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1. 发明申请

WO2019067632A1 LIQUID CHROMATOGRAPHIC SEPARATION OF CARBOHYDRATE TAUTOMERS 审中-公开
公开(公告)号：WO2019067632A1
公开(公告)日：2019-04-04
申请号：PCT/US2018/052977
申请日：2018-09-26
申请人： WATERS TECHNOLOGIES CORPORATION
发明人： PHOEBE, Charles H. , PHOEBE, Aaron D.
IPC分类号： B01D15/08 , B01D15/26 , B01J20/283 , B01J20/285 , B01J20/288 , C13K1/00 , C13K5/00 , C13K7/00 , C13K11/00 , C13K13/00
CPC分类号： C07H1/06 , B01D15/08 , B01D15/265 , B01J20/286 , B01J20/288 , B01J20/289 , B01J20/29 , B01J20/3204 , B01J20/3208 , B01J20/3257 , B01J20/3259 , B01J20/3263 , B01J20/3285 , B01J20/3293 , C13K1/00 , C13K5/00 , C13K7/00 , C13K11/00 , C13K13/00 , C13K13/002 , G01N30/482 , G01N30/74 , G01N2030/027
摘要： The present invention provides a novel, simple and reliable method for the separation of carbohydrate tautomers. The method comprises steps of chromatographically separating a sample using a chromatographic device. The method can be used to separate mono- and disaccharides tautomeric species including arabinose, xylose, fructose, mannose, galactose, glucose, lactose, and maltose.

2. 发明申请

WO2016172118A1 POROUS CYCLODEXTRIN POLYMERIC MATERIALS AND METHODS OF MAKING AND USING SAME 审中-公开
标题翻译：多孔环糊精聚合物及其制备方法
公开(公告)号：WO2016172118A1
公开(公告)日：2016-10-27
申请号：PCT/US2016/028304
申请日：2016-04-19
申请人： CORNELL UNIVERSITY
发明人： DICHTEL, William R. , ALSBAIEE, Alaaeddin , SMITH, Brian J. , HINESTROZA, Juan , ALZATE-SANCHEZ, Diego , XIAO, Leilei , LING, Yuhan , HELBLING, Damian
IPC分类号： C08L23/02 , C08L23/26
CPC分类号： B01J20/24 , B01D15/40 , B01D53/025 , B01D2253/202 , B01D2253/306 , B01D2253/308 , B01D2253/31 , B01D2257/708 , B01J20/28033 , B01J20/289 , B01J20/3204 , B01J20/3212 , B01J20/3272 , B01J20/3282 , B01J20/3425 , B01J20/3475 , B01J20/3483 , C02F1/285 , C02F2101/305 , C02F2101/322 , C02F2103/06 , C08B15/00 , C08B37/0012 , G01N30/02 , G01N30/14 , G01N30/30 , G01N30/7206 , G01N30/7233 , G01N33/02 , G01N2030/025 , G01N2030/027
摘要： A nucleophilic substitution reaction to crosslink cyclodextrin (CD) polymer with rigid aromatic groups, providing a high surface area, mesoporous CD-containing polymers (P- CDPs). The P-CDPs can be used for removing organic contaminants from water. By encapsulating pollutants to form well-defined host-guest complexes with complementary selectivities to activated carbon (AC) sorbents. The P-CDPs can rapidly sequester pharmaceuticals, pesticides, and other organic micropollutants, achieving equilibrium binding capacity in seconds with adsorption rate constants 15-200 times greater than ACs and nonporous CD sorbents. The CD polymer can be regenerated several times, through a room temperature washing procedure, with no loss in performance.
摘要翻译：亲核取代反应使具有刚性芳族基团的环糊精（CD）聚合物交联，提供高表面积的介孔含CD聚合物（P-CDP）。 P-CDP可用于从水中去除有机污染物。通过封装污染物以形成具有互补选择性的活性炭（AC）吸附剂的明确定义的主体 - 客体络合物。 P-CDP可快速螯合药物，农药和其他有机微量污染物，达到平均结合能力，秒数，吸附速率常数比AC和无孔CD吸附剂大15-200倍。 CD聚合物可以通过室温洗涤程序再生几次，性能没有损失。

