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1. 发明申请

WO2004113898A1 ELECTROPHORESIS DEVICES AND METHODS FOR FOCUSING CHARGED ANALYTES 审中-公开
标题翻译：电荷分析装置和方法用于聚焦充电分析仪
公开(公告)号：WO2004113898A1
公开(公告)日：2004-12-29
申请号：PCT/US2004/015935
申请日：2004-05-19
申请人： PROTASIS CORPORATION , STRAND, David , LEATZOW, Dan, M. , IVORY, Cornelius, F.
发明人： STRAND, David , LEATZOW, Dan, M. , IVORY, Cornelius, F.
IPC分类号： G01N27/26
CPC分类号： G01N27/44795
摘要： Devices are provided for separating and focusing charged analytes, comprising a separation chamber and two or more electrodes, for example, an electrode array. A membrane separates the separation chamber and the electrodes. The separation chamber of the device is configured, that is, the separation chamber has shaped geometry, which serves to induce a gradient in an electric field generaged by the electrodes in the electrode chamber. Optionally, molecular sieve is included in the separation chamber that is operative to shift the location at which a stationary focused band of a charged analyte forms under a given set of focusing process parameters. Methods are provided for separating and focusing charged analytes comprising introducing a first fluid comprising at least one charged analyte into the separation chamber of a device as just described, applying an electric field gradient to the charged analyte to focus the charged analyte in the electric field gradient.
摘要翻译：提供了用于分离和聚焦带电分析物的装置，包括分离室和两个或更多个电极，例如电极阵列。膜分离室和电极。设备的分离室被配置，即，分离室具有成形几何形状，其用于在由电极室中的电极产生的电场中引起梯度。任选地，分子筛包括在分离室中，其可操作以在给定的一组聚焦工艺参数下移动带电分析物的固定聚焦带的位置。提供了用于分离和聚焦带电分析物的方法，包括将如上所述将包含至少一种带电分析物的第一流体引入到装置的分离室中，对电荷分析物施加电场梯度以将带电分析物聚焦在电场梯度。

2. 发明申请

WO2004065937A2 METHOD AND APPARATUS DETERMINING THE ISOELECTRIC POINT OF CHARGED ANALYTE 审中-公开
标题翻译：方法和装置确定充电分析仪的电压点
公开(公告)号：WO2004065937A2
公开(公告)日：2004-08-05
申请号：PCT/US2004/000630
申请日：2004-01-12
申请人： PROTASIS CORPORATION , STRAND, David , LEATZOW, Dan, M.
发明人： STRAND, David , LEATZOW, Dan, M.
IPC分类号： G01N
CPC分类号： B01D61/425 , C07K1/28 , G01N27/44704
摘要： Devices are provided for determining the isoelectric point of a charged analyte, comprising a titration chamber and an electrode chamber. The electrode chamber comprises at least two electrodes, for example, an electrode array. Either or both of the titration chamber and the electrode chamber may have a shaped geometry. The electrodes are operative, in conjunction with the shaped geometry of the chamber(s) where appropriate, to generate an electric field gradient in the titration chamber. Permeable material separates the titration chamber and the electrode chamber. A pH Sensor is located in the titration chamber for obtaining the pH of the first fluid. Certain preferred embodiments further include an analyte band detector for detecting the presence and optionally the location of a focused band of charged solute. Methods are provided for determining the isoelectric point of a charged analyte comprising introducing a carrier fluid comprising a Charge analyte into the titration chamber of a device as just described and applying an electric field gradient to focus the charged analyte into a focused band. The pH of the carrier fluid is incremented or adjusted to shift the location of the focused band of charged analyte, and the pH and location of the focused band of charged analyte are obtained for a plurality of locations and pH's and the isoelectric point is determined from such data.
摘要翻译：提供了用于确定带电分析物的等电点的装置，包括滴定室和电极室。电极室包括至少两个电极，例如电极阵列。滴定室和电极室中的任一个或两者可以具有成形几何形状。电极在适当的情况下与室的成形几何结合起作用，以在滴定室中产生电场梯度。渗透材料分离滴定室和电极室。 pH传感器位于滴定室中以获得第一流体的pH。某些优选实施例还包括用于检测带电溶质的聚焦带的存在和可选地位置的分析物带检测器。提供了用于确定带电分析物的等电点的方法，包括将包含电荷分析物的载体流体引入如上所述的装置的滴定室中，并施加电场梯度以将带电分析物聚焦到聚焦带中。载体流体的pH被递增或调整以移动带电分析物的聚焦带的位置，并且对于多个位置和pH值获得带电分析物的聚焦带的pH和位置，并且等电点由这样的数据。

