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1. 发明申请

WO2017117567A1 DROPLET GENERATION IN A MICROFLUIDIC DEVICE HAVING AN OPTOELECTROWETTING CONFIGURATION 审中-公开
标题翻译：具有光电配置的微流控器件中的液滴生成
公开(公告)号：WO2017117567A1
公开(公告)日：2017-07-06
申请号：PCT/US2016/069579
申请日：2016-12-30
申请人： BERKELEY LIGHTS, INC.
发明人： BAO, X., Robert , MCEWEN, Jason, M , RABKIN, Brian, A.
IPC分类号： G01N35/10 , B01L3/00 , G01N13/00
CPC分类号： B01L3/502792 , B01L3/502784 , B01L2200/0673 , B01L2400/0427 , B01L2400/0496 , G01N2035/00237 , G01N2035/1034
摘要： Systems and methods are described herein for improved droplet generation within microfluidic apparatuses. Electrowetting forces of varying configurations may be used to separate droplets from a fluidic reservoir in a reproducible and rapid manner. In many embodiments, separation of droplets from the fluidic reservoir is performed without the use of highly specialized surfactants.
摘要翻译：本文描述了系统和方法用于改善微流体装置内的微滴生成。可以使用不同构型的电润湿力以可再现且快速的方式将液滴从流体储存器分离。在许多实施方案中，在不使用高度专业的表面活性剂的情况下进行液滴与流体储器的分离。

2. 发明申请

WO2014066624A1 SYSTEMS AND METHODS FOR DROPLET PRODUCTION AND MANIPULATION USING ACOUSTIC WAVES 审中-公开
标题翻译：使用声波进行液滴生产和操作的系统和方法
公开(公告)号：WO2014066624A1
公开(公告)日：2014-05-01
申请号：PCT/US2013/066591
申请日：2013-10-24
申请人： PRESIDENT AND FELLOWS OF HARVARD COLLEGE , UNIVERSITAT, Augsburg
发明人： WEITZ, David, A. , FRANKE, Thomas , SCHMID, Lothar
IPC分类号： B01J19/10 , B06B1/00 , C12M1/42 , F17D1/16
CPC分类号： B05B17/0653 , B01F3/0815 , B01F5/0451 , B01F5/0473 , B01F11/0266 , B01F13/0059 , B01F13/0062 , B01L3/502784 , B01L2300/0816 , B01L2400/0436 , B01L2400/0439 , B01L2400/0487 , B01L2400/0496 , B06B1/06 , C12M25/01 , C12M33/04 , C12M47/04 , G01N35/08 , G10K11/36
摘要： Acoustic waves, including surface acoustic waves, are useful to control fluids. In one aspect, acoustic waves may be applied to a fluid flowing in a channel to control or alter its flow characteristics, e.g., its flow rate or direction. Acoustic waves are typically applied using electrically-controlled acoustic wave generators, and thus, the flow of fluid can be controlled to a surprisingly high degree. If the fluid is caused to form a series of droplets, then acoustic waves may be used to control the volume of fluid in each droplet, to alter the rate droplets are formed, or the like. Acoustic waves may be used to deflect the flow of fluid in a channel, and in some cases, to cause fluid to flow to different locations.
摘要翻译：包括表面声波在内的声波可用于控制流体。在一个方面，声波可以施加到在通道中流动的流体，以控制或改变其流动特性，例如其流速或方向。通常使用电控声波发生器来施加声波，因此可以将流体的流动控制到惊人的高度。如果使流体形成一系列液滴，则可以使用声波来控制每个液滴中的流体体积，以改变液滴形成的速度等。声波可用于使通道中的流体流动偏转，并且在一些情况下可使流体流向不同的位置。