3. 发明申请

WO2015168383A1 FUNCTIONALIZED SUPPORT MATERIAL AND METHODS OF MAKING AND USING FUNCTIONALIZED SUPPORT MATERIAL 审中-公开
标题翻译：功能化支持材料及其制备和使用功能化支持材料的方法
公开(公告)号：WO2015168383A1
公开(公告)日：2015-11-05
申请号：PCT/US2015/028476
申请日：2015-04-30
申请人： W. R. GRACE & CO.-CONN.
发明人： GU, Feng
IPC分类号： B01J20/283 , B01J20/289 , G01N30/02
CPC分类号： B01J20/3272 , B01D15/362 , B01D15/363 , B01J20/289 , B01J20/3204 , B01J20/3219 , B01J39/05 , B01J39/17 , B01J39/26 , B01J41/05 , B01J41/20 , C07K1/18
摘要： Methods of making functionalized support material are disclosed. Functionalized support material suitable for use in chromatography columns or cartridges, such as in a high pressure liquid chromatography (HPLC) column or a fast protein liquid chromatography (FPLC) column, is also disclosed. Chromatography columns or cartridges containing the functionalized support material, and methods of using functionalized support material, such as a media (e.g., chromatographic material) in a chromatography column or cartridge, are also disclosed.
摘要翻译：公开了制备官能化载体材料的方法。还公开了适用于色谱柱或色谱柱的功能化支持材料，例如在高压液相色谱（HPLC）柱或快速蛋白质液相色谱（FPLC）柱中。还公开了色谱柱或含有官能化载体材料的筒，以及使用官能化载体材料的方法，例如色谱柱或筒中的介质（例如色谱材料）。

4. 发明申请

WO2015109068A1 AFFINITY CHROMATOGRAPHY MEDIA AND CHROMATOGRAPHY DEVICES 审中-公开
标题翻译：亲和色谱介质和色谱装置
公开(公告)号：WO2015109068A1
公开(公告)日：2015-07-23
申请号：PCT/US2015/011555
申请日：2015-01-15
申请人： W. R. GRACE & CO.-CONN. , REPLIGEN CORPORATION
发明人： GU, Feng , CHODAVARAPU, Surya Kiran , BOGDANOR, James , MCCREARY, Dennis , PRYOR, James Neil , RUSCHE, James , PEYSER, James , PAULY, Thomas
IPC分类号： B01D15/08 , G01N33/566 , B32B5/16
CPC分类号： B01J20/286 , B01D15/3809 , B01D15/3828 , B01J20/28004 , B01J20/28059 , B01J20/28061 , B01J20/28073 , B01J20/28085 , B01J20/28088 , B01J20/289 , B01J20/3204 , B01J20/3219 , B01J20/3274
摘要： Chromatography media and devices containing chromatography media are disclosed. Methods of making chromatography devices and methods of using chromatography devices containing the chromatography media are also disclosed.
摘要翻译：公开了含有色谱介质的色谱介质和装置。还公开了制备色谱装置的方法和使用含有色谱介质的色谱装置的方法。

5. 发明申请

WO2013134251A3 ANIONIC EXCHANGE-HYDROPHOBIC MIXED MODE 审中-公开
标题翻译：阴离子交换 - 疏水混合模式
公开(公告)号：WO2013134251A3
公开(公告)日：2015-07-02
申请号：PCT/US2013029097
申请日：2013-03-05
申请人： BIO RAD LABORATORIES
发明人： LIAO JIALI , FROST RUSSELL
IPC分类号： B01D15/08 , B01J20/26
CPC分类号： B01J41/20 , B01D15/265 , B01D15/30 , B01D15/327 , B01D15/363 , B01D15/3847 , B01J20/22 , B01J20/267 , B01J20/28016 , B01J20/281 , B01J20/286 , B01J20/288 , B01J20/289 , B01J20/3208 , B01J20/3217 , B01J20/3219 , B01J20/3253 , B01J20/3265 , B01J20/3293 , B01J41/04 , B01J41/09 , B01J2220/52 , C07K1/14 , C07K1/16 , C07K1/165 , C07K16/00 , G01N30/482
摘要： Anion exchange-hydrophobic mixed mode ligands and methods of their use are provided.
摘要翻译：提供阴离子交换疏水混合模式配体及其使用方法。

