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1. 发明申请

WO2006079814A2 REACTION METHOD 审中-公开
标题翻译：反应方法
公开(公告)号：WO2006079814A2
公开(公告)日：2006-08-03
申请号：PCT/GB2006/000264
申请日：2006-01-26
申请人： ENIGMA DIAGNOSTICS LTD , SQUIRREL, David, James , LEE, Martin, Alan
发明人： SQUIRREL, David, James , LEE, Martin, Alan
IPC分类号： G01N35/00 , B01J19/00 , B01L3/00
CPC分类号： B01J19/0046 , B01J2219/00283 , B01J2219/00335 , B01J2219/00344 , B01J2219/00421 , B01J2219/00468 , B01J2219/00704 , B01J2219/00722 , B01L3/502 , B01L3/5021 , B01L7/52 , B01L2200/16 , B01L2300/0838 , B01L2300/087 , B01L2400/0409 , C40B40/06 , G01N35/0098
摘要： A method for carrying out a multi-step reaction, said method comprising 1) adding one or more first reagents to a reaction vessel, said reaction vessel comprising an upper chamber capable of holding reagents, which is open to a lower chamber to which reagent flow is restricted, 2) subjecting said reaction vessel to a centrifugal force so as to drive the said one or more first reagents into the lower chamber; 3) adding a further reagent to the first chamber and closing said chamber; 4) subjecting at least one of the lower chamber or the upper chamber to conditions which cause said one or more first reagents or said further reagent to take part in a first reaction or reach a desired reaction condition; 5) subjecting said reaction vessel to a centrifugal force so as to drive the said further reagent into the lower chamber and allowing it to interact with the contents of the lower chamber; wherein at least steps (2) to (5) are carried out automatically . This method allows multiple steps to be carried out in vessels without opening the vessel. It is particularly suitable for use in connection with PCR reactions.
摘要翻译：一种进行多步反应的方法，所述方法包括：1）向反应容器中加入一种或多种第一试剂，所述反应容器包括能容纳试剂的上室，所述反应容器向下室开放，试剂流 2）对所述反应容器进行离心力，以驱动所述一种或多种第一试剂进入下室; 3）向第一室加入另外的试剂并关闭所述室; 4）使下室或上室中的至少一个使得使所述一种或多种第一试剂或所述另外的试剂参与第一反应或达到所需反应条件的条件; 5）使所述反应容器受到离心力，以便将所述另外的试剂驱动到下室中并允许其与下室的内容物相互作用; 其中至少步骤（2）至（5）自动进行。该方法允许在不打开容器的情况下在容器中进行多个步骤。特别适用于PCR反应。

2. 发明申请

WO03026797A2 SEALING SYSTEM WITH FLOW CHANNELS 审中-公开
标题翻译：带流道的密封系统
公开(公告)号：WO03026797A2
公开(公告)日：2003-04-03
申请号：PCT/EP0210280
申请日：2002-09-13
申请人： SOLVIAS AG , BLATTER FRITZ , CRON-ECKHARDT BRIGITTE , HOFMEIER URS CHRISTOPH , KOLLER PETER , MARCOLLI CLAUDIA , SZELAGIEWICZ MARTIN
发明人： BLATTER FRITZ , CRON-ECKHARDT BRIGITTE , HOFMEIER URS CHRISTOPH , KOLLER PETER , MARCOLLI CLAUDIA , SZELAGIEWICZ MARTIN
IPC分类号： B01L3/00 , B01L99/00 , C40B60/14 , G01N1/40 , G01N21/11 , G01N21/25 , G01N21/65
CPC分类号： G01N21/253 , B01J2219/00274 , B01J2219/00283 , B01J2219/00315 , B01J2219/00335 , B01J2219/00389 , B01J2219/00484 , B01J2219/00585 , B01J2219/00659 , B01J2219/00756 , B01L3/0293 , B01L3/5025 , B01L3/50853 , B01L2300/046 , B01L2300/0829 , B01L2400/0487 , C40B60/14 , G01N1/40 , G01N21/11 , G01N2001/4027 , G01N2021/651
摘要： Device consisting of a support (1) and at least two seals (2), which are arranged in a row and are hermetically fitted into cavities, and protrude from the support laterally with respect to inlet and outlet openings, one end of the support being provided with an inlet opening (3) and one end being provided with an outlet opening (4), and the seals being provided with a least one inlet opening and one outlet opening, and the support containing at least one first channel (5) which starts at the inlet opening (3) and is continuous, and is arranged in such a way that it opens into the inlet openings in the side walls of the seals arranged in a row, and one second channel (6) which starts at the outlet opening and is continuous, and is arranged in such a way that it opens into the outlet openings in the side walls of the seals arranged in a row. The system is suitable for simultaneous multiple studies, in particular with the use of microtitration plates, and physical measurements of the results directly in the containers, for example of a microtitration plate. The multiple studies may be used to perform screening processes to discover and develop polymorphic and pseudopolymorphic forms, new formulations and suitable crystallisation conditions.
摘要翻译：装置由一个支承件（1）和至少两个密封件（2）组成，它们排列成一排并密封配合到空腔中，并且相对于入口和出口横向地从支承件伸出，支承件的一端是设置有入口开口（3）并且一端设有出口开口（4），并且所述密封件设置有至少一个入口开口和一个出口开口，并且所述支撑件包含至少一个第一通道（5），所述第一通道从入口开口（3）开始并且是连续的，并且以这样的方式布置，使得其通向排成一排的密封件的侧壁中的入口开口和一个第二通道（6），该第二通道在出口开口并且是连续的，并且以这样的方式布置，即它通向排成一排的密封件的侧壁中的出口开口。该系统适用于同时进行多项研究，特别是使用微量滴定板，并直接在容器中对结果进行物理测量，例如微量滴定板。多项研究可用于进行筛选过程以发现和开发多晶型和假多晶型形式，新制剂和合适的结晶条件。