3. 发明申请

WO2011023949A3 FLUIDICS APPARATUS AND FLUIDICS SUBSTRATE FOR SURFACE ACOUSTIC WAVE MANIPULATION OF FLUID SAMPLES 审中-公开
标题翻译：流体表面流体装置和流体基质用于流体样品的表面声波操作
公开(公告)号：WO2011023949A3
公开(公告)日：2011-10-27
申请号：PCT/GB2010001600
申请日：2010-08-24
申请人： UNIV GLASGOW , WILSON RAB , COOPER JONATHAN M , REBOUD JULIEN
发明人： WILSON RAB , COOPER JONATHAN M , REBOUD JULIEN
IPC分类号： B01J19/00 , B01L3/00 , C12N1/06
CPC分类号： B01F13/0071 , B01F11/0266 , B01F2215/0073 , B01J19/0093 , B01J2219/00783 , B01J2219/00824 , B01J2219/00828 , B01J2219/00837 , B01J2219/0086 , B01J2219/00873 , B01J2219/00889 , B01J2219/00905 , B01J2219/00932 , B01J2219/00952 , B01L3/502792 , B01L2200/10 , B01L2300/0816 , B01L2300/0864 , B01L2300/0867 , B01L2300/089 , B01L2400/0436 , B01L2400/0439 , B01L2400/0496 , C12N13/00 , G01N33/48 , Y10T436/25125
摘要： A fluidics apparatus is disclosed for manipulation of at least one fluid sample, typically in the form of a droplet. The apparatus has a substrate surface with a sample manipulation zone for location of the fluid sample. A transducer arrangement such as an interdigitated electrode structure on a piezoelectric body provides surface acoustic waves at the substrate surface for manipulation of the fluid sample. The substrate surface has an arrangement of surface acoustic wave scattering elements forming a phononic crystal structure for affecting the transmission, distribution and/or behaviour of surface acoustic waves at the substrate surface. Also disclosed is a method for lysing a cell. In this method, the cell is comprised in a fluid sample contacting a substrate surface, the method comprising providing surface acoustic waves at the substrate surface, such that the cell lyses.
摘要翻译：公开了一种流体装置，用于操纵至少一种流体样品，通常为液滴的形式。该设备具有一个具有用于定位流体样品的样品操作区的基底表面。诸如压电体之间的交错电极结构的换能器装置在衬底表面上提供表面声波，用于操纵流体样品。衬底表面具有形成声子晶体结构的表面声波散射元件的布置，用于影响衬底表面处的表面声波的透射，分布和/或行为。还公开了一种裂解细胞的方法。在该方法中，电池被包含在与衬底表面接触的流体样品中，该方法包括在衬底表面提供表面声波，使得细胞裂解。

4. 发明申请

WO2008123591A1 LIQUID CONVEYING APPARATUS AND LIQUID CONVEYING METHOD USING MICRO-FLUID DEVICE 审中-公开
标题翻译：使用微流体装置的液体输送装置和液体输送方法
公开(公告)号：WO2008123591A1
公开(公告)日：2008-10-16
申请号：PCT/JP2008/056722
申请日：2008-03-28
申请人： CANON KABUSHIKI KAISHA , TOKITA, Toshinobu , FUJIMOTO, Kosuke
发明人： TOKITA, Toshinobu , FUJIMOTO, Kosuke
IPC分类号： G01N35/08 , B81B1/00 , G01N37/00
CPC分类号： G01N35/08 , B01L3/50273 , B01L2400/0439 , B01L2400/0496 , F04B43/046 , F04F7/00 , G01N2035/1034 , G01N2035/1058 , Y10T137/206
摘要： An apparatus system for controlling liquid in a fluid channel in a micro-fluid device has an ultrasonic oscillator for conveying liquid. The ultrasonic oscillator oscillates with amplitude modulation. The apparatus system has a holding section for holding the micro-fluid device on the ultrasonic oscillator to allow a micro-fluid device to be removably fitted to it. A liquid conveying method and a liquid conveying unit showing an improved liquid conveying efficiency are provided.
摘要翻译：用于控制微流体装置中的流体通道中的液体的装置系统具有用于输送液体的超声波振荡器。超声波振荡器以振幅调制振荡。装置系统具有用于将微流体装置保持在超声波振荡器上的保持部，以允许微流体装置可移除地装配在该超声波振荡器上。提供了液体输送方法和液体输送单元，其显示出改进的液体输送效率。