6. 发明申请

WO2013173501A2 CHROMATOGRAPHIC MATERIALS 审中-公开
标题翻译：色谱材料
公开(公告)号：WO2013173501A2
公开(公告)日：2013-11-21
申请号：PCT/US2013/041221
申请日：2013-05-15
申请人： WATERS TECHNOLOGIES CORPORATION
发明人： WYNDHAM, Kevin, D. , MORRIS, Michael, F. , BROUSMICHE, Darryl, W. , HILL, Jason, F. , FAIRCHILD, Jacob, N.
IPC分类号： B01J20/22
CPC分类号： B01J20/283 , B01D15/26 , B01D15/30 , B01D15/305 , B01D15/322 , B01D15/40 , B01D53/025 , B01J20/22 , B01J20/28004 , B01J20/28016 , B01J20/28042 , B01J20/28057 , B01J20/28059 , B01J20/28061 , B01J20/28064 , B01J20/28066 , B01J20/28069 , B01J20/28071 , B01J20/28073 , B01J20/28076 , B01J20/28078 , B01J20/28083 , B01J20/28085 , B01J20/282 , B01J20/284 , B01J20/285 , B01J20/288 , B01J20/289 , B01J20/3085 , B01J20/32 , B01J20/3204 , B01J20/3206 , B01J20/3208 , B01J20/3234 , B01J20/3246 , B01J20/3285 , B01J20/3293 , B01J2220/54 , B01J2220/80 , C07F7/1836
摘要： In one aspect, the present invention provides a chromatographic stationary phase material for various different modes of chromatography represented by Formula 1:[X](W) a (Q) b (T) c (Formula 1). X can be a high purity chromatographic core composition having a surface comprising a silica core material, metal oxide core material, an inorganic-organic hybrid material or a group of block copolymers thereof. W can be absent and/or can include hydrogen and/or can include a hydroxyl on the surface of X. Q can be a functional group that minimizes retention variation over time (drift) under chromatographic conditions utilizing low water concentrations. T can include one or more hydrophilic, polar, ionizable, and/or charged functional groups that chromatographically interact with the analyte. Additionally, b and c can be positive numbers, with the ratio 0.05 ≤ (b/c) ≤ 100, and a ≥ 0.
摘要翻译：一方面，本发明提供了用于由式1表示的各种不同色谱方式的色谱固定相材料：[X]（W）a（Q）b（T）c（式1）。 X可以是具有包含二氧化硅芯材料，金属氧化物芯材料，无机 - 有机杂化材料或其一组嵌段共聚物的表面的高纯度色谱芯组合物。 W可以不存在和/或可以包括氢和/或可以在X的表面上包括羟基.Q可以是在使用低水浓度的色谱条件下最小化随时间（漂移）的保留变化的官能团。 T可以包括与分析物色谱相互作用的一个或多个亲水性，极性的，可离子化的和/或带电的官能团。另外，b和c可以是正数，0.05 <=（b / c）<= 100，a> = 0。

7. 发明申请

WO2013162449A1 SEPARATION METHOD AND SEPARATION MATRIX 审中-公开
标题翻译：分离方法和分离矩阵
公开(公告)号：WO2013162449A1
公开(公告)日：2013-10-31
申请号：PCT/SE2013/050427
申请日：2013-04-22
申请人： GE HEALTHCARE BIO-SCIENCES AB
发明人： HANSSON, Jesper , RODRIGO, Gustav , SÖDERMAN, Tobias, E.
IPC分类号： B01D15/36 , B01J20/26 , B01J20/289 , B01J39/26 , G01N30/96
CPC分类号： B01J39/26 , B01D15/1864 , B01D15/34 , B01D15/361 , B01D15/362 , B01D15/3809 , B01J20/24 , B01J20/261 , B01J20/265 , B01J20/267 , B01J20/28014 , B01J20/28033 , B01J20/286 , B01J20/289 , B01J20/3085 , B01J20/3212 , B01J20/3278 , B01J20/3282 , B01J2220/80 , C07H1/08 , C07K1/22 , G01N2030/8827 , Y02P20/582
摘要： The invention discloses a method of separating a biomolecule from at least one other component in a liquid, comprising a step of contacting said liquid with a separation matrix comprising a solid support and polymer chains bound to said solid support. The polymer chains comprise units derived from a first monomer of structure CH 2 =CH-L-X, where L is a covalent bond or an alkyl ether or hydroxysubstituted alkyl ether chain comprising 2-6 carbon atoms, and X is a sulfonate or phosphonate group.
摘要翻译：本发明公开了一种从液体中的至少一种其它组分分离生物分子的方法，包括使所述液体与包含固体支持物和与所述固体支持物结合的聚合物链的分离基质接触的步骤。聚合物链包含衍生自结构为CH 2 = CH-L-X的第一单体的单元，其中L为共价键或包含2-6个碳原子的烷基醚或羟基取代的烷基醚链，X为磺酸盐或膦酸酯基团。

