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1. 发明申请

WO2016132258A1 APPARATUS AND METHOD FOR TREATING NEUROLOGICAL DISORDERS 审中-公开
标题翻译：装置和治疗神经病的方法
公开(公告)号：WO2016132258A1
公开(公告)日：2016-08-25
申请号：PCT/IB2016/050735
申请日：2016-02-11
申请人： ARLOTTI, Mattia , PRIORI, Alberto , ROSSI, Lorenzo
发明人： ARLOTTI, Mattia , PRIORI, Alberto , ROSSI, Lorenzo
IPC分类号： A61N1/36 , A61B5/00
CPC分类号： A61N1/3606 , A61B5/048 , A61B5/4076 , A61B5/4082 , A61B5/4836 , A61B5/7257 , A61N1/0534 , A61N1/36064 , A61N1/36067 , A61N1/36071 , A61N1/36082
摘要： The present invention concerns an apparatus for treating neurological disorders comprising (i) at least one electrode implantable in the brain of a patient and (ii) a processing and stimulation device connected to the at least one electrode, wherein the processing and stimulation device comprises (a) at least one stimulation module adapted to generate a stimulation signal to be sent to the at least one electrode, the stimulation signal being characterised by a plurality of parameters, (b) at least one acquisition module of a signal characteristic of cerebral activity coming from the brain of the patient adapted to determine its power in at least one frequency band, and (c) at least one control module of at least one parameter of the stimulation signal as a function of the power of the signal characteristic of cerebral activity acquired, based on a transfer function having a saturating trend, wherein the transfer function is such as to set the at least one parameter (Va,Vd,Vf) of the stimulation signal (Vstim) differently dependent on a plurality of power ranges, by keeping the at least one parameter within a predetermined stimulation range ([Vi_HighThreshold;Vi_LowThreshold]) with i = a,d,f.
摘要翻译：本发明涉及一种用于治疗神经障碍的装置，包括（i）至少一个可植入患者脑部的电极和（ii）连接至该至少一个电极的处理和刺激装置，其中所述处理和刺激装置包括 a）至少一个刺激模块，其适于产生要发送到所述至少一个电极的刺激信号，所述刺激信号由多个参数表征，（b）至少一个具有脑活动特征的信号获取模块适于确定其在至少一个频带中的功率的患者的脑部，以及（c）至少一个控制模块，所述至少一个控制模块作为所获取的脑活动特征信号的功率的刺激信号的至少一个参数基于具有饱和趋势的传递函数，其中所述传递函数用于设置所述st的至少一个参数（Va，Vd，Vf）通过使i = a，d，f中的至少一个参数保持在预定的刺激范围（[Vi_HighThreshold; Vi_LowThreshold]）内，不同地取决于多个功率范围的模拟信号（Vstim）。

