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1. 发明申请

WO2008127410A3 HOLOGRAPHIC MICROFABRICATION AND CHARACTERIZATION SYSTEM FOR SOFT MATTER AND BIOLOGICAL SYSTEMS 审中-公开
标题翻译：软件和生物系统的全息微型化和特征化系统
公开(公告)号：WO2008127410A3
公开(公告)日：2009-08-20
申请号：PCT/US2007083823
申请日：2007-11-06
申请人： UNIV NEW YORK , GRIER DAVID G
发明人： GRIER DAVID G
IPC分类号： G21K1/00 , G02B21/32 , G03H1/18
CPC分类号： G02B21/32 , G02B5/001 , G02B5/32 , G03H1/08 , G03H1/2294 , G03H2001/0077
摘要： A method and system for micromanipulation of objects of any shape. The method and system creates various forms of holographic optical traps for a variety of commercial purposes. Some alternate forms of traps include a dark form of optical traps, optical vortices with different helical winding numbers and optical traps with variable phase profiles imprinted thereon.
摘要翻译：用于显微操作任何形状的物体的方法和系统。该方法和系统为各种商业目的创建各种形式的全息光学阱。陷阱的一些替代形式包括暗形式的光学陷阱，具有不同螺旋线圈数的光学旋涡和其上印刷有可变相位轮廓的光学陷阱。

2. 发明申请

WO2008092107B1 HOLOGRAPHIC MICROSCOPE SYSTEM AND METHOD FOR OPTICAL TRAPPING AND INSPECTION OF MATERIALS 审中-公开
标题翻译：全息显微镜系统及材料光学跟踪检测方法
公开(公告)号：WO2008092107B1
公开(公告)日：2008-11-06
申请号：PCT/US2008052098
申请日：2008-01-25
申请人： UNIV NEW YORK , LEE SANG-HYUK , GRIER DAVID G
发明人： LEE SANG-HYUK , GRIER DAVID G
IPC分类号： G21K1/00 , G01B9/021 , G02B21/32
CPC分类号： G03H1/0005 , G01B9/021 , G02B21/0088 , G02B21/32 , G03H1/0443 , G03H1/0866 , G03H1/2294 , G03H2001/0033 , G03H2001/0077 , G03H2001/0447 , Y10S359/902
摘要： A method and system for performing three-dimensional holographic microscopy of an optically trapped structure. The method and system use an inverted optical microscope, a laser source which generates a trapping laser beam wherein the laser beam is focused by an objective lens into a plurality of optical traps. The method and system also use a collimated laser at an imaging wavelength to illuminate the structure created by the optical traps. Imaging light scattered by the optically trapped structure forms holograms that are imaged by a video camera and analyzed by optical formalisms to determine light field to reconstruct 3-D images for analysis and evaluation.
摘要翻译：用于执行光学捕获结构的三维全息显微镜的方法和系统。该方法和系统使用倒置的光学显微镜，产生捕获激光束的激光源，其中激光束被物镜聚焦成多个光阱。该方法和系统还使用成像波长处的准直激光来照亮由光阱产生的结构。通过光学捕获结构散射的成像光形成由摄像机成像的全息图，并通过光学形式来分析以确定光场以重建用于分析和评估的3-D图像。