5. 发明申请

WO2007128045A1 MICROFLUIDIC SYSTEMS USING SURFACE ACOUSTIC ENERGY AND METHOD OF USE THEREOF 审中-公开
标题翻译：使用表面声能的微流体系统及其使用方法
公开(公告)号：WO2007128045A1
公开(公告)日：2007-11-15
申请号：PCT/AU2007/000575
申请日：2007-05-02
申请人： MONASH UNIVERSITY , FRIEND, James, Robert , YEO, Leslie, Yu-Ming
发明人： FRIEND, James, Robert , YEO, Leslie, Yu-Ming
IPC分类号： B81B7/02 , B06B1/06 , C30B29/34 , C30B30/06 , G01N1/28 , H01L41/09
CPC分类号： G01N29/222 , B01F11/02 , B01F13/0071 , B01J19/0093 , B01J2219/00783 , B01J2219/00889 , B01J2219/00932 , B01L3/5027 , B01L2300/0816 , B01L2300/0864 , B01L2300/089 , B01L2400/0436 , B01L2400/0496 , B05B17/0607 , C01B39/02 , C01B39/54
摘要： A microfluidic system including a piezoelectric substrate (1), a wave generation means (5) for generating a wave in the piezoelectric substrate, and a rigid secondary substrate (11) coupled to said piezoelectric substrate (1) and providing a working surface (12) for the system, the secondary substrate (11) being formed of a relatively chemically inert material, and the coupling of the piezoelectric substrate (1) with the secondary substrate (12) being provided by a fluid coupling layer (13) located between the piezoelectric substrate (1) and the secondary substrate (12) overlaying the piezoelectric substrate (1). In one application, the system may be used to synthesize zeolite nanocrystals via atomization of a liquid droplet (15).
摘要翻译：一种微流体系统，包括压电基板（1），用于在压电基板中产生波的波发生装置（5）和耦合到所述压电基板（1）并且提供工作表面（12）的刚性二次基板），所述第二衬底（11）由相对化学惰性的材料形成，并且所述压电衬底（1）与所述次级衬底（12）的耦合由位于所述第二衬底（11）之间的流体耦合层（13）提供，压电衬底（1）和覆盖压电衬底（1）的次级衬底（12）。在一个应用中，该系统可以用于通过液滴的雾化合成沸石纳米晶体（15）。

6. 发明申请

WO2004030800A2 FLUID-HANDLING APPARATUS AND METHODS 审中-公开
标题翻译：流体处理装置和方法
公开(公告)号：WO2004030800A2
公开(公告)日：2004-04-15
申请号：PCT/US2003/031507
申请日：2003-10-03
申请人： PROTASIS CORPORATION
发明人： STRAND, David , BARROW, David , SPAREY-TAYLOR, Graham
IPC分类号： B01F11/00
CPC分类号： B01L3/5027 , B01F11/0241 , B01F13/0059 , B01F2215/0431 , B01J19/0093 , B01J19/10 , B01J2219/00783 , B01J2219/00889 , B01J2219/00932 , B01L3/502715 , B01L3/50273 , B01L3/502738 , B01L2300/0816 , B01L2300/0867 , B01L2300/0887 , B01L2400/0439 , B01L2400/0496 , G01N2035/00554 , Y10S366/04
摘要： Fluid processing apparatus comprises a fluid-handling manifold comprising a manifold body having at least a first fluid duct and a second fluid duct. The first and second fluid ducts are in fluid communication with each other at a microfluidic junction of the fluid-handling manifold. The manifold body further comprises a transducer operative to generate ultrasonic acoustic traveling wave radiation into fluid in the microfluidic junction from an active surface toward a non-reflective boundary of the microfluidic junction. The microfluidic junction is operative to pass fluid received from the first and second duct, with micro-mixing effected by the traveling wave radiated into the junction during the fluid flow.
摘要翻译：流体处理设备包括流体处理歧管，流体处理歧管包括歧管主体，所述歧管主体具有至少第一流体管道和第二流体管道。第一流体管道和第二流体管道在流体处理歧管的微流体接头处彼此流体连通。歧管主体进一步包括转换器，其可操作以从微流体接合部的活性表面向非反射性边界产生超声波行波辐射到微流体接合部中的流体中。微流体连接部可操作以使从第一和第二导管接收的流体通过流体流动期间辐射到连接部的行波所产生的微混合。

