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1. 发明申请

WO2022038376A1 H-TYPE FILTER DEVICE FOR ANALYSING A COMPONENT 审中-公开
公开(公告)号：WO2022038376A1
公开(公告)日：2022-02-24
申请号：PCT/GB2021/052172
申请日：2021-08-20
申请人： FLUIDIC ANALYTICS LIMITED
发明人： ASTHANA, Ashish , DELPORT, Jean-Paul , DEVENISH, Sean , DOUGLAS, Anthony , KENYON, Hannah , BUTZ, Maren , DENNINGER, Viola , MORLING, Simon , MUELLER, Thomas , YOUNG, Laurence , CHANDLER, Simon
IPC分类号： B01L3/00 , G01N15/10 , B01F13/00 , G01N35/10
摘要： A flow apparatus for measuring at least one biophysical property of one or more components is provided. The apparatus comprises one or more microfluidic devices. Each microfluidic device comprises: a sample channel having a sample inlet port for introducing a sample fluid flow comprising one or more components at a first flow rate into an elongate distribution channel, an auxiliary channel having an auxiliary inlet port for introducing an auxiliary fluid flow at a second flow rate into the elongate distribution channel. The distribution channel is configured to enable a lateral distribution of the components from the sample fluid flow into the auxiliary fluid flow. Each microfluidic device further comprises two or more capillary channels provided downstream and in fluid communication with the distribution channel, at least one outlet port provided downstream of each of the capillary channels. The sample inlet port and/or the outlet port further comprises an expansion feature between the channel and the corresponding port, whereby the expansion feature comprises a tapered section adjacent to the channel and a curved section adjacent to the port. The apparatus further comprises a switchable pressure source configured to control the flow of the fluids through the channels; and a detector configured to detect and measure at least one biophysical property of the or each component sequentially or simultaneously in each of the capillary channels and/or outlet ports on the microfluidic device.

2. 发明申请

WO2021234411A1 IMPROVEMENTS IN OR RELATING TO AN APPARATUS FOR CHARACTERISING A COMPONENT 审中-公开
公开(公告)号：WO2021234411A1
公开(公告)日：2021-11-25
申请号：PCT/GB2021/051244
申请日：2021-05-21
申请人： FLUIDIC ANALYTICS LIMITED , CAMBRIDGE ENTERPRISE LIMITED
发明人： DEVENISH, Sean , KNOWLES, Tuomas , KOSMOLIAPTSIS, Vasilis , MEISL, Georg , PRIDDEY, Ashley , SCHEIDT, Tom , SCHNEIDER, Matthias , XU, Catherine
IPC分类号： G01N33/52 , G01N27/447 , G01N33/68
摘要： An apparatus for characterising a biomolecule is provided. The apparatus comprising a sample inlet channel configured to introduce a sample fluid including the biomolecule to the apparatus; an auxiliary inlet channel configured to introduce an auxiliary fluid to the apparatus; a distribution channel in fluid communication with the sample inlet channel and the auxiliary inlet channel; wherein the distribution channel is adapted to generate a distribution of biomolecules; a measurement module configured to detect a signature profile of the biomolecule to obtain a measured dataset of the detected biomolecule; a storage location configured to store and maintain a stored dataset comprising a plurality of parameters that are associated with the measured dataset obtained from the measurement module; and an analysis module configured to receive the stored dataset from the storage location and correlate the stored dataset with the measured dataset from the measurement module to provide a correlation value, wherein the analysis module is further configured to use the correlation value to determine at least two characteristics of the biomolecule simultaneously using Bayesian analysis. A method for characterising a biomolecule is also provided.