3. 发明申请

WO2002066151A2 APPARATUS AND METHODS FOR PARALLEL PROCESSING OF MULTIPLE REACTION MIXTURES 审中-公开
标题翻译：多种反应混合物并行处理的装置和方法
公开(公告)号：WO2002066151A2
公开(公告)日：2002-08-29
申请号：PCT/US2002/002617
申请日：2002-01-28
申请人： SYMYX TECHNOLOGIES, INC. , SMITH, Matthew, F. , VARNI, John, F. , DALES, G., Cameron , FRANK, Trevor, G. , JAIN, Rakesh , VAN ERDEN, Lynn
发明人： SMITH, Matthew, F. , VARNI, John, F. , DALES, G., Cameron , FRANK, Trevor, G. , JAIN, Rakesh , VAN ERDEN, Lynn
IPC分类号： B01J19/00
CPC分类号： B01J19/0046 , B01J2219/00283 , B01J2219/00308 , B01J2219/00313 , B01J2219/00335 , B01J2219/00337 , B01J2219/00373 , B01J2219/00418 , B01J2219/00477 , B01J2219/00481 , B01J2219/00495 , B01J2219/00585 , B01J2219/00601 , B01J2219/00689 , B01J2219/00691 , B01J2219/00722 , C40B40/14 , C40B60/14 , Y10T436/2575 , Y10T436/25875
摘要： A parallel reactor system including a reactor and vessels in the reactor for holding reaction mixtures, and a cannula for introducing fluid reaction material into the vessels. A robot system is operable to insert the cannula into cannula passages in the reactor for delivery of reaction materials, including condensed gases, to respective vessels, and to withdraw the cannula from the cannula passages after delivery. Related methods are also disclosed.
摘要翻译：一种并联反应器系统，包括用于保持反应混合物的反应器中的反应器和容器，以及用于将流体反应材料引入容器的套管。机器人系统可操作以将插管插入反应器中的插管通道中，用于将反应材料（包括冷凝气体）输送到相应的容器，并且在输送后从插管通道中抽出插管。还公开了相关方法。

