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1. 发明申请

WO2013012817A1 METHODS AND COMPOSITIONS FOR DRYING IN THE PREPARATION OF RADIOPHARMACEUTICALS 审中-公开
标题翻译：用于干燥放射性核素制备的方法和组合物
公开(公告)号：WO2013012817A1
公开(公告)日：2013-01-24
申请号：PCT/US2012/046955
申请日：2012-07-16
申请人： CARDINAL HEALTH 414, LLC , ESHIMA, Dennis , HUSNU, Mehmet , PADGETT, Henry , KLAUSING, Thomas, A. , BOUTON, Chad, E. , BENECKE, Herman , GARBARK, Daniel, B.
发明人： ESHIMA, Dennis , HUSNU, Mehmet , PADGETT, Henry , KLAUSING, Thomas, A. , BOUTON, Chad, E. , BENECKE, Herman , GARBARK, Daniel, B.
IPC分类号： A61K51/00
CPC分类号： C07B59/00
摘要： A method of drying a radioisotope solution having radioisotopes includes passing the radioisotope solution through a solid phase extraction column containing an anion exchange group, thereby trapping the radioisotopes in the column. The method also includes passing an eluent through the column, thereby removing the radioisotopes from the column. The eluent includes a cation trapping agent/salt complex, less than 4% water, and the remainder is a solvent. A method of producing the eluent includes reacting a cation trapping agent with a salt in the presence of less than 4% water and a solvent to form solubilized cation trapping agent/salt complex, wherein one of the cation trapping agent and the salt is present in en excess of a stoichiometric amount and ending the reaction when a predetermined amount of solubilized cation trapping agent/salt complex has been formed.
摘要翻译：干燥具有放射性同位素的放射性同位素溶液的方法包括使放射性同位素溶液通过含有阴离子交换基团的固相萃取柱，从而将放射性同位素捕集在柱中。该方法还包括使洗脱液通过柱，从而从柱中除去放射性同位素。洗脱液包括阳离子捕获剂/盐络合物，小于4％的水，其余为溶剂。制备洗脱液的方法包括在小于4％的水和溶剂的存在下使阳离子捕获剂与盐反应形成溶解的阳离子捕获剂/盐络合物，其中阳离子捕获剂和盐之一存在于超过化学计量量，并且当已经形成预定量的增溶的阳离子捕获剂/盐络合物时结束反应。

2. 发明申请

WO2005094953A2 SYSTEM FOR DETERMINING PERFORMANCE CHARACTERISTICS OF A GOLF SWING 审中-公开
标题翻译：确定高尔夫挥杆性能特征的系统
公开(公告)号：WO2005094953A2
公开(公告)日：2005-10-13
申请号：PCT/US2005/009375
申请日：2005-03-22
申请人： NIKE INCORPORATED , NIKE INTERNATIONAL, LTD. , STITES, John, T. , TAVARES, Gary, G. , MADORE, Carl , KELLY, Mike , SANDER, Raymond, J. , HADDEN, Jeffrey, A. , HELD, Jeffrey, R. , MEANLE, Garrick, L. , KRAMER, Gregory, S. , BOUTON, Chad, E. , DODSON, Clifford, N. , HOFFMAN, Patrick, K.
发明人： STITES, John, T. , TAVARES, Gary, G. , MADORE, Carl , KELLY, Mike , SANDER, Raymond, J. , HADDEN, Jeffrey, A. , HELD, Jeffrey, R. , MEANLE, Garrick, L. , KRAMER, Gregory, S. , BOUTON, Chad, E. , DODSON, Clifford, N. , HOFFMAN, Patrick, K.
IPC分类号： A63B69/36
CPC分类号： A63B69/3614 , A63B53/0466 , A63B53/047 , A63B60/42 , A63B69/3632 , A63B71/0622 , A63B2024/0012 , A63B2060/464 , A63B2069/362 , A63B2069/367 , A63B2220/56 , A63B2220/802 , A63B2220/805 , A63B2220/833 , A63B2225/50 , G06F19/00 , Y02A90/26
摘要： An instrumented golf club system and methods are disclosed. A variety of golf swing parameters are measured by the instrumented golf club (200) and wirelessly transmitted to a portable computer device (120). The portable computer device (120) generates a user interface that displays the golf swing parameters against preferred golf swing parameters. The instrumented golf club system (200) allows a golfer to receive feedback in real time while playing golf.
摘要翻译：公开了一种仪表化的高尔夫球杆系统和方法。各种高尔夫挥杆参数由仪表化的高尔夫球杆（200）测量，并无线传输到便携式计算机设备（120）。便携式计算机设备（120）生成用于根据优选的高尔夫挥杆参数显示高尔夫挥杆参数的用户界面。仪表式高尔夫球杆系统（200）允许高尔夫球手在打高尔夫球时实时接收反馈。