3. 发明申请

WO2018046952A1 IMPROVEMENTS IN OR RELATING TO A DEVICE AND A METHOD FOR LABELLING A COMPONENT 审中-公开
标题翻译：设备的改进或标记组件的方法
公开(公告)号：WO2018046952A1
公开(公告)日：2018-03-15
申请号：PCT/GB2017/052648
申请日：2017-09-11
申请人： FLUIDIC ANALYTICS LIMITED
发明人： KNOWLES, Tuomas Pertti Jonathan , DEVENISH, Sean
IPC分类号： G01N33/533 , B01L3/00
摘要： A device and method for fluorescent labelling a component is provided. The device comprising a first user-replaceable reservoir comprising a strongly buffered alkaline solution of aromatic ortho-dialdehyde dye, a second user-replaceable reservoir comprising a weakly buffered acidic solution of a reducing agent, one or more fluid pathways comprising the component, and a network of connection channels linking the reservoirs and the fluid pathway to enable the alkaline solution and the acidic solution to combine with the component in order to label the component by reacting the component with the alkaline solution and the acidic solution.
摘要翻译：提供了用于荧光标记组件的装置和方法。所述装置包含第一使用者可置换贮存器和第二使用者可置换贮存器，所述第一使用者可置换贮存器包含芳香族邻二醛染料的强烈缓冲碱性溶液，第二使用者可置换贮存器包含弱缓冲酸性还原剂溶液，一个或多个流体通路包含所述组分，连接通道的网络连接储存器和流体通路，以使碱性溶液和酸性溶液与组分结合以通过使组分与碱性溶液和酸性溶液反应来标记组分。

4. 发明申请

WO2017174975A1 IMPROVEMENTS IN OR RELATING TO FLOW BALANCING 审中-公开
标题翻译：有关流量平衡的改进或与流量平衡有关的改进
公开(公告)号：WO2017174975A1
公开(公告)日：2017-10-12
申请号：PCT/GB2017/050941
申请日：2017-04-04
申请人： FLUIDIC ANALYTICS LIMITED
发明人： DOUGLAS, Anthony , MÜLLER, Thomas , KNOWLES, Tuomas Pertti Jonathan , KEMP, Colin George , GODFREY, Daniel Peterson
IPC分类号： B01L3/00
摘要： A device for controlling a fluid flow in an array of fluid pathways on a microfluidic chip is provided. The device comprising: two or more resistors provided upstream of the chip wherein each upstream resistor is configured to provide a resistance at an upstream end of a fluid pathway;two or more resistors provided downstream of the chip wherein each downstream resistor is configured to provide a resistance at a downstream end of a fluid pathway,wherein the values of the resistances are selected in order to control a proportion of fluid that flows through each fluid pathway.
摘要翻译：提供了一种用于控制微流体芯片上的流体通路阵列中的流体流动的装置。该装置包括：设置在芯片上游的两个或更多个电阻器，其中每个上游电阻器被配置为在流体路径的上游端提供电阻;两个或更多个电阻器，设置在芯片的下游，其中每个下游电阻器被配置为提供在流体路径的下游端处的阻力，其中选择阻力的值以控制流过每个流体路径的流体的比例。

5. 发明申请

WO2017141048A1 SEPARATION AND ANALYSIS OF SAMPLES BYMICROFLUIDIC FREE-FLOW ELECTROPHORESIS 审中-公开
标题翻译：样品的微流控自由流动电泳分离与分析
公开(公告)号：WO2017141048A1
公开(公告)日：2017-08-24
申请号：PCT/GB2017/050420
申请日：2017-02-17
申请人： CAMBRIDGE ENTERPRISE LIMITED , FLUIDIC ANALYTICS LIMITED
发明人： ZHANG, Yingbo , MUELLER, Thomas , KNOWLES, Tuomas Pertti Jonathan
IPC分类号： G01N27/447
CPC分类号： G01N27/44769 , G01N27/44791
摘要： A microfluidic device (11) is provided for separation and analysis of microfluidic samples. The device comprises: a separation channel (10); a first electrolyte channel (12) configured to provide a flow of high conductivity electrolyte solution, in use; and provided with a positive electrode (13) at a downstream outlet of the channel; a second electrolyte channel (14) configured to provide a flow of high conductivity electrolyte solution, in use, and provided with a negative electrode (15) at a downstream outlet of the channel; and wherein the flow of electrolyte through the first and second electrolyte channels removes electrophoresis products and gas bubbles from the device; and wherein the presence of the electrolyte provides a substantially homogenous electric field across the separation channel.
摘要翻译：提供微流体装置（11）用于微流体样品的分离和分析。该装置包括：分离通道（10）; 第一电解质通道（12），其被配置为在使用中提供高电导率电解质溶液流; 并在通道的下游出口处设置有正极（13）第二电解质通道（14），所述第二电解质通道（14）构造成在使用中提供高电导率电解质溶液流，并且在所述通道的下游出口处设置有负电极（15）; 并且其中电解质通过第一和第二电解质通道的流动从装置中去除电泳产物和气泡; 并且其中电解质的存在提供跨越分离通道的基本上均匀的电场。