4. 发明申请

WO2002060585A1 METHOD AND APPARATUS FOR SOLID OR SOLUTION PHASE REACTION UNDER AMBIENT OR INERT CONDITIONS 审中-公开
标题翻译：用于在环境或惰性条件下进行固体或溶液相反应的方法和装置
公开(公告)号：WO2002060585A1
公开(公告)日：2002-08-08
申请号：PCT/US2002/001927
申请日：2002-01-25
申请人： SENOMYX, INC. , GUBERNATOR, Klaus , COHN, Joseph , PATRON, Andrew , ROGERS, Daniel
发明人： GUBERNATOR, Klaus , COHN, Joseph , PATRON, Andrew , ROGERS, Daniel
IPC分类号： B01L11/00
CPC分类号： B01L3/50853 , B01J19/0046 , B01J2219/00283 , B01J2219/00308 , B01J2219/00315 , B01J2219/00335 , B01J2219/00344 , B01J2219/00373 , B01J2219/00418 , B01J2219/00423 , B01J2219/00454 , B01J2219/00477 , B01J2219/005 , B01J2219/00585 , B01J2219/0059 , B01J2219/00596 , B01J2219/00599 , B01L2200/026 , B01L2300/042 , B01L2300/046 , B01L2300/048 , B01L2300/0829 , C07B2200/11 , C40B50/08 , C40B50/14 , C40B60/14
摘要： A reaction vessel (210) comprises a microplate assembly (211) with solid phases within each reaction well (250), vent caps (260) with vent tubes (280), upper inert atmosphere cap (212) with at least one inert gas inlet (203) in communication with common gas volume (201) and inert gas outlets (202). Vent tubes (280) terminate in vents (290) in communication with interior volumes (270) formed by coupling caps (260) to wells (250). Materials can be removed or added to the wells (280) for a positive pressure of inert gas in common gas volume (201). When outlets (202) align with caps (260), passages form through outlets (202) and caps (260) into interior volumes (270) of reactionn wells (250) to provide a constant positive pressure of insert gas to wells (250).
摘要翻译：反应容器（210）包括在每个反应井（250）内具有固相的微板组件（211），具有通气管（280）的通气帽（260），具有至少一个惰性气体入口（203）与公共气体容积（201）和惰性气体出口（202）连通。通风管（280）终止于通过将帽（260）连接到井（250）形成的内部容积（270）的通风孔（290）。材料可以在普通气体体积（201）中除去或添加到孔（280）中以获得惰性气体的正压。当出口（202）与盖（260）对准时，通道通过出口（202）和盖（260）形成反应孔（250）的内部体积（270），以向孔（250）提供恒定的插入气体的正压力，。

5. 发明申请

WO02041992A2 METHOD FOR BIOCHEMICAL ANALYSIS AND CORRESPONDING ARRANGEMENT 审中-公开
标题翻译：生化分析和相关安排的过程
公开(公告)号：WO02041992A2
公开(公告)日：2002-05-30
申请号：PCT/DE2001/004437
申请日：2001-11-26
IPC分类号： G01N33/53 , B01J19/00 , B01L3/00 , C40B60/14 , G01N35/02 , G01N37/00
CPC分类号： B01J19/0093 , B01J19/0046 , B01J2219/00317 , B01J2219/00333 , B01J2219/00335 , B01J2219/00351 , B01J2219/00608 , B01J2219/00612 , B01J2219/00621 , B01J2219/00644 , B01J2219/00659 , B01J2219/00783 , B01J2219/00828 , B01J2219/0086 , B01J2219/00867 , B01L3/502 , B01L3/50853 , B01L2200/0642 , B01L2200/0673 , B01L2300/0819 , B01L2300/0829 , C40B60/14 , G01N27/3277
摘要： The invention relates to a method for biochemical analysis using a micro-reaction array with at least two reaction chambers for materials which react together chemically or biochemically. According to the invention, the reaction chambers are smaller than 1 µl, said reaction chambers are filled together by throughflow, the chemical or biochemical reactions of the substances retained therein then occurs in the individual isolated reaction chambers, thus preventing an interference between the reactions in the individual reaction chambers and the reaction products remain enclosed in the relevant reaction chambers. According to the invention, in said arrangement the planar array has at least two reaction chambers for substances, whereby means are provided for closing the reaction chambers with the goal of preventing an exchange of substances.
摘要翻译：在用于生化分析的方法，微阵列是具有至少两个反应室为化学或生化反应的相互使用的物质反应。根据本发明，所述反应空间是小于1微米时，反应空间被填充在一起的流动，发生随后在每个单独的反应空间，所述化学或被困在那里物质的生化反应，其中各个反应室之间的反应的串扰排除，并且反应产物保留在相应的反应室中。在平面阵列的相关布置具有用于物质至少两个反应室，其特征在于，用于关闭设置用于防止传质的目的场所的反应。