3. 发明申请

WO2005089437A2 SYSTEM AND METHOD FOR MANIPULATING AND PROCESSING MATERIALS USING HOLOGRAPHIC OPTICAL TRAPPING 审中-公开
标题翻译：使用全息光学跟踪处理和处理材料的系统和方法
公开(公告)号：WO2005089437A2
公开(公告)日：2005-09-29
申请号：PCT/US2005/008934
申请日：2005-03-17
申请人： ARRYX, INC. , PLEWA, Joseph , TANNER, Evan , MUETH, Dan , GRUBER, Lewis , BRADLEY, Kenneth
发明人： PLEWA, Joseph , TANNER, Evan , MUETH, Dan , GRUBER, Lewis , BRADLEY, Kenneth
IPC分类号： G21K1/00 , H05H3/04
CPC分类号： B82Y20/00 , B82Y10/00 , G03H1/08 , G03H1/2294 , G03H2001/0077 , G03H2225/32
摘要： A method and apparatus for manipulating particles (micro, nano, and pico) having one or more characteristics with an optical trap formed by modulating a laser beam with a Diffractive Optical Element (DOE). At least one characteristic of the material is selected; and a laser beam having a selected wavelength corresponding to the at least one selected characteristic of the material is generated. Values of the DOE are calculated corresponding to the least one selected characteristic of the material. The beam and the DOE are modulated to produce a holographic optical trap having properties corresponding to the at least one selected characteristic; the trap is focused to a beam focus or selected spot size; and the beam focus is located near a particle location for trapping the particle therein.
摘要翻译：一种用于通过用衍射光学元件（DOE）调制激光束而形成的光阱来操纵具有一个或多个特性的微粒（微，纳米和微微）的方法和装置。选择材料的至少一种特性; 并且产生具有与材料的至少一个所选特征对应的选定波长的激光束。根据材料的至少一个选定特征计算DOE的值。光束和DOE被调制以产生具有对应于至少一个所选特征的性质的全息光阱; 陷阱聚焦到光束焦点或选定的光斑尺寸; 并且束聚焦位于颗粒位置附近以将颗粒捕获在其中。

4. 发明申请

WO2004097844A3 APPARATUS FOR HANDLING MINUTE OBJECT 审中-公开
标题翻译：用于处理MINUTE对象的装置
公开(公告)号：WO2004097844A3
公开(公告)日：2005-02-24
申请号：PCT/JP2004005550
申请日：2004-04-19
申请人： CANON KK , MAEHARA HIROSHI
发明人： MAEHARA HIROSHI
IPC分类号： G02B5/32 , B25J7/00 , C12M1/00 , C12M1/42 , G02B21/34 , G03H1/18 , G21K1/00
CPC分类号： G03H1/0005 , G03H1/0244 , G03H1/2205 , G03H2001/0077 , G03H2001/0478 , G03H2001/085 , G03H2001/221 , G03H2210/55
摘要： An apparatus for handling a minute object such as a cell by using a holographic optical tweezers that comprises a laser light source 1, holographic plate 3 having a specified pattern to form a hologram with light emitted from the light source, and a transparent plate that holds a liquid including a minute object, wherein the holographic plate 3 is irradiated with laser light emitted from the laser light source 1, and the laser light passed through the holographic plate 3 is focused in a sample solution 7 held on the transparent plate 6 to form a hologram having a pattern according to the pattern of the holographic plate 3 in the sample solution 7.
摘要翻译：一种用于通过使用全息光学镊子来处理诸如单元的微小物体的装置，其包括激光光源1，具有指定图案的全息板3，以从光源发射的光形成全息图;以及透明板，其保持包含微小物体的液体，其中，从激光光源1发射的激光照射全息板3，并且穿过全息板3的激光聚焦在保持在透明板6上的样品溶液7中，以形成具有根据样品溶液7中的全息板3的图案的图案的全息图。

5. 发明申请

WO2004097844A2 APPARATUS FOR HANDLING MINUTE OBJECT 审中-公开
标题翻译：用于处理MINUTE对象的装置
公开(公告)号：WO2004097844A2
公开(公告)日：2004-11-11
申请号：PCT/JP2004/005550
申请日：2004-04-19
申请人： CANON KABUSHIKI KAISHA , MAEHARA, Hiroshi
发明人： MAEHARA, Hiroshi
IPC分类号： G21K1/00
CPC分类号： G03H1/0005 , G03H1/0244 , G03H1/2205 , G03H2001/0077 , G03H2001/0478 , G03H2001/085 , G03H2001/221 , G03H2210/55
摘要： An apparatus for handling a minute object such as a cell by using a holographic optical tweezers that comprises a laser light source 1, holographic plate 3 having a specified pattern to form a hologram with light emitted from the light source, and a transparent plate that holds a liquid including a minute object, wherein the holographic plate 3 is irradiated with laser light emitted from the laser light source 1, and the laser light passed through the holographic plate 3 is focused in a sample solution 7 held on the transparent plate 6 to form a hologram having a pattern according to the pattern of the holographic plate 3 in the sample solution 7.
摘要翻译：一种用于通过使用包括激光光源1，具有指定图案的全息板3与从光源发射的光形成全息图的全息光学镊子来处理诸如单元的微小物体的装置，以及保持包含微小物体的液体，其中从激光光源1发射的激光照射全息板3，并且通过全息板3的激光聚焦在保持在透明板6上的样品溶液7中，以形成具有根据样品溶液7中的全息板3的图案的图案的全息图。