3. 发明申请

WO2013033162A1 DISTRIBUTED EXTRAVASATION DETECTION SYSTEM 审中-公开
标题翻译：分布式提取检测系统
公开(公告)号：WO2013033162A1
公开(公告)日：2013-03-07
申请号：PCT/US2012/052796
申请日：2012-08-29
申请人： BATTELLE MEMORIAL INSTITUTE , BOUTON, Chad, E.
发明人： BOUTON, Chad, E.
IPC分类号： A61B5/05 , A61M5/168
CPC分类号： A61B5/0507 , A61B5/0022 , A61B5/0537 , A61B5/4839 , A61B5/4875 , A61B5/4878 , A61B5/6824 , A61B5/7203 , A61B5/7246 , A61B5/7282 , A61B8/08 , A61M5/16831 , A61M5/16836 , A61M2205/3317 , F04C2270/041
摘要： A system and method enhance clinical effectiveness for monitoring for a change in a level of fluid in tissue by using a device attached to a body portion that wirelessly reports to a remote apparatus or receiver a current received power level for indications of extravasation or infiltration. Adjusting an activation rate of fluid detection, reporting or both extends service life of the device.
摘要翻译：一种系统和方法提高临床有效性，以通过使用连接到身体部分的装置来监测组织中的流体水平的变化，所述装置向远程装置或接收器无线地报告用于外渗或渗透的指示的当前接收功率水平。调整流体检测，报告或两者的激活速率可延长设备的使用寿命。

4. 发明申请

WO2009042263A1 ACCESS DISCONNECT DETECTION 审中-公开
标题翻译：访问断开检测
公开(公告)号：WO2009042263A1
公开(公告)日：2009-04-02
申请号：PCT/US2008/066114
申请日：2008-06-06
申请人： BAXTER INTERNATIONAL INC. , BAXTER HEALTHCARE S.A. , BOUTON, Chad E.
发明人： BOUTON, Chad E.
IPC分类号： A61M1/36
CPC分类号： A61M1/3653 , A61B5/02042 , A61M1/3656
摘要： Techniques are disclosed for monitoring the flow of blood returning to a patient from an extracorporeal therapy machine, such as a hemodialysis machine or an apheresis machine. Blood returning from such a machine is pumped, typically by a peristaltic- pump, which returns the blood in pulsed flow or pulses. This flow can be sensed by Doppler flow sensors or accelerometers (41) as it returns to the patient. If the flow is interrupted by dislodgement of. the venous access needle, or by leaking of blood from the needle, these sensors will detect significantly different flow or vibrations. A controller can then cease therapy, alert a caregiver, or sound an alarm.
摘要翻译：公开了用于监测从诸如血液透析机或单采血浆机的体外治疗机返回患者的血液流动的技术。从这种机器返回的血液通常通过蠕动泵泵送，脉冲泵以脉冲流或脉冲返回血液。多普勒流量传感器或加速度计（41）可以在患者返回时检测该流量。如果流动被中断。静脉入口针或通过从针中泄漏血液，这些传感器将检测出显着不同的流动或振动。然后，控制员可以停止治疗，警惕看护者或发出警报。

5. 发明申请

WO2006014377A3 ELECTRICAL ARCING PROTECTION CIRCUIT 审中-公开
标题翻译：电弧保护电路
公开(公告)号：WO2006014377A3
公开(公告)日：2006-10-05
申请号：PCT/US2005023612
申请日：2005-07-01
申请人： HUDSON RESPIRATORY CARE INC , BOUTON CHAD E , RUGGERI FELICIA R
发明人： BOUTON CHAD E , RUGGERI FELICIA R
IPC分类号： G01R31/08
CPC分类号： H02H1/0015 , A61M16/1095
摘要： A protection circuit (16), configured to detect electrical pre-arcing and arcing conditions in a resistive heater wire circuit (14), comprises a voltage suppressor (18), signal level sensing load (20) coupled to the output of the voltage suppressor (18), control circuitry (22), and a switch (24). The control circuitry (22) is configured to control the operation of the switch (24), coupled between said control circuitry (22) and the heater wire (14), wherein the switch is opened in response to an electrical arcing condition.
摘要翻译：一种保护电路（16），被配置为检测电阻加热器线路电路（14）中的电预加电和电弧状态，包括电压抑制器（18），信号电平感测负载（20），耦合到电压抑制器（18），控制电路（22）和开关（24）。控制电路（22）被配置为控制耦合在所述控制电路（22）和加热器线（14）之间的开关（24）的操作，其中开关响应于电弧状态而被打开。