8. 发明申请

WO2013117707A1 LIGANDS FOR ANTIBODY AND FC-FUSION PROTEIN PURIFICATION BY AFFINITY CHROMOTOGRAPHY IV 审中-公开
标题翻译：抗生素和FC融合蛋白质纯化的配体通过染色体色谱IV
公开(公告)号：WO2013117707A1
公开(公告)日：2013-08-15
申请号：PCT/EP2013/052564
申请日：2013-02-08
申请人： GRAFFINITY PHARMACEUTICALS GMBH , BITTERMANN, Holger , ARNOLD, Marc , NEUMANN, Thomas , OTT, Inge , SCHMIDT, Kristina , SEKUL, Renate
发明人： BITTERMANN, Holger , ARNOLD, Marc , NEUMANN, Thomas , OTT, Inge , SCHMIDT, Kristina , SEKUL, Renate
IPC分类号： C07K1/22 , B01D15/38 , C07D317/66
CPC分类号： C07K1/22 , B01D15/3804 , B01D15/3809 , B01J20/289 , B01J20/3204 , B01J20/3208 , B01J20/321 , B01J20/3212 , B01J20/3219 , B01J20/3274 , C07D231/56 , C07D403/12 , C07D405/14 , C07D413/12 , C07D417/04 , C07D417/12 , C07D417/14 , C07D513/04 , C07K16/065 , C07K16/1027 , C07K16/22 , C07K16/2863 , C07K16/2866
摘要： The present invention relates to the use, for affinity purification of an antibody or an fragment of an antibody, of a ligand-substituted matrix comprising a support material and at least one ligand covalently bonded to the support material, the ligand being represented by formula (I) L-(Sp) v -Ar 1 -Am-Ar 2 wherein L is the linking point on the support material to which the ligand is attached; Sp is a spacer group; v is 0 or 1; Am is an amide group -NR 1 -C(O)-, and wherein either NR 1 is attached to Ar 1 and -C(O)- is attached to Ar 2 , or -C(O)- is attached to Ar 1 and NR 1 is attached to Ar 2 ; and R 1 is hydrogen or C 1 to C 4 alkyl, more preferably hydrogen or methyl; and most preferably hydrogen; Ar 1 is a 5-, 6- or 7-membered mononuclear aromatic ring or partially saturated aromatic ring connected to Sp or L via a chemical bond and which is optionally furthermore (a) attached to a further 5- or 6-membered mononuclear aromatic ring via a chemical bond; or (b) fused to a mononuclear or binuclear aromatic ring as part of a multinuclear ring system wherein Ar 1 is directly connected to Am via a chemical bond present on the said 5-, 6- or 7- membered aromatic ring constituting Ar 1 , or indirectly via a chemical bond which is either present at the further 5- or 6-membered aromatic ring attached to Ar 1 , or on the further 5- or 6- membered