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1. 发明申请

WO2020185902A1 CHARGING DEVICE WITH OFF-CENTER COIL 审中-公开
公开(公告)号：WO2020185902A1
公开(公告)日：2020-09-17
申请号：PCT/US2020/022110
申请日：2020-03-11
申请人： AXONICS MODULATION TECHNOLOGIES, INC.
发明人： NASSIF, Rabhif
IPC分类号： H01M10/46
摘要： Systems and methods for improved power transmission are disclosed herein. The system can include an implantable neurostimulator for delivering the one or more electrical pulses to a patient's body. The implantable neurostimulator can include a hermetic housing made of a biocompatible material, an energy storage feature for powering the implantable neurostimulator, a receiving coil assembly including an elongate wire winding wound around a first ferritic core, and control circuitry for controlling recharging of the energy storage feature. The system can include a charging device for wirelessly delivering energy to the implantable neurostimulator. The charging device can include a sending coil assembly including a planar wire winding coupled to a surface of a second ferritic core.

2. 发明申请

WO2016112398A1 PATIENT REMOTE AND ASSOCIATED METHODS OF USE WITH A NERVE STIMULATION SYSTEM 审中-公开
标题翻译：患者远程和相关的使用神经刺激系统的方法
公开(公告)号：WO2016112398A1
公开(公告)日：2016-07-14
申请号：PCT/US2016/012918
申请日：2016-01-11
申请人： AXONICS MODULATION TECHNOLOGIES, INC. , SCHROEDER, Dennis , SCHMID, Eric
发明人： SCHROEDER, Dennis , SCHMID, Eric , JIANG, Guangqiang , WOOCK, John
IPC分类号： A61N1/05 , A61N1/08 , A61N1/36
CPC分类号： A61N1/37247 , A61N1/36057 , A61N1/36128 , A61N1/36132 , A61N1/36142 , A61N1/36146 , A61N1/37211 , A61N1/37235 , A61N1/37241
摘要： A neurostimulation system having an external or an implantable pulse generator programmed to innervate a specific nerve or group of nerves in a patient through an electrode as a mode of treatment, having a patient remote that wirelessly communicates with the pulse generator to increase stimulation, decrease stimulation, and provide indications to a patient regarding the status of the neurostimulation system. The patient remote can allow for adjustment of stimulation power within a clinically effective range and for turning on and turning off the pulse generator. The patient remote and neurostimulation system can also store a stimulation level when the pulse generator is turned off and automatically restore the pulse generator to the stored stimulation level when the pulse generator is turned on.
摘要翻译：具有外部或可植入脉冲发生器的神经刺激系统，该外部或可植入脉冲发生器被编程为通过电极作为治疗方式通过电极来支配患者中的特定神经或神经组，患者远程与脉冲发生器无线通信以增加刺激，减少刺激并且向患者提供关于神经刺激系统的状态的指示。患者远程可以允许在临床有效范围内调整刺激功率，并且用于打开和关闭脉冲发生器。患者远程和神经刺激系统还可以在脉冲发生器关闭时存储刺激水平，并且当脉冲发生器接通时，将脉冲发生器自动恢复到存储的刺激水平。

3. 发明申请

WO2017139784A1 EXTERNAL PULSE GENERATOR DEVICE AND ASSOCIATED METHODS FOR TRIAL NERVE STIMULATION 审中-公开
标题翻译：外部脉冲发生器装置以及用于试验性神经刺激的相关方法
公开(公告)号：WO2017139784A1
公开(公告)日：2017-08-17
申请号：PCT/US2017/017699
申请日：2017-02-13
申请人： AXONICS MODULATION TECHNOLOGIES, INC.
发明人： MATHUR, Prabodh , SCHROEDER, Dennis , WOOCK, John
IPC分类号： A61N1/375 , A61N1/372 , A61N1/36
CPC分类号： A61N1/3787 , A61N1/0502 , A61N1/0558 , A61N1/36017 , A61N1/3603 , A61N1/37241 , A61N1/375 , A61N1/3752
摘要： Systems and methods for providing a trial neurostimulation to a patient for assesssing suitability of a permanently implanted neurostimulation are provided herein. In one aspect, a trial neurostimulation system includes an EPG affixation device that secures the EPG to the patient when connected to a lead extending through a percutaneous incission to a target tissue location, while allowing for ready removal of the EPG for charging or bathing. In another aspect, the system includes an EPG provided with a multi-purpose connector rectacle through which the the EPG can deliver neurostimulation therapy to an implanted lead or the EPG can be charged. In yet another aspect, the EPG can include a multi-purpose connector receptacle that is alternatingly connectable with a purality of differing connector to faciltiate differing types of therapies with one or more neurostimulation devices, ground patches or various other devices, such as charging or testing devices.
摘要翻译：本文提供了用于向患者提供用于评估永久植入的神经刺激的适合性的试验性神经刺激的系统和方法。在一个方面，试验性神经刺激系统包括EPG附加装置，其在连接到延伸通过经皮切口到达目标组织位置的引线时将EPG固定到患者，同时允许EPG准备好用于充电或沐浴。另一方面，该系统包括设有多用途连接器直肠的EPG，EPG可通过该多用途连接器将神经刺激治疗递送至植入的导线，或者EPG可带电。在又一方面，EPG可以包括多用途连接器插座，其可交替地与多个不同连接器连接以利用一个或多个神经刺激设备，接地片或各种其他设备（例如充电或测试）来促成不同类型的治疗设备