6. 发明申请

WO2011127469A1 RADIOPHARMACEUTICAL CONCENTRATION MEASUREMENT SYSTEM AND METHOD 审中-公开
标题翻译：放射技术浓度测量系统及方法
公开(公告)号：WO2011127469A1
公开(公告)日：2011-10-13
申请号：PCT/US2011/031949
申请日：2011-04-11
申请人： MEDRAD, INC. , MABIE, Marc, A. , MCCUTCHAN, Larry, A. , BOUTON, Chad, E. , DVORSKY, James, E.
发明人： MABIE, Marc, A. , MCCUTCHAN, Larry, A. , BOUTON, Chad, E. , DVORSKY, James, E.
IPC分类号： A61K51/00 , A61N5/00
CPC分类号： G01T1/167 , G01T1/20 , G01T7/02
摘要： The system for measuring the radioactive concentration of a radiopharmaceutical includes a container, an interrogation region, a radiation detector, a signal capture device and microprocessor system. The interrogation region associated with the container. The radiation detector to focus detecting radiation emitted from the interrogation region. The signal capture device capable of obtaining a radiation measurement of the interrogation region. The microprocessor system in data communication with the signal capture device. The microprocessor system is capable of calculating a radioactive concentration of a radiopharmaceutical emitting radiation contained in the interrogation region from the signal capture device.
摘要翻译：用于测量放射性药物的放射性浓度的系统包括容器，询问区域，辐射检测器，信号捕获装置和微处理器系统。与容器关联的询问区域。用于对来自询问区域的辐射进行聚焦的放射线检测器。能够获得询问区域的辐射测量的信号捕获装置。微处理器系统与信号捕获设备进行数据通信。微处理器系统能够计算从信号捕捉装置发出的询问区域中包含的辐射放射性药物的放射性浓度。

7. 发明申请

WO2013033174A1 EXTRAVASATION AND INFILTRATION DETECTION DEVICE 审中-公开
标题翻译：提取和渗透检测装置
公开(公告)号：WO2013033174A1
公开(公告)日：2013-03-07
申请号：PCT/US2012/052813
申请日：2012-08-29
申请人： BATTELLE MEMORIAL INSTITUTE , BOUTON, Chad, E.
发明人： BOUTON, Chad, E.
IPC分类号： A61B5/05 , A61M5/168 , A61B8/08 , A61B5/00
CPC分类号： A61B5/0507 , A61B5/0022 , A61B5/0537 , A61B5/4839 , A61B5/4875 , A61B5/4878 , A61B5/6824 , A61B5/7203 , A61B5/7246 , A61B5/7282 , A61B8/08 , A61M5/16831 , A61M5/16836 , A61M2205/3317 , F04C2270/041
摘要： An integrated device of a patch and sensor assembly detects extravasation or infiltration. A transmitter is positioned to direct power into a body portion. A sensor is positioned to receive the power transmitted through the body portion. A substrate is attachable to an outer surface of the body portion and supports the transmitter and the sensor. A signal processor is coupled to the transmitter and the sensor for detecting a change in a fluid level in the body portion from extravasation or infiltration based on the power received by the sensor. A power supply is coupled to the transmitter and the sensor. An indicator is responsive to the signal processor to indicate a detected change in a fluid level in the body portion from extravasation or infiltration.
摘要翻译：贴片和传感器组件的集成装置检测外渗或渗透。发射器被定位成将动力引导到身体部分。定位传感器以接收透过身体部分的动力。衬底可附接到主体部分的外表面并支撑发射器和传感器。信号处理器耦合到发射器和传感器，用于基于由传感器接收的功率来检测身体部分中的液体水平从外渗或渗透中的变化。电源耦合到发射器和传感器。指示器响应于信号处理器以指示检测到的身体部分中的流体水平的变化（从外渗或渗透）。