aromatic ring fused to Ar 1 ; and wherein Ar 1 is either not further substituted or attached to at least one substituent selected from C 1 to C 4 alkyl; C 3 and C 4 cycloalkyl; C 2 to C 4 alkenyl;; C 2 to C 4 alkynyl; a halogen; C 1 to C 4 haloalkyl;;; hydroxyl-substituted C 1 to C 4 alkyl; C 1 to C 4 alkoxy; hydroxyl-substituted C 1 to C 4 alkoxy; halogen-substituted C 1 to C 4 alkoxy; C 1 to C 4 alkylamino; C 1 to C 4 alkylthio; -NO 2 ; =O; =S; =NH; -OH?; and combinations thereof; Ar 2 is a 5- or 6-membered mononuclear aromatic ring which is unsubstituted, or via a chemical bond attached to at least one substituent selected from C 1 to C 6 alkyl; C 3 to C 6 cycloalkyl; C 2 to C 6 alkenyl; C 5 and C 6 cycloalkenyl; C 2 to C 6 alkynyl; a halogen; C 1 to C 6 haloalkyl; hydroxyl-substituted C 1 to C 6 alkyl; C 1 to C 6 alkoxy; hydroxyl-substituted C 1 to C 6 alkoxy; halogen-substituted C 1 to C 6 alkoxy; C 1 to C 6 alkylamino; C 1 to C 6 alkylthio; carbamoyl; methylenedioxy; ethylenedioxy; -OH; SH; a 5- or 6-membered mononuclear aromatic ring; and combinations thereof; and wherein Ar 2 optionally, further to the substituents to which it may be attached via a chemical bond as cited above, is fused to a 5- or 6-membered mononuclear aromatic ring as part of a multinuclear ring system.
摘要翻译：本发明涉及用于亲和纯化抗体或抗体片段的配体取代基质，其包括载体材料和至少一种与载体材料共价结合的配体，所述配体由式（ I）L-（Sp）v -Ar1-Am-Ar2其中L是与配体连接的载体材料上的连接点; Sp是间隔基; v为0或1; Am是酰胺基-NR1-C（O） - ，并且其中NR1与Ar1连接，-C（O） - 连接到Ar2上，或-C（O） - 连接到Ar1上，并且NR1连接到 AR2; 并且R 1是氢或C 1至C 4烷基，更优选氢或甲基; 最优选氢; Ar1是通过化学键连接到Sp或L的5-，6-或7-元单核芳环或部分饱和芳环，并且任选地另外（a）连接到另外的5或6元单核芳环上通过化学键; 或（b）与作为多核环体系的一部分的单核或双核芳环稠合，其中Ar1通过存在于构成Ar1的所述5-，6-或7-元芳族环上的化学键或间接直接与Am直接连接通过化学键，其存在于与Ar 1连接的另外的5或6元芳香环上，或存在于与Ar 1稠合的另外的5或6元芳环上; 并且其中Ar1不被进一步取代或连接至至少一个选自C 1至C 4烷基的取代基; C3和C4环烷基; C2至C4烯基; C2至C4炔基; 卤素 C1至C4卤代烷基; 羟基取代的C1至C4烷基; C1至C4烷氧基; 羟基取代的C1至C4烷氧基; 卤素取代的C1至C4烷氧基; C1至C4烷基氨基; C1〜C4烷硫基; NO 2; = O; = S; = NH; -哦？; 及其组合; Ar2是未取代的或通过连接至至少一个选自C 1至C 6烷基的取代基的化学键的5或6元单环芳环; C3至C6环烷基; C2至C6烯基; C5和C6环烯基; C2〜C6炔基; 卤素 C1至C6卤代烷基; 羟基取代的C1至C6烷基; C1至C6烷氧基; 羟基取代的C1至C6烷氧基; 卤素取代的C1至C6烷氧基; C1至C6烷基氨基; C1至C6烷硫基; 氨基甲酰基; 亚甲二氧基; 亚; -哦; SH; 5-或6-元单核芳环; 及其组合; 并且其中Ar2任选地进一步与其所连接的取代基通过如上所述的化学键连接，作为多核环体系的一部分与5或6元单核芳香环稠合。