6. 发明申请

WO2020058715A1 IMPROVEMENTS IN OR RELATING TO PROFILING OF PARTICLES USING MICROFLUIDIC DEVICES 审中-公开
公开(公告)号：WO2020058715A1
公开(公告)日：2020-03-26
申请号：PCT/GB2019/052635
申请日：2019-09-19
申请人： FLUIDIC ANALYTICS LIMITED , CAMBRIDGE ENTERPRISE LIMITED
发明人： KARTANAS, Tadas , KNOWLES, Tuomas Pertti Jonathan , PETER, Quentin Alexis Eric , SAAR, Kadi Liis , SCHEIDT, Tom , MUELLER, Thomas , DEVENISH, Sean
IPC分类号： G01N30/78
摘要： A device and a method is provided for profiling particles such as proteins. The device comprises: a liquid chromatography column (16) in a mixture separation module (10); a fractionation device (22, 24) and a plurality of microfluidic analysis modules (26, 28) in a microfluidic network (14). The microfluidic analysis modules are configured to provide multi-dimensional analysis of the particles. Furthermore, a fluidic flow adaptor (20) allows for controlled flow between separator (16) and the microfluidic network to provide a continuous fluid flow.

7. 发明申请

WO2019116016A1 FLUIDIC APPARATUS AND METHOD 审中-公开
公开(公告)号：WO2019116016A1
公开(公告)日：2019-06-20
申请号：PCT/GB2018/053583
申请日：2018-12-11
申请人： CAMBRIDGE ENTERPRISE LIMITED , FLUIDIC ANALYTICS LIMITED
发明人： KNOWLES, Tuomas Pertti Jonathan , SAAR, Kadi Liis , KARTANAS, Tadas , MUELLER, Thomas
IPC分类号： B01L3/00 , G01N27/447 , G01N15/02
CPC分类号： B01L3/502776 , B01L3/502715 , B01L2200/027 , B01L2200/0636 , B01L2300/0816 , B01L2300/0867 , B01L2300/0883 , B01L2400/0421 , G01N15/0266 , G01N27/44704 , G01N27/44769 , G01N2015/0288
摘要： A fluidic device is provided. The fluidic device comprises a separation channel having at its upstream end a junction, a first channel for supplying a first fluid flow, a second channel for supplying a second fluid flow. The first and second channels meet at the junction are adapted to provide the first fluid flow in the separation channel sheathed by the second fluid flow,such that the first fluid flow does not contact the separation channel walls. The separation channel, the first and second channels are provided as a unitary piece, or where the separation channel and the first and second channels are provided as a non-unitary piece comprising a plurality of parts, the parts are of the same material.

8. 发明申请

WO2018046953A1 IMPROVEMENTS IN OR RELATING TO A REAGENT CARTRIDGE 审中-公开
标题翻译：与试剂盒有关的改进或与试剂盒有关的改进
公开(公告)号：WO2018046953A1
公开(公告)日：2018-03-15
申请号：PCT/GB2017/052649
申请日：2017-09-11
申请人： FLUIDIC ANALYTICS LIMITED
发明人： DOUGLAS, Anthony , KNOWLES, Tuomas Pertti Jonathan , MUELLER, Thomas , DOWER, Liam , DEVENISH, Sean
IPC分类号： B01L3/00 , G01N35/10
摘要： A fluidic system is provided. The system comprises: a rigid housing (12), a plurality of flexible reagent containers (14) contained within the housing (12); wherein each reagent container (14) has a connection port (16) through which a reagent can flow, in use, on the application of pressure. The system further comprises a single pressure source (18) configured to apply pressure to the interior of the rigid housing (12); a microfluidic device configured to analyse one or more fluids provided from the plurality of reagent containers; and a plurality of channels (20) configured to transfer fluid from the plurality of reagent containers (14) to the microfluidic device. The ratio of resistances provided by a combination of the connection ports and the plurality of channels dictates the ratio of flow rates of the reagents. The claimed system allows for an accurate control of the various reagent flow rates while minimizing fluctuations in the relative flow rates.
摘要翻译：提供流体系统。该系统包括：刚性外壳（12），包含在外壳（12）内的多个柔性试剂容器（14）; 其中每个试剂容器（14）具有连接端口（16），在使用时，试剂可以通过该连接端口在施加压力时流动。该系统还包括构造成向刚性壳体（12）的内部施加压力的单个压力源（18）; 微流体装置，其被配置为分析从所述多个试剂容器提供的一种或多种流体; 以及构造成将流体从所述多个试剂容器（14）转移到所述微流体装置的多个通道（20）。由连接端口和多个通道的组合提供的电阻的比率决定了试剂流速的比率。所要求保护的系统允许精确控制各种试剂流速，同时最小化相对流速的波动。