4. 发明申请

WO2016025910A1 IMPLANTABLE LEAD AFFIXATION STRUCTURE FOR NERVE STIMULATION TO ALLEVIATE BLADDER DYSFUNCTION AND OTHER INDICATIONS 审中-公开
标题翻译：用于神经刺激以改善牙齿功能障碍和其他适应症的可塑性引导结构
公开(公告)号：WO2016025910A1
公开(公告)日：2016-02-18
申请号：PCT/US2015/045401
申请日：2015-08-14
申请人： AXONICS MODULATION TECHNOLOGIES, INC.
发明人： LEE, Henry , HWU, Alexander
IPC分类号： A61N1/04 , A61N1/05 , A61N1/36
CPC分类号： A61N1/0558 , A61N1/36007 , A61N1/3606 , B23K26/242 , B23K26/38 , B23K26/40 , B23K2203/14 , B23K2203/18 , B23K2203/26 , B29C45/14065 , B29C45/14598 , B29C45/14778 , B29L2031/753
摘要： Anchoring devices and methods for affixing an implanted lead of a neurostimulation system at a target location in a patient are provided herein. Such anchoring devices includes a helical body having a plurality of tines extending laterally outward from the lead when deployed that engage tissue to inhibit axial movement of the implanted lead. The plurality of tines are biased towards the laterally extended deployed configuration and fold inward towards the lead to a delivery configuration to facilitate delivery of the lead through a sheath. The tines may be angled in a proximal direction or in both proximal and distal directions and may include various features to assist in visualization and delivery of the lead. The anchor may be formed according to various methods, including laser cutting of a tubular section along with heat or reflow to set the material with the anchor in the deployed configuration and injection molding.
摘要翻译：这里提供了用于将神经刺激系统的植入引线固定在患者的目标位置的锚定装置和方法。这种锚固装置包括螺旋体，该螺旋体具有多个尖齿，当展开时从导向件横向向外延伸，这些齿接合组织以阻止植入的导线的轴向移动。多个尖齿被朝向横向延伸的展开构型偏置，并且朝向导向物向内折叠成输送构型，以促进引线穿过护套的传送。尖齿可以在近端方向上或在近端方向和远端方向上成角度，并且可以包括各种特征以辅助铅的可视化和递送。锚可以根据各种方法形成，包括激光切割管状部分以及加热或回流以将锚固件的材料设置在展开构型和注射成型中。

5. 发明申请

WO2020242900A1 TRAINER DEVICE FOR A NEUROSTIMULATOR PROGRAMMER AND ASSOCIATED METHODS OF USE WITH A NEUROSTIMULATION SYSTEM 审中-公开
公开(公告)号：WO2020242900A1
公开(公告)日：2020-12-03
申请号：PCT/US2020/034100
申请日：2020-05-21
申请人： AXONICS MODULATION TECHNOLOGIES, INC.
发明人： ABDEEN, Faizal , BORLASE, Charles , MATHUR, Prabodh , NASSIF, Rabih , ONO, Flavio , PORTILLO, Franklin S. , WOOCK, John
IPC分类号： A61B5/05
摘要： A training system for a neurostimulation system that may be used to simulate a neurostimulator programming session and/or lead placement. The system may include a training device that may be coupled to a neurostimulator programmer and may include an interface to allow user interaction and/or display information relevant to the stimulation. The trainer device may include circuitry for simulating a neurostimulator such as an IPG or EPG, and may include circuitry for simulating impedance associated with lead placement.

