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1. 发明申请

WO2008156804A2 MODIFIED ASPHALT BINDERS AND ASPHALT PAVING COMPOSITIONS 审中-公开
标题翻译：改性沥青混合料和沥青混合料
公开(公告)号：WO2008156804A2
公开(公告)日：2008-12-24
申请号：PCT/US2008/007629
申请日：2008-06-19
申请人： FIRESTONE POLYMERS LLC , HERITAGE RESEARCH GROUP , RADEMACHER, Christine , GRAVES, Daniel , WISSEL, Herb , REECE, Timothy
发明人： RADEMACHER, Christine , GRAVES, Daniel , WISSEL, Herb , REECE, Timothy
IPC分类号： C08L95/00
CPC分类号： C07F9/65785 , C08L21/00 , C08L23/00 , C08L55/00 , C08L95/00 , C08L2666/04
摘要： A process for preparing a modified asphalt binder composition, the process comprising mixing asphalt, an unsaturated polymer, and an organothionating agent to form a modified asphalt composition.
摘要翻译：一种制备改性沥青粘合剂组合物的方法，该方法包括混合沥青，不饱和聚合物和有机硫化剂以形成改性沥青组合物。

2. 发明申请

WO2016176423A1 NOVEL PRODRUGS OF DITHIOL MUCOLYTIC AGENTS 审中-公开
标题翻译： DITHIOL MUCOLYTIC代理商的新产品
公开(公告)号：WO2016176423A1
公开(公告)日：2016-11-03
申请号：PCT/US2016/029729
申请日：2016-04-28
申请人： PARION SCIENCES, INC.
发明人： JOHNSON, Michael, Ross , THELIN, William, R.
IPC分类号： A61K31/145 , A61K31/14 , C07C323/16
CPC分类号： C07C327/28 , A61K9/0075 , A61K9/16 , A61K31/047 , A61K31/133 , A61K31/265 , A61K31/341 , A61K31/385 , A61K31/683 , A61K33/14 , C07C323/16 , C07C327/22 , C07D307/68 , C07D339/00 , C07D339/08 , C07F9/65785 , C12N9/0071 , C12N9/0073 , C12N9/1051 , C12N9/13 , C12P17/165 , C12P19/60 , C12Y114/13008 , C12Y114/14001 , C12Y208/02001
摘要： Provided are mucolytic compounds that are more effective, and/or absorbed less rapidly from mucosal surfaces, and/or are better tolerated as compared to N-acetylcysteine (NAC) and DTT. The compounds are represented by compounds of Formula I which embrace structures (la)-(Ib), where the structural variables are as defined herein.
摘要翻译：提供了比N-乙酰半胱氨酸（NAC）和DTT相比更有效和/或从粘膜表面迅速吸收的和/或更好的耐受性的粘液溶解化合物。化合物由式I化合物表示，其包含结构（Ia） - （Ib），其中结构变量如本文所定义。

3. 发明申请

WO0220500A3 MATERIALS AND METHODS TO POTENTIATE CANCER TREATMENT 审中-公开
标题翻译：阻止癌症治疗的材料和方法
公开(公告)号：WO0220500A3
公开(公告)日：2003-07-31
申请号：PCT/US0126709
申请日：2001-08-28
申请人： ICOS CORP
发明人： HALBROOK JAMES , KESICKI EDWARD , BURGESS LAURENCE E , SCHLACHTER STEPHEN T , EARY CHARLES T , SCHIRO JUSTIN G , HUANG HONGMEI , EVANS MICHAEL , HAN YONGXIN
IPC分类号： A61K45/06 , A61P35/00 , C07C309/66 , C07D209/36 , C07D211/42 , C07D211/46 , C07D213/40 , C07D213/50 , C07D213/74 , C07D213/75 , C07D233/54 , C07D235/26 , C07D239/48 , C07D277/24 , C07D277/42 , C07D277/46 , C07D277/54 , C07D279/12 , C07D295/096 , C07D295/112 , C07D295/13 , C07D295/135 , C07D295/155 , C07D295/185 , C07D295/215 , C07D295/30 , C07D307/83 , C07D309/10 , C07D311/30 , C07D333/22 , C07D405/04 , C07D417/12 , C07D521/00 , C07F9/6533 , C07F9/6578 , C07D295/12 , A61K31/435 , C07C309/44 , C07D211/26 , C07D239/42 , C07D295/08 , C07D295/10 , C07D295/14 , C07D295/18 , C07D295/20 , C07D295/22 , C07D417/04 , C07F11/00 , G01N33/53
CPC分类号： C07D213/40 , A61K45/06 , C07C309/66 , C07D209/36 , C07D211/42 , C07D211/46 , C07D213/50 , C07D213/74 , C07D213/75 , C07D231/12 , C07D233/56 , C07D235/26 , C07D239/48 , C07D249/08 , C07D277/24 , C07D277/54 , C07D279/12 , C07D295/096 , C07D295/112 , C07D295/13 , C07D295/135 , C07D295/155 , C07D295/185 , C07D295/215 , C07D295/30 , C07D307/83 , C07D309/10 , C07D311/30 , C07D333/22 , C07D405/04 , C07D417/12 , C07F9/6533 , C07F9/65785
摘要： Compounds of Formula (I) that inhibit DNA-dependent protein kinase, compositions comprising the compounds, methods to inhibit the DNA-PK biological activity, methods to sensitize cells the agents that cause DNA lesions, and methods to potentiate cancer treatment are disclosed.
摘要翻译：公开了抑制DNA依赖性蛋白激酶的式（I）化合物，包含该化合物的组合物，抑制DNA-PK生物活性的方法，使细胞致敏引起DNA损伤的试剂的方法以及加强癌症治疗的方法。