2. 发明申请

WO2009150687A1 APPARATUS FOR THE CONTROLLED PRESCRIPTION AND ADMINISTRATION OF TRANSCRANIAL DIRECT CURRENT STIMULATION TREATMENTS IN HUMANS 审中-公开
标题翻译：用于人控制的交叉直接电流刺激治疗的处方和管理的装置
公开(公告)号：WO2009150687A1
公开(公告)日：2009-12-17
申请号：PCT/IT2009/000252
申请日：2009-06-10
申请人： ROSSI, Lorenzo , MARCEGLIA, Sara Renata Francesca , MRAKIC-SPOSTA, Simona , BERTOLASI, Laura
发明人： ROSSI, Lorenzo , MARCEGLIA, Sara Renata Francesca , MRAKIC-SPOSTA, Simona , BERTOLASI, Laura
IPC分类号： A61N1/372 , A61N1/08
CPC分类号： A61N1/08 , A61N1/05 , A61N1/37264 , A61N1/37282
摘要： The invention proposes a system and a method for controlling the process of prescription and administration of direct current stimulation treatments in humans. In the proposed system, the stimulation parameters are all set by a specialist whose credentials are verified through a specific control device different from the device that delivers electrical stimulation. The stimulating device can deliver the stimulation only if the credentials of the specialized subject making the prescription are verified and if the prescription is made according to safety criteria. The system is composed by at least one device for the administration of electrical current connected to two electrodes applied over the skin and by a control device. The control device is connected to one or more devices for the administration of the direct current through a communication channel. The specialist gives his own credentials and is authorized at making the prescription and, accordingly, programming the stimulating device. The prescription defines the stimulus intensity, waveform, polarity, duration, the minimum interval between two consecutive stimulations and the maximum number of stimulations allowed. The stimulating device delivers the stimulation only if the credentials of the specialist are verified and only according to the prescription.
摘要翻译：本发明提出了一种用于控制人体直接刺激治疗处方和给药过程的系统和方法。在所提出的系统中，刺激参数都由专家设置，其专家通过与提供电刺激的装置不同的特定控制装置来验证其凭证。刺激装置只有在验证了处方专门科目的凭证并且按照安全标准进行处方的情况下才能进行刺激。该系统由至少一个用于管理连接到施加在皮肤上的两个电极和由控制装置施加的电流的装置构成。控制装置连接到一个或多个装置，用于通过通信信道管理直流电流。专家提供自己的证书，并授权进行处方，因此编程刺激装置。处方定义刺激强度，波形，极性，持续时间，两次连续刺激之间的最小间隔和允许的最大刺激次数。刺激装置仅在专家证书得到验证且仅根据处方才能传递刺激。

3. 发明申请

WO2007049105A1 APPARATUS FOR TREATING NEUROLOGICAL DISORDERS BY MEANS OF CHRONIC ADAPTIVE BRAIN STIMULATION AS A FUNCTION OF LOCAL BIOPOTENTIALS 审中-公开
标题翻译：通过慢性自适应脑刺激作为局部生物功能的手段治疗神经病变的装置
公开(公告)号：WO2007049105A1
公开(公告)日：2007-05-03
申请号：PCT/IB2006002184
申请日：2006-08-03
申请人： UNIV DEGLI STUDI MILANO , FOND IRCCS ISTITUTO DI RICOVER , PRIORI ALBERTO , FOFFANI GUGLIELMO , ROSSI LORENZO
发明人： PRIORI ALBERTO , FOFFANI GUGLIELMO , ROSSI LORENZO
IPC分类号： A61N1/36 , A61N1/34
CPC分类号： A61N1/3605 , A61N1/36067 , A61N1/36082
摘要： An apparatus and a related method for the deep brain stimulation have been invented wherein the parameters of the stimulation supplied at the human nervous system level are adjusted and optimized continuously by the analysis of the bioelectric signals coming from the tissue adjacent the stimulation electrode itself, adapting the therapy continuously and in line to the patient's clinical state. The apparatus is constituted at least by an electro- catheter (1) implantable in a patient's brain and equipped with four contacts (4, 5, 6, 7) . Then, there is at least a stimulation module (9) which generates the stimulating signal (15) sent to the electro-catheter (1) and in particular to one of the contacts thereof (6) . The electro- catheter (1) contemporarily sends a signal characterizing the brain activity coming from the tissue involved by the stimulating signal (15) to an acquisition module (8) . The characterizing signal is used to determine the feedback of the stimulation parameters (15) and, consequently, to adapt the therapy continuously to the patient's clinical state.
摘要翻译：已经发明了一种用于深部脑刺激的装置和相关方法，其中通过分析来自邻近刺激电极本身的组织的生物电信号，连续地调节和优化在人类神经系统水平提供的刺激参数，适应治疗不断，符合患者的临床状态。该装置至少由可植入患者大脑中的电导管（1）构成，并配备有四个触点（4,5,6,7）。然后，至少有一个刺激模块（9）产生发送到电导管（1）的刺激信号（15），特别是其中一个触点（6）。电导管（1）同时将来自刺激信号（15）所涉及的组织的大脑活动的信号发送到采集模块（8）。特征信号用于确定刺激参数（15）的反馈，从而使治疗持续适应患者的临床状态。

