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1. 发明申请

WO2006078759A3 MODULATED OPTICAL TWEEZERS 审中-公开
标题翻译：调制光学仪器
公开(公告)号：WO2006078759A3
公开(公告)日：2006-12-21
申请号：PCT/US2006001806
申请日：2006-01-19
申请人： UNIV NEW YORK , GRIER DAVID G
发明人： GRIER DAVID G
IPC分类号： G21K1/00 , G03H1/08
CPC分类号： B01L3/502761 , B01L3/502715 , B01L2200/0636 , B01L2200/0647 , B01L2300/0864 , B01L2400/0454 , G01N30/00 , G01N30/02 , G01N2015/0288 , G03H1/0808 , G03H2001/0077 , G03H2001/0816 , G03H2210/30 , B01D2015/3895
摘要： A method and apparatus for selecting a specific fraction from a heterogeneous fluid-borne sample using optical gradient forces in a microfluidic or fluidic system are presented. Samples may range in size from a few nanometers to at least tens of micrometers, may be dispersed in any fluid medium transported from input channels (410) to output channels (430), and may be sorted on the basis of size, shape, optical characteristics, charge, and other physical properties. The selection process involves passive transport through optical intensity field - an array of optical traps or optical tweezers driven by flowing fluid, and so offers several advantages over competing techniques. These include continuous rather than batch-mode operation, continuous and dynamic tunability, operation over a wide range of samples, compactness, and low cost.
摘要翻译：提出了一种用于在微流体或流体系统中使用光学梯度力从异质流体样品中选择特定部分的方法和装置。样品的尺寸范围可以从几纳米到至少几十微米，可以分散在从输入通道（410）输送到输出通道（430）的任何流体介质中，并且可以基于尺寸，形状，光学特性，电荷等物理性质。选择过程包括通过光强度场的被动传输 - 由流动流体驱动的光学陷阱或光学镊子阵列，因此与竞争技术相比提供了几个优点。这些包括连续而不是批模式操作，连续和动态可调性，在各种样品中的操作，紧凑性和低成本。

2. 发明申请

WO1989005973A1 SENSORS FOR DISSOLVED SUBSTANCES IN FLUIDS 审中-公开
标题翻译：流体中溶解物质的传感器
公开(公告)号：WO1989005973A1
公开(公告)日：1989-06-29
申请号：PCT/US1988004275
申请日：1988-12-01
申请人： BIO-RECOVERY SYSTEMS, INC.
发明人： BIO-RECOVERY SYSTEMS, INC. , BEDELL, Glenn, W. , GREENE, Benjamin , DAVIS, Marion , ABBOTT, Floyd, J.
IPC分类号： G01N21/85
CPC分类号： G01N21/85 , G01N30/02 , G01N30/6082 , G01N30/74 , G01N2021/1738 , G01N2021/8405 , B01D2015/3895
摘要： The present invention comprises a simple multipurpose on-line system (150) for monitoring the concentration and/or the total amount of an organic analyte species or inorganic analyte species in an aqueous solution. The on-line detection system (150) comprises a detection column (103) and a sensor (104) mounted around the detection column (103). The sensor (104) consists of an electomagnetic radiation source (210) (typically a light source) and an appropriate detector (240) for the electromagnetic radiation. The response from the detector (240) drives an electric circuit (302), which provides a signal to a recorder as well as a means to trip an alarm system and/or a process system.