3. 发明申请

WO2003102737A3 METHOD AND DEVICE FOR ULTRASONICALLY MANIPULATING PARTICLES WITHIN A FLUID 审中-公开
公开(公告)号：WO2003102737A3
公开(公告)日：2003-12-11
申请号：PCT/US2003/017274
申请日：2003-06-03
申请人： PROTASIS CORPORATION , STRAND, David , BARROW, David , CEFAI, Joseph
发明人： STRAND, David , BARROW, David , CEFAI, Joseph
IPC分类号： B01D43/00
摘要： Fluid-handling methods and devices for ultrasonic manipulation of fluid-borne particles comprise a fluid-handling manifold and an ultrasonic particle manipulator defining an ultrasonic cavity within the manifold. Fluid-borne particles introduced into the manifold are manipulated by controlling ultrasonic standing waves at the ultrasonic cavity. Cavities having non-uniform configurations, asymmetric standing waves and/or multiple ultrasonic cavities within the manifold are operative to control the movement of the fluid-borne particles, optionally including collecting and holding such particles, transferring particles through an intersection from one channel to another, etc. Solid phase extraction (SPE) particles, biological particles and other fluid-borne particles can be manipulated within the fluid-handling manifold.

4. 发明申请

WO2004104555A3 FLUID LOGIC DEVICE 审中-公开
公开(公告)号：WO2004104555A3
公开(公告)日：2004-12-02
申请号：PCT/US2004/016267
申请日：2004-05-19
申请人： PROTASIS CORPORATION , STRAND, David , LEATZOW, Dan, M
发明人： STRAND, David , LEATZOW, Dan, M
IPC分类号： B01D15/08
摘要： Novel fluid logic devices are disclosed. Certain examples of the fluid logic devices include two or more fluid logic gates that are each operative to select and/or directy analytes in a sample into one or more fluid flow channels in communication with the fluid logic gates. The fluid logic device can be part of a larger system, such as a chromatogarphy system, or can be stand-alone device.

5. 发明申请

WO2004065619A2 DEVICES AND METHODS FOR FOCUSING ANALYTES IN AN ELECTRIC FIELD GRADIENT II 审中-公开
标题翻译：用于在电场梯度中聚焦分析物的装置和方法II
公开(公告)号：WO2004065619A2
公开(公告)日：2004-08-05
申请号：PCT/US2004/000659
申请日：2004-01-12
申请人： PROTASIS CORPORATION , STRAND, David , LEATZOW, Dan, M.
发明人： STRAND, David , LEATZOW, Dan, M.
IPC分类号： C12Q
CPC分类号： G01N27/44795 , C07K1/26
摘要： Devices are provided for separating and focusing analytes, comprising a separation chamber and electrodes separated from the separation chamber by a membrane. The electrodes are operative to generate an electric field in the separation chamber. Molecular sieve in the separation chamber is operative to shift the location at which a stationary focused band of the analyte forms under a given set of focusing process parameters. Methods are provided for separating and focusing charged analytes, comprising introducing a first fluid comprising at least one charged analyte into the separation chamber of a device as just described, applying an electric field gradient to the separation chamber to focus the charged analyte at a location in the separation chamber. Methods are provided for separating and focusing un-charged (including inadequately charged) analytes, comprising introducing a fluid comprising at least the uncharged analyte and lipids, micelles and/or vesicles into the separation chamber of a device as just described, and applying an electric field gradient to the separation chamber to focus the analyte (in association with the lipids, micelles and/or vesicles) at a location in the separation chamber.
摘要翻译：提供了用于分离和聚焦分析物的装置，包括分离室和通过膜与分离室分离的电极。电极可操作以在分离室中产生电场。分离室中的分子筛可操作以在给定的一组聚焦过程参数下移动分析物的固定聚焦带形成的位置。提供了用于分离和聚焦带电分析物的方法，包括将如上所述将包含至少一种带电分析物的第一流体引入装置的分离室中，向分离室施加电场梯度以将带电分析物聚焦在位于分离室。提供了用于分离和聚焦未充电（包括未充足电）的分析物的方法，包括将至少包含不带电荷的分析物和脂质，胶束和/或囊泡的流体引入到刚刚描述的装置的分离室中，并施加电场分离室，以将分析物（与脂质，胶束和/或囊泡结合）聚焦在分离室中的位置。