4. 发明申请

WO2008156804A3 MODIFIED ASPHALT BINDERS AND ASPHALT PAVING COMPOSITIONS 审中-公开
标题翻译：改性沥青混合料和沥青混合料
公开(公告)号：WO2008156804A3
公开(公告)日：2009-03-19
申请号：PCT/US2008007629
申请日：2008-06-19
申请人： FIRESTONE POLYMERS LLC , HERITAGE RES GROUP , RADEMACHER CHRISTINE , GRAVES DANIEL , WISSEL HERB , REECE TIMOTHY
发明人： RADEMACHER CHRISTINE , GRAVES DANIEL , WISSEL HERB , REECE TIMOTHY
IPC分类号： C08L95/00
CPC分类号： C07F9/65785 , C08L21/00 , C08L23/00 , C08L55/00 , C08L95/00 , C08L2666/04
摘要： A process for preparing a modified asphalt binder composition, the process comprising mixing asphalt, an unsaturated polymer, and an organothionating agent to form a modified asphalt composition.
摘要翻译：一种制备改性沥青粘合剂组合物的方法，该方法包括混合沥青，不饱和聚合物和有机硫化剂以形成改性沥青组合物。

5. 发明申请

WO2005058330A1 PHOSPHORUS CONTAINING COMPOUNDS USEFUL FOR THE REGULATION OF LDL AND LP(A) LEVELS 审中-公开
标题翻译：适用于低密度脂蛋白和LP（A）水平调节的含磷化合物
公开(公告)号：WO2005058330A1
公开(公告)日：2005-06-30
申请号：PCT/US2004/042603
申请日：2004-12-14
申请人： QUATRX PHARMACEUTICALS CO. , BRIDGES, Alexander, J.
发明人： BRIDGES, Alexander, J.
IPC分类号： A61K31/67
CPC分类号： C07F9/65685 , C07F9/582 , C07F9/60 , C07F9/65062 , C07F9/650917 , C07F9/65583 , C07F9/65586 , C07F9/657181 , C07F9/65719 , C07F9/65785 , C07F9/65842 , C07F9/65848
摘要： The invention provides phosphorus containing compounds, pharmaceutical compositions comprising the compounds, and methods of administering the compounds to a subject, wherein the phosphorus containing compounds are of the Formula (I) wherein B 1 , B 2 , B 3 , B 4 , Ar, F, E, G, Y 1 , Y 2 , Y 3 , X, U, V, R 4 , R 5 , Q, D, n, Het, Z 1 , and Z 2 , are as defined herein.
摘要翻译：本发明提供含磷化合物，包含该化合物的药物组合物，以及向受试者施用化合物的方法，其中含磷化合物为式（I），其中B 1，B 2，B 3，，B 4，Ar，F，E，G，Y 1，Y 2，Y 3，X，U，V，R 4，R 5，Q，D，n ，Het，Z 1和Z 2如本文所定义。

6. 发明申请

WO1995007919A1 METHOD FOR DOSING THERAPEUTIC COMPOUNDS 审中-公开
标题翻译：用于治疗化合物的方法
公开(公告)号：WO1995007919A1
公开(公告)日：1995-03-23
申请号：PCT/US1994010467
申请日：1994-09-16
申请人： GILEAD SCIENCES, INC. , ALEXANDER, Petr , ARIMILLI, Murty, N. , BISCHOFBERGER, Norbert, W. , HITCHCOCK, Michael, J., M.
发明人： GILEAD SCIENCES, INC.
IPC分类号： C07H19/10
CPC分类号： C07F9/65785 , C07F9/6512 , C07F9/65616 , C07F9/657181 , C07F9/65742 , C07F9/65744 , C07H19/10 , C07H19/20
摘要： The internally cyclized congeners of hydroxy-substituted nucleotide analogues have been found to exhibit substantially lower toxicity in vivo than their uncyclized analogues, while retaining essentially the same antiviral activity. This was unexpected because the prior art would have suggested that the cyclic analogues offered no significant advantages in respect to toxicity in vivo. This finding permits the administration of much greater doses of the cyclic congeners than otherwise would have been possible and/or allows the clinician to omit toxicity ameliorating interventions. Novel compounds are provided for use in the method of this invention. Novel methods for the preparation of these compounds also are provided.
摘要翻译：已经发现羟基取代的核苷酸类似物的内部环化同系物在体内表现出比其未环化的类似物显着更低的毒性，同时保持基本相同的抗病毒活性。这是意想不到的，因为现有技术将表明环状类似物在体内毒性方面没有显着的优点。该发现允许给予更大剂量的循环同源物，否则可能是可能的，和/或允许临床医生省略改善干预的毒性。提供了新的化合物用于本发明的方法。还提供了制备这些化合物的新方法。