3. 发明申请

WO2003062867A2 METHODS AND APPARATUS FOR GENERATING AND UTILIZING LINEAR MOVING OPTICAL GRADIENTS 审中-公开
标题翻译：用于生成和使用线性运动光学等级的方法和装置
公开(公告)号：WO2003062867A2
公开(公告)日：2003-07-31
申请号：PCT/US2003/000340
申请日：2003-01-06
申请人： GENOPTIX, INC. , ZHANG, Haichuan
发明人： ZHANG, Haichuan
IPC分类号： G02B
CPC分类号： C12N5/0087 , B03C1/00 , B03C5/00 , B03C2201/18 , B03C2201/26 , C12N5/0093 , G01N30/00 , G01N30/02 , G01N2015/0073 , G01N2015/008 , G01N2015/144 , G01N2015/1486 , G01N2015/149 , H05H3/04 , B01D2015/3895
摘要： Apparatus and methods are provided for interacting light with particles, including but not limited to biological matter such as cells, in unique and highly useful ways. Optophoresis consists of subjecting particles to various optical forces, especially optical gradient forces, and more particularly moving optical gradient forces, so as to obtain useful results. In one implementation, a population of particles, comprising two or more differing particles, e.g., red blood cells and white blood cells, are illuminated by a line of light which is moved slowly relative to the particle population. The particles are moved with the line until the population is aligned. Next, the line of particles is subject to relative motion of light relative to the particles, such as by rapidly moving the line of illumination relative to the physical position of the particles. By moving the line away from the particles at a rate great enough that certain particles remain behind, effective separation, characterization and/or identification of the particles may be made. Optionally, the direction of the low initial scan is in a direction opposition to the more rapid scan after the particles have been aligned.
摘要翻译：提供了用于以独特且非常有用的方式将光与颗粒（包括但不限于生物物质如细胞）相互作用的装置和方法。电渗疗法包括使颗粒经受各种光学力，特别是光学梯度力，尤其是移动的光学梯度力，从而获得有用的结果。在一个实施方案中，包含两个或更多个不同颗粒（例如红细胞和白细胞）的颗粒群体被相对于颗粒群体缓慢移动的光线照射。颗粒与线一起移动，直到群体对齐。接下来，颗粒线相对于颗粒进行光的相对运动，例如通过相对于颗粒的物理位置快速移动照明线。通过以足够大的速度将线移离颗粒，使得某些颗粒保留在后面，可以进行有效的分离，表征和/或识别颗粒。可选地，低的初始扫描的方向是在颗粒对准之后与更快速扫描相反的方向。

4. 发明申请

WO2003024163A1 APPARATUS AND PROCESS FOR THE LATERAL DEFLECTION AND SEPARATION OF FLOWING PARTICLES BY A STATIC ARRAY OF OPTICAL TWEEZERS 审中-公开
标题翻译：通过光学平台的静态阵列分离流动颗粒的方法和方法
公开(公告)号：WO2003024163A1
公开(公告)日：2003-03-20
申请号：PCT/US2002/028819
申请日：2002-09-11
申请人： UNIVERSITY OF CHICAGO
发明人： GRIER, David, G. , KORDA, Pamela, T.
IPC分类号： H05H3/04
CPC分类号： G01N30/00 , G01N30/02 , G01N2015/149 , G03H2001/0077 , B01D2015/3895
摘要： A method and apparatus for laterally deflecting and/or separating a flow of particles using a static array of optical tweezers. In an array of optical tweezers with a lattice constant larger than the size of a particle of interest, particles driven past the array by an external force experience an additional interaction with the array of traps. By altering the angle of the array of traps relative to the external force, the particles' movement from trap to trap inside the array can be biased away from the direction of the external force, thereby enabling selective deflection and/or separation of particles.
摘要翻译：一种使用光学镊子的静态阵列横向偏转和/或分离颗粒流的方法和装置。在具有大于感兴趣的粒子的大小的晶格常数的光学镊子的阵列中，通过外力驱动通过阵列的颗粒经历与陷阱阵列的额外的相互作用。通过改变陷阱阵列相对于外力的角度，颗粒从阵列内的陷阱到陷阱的移动可以被偏离远离外力的方向，从而使得能够选择性地偏转和/或分离颗粒。

5. 发明申请

WO0239104B1 SYSTEM AND METHOD FOR SEPARATING MICRO-PARTICLES 审中-公开
标题翻译：用于分离微粒子的系统和方法
公开(公告)号：WO0239104B1
公开(公告)日：2002-08-01
申请号：PCT/US0147421
申请日：2001-11-09
申请人： GENOPTIX INC
发明人： KIBAR OSMAN
IPC分类号： B82B3/00 , B01J19/12 , B03B13/02 , G01N15/14 , G01N30/00 , G01N30/02 , H05H3/04
CPC分类号： H05H3/04 , G01N30/00 , G01N30/02 , G01N2015/149 , B01D2015/3895
摘要： A system and method for separating particles is disclosed in which the particles are exposed to a moving light intensity pattern which causes the particles to move a different velocities based on the physical properties of the particles. This system and method allows particles of similar size and shape to be separated based on differences in the particles dielectric properties.
摘要翻译：公开了一种用于分离颗粒的系统和方法，其中颗粒暴露于移动的光强度图案，其使颗粒基于颗粒的物理性质移动不同的速度。该系统和方法允许基于颗粒介电性质的差异来分离类似尺寸和形状的颗粒。