6. 发明申请

WO0205367A2 METHOD OF SCREENING COMPOSITIONS FOR ELECTROCATALYTIC ACTIVITY IN A GAS DIFFUSION ELECTRODE 审中-公开
标题翻译：筛选气体扩散电极中电化学活性组合物的方法
公开(公告)号：WO0205367A2
公开(公告)日：2002-01-17
申请号：PCT/US0121011
申请日：2001-06-29
申请人： UOP LLC , MALLOUK THOMAS E , SMOTKIN EUGENE S , CHAN BENNY S , CHEN GUOYING , LIU BENZUAN
发明人： MALLOUK THOMAS E , SMOTKIN EUGENE S , CHAN BENNY S , CHEN GUOYING , LIU BENZUAN
IPC分类号： B01J19/00 , C40B30/08 , C40B40/18 , C40B60/14 , G01N31/10 , H01M4/86 , H01M4/88 , H01M4/90 , H01M4/92 , H01M8/00
CPC分类号： G01N31/10 , B01J19/0046 , B01J2219/00274 , B01J2219/00283 , B01J2219/00286 , B01J2219/00313 , B01J2219/00335 , B01J2219/00427 , B01J2219/00527 , B01J2219/00531 , B01J2219/00576 , B01J2219/00585 , B01J2219/00596 , B01J2219/00605 , B01J2219/00612 , B01J2219/00621 , B01J2219/00641 , B01J2219/00659 , B01J2219/00702 , B01J2219/00745 , B01J2219/00747 , B01J2219/00756 , C40B30/08 , C40B40/18 , C40B60/14 , H01M4/8605 , H01M4/8828 , H01M4/8878 , H01M4/90 , H01M4/92
摘要： A novel process and apparatus to combinatorially screen a large number of discrete compositions for electrocatalytic activity have been developed. The apparatus contains a cell body adjacent to a fluid permeable catalyst array support supporting multiple solids. A catalyst mask having holes that are in alignment with the multiple locations for supporting solids is placed over the catalyst array support, masking the solids. A cell cover is positioned adjacent to the catalyst array support, with the cell cover having a passage for monitoring the solids through the mask. A detector may be in alignment with the passage of the cell cover.
摘要翻译：已经开发了用于组合筛选大量用于电催化活性的离散组合物的新方法和装置。该装置包含与支持多个固体的流体可渗透的催化剂阵列支撑体相邻的电池体。具有与支撑固体的多个位置对准的孔的催化剂掩模放置在催化剂阵列支撑体上，掩蔽固体。电池盖邻近催化剂阵列支撑件定位，电池盖具有用于通过掩模监测固体的通道。检测器可以与电池盖的通道对准。

7. 发明申请

WO99020394A3 SPILLPROOF MICROPLATE ASSEMBLY 审中-公开
标题翻译：防漏麦克风组件
公开(公告)号：WO99020394A3
公开(公告)日：1999-07-29
申请号：PCT/US1998/019812
申请日：1998-09-23
IPC分类号： B01J19/00 , B01L3/00 , C40B60/14 , G01N35/02
CPC分类号： B01L3/50853 , B01J19/0046 , B01J2219/00313 , B01J2219/00315 , B01J2219/00335 , B01J2219/00423 , B01J2219/00585 , B01J2219/00587 , B01J2219/00702 , B01J2219/0072 , C40B60/14 , G01N35/028
摘要： A microplate assembly comprising a multi-well microplate, a plurality of vent caps and a porous vent film. Vent caps mount on the microplate to seal and vent the wells. When the vent caps are coupled to the wells, an interior volume is formed in each well. The wells function as a vessel for liquid samples, which remain within their predetermined spaces for all orientations of the microplate assembly. The vent cap comprises an array of well inserts. The well inserts are interconnected by a perforated web. The vents permit the pressure within the interior volume to be equalized with the ambient pressure. Material may be added to or removed from each well without removing the vent cap. The porous vent film, adheres to the vent caps while covering the passages, thereby inhibiting evaporation of the liquid samples.
摘要翻译：微板组件包括多孔微板，多个通气帽和多孔排气膜。通气盖安装在微板上以密封和排出孔。当通气盖连接到井时，在每个井中形成内部容积。这些孔用作液体样品的容器，其保持在其用于微板组件的所有取向的其预定空间内。排气盖包括一系列井插件。井插入物通过穿孔网互连。通风口允许内部空间内的压力与环境压力相等。可以将材料添加到每个孔中或从每个孔移除，而不移除通气盖。多孔排气膜在覆盖通道时粘附到排气盖上，从而抑制液体样品的蒸发。

8. 发明申请

WO99029588A1 CHEMICAL VESSEL CAP 审中-公开
标题翻译：化学船帽
公开(公告)号：WO99029588A1
公开(公告)日：1999-06-17
申请号：PCT/GB1998/003459
申请日：1998-11-17
IPC分类号： B65D51/00 , B65D51/16 , C40B60/14
CPC分类号： B65D51/002 , B01J2219/00283 , B01J2219/00335 , B01J2219/00346 , B65D51/1661 , C40B60/14
摘要： A cap (1) for a chemical storage or reaction vessel comprises a seat for attachment, in use, to an opening of the vessel. A membrane (6) formed from a resilient material and having a slit (11) formed therein allows a substance sampling or delivery apparatus to pass therethrough in use, the membrane being positioned to slide within the seat substantially in the direction of passage of the sampling or delivery apparatus.
摘要翻译：用于化学品储存或反应容器的盖（1）包括用于在使用中附接到容器的开口的座。由弹性材料形成并具有形成在其中的狭缝（11）的膜（6）允许物质采样或输送装置在使用中通过其中，所述膜定位成基本上沿着取样通过方向在座内滑动或输送装置。