7. 发明申请

WO2016040479A1 N-HETEROCYCLIC PHOSPHINES 审中-公开
标题翻译： N-杂环磷脂
公开(公告)号：WO2016040479A1
公开(公告)日：2016-03-17
申请号：PCT/US2015/049181
申请日：2015-09-09
申请人： THE BOARD OF REGENTS OF THE NEVADA SYSTEM OF HIGHER EDUCATION ON BEHALF OF THE UNIVERSITY OF NEVADA, LAS VEGAS
发明人： KANG, Jun, Yong , MULLA, Karimulla , ALESHIRE, Kyle , FORSTER, Paul, M.
IPC分类号： C07F9/02
CPC分类号： C07F9/65848 , C07F9/657181 , C07F9/65719 , C07F9/65742 , C07F9/65744 , C07F9/6578 , C07F9/65785
摘要： Provided herein are N-heterocyclic phosphines (NHPs) useful in metal-free phosphorus-carbon bond forming reactions. Methods for preparing vinylphosphonates using NHPs also are provided. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
摘要翻译：本文提供可用于无金属磷碳键形成反应的N-杂环膦（NHP）。还提供了使用NHP制备乙烯基膦酸盐的方法。该摘要旨在作为用于在特定技术中进行搜索的扫描工具，而不意在限制本发明。

8. 发明申请

WO02020500A2 MATERIALS AND METHODS TO POTENTIATE CANCER TREATMENT 审中-公开
标题翻译：阻止癌症治疗的材料和方法
公开(公告)号：WO02020500A2
公开(公告)日：2002-03-14
申请号：PCT/US2001/026709
申请日：2001-08-28
IPC分类号： A61K45/06 , A61P35/00 , C07C309/66 , C07D209/36 , C07D211/42 , C07D211/46 , C07D213/40 , C07D213/50 , C07D213/74 , C07D213/75 , C07D233/54 , C07D235/26 , C07D239/48 , C07D277/24 , C07D277/42 , C07D277/46 , C07D277/54 , C07D279/12 , C07D295/096 , C07D295/112 , C07D295/13 , C07D295/135 , C07D295/155 , C07D295/185 , C07D295/215 , C07D295/30 , C07D307/83 , C07D309/10 , C07D311/30 , C07D333/22 , C07D405/04 , C07D417/12 , C07D521/00 , C07F9/6533 , C07F9/6578 , C07D295/12 , A61K31/435 , C07D211/26 , C07D239/42 , C07D295/10 , C07D295/14 , C07D295/18 , C07D295/20 , C07D295/22
CPC分类号： C07D213/40 , A61K45/06 , C07C309/66 , C07D209/36 , C07D211/42 , C07D211/46 , C07D213/50 , C07D213/74 , C07D213/75 , C07D231/12 , C07D233/56 , C07D235/26 , C07D239/48 , C07D249/08 , C07D277/24 , C07D277/54 , C07D279/12 , C07D295/096 , C07D295/112 , C07D295/13 , C07D295/135 , C07D295/155 , C07D295/185 , C07D295/215 , C07D295/30 , C07D307/83 , C07D309/10 , C07D311/30 , C07D333/22 , C07D405/04 , C07D417/12 , C07F9/6533 , C07F9/65785
摘要： Compounds of Formula (I) that inhibit DNA-dependent protein kinase, compositions comprising the compounds, methods to inhibit the DNA-PK biological activity, methods to sensitize cells the agents that cause DNA lesions, and methods to potentiate cancer treatment are disclosed.
摘要翻译：公开了抑制DNA依赖性蛋白激酶的式（I）化合物，包含该化合物的组合物，抑制DNA-PK生物活性的方法，使细胞致敏引起DNA损伤的试剂的方法以及加强癌症治疗的方法。