6. 发明申请

WO2004051247A3 ELECTROPHORETIC DEVICE COMPRISING SEPARATION CHAMBER, NON-UNIFORM ELECTRODE CHAMBER, AND A POROUS MEMBRANE BETWEEN THEM 审中-公开
公开(公告)号：WO2004051247A3
公开(公告)日：2004-06-17
申请号：PCT/US2003/038170
申请日：2003-12-01
申请人： PROTASIS CORPORATION , STRAND, David , LEATZOW, Dan, M.
发明人： STRAND, David , LEATZOW, Dan, M.
IPC分类号： G01N27/447
摘要： An electrophoretic device comprises a separation chamber and an electrode chamber, which is non-uniform. The electrode chamber includes two or more electrodes or may include an electrode array. Molecular sieve may be included in the separation chamber, and the molecular sieve is operative to shift the location at which a stationary focused band of a charged analyte forms under a given set of focusing process parameters. Such systems are especially suitable for linking up analytical instruments in a hyphenated fashion, particularly where the instruments have differing system parameters.

7. 发明申请

WO2004104457A3 BULK FLUID FLOW GATE 审中-公开
公开(公告)号：WO2004104457A3
公开(公告)日：2004-12-02
申请号：PCT/US2004/015934
申请日：2004-05-19
申请人： PROTASIS CORPORATION , STRAND, David , LEATZOW, Dan, M.
发明人： STRAND, David , LEATZOW, Dan, M.
IPC分类号： F15C1/04
摘要： A bulk fluid flow gate is provided. In accordance with certain exemplary embodiments the bulk fluid flow gate includes a first and second entry port and first and second exit ports. Bulk fluid is flowed into the chamber to provide greater hydrodynamic resistance at the first exit port than at the second exit port. The bulk fluid flow gate is useful for separation, testing and or analysis of analytes. Methods of making and using the bulk fluid flow gate are also provided. In accordance with certain exemplary embodiments a fluid flow gate includes a first entry port into a microscale chamber and first and second exit ports. In accordance with certain embodiments a fluid flow gate includes a first entry port to a chamber and first and second exit ports, wherein greater hydrodynamic resistance is provided at the first exit port than at the second exit port.

8. 发明申请

WO2004052540A2 CONFIGURABLE MICROFLUIDIC SUBSTRATE ASSEMBLY 审中-公开
标题翻译：可配置微流体基板组件
公开(公告)号：WO2004052540A2
公开(公告)日：2004-06-24
申请号：PCT/US2003/038707
申请日：2003-12-05
申请人： PROTASIS CORPORATION , STRAND, David , BARROW, David
发明人： STRAND, David , BARROW, David
IPC分类号： B01L
CPC分类号： B01L3/502715 , B01J2219/00783 , B01J2219/00804 , B01J2219/0081 , B01L2200/027 , B01L2200/028 , B01L2200/04 , B01L2200/10 , B01L2300/023 , B01L2300/024 , B01L2300/0816 , B01L2300/0887 , G01N30/6047 , G01N30/6095
摘要： A microfluidic substrate assembly includes a substrate body having at least one fluid inlet port. At least one microscale fluid flow channel in the substrate is in fluid communication with the inlet port for transport of a fluid to be tested. The substrate body also has a plurality of sockets, with each of one or sockets configured to receive an operative component. At least one socket is in communication with the microscale fluid flow channel.
摘要翻译：微流体衬底组件包括具有至少一个流体入口的衬底本体。衬底中的至少一个微流体流动通道与入口端口流体连通，用于输送被测流体。衬底主体还具有多个插座，其中一个或多个插座中的每一个被配置为接收操作部件。至少一个插座与微型流体流动通道连通。