7. 发明申请

WO2018017120A1 MICROFLUIDIC DEVICES 审中-公开
标题翻译： MICROFLUIDIC设备
公开(公告)号：WO2018017120A1
公开(公告)日：2018-01-25
申请号：PCT/US2016/043528
申请日：2016-07-22
申请人： HEWLETT-PACKARD DEVELOPMENT COMPANY, L.P.
发明人： GOVYADINOV, Alexander
IPC分类号： G01N33/487 , F04B19/04
CPC分类号： F04B19/04 , B01L3/50273 , B01L2300/088 , B01L2400/0439 , B01L2400/0442 , B01L2400/0496 , B01L2400/086 , F04B17/00 , F04B17/003 , F04B17/03 , F04B19/006 , F04B19/24
摘要： According to an example, a microfluidic device may include a transport channel having an inlet and an outlet and a plurality of pump loops extending along the transport channel. Each of the plurality of pump loops may include a first branch, a second branch, and a connecting section connecting the first branch and the second branch. The first branch may include a first opening and the second branch may include a second opening, in which the first opening and the second opening are in direct fluid communication with the transport channel. The pump loops may also each include an actuator positioned in the first branch, in which the actuators in the pump loops are to be activated to induce a traveling wave that is to transport the fluid through the transport channel from the inlet to the outlet.
摘要翻译：根据一个示例，微流体装置可以包括具有入口和出口的输送通道以及沿着输送通道延伸的多个泵回路。多个泵回路中的每一个可以包括第一分支，第二分支以及连接第一分支和第二分支的连接部分。第一分支可以包括第一开口并且第二分支可以包括第二开口，其中第一开口和第二开口与传输通道直接流体连通。泵回路还可以各自包括位于第一分支中的致动器，其中泵回路中的致动器将被激活以引起行进波，该行波将流体从入口传输到出口通过传输通道。 / p>

8. 发明申请

WO2017075344A1 SENSOR DEVICE WITH BAW RESONATOR AND THROUGH-SUBSTRATE FLUIDIC VIAS 审中-公开
标题翻译：带有BAW谐振器和通孔基板流体VIAS的传感器装置
公开(公告)号：WO2017075344A1
公开(公告)日：2017-05-04
申请号：PCT/US2016/059312
申请日：2016-10-28
申请人： QORVO US, INC.
发明人： RIVAS, Rio
IPC分类号： G01N29/02 , G01N29/036 , G01N29/22
CPC分类号： B01L3/50273 , B01L2200/10 , B01L2300/0645 , B01L2300/0816 , B01L2300/0887 , B01L2400/0496 , G01N29/022 , G01N29/036 , G01N29/222 , G01N33/54386 , G01N2291/0255 , G01N2291/0256 , G01N2291/0426 , G01N2610/00 , H03H9/17 , H03H9/175
摘要： A fluidic device incorporating a substrate, at least one bulk acoustic wave (BAW) resonator structure, and a fluidic channel bound at least in part by the at least one BAW resonator structure. The fluidic device further includes at least one fluidic via defined through at least a portion of the substrate, thereby permitting fluidic connections and electrical connections to be provided on opposing upper and lower surfaces of the fluidic device. The at least one BAW resonator structure may include a piezoelectric material comprising a c-axis having an orientation distribution that is predominantly non-parallel to normal of a face of the substrate, and may be overlaid with a functionalization material (e.g., a specific binding material overlying a self-assembled monolayer) to enable detection of a target species in a sample supplied to the fluidic device.
摘要翻译：包含衬底，至少一个体声波（BAW）谐振器结构以及至少部分地由所述至少一个BAW谐振器结构限定的流体通道的流体装置。流体装置还包括至少一个流体通孔，该流体通孔限定为穿过基体的至少一部分，由此允许在流体装置的相对的上表面和下表面上提供流体连接和电连接。至少一个BAW谐振器结构可以包括压电材料，该压电材料包括具有主要不平行于衬底表面的法线的取向分布的c轴，并且可以用官能化材料（例如，特定的结合材料覆盖自组装单层）以能够检测供应到流体装置的样品中的目标物质。