9. 发明申请

WO9920394A2 SPILLPROOF MICROPLATE ASSEMBLY 审中-公开
标题翻译：防漏麦克风组件
公开(公告)号：WO9920394A2
公开(公告)日：1999-04-29
申请号：PCT/US9819812
申请日：1998-09-23
申请人： TEXPERTS INC
发明人： BOULTON DAVID A , SOLEWSKI CAROLYN I
IPC分类号： B01J19/00 , B01L3/00 , C40B60/14 , G01N35/02 , B01L
CPC分类号： B01L3/50853 , B01J19/0046 , B01J2219/00313 , B01J2219/00315 , B01J2219/00335 , B01J2219/00423 , B01J2219/00585 , B01J2219/00587 , B01J2219/00702 , B01J2219/0072 , C40B60/14 , G01N35/028
摘要： A microplate assembly comprising a multi-well microplate, a plurality of vent caps and a porous vent film. The microplate includes a frame that houses a plurality of open wells in a rectangular array. Vent caps mount on the microplate to seal and vent the wells. When the vent caps are coupled to the wells, an interior volume is formed in each well. The wells function as a vessel for liquid samples that occupy predetermined spaces within the interior volumes. The liquid samples remain within its predetermined space for all orientations of the microplate assembly. The vent cap comprises an array of well inserts. Each well insert comprises a sealing plug and a vent tube. The well inserts are interconnected by a perforated web. The sealing plugs form a seal at the mouth of the open wells. The vent tubes, which are fixed to the sealing plugs, terminate in a vent that communicates with the interior volumes outside the predetermined spaces occupied by the liquid samples. The vents permit the pressure within the interior volume to be equalized with the ambient pressure via a passage that runs through the vent tube and the sealing plugs. Material may be added to or removed from each well without removing the vent cap. The porous vent film, which has an adhesive coating, adheres to the vent caps while covering the passages, thereby inhibiting evaporation of the liquid samples.
摘要翻译：微板组件包括多孔微板，多个通气帽和多孔排气膜。微孔板包括容纳多个矩形阵列的开放井的框架。通气盖安装在微板上以密封和排出孔。当通气盖连接到井时，在每个井中形成内部容积。这些孔用作在内部容积中占据预定空间的液体样品的容器。液体样品保留在其预定空间内用于微板组件的所有取向。排气盖包括一系列井插件。每个井插件包括密封塞和排气管。井插入物通过穿孔网互连。密封塞在开口孔的口处形成密封。固定到密封塞上的排气管终止于与液体样品占据的预定空间外的内部容积连通的排气口。通风口允许内部空间内的压力经由通过通气管和密封塞的通道与环境压力相等。可以将材料添加到每个孔中或从每个孔移除，而不移除通气盖。具有粘合剂涂层的多孔通气膜在覆盖通道的同时粘附到通气盖上，从而抑制液体样品的蒸发。

10. 发明申请

WO2013148669A1 PARALLEL REACTOR SYSTEMS AND METHODS FOR PREPARING MATERIALS 审中-公开
标题翻译：并行反应器系统及其制备方法
公开(公告)号：WO2013148669A1
公开(公告)日：2013-10-03
申请号：PCT/US2013/033861
申请日：2013-03-26
申请人： FREESLATE, INC.
发明人： GIAQUINTA, Daniel , BUSACCA, Robert S. , ROSEN, Robert K. , VARNI, John F. , YODER, Jeffrey C.
IPC分类号： B01J19/00 , C40B60/14 , C40B60/12
CPC分类号： B01J19/0053 , B01F15/00025 , B01F15/00987 , B01F15/00993 , B01F15/026 , B01F2215/0036 , B01J19/0046 , B01J27/138 , B01J2219/00308 , B01J2219/00335 , B01J2219/00337 , B01J2219/00376 , B01J2219/00423 , B01J2219/00477 , B01J2219/00481 , B01J2219/00495 , B01J2219/00585 , B01J2219/00736 , B01J2219/00738 , B01J2219/00761 , C40B60/12 , C40B60/14
摘要： Parallel reactor systems for synthesizing materials are disclosed. The reactor systems may be suitable for synthesizing materials produced from corrosive reagents. Methods for preparing materials by use of such parallel reactor systems are also disclosed.
摘要翻译：公开了用于合成材料的平行反应器系统。反应器系统可适用于合成由腐蚀性试剂产生的材料。还公开了通过使用这种平行反应器系统制备材料的方法。

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