6. 发明申请

WO2004012133A9 SYSTEM AND METHOD OF SORTING MATERIALS USING HOLOGRAPHIC LASER STEERING 审中-公开
标题翻译：使用全息激光转向分选材料的系统和方法
公开(公告)号：WO2004012133A9
公开(公告)日：2004-04-29
申请号：PCT/US0323822
申请日：2003-07-31
申请人： ARRYX INC , GRUBER LEWIS , BRADLEY KENNETH , LOPES WARD , LANCELOT ROBERT W , PLEWA JOSEPH S , GRIER DAVID
发明人： GRUBER LEWIS , BRADLEY KENNETH , LOPES WARD , LANCELOT ROBERT W , PLEWA JOSEPH S , GRIER DAVID
IPC分类号： B01L3/00 , G01N15/14 , G01N30/00 , G01N30/02 , G21K1/00 , G06K
CPC分类号： G01N15/1459 , B01L3/5027 , G01N2015/149 , G02B21/32 , G03H1/08 , G03H1/2294 , G03H2001/0077 , G03H2001/085 , G03H2225/32 , H05H3/04
摘要： The present invention employs a beam steering apparatus to isolate valuable cells from others cells, tissues, and contaminants. In one embodiment, the system balances optical trapping agains flow to parallelize cell sorting under the flexible control of computer program-directed traps which differentially manipulate cells based on their composition or labels to direct separation.
摘要翻译：本发明采用光束转向装置来从其它细胞，组织和污染物中分离有价值的细胞。在一个实施例中，系统平衡光学捕获流程，以在计算机程序导向的陷阱的灵活控制下平行化细胞分选，其基于它们的组成或标签差异地操纵细胞以引导分离。

7. 发明申请

WO2017097417A1 APPARATUS AND METHOD FOR CREATING A HOLOGRAPHIC ULTRASOUND FIELD IN AN OBJECT 审中-公开
公开(公告)号：WO2017097417A1
公开(公告)日：2017-06-15
申请号：PCT/EP2016/002062
申请日：2016-12-07
申请人： MAX-PLANCK-GESELLSCHAFT ZUR FÖRDERUNG DER FÖRDERUNG DER WISSENSCHAFTEN E. V. , FRAUNHOFER-GESELLSCHAFT ZUR FORDERUNG DER ANGEWANDTEN FORSCHUNG E. V.
发明人： MELDE, Kai , FISCHER, Peer , WEBER, Peter-Karl
IPC分类号： G03H1/04 , G03H1/08 , A61N7/00 , G01N29/06 , G03H1/02 , G03H3/00
CPC分类号： G03H1/0891 , A61B17/22012 , A61B90/90 , A61B90/98 , A61N7/02 , A61N7/022 , A61N2007/0056 , A61N2007/006 , A61N2007/0078 , G01N29/0663 , G01N29/2418 , G03H1/0244 , G03H1/0256 , G03H1/0476 , G03H3/00 , G03H2001/0077 , G03H2001/0094 , G03H2001/0484 , G03H2001/0816 , G03H2001/2234 , G03H2210/36 , G03H2210/63 , G03H2223/25 , G03H2227/02 , G03H2227/06
摘要： An ultrasonic apparatus (100) for creating a holographic ultrasound field (1) comprises an ultrasound source device (10) being adapted for creating an ultrasound wave, and a transmission hologram device (20) having a transmission hologram (21) and an exposed acoustic emitter surface (22), said transmission hologram device (20) being acoustically coupled with the ultrasound source device (10) and being arranged for transmitting the ultrasound wave through the acoustic emitter surface (22) and creating the holographic ultrasound field in a surrounding space, wherein the acoustic emitter surface (22) is a smooth surface which do not influence the field distribution of the ultrasound wave. Furthermore, a method of creating a holographic ultrasound field in an object (3), wherein the ultrasonic apparatus (100) is used, and applications of the ultrasonic apparatus (100) are described.