9. 发明申请

WO2013051715A1 パラジウム分離剤、並びにその製造方法及び用途审中-公开
标题翻译：纸分离剂，其制备方法和使用方法
公开(公告)号：WO2013051715A1
公开(公告)日：2013-04-11
申请号：PCT/JP2012/076026
申请日：2012-10-05
申请人：東ソー株式会社
发明人：須藤　幸徳 , 増田　隆洋 , 吉田　節夫
IPC分类号： C22B11/00 , B01D15/08 , B01J20/281 , B01J20/34 , C02F1/28 , C07C323/60 , C22B3/42
CPC分类号： C22B11/04 , B01D15/08 , B01J20/289 , B01J20/3204 , B01J20/3219 , B01J20/3251 , B01J20/3425 , B01J20/345 , C02F1/004 , C02F1/285 , C02F1/288 , C02F1/42 , C02F1/461 , C02F1/66 , C02F1/683 , C02F1/70 , C02F2101/20 , C02F2303/16 , C07B2200/11 , C07C323/60 , C22B3/42 , Y02P10/234
摘要：　低濃度から高濃度のパラジウムイオンを含有する溶液から短時間で、且つ、高選択率でパラジウムイオンが分離できるパラジウム分離剤、及びパラジウムの分離方法を提供する。　一般式（１）で示される官能基が担体に結合しているパラジウム分離剤を用いる。（式中、Ｒは炭素数１～１８の鎖式炭化水素基、炭素数３～１０の脂環式炭化水素基、炭素数６～１４の芳香族炭化水素基、カルボキシメチル基、又はカルボキシエチル基を表し、ｎは１～４の整数を表す。Ｚはアミド結合を表す。）
摘要翻译：提供：钯分离剂，能够以低浓度至高浓度的钯离子溶液以高选择性在短时间内分离钯离子; 和分离钯的方法。使用通式（1）表示的官能团与载体结合的钯分离剂。（式中，R表示碳原子数1〜18的链状烃基，碳原子数3〜10的脂环式烃基，碳原子数为6〜14的芳香族烃基，羧甲基或羧乙基，n表示 1-4的整数; Z表示酰胺键。）

10. 发明申请

WO2012019134A3 FUNCTIONALIZED CHROMATOGRAPHIC MATERIALS AND METHODS OF MAKING AND USING THEREFOR 审中-公开
标题翻译：功能化的色谱材料及其制备和使用方法
公开(公告)号：WO2012019134A3
公开(公告)日：2012-05-31
申请号：PCT/US2011046810
申请日：2011-08-05
申请人： UNIV BROWN , HUANG YONGSONG , APONTE JOSE C , TAROZO RAFAEL , DILLON JAMES
发明人： HUANG YONGSONG , APONTE JOSE C , TAROZO RAFAEL , DILLON JAMES
IPC分类号： B01J20/282 , B01D15/08 , B01J20/291 , C07C7/12 , G01N30/02
CPC分类号： B01J20/0262 , B01J20/289 , B01J20/291 , B01J20/3204 , B01J20/3208 , B01J20/3219 , B01J20/3236 , B01J2220/62
摘要： Methods, compositions, devices and kits having a novel chromatographic material are provided herein for separating and identifying organic molecules and compounds, for example molecules and compounds containing electron rich functional groups such as carbon-carbon double bonds. The methods, compositions, and kits include a metal-thiolate chromatographic medium (MTCM) with a sulfur-containing functional group or a metal-selenolate chromatographic medium (MSCM) comprising a selenium-containing functional group covalently attached to a support medium, such that the sulfur-containing functional group or selenium-containing functional group is bound to at least one metal atom. The MTCM and/or MSCM has affinity and specificity to compounds having one or more carbon-carbon double bonds, and performs a highly efficient and rapid separation of samples yielding non-overlapping peaks of purified materials compared to traditional media.
摘要翻译：本文提供了具有新型色谱材料的方法，组合物，装置和试剂盒，用于分离和鉴定有机分子和化合物，例如含有富含电子的官能团如碳 - 碳双键的分子和化合物。方法，组合物和试剂盒包括含有含硫官能团的金属硫醇盐色谱介质（MTCM）或含有共价连接到载体介质上的含硒官能团的金属硒酸盐层析介质（MSCM），使得含硫官能团或含硒官能团与至少一个金属原子结合。 MTCM和/或MSCM对具有一个或多个碳 - 碳双键的化合物具有亲和性和特异性，并且与传统介质相比，能够实现产生非重叠的纯化材料峰的样品的高效快速分离。

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