9. 发明申请

WO2013172708A8 METHOD FOR SIZE-SORTING MICROBUBBLES AND APPARATUS FOR THE SAME 审中-公开
标题翻译：用于对其进行分选的方法和装置
公开(公告)号：WO2013172708A8
公开(公告)日：2014-05-30
申请号：PCT/NL2013050357
申请日：2013-05-14
申请人： UNIV TWENTE
发明人： VERSLUIS ANDREAS MICHAEL , SEGERS TIM JOSEPH
IPC分类号： A61K49/22 , B01D19/00 , B01L3/00
CPC分类号： A61K49/223 , B01L3/502761 , B01L2200/0652 , B01L2300/0816 , B01L2300/0864 , B01L2400/0439 , B01L2400/0487 , B01L2400/0496 , G01N15/0255 , G01N2015/0288 , G01N2015/142 , G01N2015/149
摘要： Disclosed is a continuous method of size-sorting microbubbles, comprising: providing a polydisperse plurality of microbubbles (70); entraining said microbubbles (70) in a fluid flow (46) flowing in a flow direction (x+) towards a collection location (62); at an insonification location (60) upstream of the collection location (62), subjecting the microbubbles (70) in said fluid flow (46) to an acoustic pressure wave (52) propagating in a wave direction with a non-zero directional component in a microbubble segregation dimension (y) that extends perpendicular to the flow direction (x+), thereby segregating microbubbles of different equilibrium radius (ro) in said microbubble segregation dimension (y) as they pass the insonification location; and at said collection location (62), collecting the microbubbles (70) present within at least two spatial ranges (44a-c) of said microbubble segregation dimension (y). Also disclosed is an apparatus (1) implementing the method.
摘要翻译：公开了一种连续的尺寸分选微泡的方法，包括：提供多分散的多个微泡（70）; 在流向（x +）朝向收集位置（62）流动的流体流（46）中夹带所述微泡（70）; 在收集位置（62）上游的增音位置（60）处，使所述流体流（46）中的微泡（70）经受在波方向上以非零方向分量传播的声压波（52）所述微气泡分离尺寸（y）垂直于所述流动方向（x +）延伸，从而在所述微泡偏析尺寸（y）中通过所述微泡位置时分离不同平衡半径（ro）的微泡; 并且在所述收集位置（62）处收集存在于所述微泡分离尺寸（y）的至少两个空间范围（44a-c）内的微泡（70）。还公开了实现该方法的装置（1）。

10. 发明申请

WO2012114076A1 FLUIDICS APPARATUS FOR SURFACE ACOUSTIC WAVE MANIPULATION OF FLUID SAMPLES, USE OF FLUIDICS APPARATUS AND PROCESS FOR THE MANUFACTURE OF FLUIDICS APPARATUS 审中-公开
标题翻译：流体表面波动控制的流体装置，流体装置的使用和流体装置的制造工艺
公开(公告)号：WO2012114076A1
公开(公告)日：2012-08-30
申请号：PCT/GB2012/000192
申请日：2012-02-24
申请人： THE UNIVERSITY COURT OF THE UNIVERSITY OF GLASGOW , WILSON, Rab , COOPER, Johnathan, M. , REBOUD, Julien
发明人： WILSON, Rab , COOPER, Johnathan, M. , REBOUD, Julien
IPC分类号： B01L3/00
CPC分类号： G01N1/286 , B01L3/502707 , B01L3/50273 , B01L3/502792 , B01L2200/10 , B01L2300/0816 , B01L2400/0436 , B01L2400/0439 , B01L2400/0496 , G01N29/222 , G01N2291/0423
摘要： A fluidics apparatus for manipulation of at least one fluid sample is disclosed. A manipulation surface locates the fluid sample. A surface acoustic wave (SAW) generation material layer is provided. This is a polycrystalline material, textured polycrystalline material, biaxially textured polycrystalline material, microcrystalline material, nanocrystalline material, amorphous material or composite material. A transducer electrode structure arranged at the SAW generation material layer provides SAWs at the manipulation surface for interaction with the fluid sample. The manipulation surface has a phononic structure, for affecting the transmission, distribution and/or behaviour of SAWs at the manipulation surface. The apparatus is typically manufactured by reel-to-reel processes, to reduce the unit cost to a level at which the apparatus can be considered to be disposable after a single use.
摘要翻译：公开了一种用于操纵至少一种流体样品的流体装置。操纵表面定位流体样品。提供表面声波（SAW）生成材料层。这是多晶材料，纹理多晶材料，双轴纹理多晶材料，微晶材料，纳米晶体材料，无定形材料或复合材料。布置在SAW生成材料层处的换能器电极结构在操作表面处提供SAW以与流体样品相互作用。操纵表面具有声子结构，用于影响SAW在操纵表面上的传输，分布和/或行为。该设备通常通过卷对卷工艺制造，以将单位成本降低到在单次使用之后该装置可以被认为是一次性的水平。

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