6. 发明申请

WO2004100175A1 FRACTIONATION OF PARTICLES 审中-公开
标题翻译：颗粒的分离
公开(公告)号：WO2004100175A1
公开(公告)日：2004-11-18
申请号：PCT/GB2004/001993
申请日：2004-05-07
申请人： THE UNIVERSITY COURT OF THE UNIVERSITY OF ST ANDREWS , MACDONALD, Michael, Peter , DHOLAKIA, Kishan , NEALE, Steven, Leonard , SPALDING, Gabriel, Cooper
发明人： MACDONALD, Michael, Peter , DHOLAKIA, Kishan , NEALE, Steven, Leonard , SPALDING, Gabriel, Cooper
IPC分类号： G21K1/00
CPC分类号： B01L3/502753 , B01L3/502761 , B01L2200/0647 , B01L2300/0864 , B01L2400/0454 , G01N15/1434 , G01N15/1459 , G01N2015/145 , G01N2015/149 , G01N30/02 , B01D2015/3895
摘要： A fractionation system comprising means for forming a three dimensional optical lattice that is operable to separate particles that have different physical characteristics. Preferably, the wells of the optical lattice are interlinked. For example, the wells may be linked in such a manner as to provide deflection greater than or equal to 15 degrees.
摘要翻译：分级系统包括用于形成三维光学晶格的装置，其可操作以分离具有不同物理特性的颗粒。优选地，光栅的阱是相互连接的。例如，孔可以以提供大于或等于15度的偏转的方式连接。

7. 发明申请

WO02087792A8 METHODS AND APPARATUS FOR USE OF OPTICAL FORCES FOR IDENTIFICATION, CHARACTERIZATION AND/OR SORTING OF PARTICLES 审中-公开
标题翻译：用于识别，表征和/或分配颗粒的光学强度的方法和装置
公开(公告)号：WO02087792A8
公开(公告)日：2003-11-20
申请号：PCT/US0151001
申请日：2001-11-09
申请人： GENOPTIX INC , WANG MARK M , TU EUGENE , PESTANA LUIS M , SENYEI ANFREW E , O'CONNELL JAMES P , NOVA TINA S , LYKSTAD KRISTIE L , HALL JEFFREY M , BUTLER WILLIAM F
发明人： WANG MARK M , TU EUGENE , PESTANA LUIS M , SENYEI ANFREW E , O'CONNELL JAMES P , NOVA TINA S , LYKSTAD KRISTIE L , HALL JEFFREY M , BUTLER WILLIAM F
IPC分类号： G01N15/00 , B07C5/34 , C12Q1/04 , G01N15/14 , G01N30/02 , G21K1/00 , B07C5/02
CPC分类号： G01N15/1463 , B07C5/34 , G01N15/1459 , G01N30/02 , G01N2015/1486 , G01N2015/149 , H05H3/04 , B01D2015/3895
摘要： Apparatus and methods are provided for interacting light with particles, including but not limited to biological matter such as cells in unique and highly useful ways. Optophoresis consists of subjecting particles to various optical forces, especially optical gradient forces, and more particularly moving optical gradient forces, so as to obtain useful results. In biology, this technology represents a practical approach to probing the inner workings of a living cell, preferably without any dyes, labels or other markers. In one aspect, a particle may be characterized by determining its optophoretic constant or signature. For example, a diseased cell has a different optophoretic constant from a healthy cell, thereby providing information, or the basis for sorting. In the event of physical sorting, various forces may be used for separation, including fluidic forces, such as through the use of laminar flow, or optical forces, or mechanical forces, such as through adhesion. Various techniques for measuring the dielectric constant of particles are provided.
摘要翻译：提供了用于使光与颗粒相互作用的装置和方法，包括但不限于生物物质如细胞，其独特且非常有用的方式。电渗疗法包括使颗粒经受各种光学力，特别是光学梯度力，尤其是移动的光学梯度力，从而获得有用的结果。在生物学中，该技术是探测活细胞内部运作的实际方法，优选没有任何染料，标签或其他标记物。在一个方面，粒子的特征可以在于确定其荧光特性常数或特征。例如，患病细胞与健康细胞具有不同的视觉波动常数，从而提供信息或分选的基础。在物理分选的情况下，各种力可以用于分离，包括流体力，例如通过使用层流，或光学力，或机械力，例如通过粘附。提供了用于测量颗粒的介电常数的各种技术。