9. 发明申请

WO2018042190A1 IMPROVEMENTS IN OR RELATING TO A FLUID FLOW CONTROLLER FOR MICROFLUIDIC DEVICES 审中-公开
标题翻译：微流控设备的流体流量控制器或与之相关的改进
公开(公告)号：WO2018042190A1
公开(公告)日：2018-03-08
申请号：PCT/GB2017/052552
申请日：2017-09-01
申请人： FLUIDIC ANALYTICS LIMITED
发明人： DOUGLAS, Anthony , KNOWLES, Tuomas Pertti Jonathan , MUELLER, Thomas , LYNN, Andrew
IPC分类号： B01L3/00 , B01J19/00
摘要： A fluid flow controller for introducing fluids into a microfluidic device is provided. The fluid flow controller comprising, at least one high resistance fluid pathway provided between an inlet port and a connection port; at least one low resistance fluid pathway between the inlet and connection port; and at least one valve configured to enable fluid flow through the high resistance fluid pathway, the low resistance fluid pathway or both.
摘要翻译：提供了用于将流体引入微流体装置的流体流量控制器。所述流体流量控制器包括：至少一个设置在入口端口和连接端口之间的高阻力流体通道; 在入口和连接端口之间的至少一个低阻力流体路径; 以及至少一个阀门，其构造成使流体能够流过高阻力流体路径，低阻力流体路径或两者。

10. 发明申请

WO2018046954A1 IMPROVEMENTS IN OR RELATING TO VALVES FOR MICROFLUIDIC DEVICES 审中-公开
标题翻译：微流体设备阀门的改进或与微流控设备的阀门有关的改进
公开(公告)号：WO2018046954A1
公开(公告)日：2018-03-15
申请号：PCT/GB2017/052652
申请日：2017-09-11
申请人： FLUIDIC ANALYTICS LIMITED
发明人： DOUGLAS, Anthony , KNOWLES, Tuomas , MUELLER, Thomas , DOWER, Liam
IPC分类号： F16K99/00 , B01L3/00
CPC分类号： F16K99/0015 , B01L3/502707 , B01L3/502715 , B01L3/50273 , B01L3/502738 , B01L3/502746 , B01L2200/0689 , B01L2300/049 , B01L2300/0816 , B01L2300/0887 , B01L2300/123 , B01L2300/14 , F16K99/0057 , F16K2099/0084
摘要： A single-layer valve is provided. The valve comprises a microfluidic pathway at least partially defined by a flexible membrane which is configured to deform when subjected to an actuation torque,and a discontinuity bounded by a first surface. The length of the discontinuity is constant across the full width of the first surface. The valve is configured such that the actuation torque on the membrane is larger in a first direction than a second direction substantially opposite to the first direction.
摘要翻译：
提供单层阀。该阀包括微流体路径，该微流体路径至少部分地由柔性膜限定，该柔性膜被配置成当受到致动转矩时变形，以及由第一表面界定的不连续性。不连续面的长度在第一表面的整个宽度上是恒定的。该阀构造成使得膜上的致动转矩在第一方向上大于与第一方向基本相反的第二方向。

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