测定从受试者获得的样品中表达CCR7或CCR9或CCR7和CCR9两者的CD14 + HLA-DRhi单核细胞或单核细胞的水平，其中高水平与对照相比，CD14 + HLA-DRhi单核细胞或表达CCR7或CCR9或CCR7和CCR9两者的单核细胞或表达CCR7或CCR9或CCR7或CCR9的CD14 + HLA-DRhi单核细胞或单核细胞水平升高表明炎症的存在或进展肠病还描述了用于诊断肠易激综合征的类似方法。还描述了各种伴侣治疗方法和有用的结合试剂。

8. 发明申请

WO2012172346A2 TREATING RESPIRATORY CONDITIONS 审中-公开
标题翻译：治疗呼吸条件
公开(公告)号：WO2012172346A2
公开(公告)日：2012-12-20
申请号：PCT/GB2012/051356
申请日：2012-06-13
申请人： ITH IMMUNE THERAPY HOLDINGS , COTTON, Graham , WINQVIST, Ola
发明人： COTTON, Graham , WINQVIST, Ola
IPC分类号： C07K14/52 , A61M1/36 , B01J20/32 , C07K17/02 , G01N33/68
CPC分类号： C07K14/522 , A61M1/3618 , A61M1/3679 , C07K14/523 , C07K17/02 , G01N33/6863 , G01N2333/7158 , G01N2800/122 , G01N2800/52 , G01N2800/60
摘要： A method for treating a respiratory conditions comprises applying peripheral blood from a patient or subject to an apheresis column loaded with a solid support comprising one or more binding reagents capable of specifically binding to a chemokine receptor, optionally the chemokine receptor CCR2, CCR1, CCR3, CCR5, CXCR1, CXCR2 and/or CCR7 immobilized directly or indirectly on the support thus removing one or more chemokine receptor, optionally CCR2, CCR1, CCR3, CCR5, CXCR1, CXCR2 and/or CCR7 expressing cells from the peripheral blood of the patient or subject. Various companion diagnostic methods and useful binding reagents are also described.
摘要翻译：用于治疗呼吸病症的方法包括施用来自患者或受试者的外周血，所述血液分离柱装载有固体支持物，所述固体支持物包含一种或多种能够特异性结合趋化因子受体的结合试剂，任选的趋化因子受体CCR2，CCR1，CCR3， CCR5，CXCR1，CXCR2和/或CCR7直接或间接固定在载体上，从而从患者的外周血中除去一种或多种趋化因子受体，任选CCR2，CCR1，CCR3，CCR5，CXCR1，CXCR2和/或CCR7表达细胞; 学科。还描述了各种伴侣诊断方法和有用的结合试剂。

9. 发明申请

WO2012172343A2 TREATING PRIMARY SCLEROSING CHOLANGITIS 审中-公开
标题翻译：治疗原发性硬化症
公开(公告)号：WO2012172343A2
公开(公告)日：2012-12-20
申请号：PCT/GB2012/051353
申请日：2012-06-13
申请人： ITH IMMUNE THERAPY HOLDINGS , COTTON, Graham , WINQVIST, Ola
发明人： COTTON, Graham , WINQVIST, Ola
IPC分类号： C07K14/52 , A61M1/36 , B01J20/32 , C07K17/02 , G01N33/68
CPC分类号： C07K14/522 , A61M1/3679 , C07K14/523 , C07K17/02 , G01N33/6893 , G01N2333/7158 , G01N2800/08
摘要： A method for treating primary sclerosing cholangitis comprises applying peripheral blood from a patient or subject to an apheresis column loaded with a solid support comprising one or more binding reagents capable of specifically binding to a chemokine receptor, optionally the chemokine receptor CCR9, CXCR4, CCR7 or CCR5 immobilized directly or indirectly on the support thus removing one or more chemokine receptor, optionally CCR9, CXCR4, CCR7 and CCR5 expressing cells from the peripheral blood of the patient or subject. Various companion therapeutic methods and useful binding reagents are also described.
摘要翻译：用于治疗原发性硬化性胆管炎的方法包括施用来自患者或受试者的外周血，所述血液分离柱装载有包含一种或多种能够特异性结合趋化因子受体的结合试剂，任选地趋化因子受体CCR9，CXCR4，CCR7或 CCR5直接或间接地固定在载体上，从而从患者或受试者的外周血中除去一种或多种趋化因子受体，任选CCR9，CXCR4，CCR7和CCR5表达细胞。还描述了各种伴侣治疗方法和有用的结合试剂。

10. 发明申请

WO2012172342A2 TREATING MULTIPLE SCLEROSIS 审中-公开
标题翻译：治疗多发性硬化症
公开(公告)号：WO2012172342A2
公开(公告)日：2012-12-20
申请号：PCT/GB2012/051352
申请日：2012-06-13
申请人： ITH IMMUNE THERAPY HOLDINGS , COTTON, Graham , WINQVIST, Ola
发明人： COTTON, Graham , WINQVIST, Ola
IPC分类号： C07K14/52 , A61M1/36 , B01J20/32 , C07K17/02 , G01N33/68
CPC分类号： C07K14/523 , A61M1/3679 , B01J20/3208 , B01J20/3219 , B01J20/3274 , C07K14/522 , G01N33/6863 , G01N2800/285
摘要： A method for treating multiple sclerosis comprises applying peripheral blood from a patient or subject to an apheresis column loaded with a solid support comprising one or more binding reagents capable of specifically binding to a chemokine receptor, optionally the chemokine receptor CCR2, CCR6, CCR3, CCR5, CCR1, CXCR3 and/or CCR9 immobilized directly or indirectly on the support thus removing one or more chemokine receptor, optionally CCR2, CCR6, CCR3, CCR5, CCR1, CXCR3 and/or CCR9 expressing cells from the peripheral blood of the patient or subject. Various companion diagnostic methods and useful binding reagents are also described.
摘要翻译：一种治疗多发性硬化症的方法包括施用来自患者或受试者的外周血，所述血液分离柱装载有包含一种或多种能够特异性结合趋化因子受体，任选地趋化因子受体CCR2，CCR6，CCR3，CCR5的结合试剂的固体支持物，CCR1，CXCR3和/或CCR9直接或间接固定在载体上，从而从患者或受试者的外周血中除去一种或多种趋化因子受体，任选地CCR2，CCR6，CCR3，CCR5，CCR1，CXCR3和/或CCR9表达细胞。还描述了各种伴侣诊断方法和有用的结合试剂。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式