9. 发明申请

WO2004030800A2 FLUID-HANDLING APPARATUS AND METHODS 审中-公开
标题翻译：流体处理装置和方法
公开(公告)号：WO2004030800A2
公开(公告)日：2004-04-15
申请号：PCT/US2003/031507
申请日：2003-10-03
申请人： PROTASIS CORPORATION
发明人： STRAND, David , BARROW, David , SPAREY-TAYLOR, Graham
IPC分类号： B01F11/00
CPC分类号： B01L3/5027 , B01F11/0241 , B01F13/0059 , B01F2215/0431 , B01J19/0093 , B01J19/10 , B01J2219/00783 , B01J2219/00889 , B01J2219/00932 , B01L3/502715 , B01L3/50273 , B01L3/502738 , B01L2300/0816 , B01L2300/0867 , B01L2300/0887 , B01L2400/0439 , B01L2400/0496 , G01N2035/00554 , Y10S366/04
摘要： Fluid processing apparatus comprises a fluid-handling manifold comprising a manifold body having at least a first fluid duct and a second fluid duct. The first and second fluid ducts are in fluid communication with each other at a microfluidic junction of the fluid-handling manifold. The manifold body further comprises a transducer operative to generate ultrasonic acoustic traveling wave radiation into fluid in the microfluidic junction from an active surface toward a non-reflective boundary of the microfluidic junction. The microfluidic junction is operative to pass fluid received from the first and second duct, with micro-mixing effected by the traveling wave radiated into the junction during the fluid flow.
摘要翻译：流体处理设备包括流体处理歧管，流体处理歧管包括歧管主体，所述歧管主体具有至少第一流体管道和第二流体管道。第一流体管道和第二流体管道在流体处理歧管的微流体接头处彼此流体连通。歧管主体进一步包括转换器，其可操作以从微流体接合部的活性表面向非反射性边界产生超声波行波辐射到微流体接合部中的流体中。微流体连接部可操作以使从第一和第二导管接收的流体通过流体流动期间辐射到连接部的行波所产生的微混合。

10. 发明申请

WO2003102737A2 DEVICE AND METHOD FOR ULTRASONICALLY MANIPULATING FLUID-BORNE PARTICLES 审中-公开
标题翻译：用于超声波操作流体 - 液体颗粒的装置和方法
公开(公告)号：WO2003102737A2
公开(公告)日：2003-12-11
申请号：PCT/US2003/017274
申请日：2003-06-03
申请人： PROTASIS CORPORATION , STRAND, David , BARROW, David , CEFAI, Joseph
发明人： STRAND, David , BARROW, David , CEFAI, Joseph
IPC分类号： G06F
CPC分类号： B01D21/283 , B01D49/006 , B01D51/08 , B01F11/0266 , B01F13/0059 , B01L3/50273 , B01L3/502746 , B01L3/502761 , B01L2200/0631 , B01L2200/0647 , B01L2200/0652 , B01L2200/0668 , B01L2400/0433 , B01L2400/0439 , B01L2400/086 , G01N2015/0288 , G01N2015/1415 , G01N2015/142 , G01N2015/149
摘要： Fluid-handling methods and devices for ultrasonic manipulation of fluid-borne particles comprise a fluid-handling manifold and an ultrasonic particle manipulator defining an ultrasonic cavity within the manifold. Fluid-borne particles introduced into the manifold are manipulated by controlling ultrasonic standing waves at the ultrasonic cavity. Cavities having non-uniform configurations, asymmetric standing waves and/or multiple ultrasonic cavities within the manifold are operative to control the movement of the fluid-borne particles, optionally including collecting and holding such particles, transferring particles through an intersection from one channel to another, etc. Solid phase extraction (SPE) particles, biological particles and other fluid-borne particles can be manipulated within the fluid-handling manifold.
摘要翻译：用于流体传播颗粒的超声操作的流体处理方法和装置包括在歧管内限定超声波腔的流体处理歧管和超声波粒子操纵器。引入到歧管中的流体颗粒通过在超声腔处控制超声波驻波来操纵。在歧管内具有不均匀构型，不对称驻波和/或多个超声腔的腔可用于控制流体传播颗粒的运动，任选地包括收集和保持这种颗粒，将颗粒从一个通道转移到另一个通道固相萃取（SPE）颗粒，生物颗粒和其它流体传导的颗粒可在流体处理歧管内操纵。

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