8. 发明申请

WO2002089496A2 EYEWEAR WITH EXCHANGEABLE TEMPLES HOUSING BLUETOOTH ENABLED APPARATUS 审中-公开
标题翻译：具有可交换路线的眼镜外壳蓝牙启用装置
公开(公告)号：WO2002089496A2
公开(公告)日：2002-11-07
申请号：PCT/US2002/013681
申请日：2002-04-29
申请人： QR SPEX, INC. , SWAB, Gregory , GREAVES, Mikal , MILESI, Rolf , LIGTENBERG, Christiaan , MEIER, Thomas , MALACKOWSKI, James, E.
发明人： SWAB, Gregory , GREAVES, Mikal , MILESI, Rolf , LIGTENBERG, Christiaan , MEIER, Thomas , MALACKOWSKI, James, E.
IPC分类号： H04Q
CPC分类号： G02C11/10 , G01N30/02 , G02C5/146 , G02C5/22 , G06F1/163 , H04W4/80 , H04W52/248 , H04W56/0015 , H04W84/18 , Y10T16/526 , B01D2015/3895
摘要： A wireless and hoc pico network is formed by eyewear and other devices sucha as a computer, a bracelet and a telephone having similar transceivers mounted on them. Master slave relationships are configurable. Other devices, such as a radio, a CD plaxer, a hand held global positioning satellite system and a heart rate monitor, having similar transceivers, can also be connected with the transceiver of the eyewear. The transceivers operate on globally available, unlicensed radio band, 2.45 gigahertz (GHz) and conforms to the Bluetooth standard. The power consumption of Bluetooth enabled devices is less than three percent of the power consumption of a mobile phone. The eyewear includes a frame and connected to the frame are two temples. Temples are connected to frame via hinges. Temples have a male portion of a connector incorporated in them. Female portion of the connector is made integral with the hinges. When the male portion is inserted in the female portion the temple is attached to the frame. The temples can be removed by pulling the connector apart, and a temple with different apparatus within it can be inserted in place of the removed temples. The temple may have co-molded within its body, an apparatus such as an audio device, a camera, a speaker, and a microphone, and a display device such as liquid crystal or an alarm. In another embodiment, eyewear constitutes a distance alarm to monitor the movement o, for example, a child. A device in form of, for example, a bracelet is worn by the child. The transceivers in the eyewear and the bracelet form a small-range wireless network, i.e., piconet, wherein the eyewear and the bracelet communicate using signals conforming to the Bluetooth technology. The transceiver in the eyewear is configured to generate an alarm when the bracelet exceeds a predetermined distance from eyewear.
摘要翻译：无线和hoc微微网络由眼镜和其他设备形成，例如计算机，手镯和具有安装在其上的类似收发器的电话。主从关系是可配置的。也可以与眼镜的收发器连接具有类似的收发器的其它设备，例如无线电，CD扩展器，手持式全球定位卫星系统和心率监测器。收发器在全球可用的无符号无线电频段（2.45千兆赫兹（GHz））上运行，符合蓝牙标准。蓝牙设备的功耗小于手机功耗的3％。眼镜包括框架并连接到框架上是两个寺庙。寺庙通过铰链连接到框架。寺庙具有并入其中的连接器的阳性部分。连接器的母头部分与铰链成一体。当阳部插入阴部时，镜腿与框架相连。可以通过将连接器分开拉出来去除镜腿，并且可以插入具有不同装置的镜腿以代替去除的镜腿。镜子可以在其主体内共模塑，诸如音频设备，照相机，扬声器和麦克风之类的装置，以及诸如液晶或报警器的显示装置。在另一个实施例中，眼镜构成监视例如儿童的运动的距离警报。例如，手镯的形式的装置由小孩佩戴。眼镜和手镯中的收发器形成小范围无线网络，即微微网，其中眼镜和手镯使用符合蓝牙技术的信号进行通信。眼镜上的收发器配置为当手链超过眼镜预定距离时产生报警。