8. 发明申请

WO2008063809A8 THREE-DIMENSIONAL HOLOGRAPHIC RING TRAPS 审中-公开
标题翻译：三维全息环圈
公开(公告)号：WO2008063809A8
公开(公告)日：2008-07-10
申请号：PCT/US2007082418
申请日：2007-10-24
申请人： UNIV NEW YORK , ROICHMAN YOHAI , GRIER DAVID G
发明人： ROICHMAN YOHAI , GRIER DAVID G
CPC分类号： G03H1/0005 , G03H1/08 , G03H2001/0077 , G03H2001/085
摘要： A method and system for preparing and using three dimensional optical ring traps. The method and system includes applying a single phase hologram to be able to independently control shape and force profile of an optical trap but without employing orbital angular momentum for the control parameter of an optical ring trap to manipulate an object.
摘要翻译：制备和使用三维光环陷阱的方法和系统。该方法和系统包括应用单相全息图以能够独立地控制光学阱的形状和力分布，但不使用光环形阱的控制参数的轨道角动量来操纵物体。

9. 发明申请

WO2005060431A9 SYSTEM AND METHOD FOR MANIPULATING AND PROCESSING MATERIALS USING HOLOGRAPHIC OPTICAL TRAPPING 审中-公开
标题翻译：使用全息光学跟踪处理和处理材料的系统和方法
公开(公告)号：WO2005060431A9
公开(公告)日：2005-09-22
申请号：PCT/US2004035538
申请日：2004-10-28
申请人： ARRYX INC , PLEWA JOSEPH , TANNER EVAN , MUETH DAN , GRUBER LEWIS , BRADLEY KENNETH
发明人： PLEWA JOSEPH , TANNER EVAN , MUETH DAN , GRUBER LEWIS , BRADLEY KENNETH
IPC分类号： G02B5/32 , G03H1/08 , G03H1/22
CPC分类号： G03H1/22 , G02B5/32 , G03H1/0005 , G03H1/08 , G03H1/2294 , G03H2001/0077 , G03H2001/2284
摘要： A method for trapping particles where a characteristic of a particle is selected, a laser is used to generate a holographic optical trap, and the beams are modulated and focused as desired.
摘要翻译：一种用于捕获其特征为粒子的颗粒的方法，使用激光来产生全息光阱，并且根据需要调制和聚焦光束。

10. 发明申请

WO2004025668A3 OPTICAL ACCELERATOR AND GENERALIZED OPTICAL VORTICES 审中-公开
标题翻译：光学加速器和普通光学VORTICES
公开(公告)号：WO2004025668A3
公开(公告)日：2005-02-03
申请号：PCT/US0328535
申请日：2003-09-11
申请人： UNIV CHICAGO
发明人： GRIER DAVID G , CURTIS JENNIFER E
IPC分类号： G02B27/00 , G21K1/00 , H05H3/04
CPC分类号： G02B21/32 , G03H1/08 , G03H1/2294 , G03H2001/0077 , G03H2001/085 , G03H2225/32
摘要： A method and system for generating modulated optical vortices. Optical vortices can be used for a variety of applications, such as applying controlled torque or controlled force patterns to objects from a few nanometers to hundreds of micrometers in size. Numerous optical modes of optical vortices can be created to meet virtually any desired need in manipulating of objects. Furthermore, one can modify the wavefront of a beam of light in a specific way to create a new type of optical trap useful for manipulating mesoscopic materials. When the modified beam is brought to a focus, the resulting optical trap exerts forces transverse to the optical axis that can be used to transport mesoscopic matter such as nanoclusters, colloidal particles, and biological cells.
摘要翻译：一种用于产生调制光学旋涡的方法和系统。光学旋涡可用于各种应用，例如将受控扭矩或受控力图案应用于尺寸从几纳米到几百微米的物体。可以创建光学旋涡的许多光学模式，以满足在操纵物体时几乎任何所需的需要。此外，可以以特定方式修改光束的波前，以产生用于操纵介观材料的新型光阱。当修改的光束被聚焦时，所产生的光阱被施加横向于光轴的力，该光轴可用于传输诸如纳米团簇，胶体粒子和生物细胞的介观物质。

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