8. 发明申请

WO2013033166A1 WIRELESS AND POWER-SOURCE-FREE EXTRAVASATION AND INFILTRATION DETECTION SENSOR 审中-公开
标题翻译：无线和无源无源扩展和渗透检测传感器
公开(公告)号：WO2013033166A1
公开(公告)日：2013-03-07
申请号：PCT/US2012/052801
申请日：2012-08-29
申请人： BATTELLE MEMORIAL INSTITUTE , BOUTON, Chad, E.
发明人： BOUTON, Chad, E.
IPC分类号： A61B5/05 , A61M5/168
CPC分类号： A61B5/0507 , A61B5/0022 , A61B5/0537 , A61B5/4839 , A61B5/4875 , A61B5/4878 , A61B5/6824 , A61B5/7203 , A61B5/7246 , A61B5/7282 , A61B8/08 , A61M5/16831 , A61M5/16836 , A61M2205/3317 , F04C2270/041
摘要： A system detects extravasation or infiltration by segregating active components that drive a passive sensor for economical single use. A receiving antenna of the passive sensor receives antenna for receiving a transmitted signal comprising RF electromagnetic power. A first circuit transmits a first portion of the received signal through a body portion. A sensor detects a resultant signal from the body portion. A second circuit combines a reference signal comprising a second portion of the received signal with the resultant signal so as to define an output signal. A transmit antenna transmits the output signal to a receiver.
摘要翻译：系统通过隔离驱动无源传感器的有源组件来经济地单次使用来检测外渗或渗透。无源传感器的接收天线接收用于接收包括RF电磁功率的发射信号的天线。第一电路通过主体部分传输接收信号的第一部分。传感器检测来自主体部分的结果信号。第二电路将包括接收信号的第二部分的参考信号与所得到的信号组合，以便定义输出信号。发射天线将输出信号发送到接收机。

9. 发明申请

WO2004078244A1 IMPROVED NOZZLE FOR HANDHELD PULMONARY AEROSOL DELIVERY DEVICE 审中-公开
标题翻译：用于手持式气溶胶输送装置的改进喷嘴
公开(公告)号：WO2004078244A1
公开(公告)日：2004-09-16
申请号：PCT/US2004/005993
申请日：2004-02-26
申请人： VENTAIRA PHARMACEUTICALS, INC. , ATTERBURY, William, G. , BOUTON, Chad, E. , BUSICK, David, R. , DVORSKY, James, E. , GAYDOS, Peter, A. , HOLLEY, David, A. , MEEK, Daniel, D. , TREES, Gregory, A.
发明人： ATTERBURY, William, G. , BOUTON, Chad, E. , BUSICK, David, R. , DVORSKY, James, E. , GAYDOS, Peter, A. , HOLLEY, David, A. , MEEK, Daniel, D. , TREES, Gregory, A.
IPC分类号： A61M15/02
CPC分类号： A61M15/02 , A61M11/001 , B05B1/18 , B05B5/025 , B05B5/03 , B05B5/0533 , B05B5/1691
摘要： An improved Electrohydrodynamic (EHD) nozzle (20a) particularly suitable for a handheld pulmonary aerosol inhaler increases the consistent and efficient dispensing of therapeutic liquids by reducing or eliminating wetting through shielding of discharge electrodes (26). Some versions further eliminate wetting while enhances neutralization of the aerosol through presentation of a corona wind of ions annularly surround the aerosol. Incorporation of improved liquid distribution with consistent pressure drops to each EHD nozzle tip (32) allows horizontal dispensing, and by using dielectric nozzle tips (32) with low surface energy to thereby avoid wicking between dispenses and to advantageously reduce achievable particle size when dispensing. Some versions feature enhanced snap-fit assembly and other manufacturability advantages. One of the unique features of the EHD nozzles (32) is achieved high dose rate (microliters/minute) with low wetting and small particle size (1.0-5 microns), although these properties tend to be mutually exclusive. Furthermore, these attributes are incorporated into a conveniently small, handheld device.
摘要翻译：特别适用于手持式肺部气溶胶吸入器的改进的电动力学（EHD）喷嘴（20a）通过减少或消除通过屏蔽放电电极（26）的润湿来增加治疗液体的一致和有效的分配。一些版本进一步消除了润湿，同时通过环绕环绕气溶胶的离子的电晕放电来增强气溶胶的中和。将具有一致的压降的改进的液体分布结合到每个EHD喷嘴尖端（32）允许水平分配，并且通过使用具有低表面能的介电喷嘴尖端（32），从而避免分配之间的芯吸，并且有利地减少分配时可实现的粒度。某些版本具有增强的卡扣配合和其他可制造性优势。 EHD喷嘴（32）的独特特征之一是实现高剂量率（微升/分钟），具有低润湿和小粒径（1.0-5微米），尽管这些性质倾向于相互排斥。此外，这些属性被并入到便利的小型手持设备中。