9. 发明申请

WO2002087792A1 METHODS AND APPARATUS FOR USE OF OPTICAL FORCES FOR IDENTIFICATION, CHARACTERIZATION AND/OR SORTING OF PARTICLES 审中-公开
标题翻译：用于识别，表征和/或分配颗粒的光学强度的方法和装置
公开(公告)号：WO2002087792A1
公开(公告)日：2002-11-07
申请号：PCT/US2001/051001
申请日：2001-11-09
申请人： GENOPTIX, INC. , WANG, Mark, M. , TU, Eugene , PESTANA, Luis, M. , SENYEI, Anfrew, E. , O'CONNELL, James, P.
发明人： WANG, Mark, M. , TU, Eugene , PESTANA, Luis, M. , SENYEI, Anfrew, E. , O'CONNELL, James, P.
IPC分类号： B07C5/02
CPC分类号： G01N15/1463 , B07C5/34 , G01N15/1459 , G01N30/02 , G01N2015/1486 , G01N2015/149 , H05H3/04 , B01D2015/3895
摘要： Apparatus and methods are provided for interacting light with particles, including but not limited to biological matter such as cells in unique and highly useful ways. Optophoresis consists of subjecting particles to various optical forces, especially optical gradient forces, and more particularly moving optical gradient forces, so as to obtain useful results. In biology, this technology represents a practical approach to probing the inner workings of a living cell, preferably without any dyes, labels or other markers. In one aspect, a particle may be characterized by determining its optophoretic constant or signature. For example, a diseased cell has a different optophoretic constant from a healthy cell, thereby providing information, or the basis for sorting. In the event of physical sorting, various forces may be used for separation, including fluidic forces, such as through the use of laminar flow, or optical forces, or mechanical forces, such as through adhesion. Various techniques for measuring the dielectric constant of particles are provided.
摘要翻译：提供了用于使光与颗粒相互作用的装置和方法，包括但不限于生物物质如细胞，其独特且非常有用的方式。电渗疗法包括使颗粒经受各种光学力，特别是光学梯度力，尤其是移动的光学梯度力，从而获得有用的结果。在生物学中，该技术是探测活细胞内部运作的实际方法，优选没有任何染料，标签或其他标记物。在一个方面，粒子的特征可以在于确定其荧光特性常数或特征。例如，患病细胞与健康细胞具有不同的视觉波动常数，从而提供信息或分选的基础。在物理分选的情况下，各种力可以用于分离，包括流体力，例如通过使用层流，或光学力，或机械力，例如通过粘附。提供了用于测量颗粒的介电常数的各种技术。

10. 发明申请

WO2006078759A2 MODULATED OPTICAL TWEEZERS 审中-公开
标题翻译：调制光学仪器
公开(公告)号：WO2006078759A2
公开(公告)日：2006-07-27
申请号：PCT/US2006/001806
申请日：2006-01-19
申请人： NEW YORK UNIVERSITY , GRIER, David G.
发明人： GRIER, David G.
IPC分类号： G21K1/00
CPC分类号： B01L3/502761 , B01L3/502715 , B01L2200/0636 , B01L2200/0647 , B01L2300/0864 , B01L2400/0454 , G01N30/00 , G01N30/02 , G01N2015/0288 , G03H1/0808 , G03H2001/0077 , G03H2001/0816 , G03H2210/30 , B01D2015/3895
摘要： A method and apparatus for selecting a specific fraction from a heterogeneous fluid-borne sample using optical gradient forces in a microfluidic or fluidic system are presented. Samples may range in size from a few nanometers to at least tens of micrometers, may be dispersed in any fluid medium, and may be sorted on the basis of size, shape, optical characteristics, charge, and other physical properties. The selection process involves passive transport through optical intensity field driven by flowing fluid, and so offers several advantages over competing techniques. These include continuous rather than batch-mode operation, continuous and dynamic tunability, operation over a wide range of samples, compactness, and low cost.
摘要翻译：提出了一种用于在微流体或流体系统中使用光学梯度力从异质流体样品中选择特定部分的方法和装置。样品的尺寸可以从几纳米至至少几十微米，可以分散在任何流体介质中，并且可以基于尺寸，形状，光学特性，电荷和其它物理性质进行分类。选择过程涉及通过由流动流体驱动的光强度场的被动传输，因此提供了优于竞争技术的几个优点。这些包括连续而不是批模式操作，连续和动态可调性，在各种样品中的操作，紧凑性和低成本。

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