4. 发明申请

WO2007049105A9 APPARATUS FOR TREATING NEUROLOGICAL DISORDERS BY MEANS OF CHRONIC ADAPTIVE BRAIN STIMULATION AS A FUNCTION OF LOCAL BIOPOTENTIALS 审中-公开
公开(公告)号：WO2007049105A9
公开(公告)日：2007-05-03
申请号：PCT/IB2006/002184
申请日：2006-08-03
申请人： UNIVERSITA' DEGLI STUDI DI MILANO , FONDAZIONE IRCCS ISTITUTO DI RICOVERO E CURA A CARATTERE SCIENTIFICO DI NATURA PUBBLICA OSPEDALE MAGGIORE POLICLINICO, MANGIAGALLI E REGINA ELENA , PRIORI, Alberto , FOFFANI, Guglielmo , ROSSI, Lorenzo
发明人： PRIORI, Alberto , FOFFANI, Guglielmo , ROSSI, Lorenzo
IPC分类号： A61N1/36 , A61N1/34
摘要： An apparatus and a related method for the deep brain stimulation have been invented wherein the parameters of the stimulation supplied at the human nervous system level are adjusted and optimized continuously by the analysis of the bioelectric signals coming from the tissue adjacent the stimulation electrode itself, adapting the therapy continuously and in line to the patient's clinical state. The apparatus is constituted at least by an electro- catheter (1) implantable in a patient's brain and equipped with four contacts (4, 5, 6, 7). Then, there is at least a stimulation module (9) which generates the stimulating signal (15) sent to the electro-catheter (1) and in particular to one of the contacts thereof (6). The electro- catheter (1) contemporarily sends a signal characterizing the brain activity coming from the tissue involved by the stimulating signal (15) to an acquisition module (8). The characterizing signal is used to determine the feedback of the stimulation parameters (15) and, consequently, to adapt the therapy continuously to the patient's clinical state.

5. 发明申请

WO2006013585A1 METHOD AND EQUIPMENT FOR MONITORING THE FUNCTIONALITY OF THE SPINAL CORD 审中-公开
标题翻译：用于监测脊髓功能的方法和设备
公开(公告)号：WO2006013585A1
公开(公告)日：2006-02-09
申请号：PCT/IT2004/000440
申请日：2004-08-05
申请人： UNIVERSITA' DEGLI STUDI DI MILANO , BRACCHI, Francesco , ROSSI, Lorenzo , MERZAGORA, Anna Caterina
发明人： BRACCHI, Francesco , ROSSI, Lorenzo , MERZAGORA, Anna Caterina
IPC分类号： A61B5/0484
CPC分类号： A61B5/0484 , A61B5/0488 , A61B5/407 , A61B2018/0044 , A61N1/08
摘要： A method for monitoring the functionality of the spinal cord of a living creature comprises the steps of: a) acquiring an electric signal (S1) obtained in response to an electric stimulation applied to the creature's body; this signal comprises a first signal (S) indicative of a somatosensory evoked potential generated by said pulse; b) acquiring a second electric signal (S2) indicative of a H-reflex potential generated by said electric stimulation; c) processing the first and second electric signals to simultaneously provide first and second information, which are correlated to the first and second electric signals thus enabling to check the functionality of the spinal cord.
摘要翻译：一种用于监测活体脊髓功能的方法包括以下步骤：a）获取响应于施加到生物身体的电刺激获得的电信号（S1）; 该信号包括指示由所述脉冲产生的体感诱发电位的第一信号（S） b）获取指示由所述电刺激产生的H反射电位的第二电信号（S2）; c）处理第一和第二电信号以同时提供与第一和第二电信号相关的第一和第二信息，从而能够检查脊髓的功能。

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