10. 发明申请

WO2013012822A1 SYSTEMS, METHODS, AND DEVICES FOR PRODUCING, MANUFACTURING, AND CONTROL OF RADIOPHARMACEUTICALS 审中-公开
标题翻译：用于制造，制造和控制放射线虫的系统，方法和装置
公开(公告)号：WO2013012822A1
公开(公告)日：2013-01-24
申请号：PCT/US2012/046968
申请日：2012-07-16
申请人： CARDINAL HEALTH 414, LLC , ESHIMA, Dennis , HUSNU, Mehmet , STONE, Jim , ALCAIDE, Derrick , PADGETT, Henry , ZAMBANINI, Joseph, E. , KLAUSING, Thomas, A. , BOUTON, Chad, E. , KELLEY, Brian, C. , DANHOF, Scot, N. , HOLLEY, David, A. , STROUP, Jeffery, T. , GLEESON, Jim , HASSENPFLUG, Eric , PRESCOTT, Jim , BENECKE, Herman , GARBARK, Daniel, B.
发明人： ESHIMA, Dennis , HUSNU, Mehmet , STONE, Jim , ALCAIDE, Derrick , PADGETT, Henry , ZAMBANINI, Joseph, E. , KLAUSING, Thomas, A. , BOUTON, Chad, E. , KELLEY, Brian, C. , DANHOF, Scot, N. , HOLLEY, David, A. , STROUP, Jeffery, T. , GLEESON, Jim , HASSENPFLUG, Eric , PRESCOTT, Jim , BENECKE, Herman , GARBARK, Daniel, B.
IPC分类号： G21C1/00
CPC分类号： B01J19/0006 , A61J3/002 , A61K51/0491 , B01J19/004 , B01J19/0046 , B01J2219/00049 , B01J2219/00351 , B01J2219/00355 , B01J2219/00585 , B01J2219/00693 , B01J2219/00702 , B01J2219/0072 , B01J2219/00722 , B01J2219/00759 , B65B1/00 , B65B3/003 , G21G1/10 , G21G2001/0015
摘要： Systems, methods, and devices for generating radionuclides for use in production of radiophamiaceuticals; synthesizing the radionuclides generated and removing any unwanted products; measuring the quantity and activity level of the synthesized radionuclides; distributiveiv delivering the radionuclides in appropriate quantities to modular cassette synthesis units in a modular cassette subsystem for contemporaneous/parallel production of radiopharmaceutical output and that allow reuse and/or quick, safe, and disposable replacement of portions of the subsystem; delivering non-radionuclide components to the modular cassette synthesis units as pari of production of radiopharmaceutical output; measuring the quantity and activity level of each stream of radiopharmaceutical output; purifying the radiopharmaceutical output; dispensing individual doses in sterile vial(s); automatically producing labeling and dose related information; performing automated quality control on extracted samples of produced radiopharmaceutical output; and providing software and hardware controls for overall and sub-portion operation for optional remote data collection, communication, and/or control.
摘要翻译：用于产生用于放射性药物生产的放射性核素的系统，方法和装置; 合成生成的放射性核素并除去任何不需要的产物; 测量合成放射性核素的数量和活度水平; 将放射性核素分配给模块化盒式系统中的模块化盒式合成单元，用于同时/并行生产放射性药物输出，并允许重新使用和/或快速，安全和一次性更换子系统的一部分; 将非放射性核素组分递送到模块化盒式合成单元作为放射性药物输出的生产; 测量每个放射性药物输出流量的数量和活动水平; 净化放射性药物输出; 在无菌小瓶中分配单个剂量; 自动生成标签和剂量相关信息; 对提取的放射性药物输出样品进行自动化质量控制; 并为可选的远程数据收集，通信和/或控制提供用于整体和子部分操作的软件和硬件控制。

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