9. 发明申请

WO00064912A1 PHOSPHORIC BENZOYL DERIVATIVES AND THEIR USE AS HERBICIDES 审中-公开
标题翻译：含磷BENZOYL衍生物及其作为除草剂
公开(公告)号：WO00064912A1
公开(公告)日：2000-11-02
申请号：PCT/EP2000/003548
申请日：2000-04-19
IPC分类号： A01N57/14 , A01N57/22 , A01N57/24 , A01N57/30 , A01N57/32 , C07F9/40 , C07F9/44 , C07F9/53 , C07F9/572 , C07F9/6503 , C07F9/653 , C07F9/6568 , C07F9/6571 , C07F9/6574 , C07F9/6578 , A01N57/02
CPC分类号： C07F9/65685 , A01N57/22 , A01N57/24 , C07F9/4021 , C07F9/4025 , C07F9/4419 , C07F9/5325 , C07F9/5329 , C07F9/5721 , C07F9/65033 , C07F9/653 , C07F9/657181 , C07F9/65785
摘要： The invention relates to phosphoric benzoyl derivatives of formula (I), in which the variables have the following meanings: P(=X)R R X represents an organic phosphorous group; R represents hydrogen, nitro, cyano, halogen, optionally substituted alkyl, alkylcarbonyl, alkoxycarbonyl, optionally substituted alkoxy, optionally substituted alkylthio, optionally substituted alkylsulfinyl, optionally substituted alkylsulfonyl, optionally substituted aminosulfonyl, optionally substituted amino, P(=X)R R , optionally substituted phenyl or optionally substituted heterocyclyl; R represents nitro, cyano, halogen, alkyl, alkoxy, alkylthio, alkylsulfinyl or alkylsulfonyl; l is 0, 1 or 2; Q represents optionally substituted 1-hydroxy-3-oxo-cylcohex-1-ene-2-yl, optionally substituted 5-hydroxy-pyrazole-4-yl, optionally substituted isoxazole-4-yl or optionally substituted 2-cyano-1-oxo-eth-2-yl. The invention also relates to their agriculturally useful salts, to methods and intermediates for producing said phosphoric benzoyl derivatives, to agents containing them, to the use of said derivatives or of the agents containing them for controlling undesirable plants.
摘要翻译：含磷的式（I）的苯甲酰基衍生物，其中各变量具有以下含义：P（= X）R <1> [R <2> X有机磷残基; [R <3>为氢，硝基，氰基，卤素，任选附属烷基，烷基羰基，烷氧基羰基，可能是子，烷氧基，可能子。烷硫基，可能子。烷基亚磺酰基，可能子。烷基磺酰基，可能子。。氨基磺酰基，任选子氨基，P（= X）R <1> [R <2>，任选子的苯基或任意子杂环..; [R <4>硝基，氰基，卤素，烷基，烷氧基，烷硫基，烷基亚磺酰基或烷基磺酰基; l为0，1或2; Q通讯，可能子。1-羟基-3-氧代cyclcohex -1-烯-2-基，可能子。-5-羟基吡唑-4-基，可能子。异恶唑-4-基或任选子。2-氰基-1-氧代 - 乙-2-基; 和其农业上有用的盐; 方法和中间体含磷苯甲酰衍生物的制备; 含有它们的所述用途包含用于控制不希望的植物，这些衍生物或试剂的组合物。

10. 发明申请

WO1995007920A1 NUCLEOTIDE ANALOGS 审中-公开
标题翻译：核素类似物
公开(公告)号：WO1995007920A1
公开(公告)日：1995-03-23
申请号：PCT/US1994010539
申请日：1994-09-16
申请人： GILEAD SCIENCES, INC. , BISCHOFBERGER, Norbert, W. , JONES, Robert, J. , ARIMILLI, Murty, N. , LIN, Kuei-Ying , LOUIE, Michael, S. , MCGEE, Lawwrence, R. , PRISBE, Ernest, J. , LEE, William, A. , CUNDY, Kenneth, C.
发明人： GILEAD SCIENCES, INC.
IPC分类号： C07H19/10
CPC分类号： C07H19/20 , C07F9/6512 , C07F9/65616 , C07F9/657181 , C07F9/65742 , C07F9/65744 , C07F9/65785 , C07H11/00 , C07H19/10
摘要： Nucleotide analogs characterized by the presence of an amidate linked amino acid or an ester linked group which is bonded to the phosphorus atom of phosphonate nucleotide analogs are disclosed. The analogs comprise a phosphoamidate or ester bond that is hydrolysed in vivo to yield a corresponding phosphonate nucleotide analog. Methods and intermediates for the synthesis and use are described.
摘要翻译：公开了以与磷酸酯核苷酸类似物的磷原子结合的氨基酸连接的氨基酸或酯连接基团的存在为特征的核苷酸类似物。类似物包含在体内水解产生相应的膦酸酯核苷酸类似物的磷酰胺化物或酯键。描述了合成和使用的方法和中间体。

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