6. 发明申请

WO2017132374A1 METHODS AND SYSTEMS FOR FREQUENCY ADJUSTMENT TO OPTIMIZE CHARGING OF IMPLANTABLE NEUROSTIMULATOR 审中-公开
标题翻译：频率调整优化可植入神经刺激器充电的方法和系统
公开(公告)号：WO2017132374A1
公开(公告)日：2017-08-03
申请号：PCT/US2017/015124
申请日：2017-01-26
申请人： AXONICS MODULATION TECHNOLOGIES, INC.
发明人： NASSIF, Rabih , HANKINS, Steve , BOWES, Christopher J.
IPC分类号： A61N1/05 , A61N1/37
CPC分类号： A61N1/3787 , A61N1/36007 , A61N1/3605 , A61N1/36107 , H02J7/0072 , H02J7/025 , H02J50/12 , H02J50/80
摘要： Devices, systems, and methods for coupling with an implantable neurostimulator for delivering one or more electrical pulses to a target region within a patient's body are disclosed herein. A device, such as a charger, can include: a power source for storing electrical energy; a resonant circuit that can have a plurality of selectable natural frequencies; a driver coupled to the power source and the resonant circuit; and a processor coupled to the resonant circuit to control the natural frequency of the resonant circuit. The processor can control the natural frequency of the resonant circuit according to stored data associated with the implantable neurostimulator.
摘要翻译：本文公开了用于与用于将一个或多个电脉冲递送至患者体内的目标区域的可植入神经刺激器耦合的装置，系统和方法。诸如充电器的装置可以包括：用于存储电能的电源; 谐振电路，其可以具有多个可选择的固有频率; 耦合到电源和谐振电路的驱动器; 以及耦合到谐振电路的处理器，用于控制谐振电路的固有频率。处理器可以根据存储的与植入式神经刺激器相关的数据来控制谐振电路的固有频率。

7. 发明申请

WO2016112401A1 ATTACHMENT DEVICES AND ASSOCIATED METHODS OF USE WITH A NERVE STIMULATION CHARGING DEVICE 审中-公开
标题翻译：附件装置及相关的使用神经刺激装置的方法
公开(公告)号：WO2016112401A1
公开(公告)日：2016-07-14
申请号：PCT/US2016/012923
申请日：2016-01-11
申请人： AXONICS MODULATION TECHNOLOGIES, INC. , SCHROEDER, Dennis , COHEN, Raymond W.
发明人： SCHROEDER, Dennis , COHEN, Raymond W. , JIANG, Guangqiang
IPC分类号： A61N1/378
CPC分类号： A61N1/3787 , A61N1/0551 , A61N1/36125
摘要： Devices, systems and methods for transcutaneous charging of implanted medical devices are provided herein. Such devices include a portable charging device and an attachment device for affixing the portable charging device to a skin of the patient in a suitable location and alignment over the implanted medical device to faciliate charging. The attachment device can include a frame having an opening through which the charging device is mounted and one or more tabs extending laterally from the opening, each tab including an adhesive surface and being movable from a first position extending away from a skin of the patient to facilitate positioning of the charging device and a second position extending toward the skin of the patient so as to engage the skin of the patient and affix the charging device to the patient after being properly positioned.
摘要翻译：本文提供了用于植入医疗装置的经皮充电的装置，系统和方法。这样的设备包括便携式充电装置和用于将便携式充电装置固定在患者的皮肤上的适当位置并且在植入的医疗装置上对准以附加充电的附接装置。附接装置可以包括具有开口的框架，充电装置通过该开口安装，以及从开口横向延伸的一个或多个翼片，每个翼片包括粘合剂表面，并且可从远离患者皮肤延伸的第一位置移动到便于充电装置的定位和朝向患者皮肤延伸的第二位置，以便接合病人的皮肤，并且在正确定位之后将充电装置贴在患者身上。

8. 发明申请

WO2016025915A1 INTEGRATED ELECTROMYOGRAPHIC CLINICIAN PROGRAMMER FOR USE WITH AN IMPLANTABLE NEUROSTIMULATOR 审中-公开
标题翻译：综合电磁诊断系统编程器可与可植入式神经细胞器一起使用
公开(公告)号：WO2016025915A1
公开(公告)日：2016-02-18
申请号：PCT/US2015/045410
申请日：2015-08-14
申请人： AXONICS MODULATION TECHNOLOGIES, INC. , SCHROEDER, Dennis
发明人： SCHROEDER, Dennis , JIANG, Guangqiang , WOOCK, John , SCHMID, Eric
IPC分类号： A61N1/05 , A61N1/36 , A61N1/372
CPC分类号： A61N1/37241 , A61N1/0551 , A61N1/36007 , A61N1/36017 , A61N1/36107 , A61N1/36139 , A61N1/36157 , A61N1/36185 , A61N1/37247
摘要： An integrated electromyography (EMG) and signal/stimulation generation clinician programmer may be coupled with an implantable temporary or permanent lead in a patient and at least one EMG sensing electrode minimally invasively positioned on a skin surface or within the patient. Generally, the integrated clinician programmer may comprise a portable housing, a signal/stimulation generator, and EMG signal processor, and a graphical user interface. The housing has an external surface and encloses circuitry at least partially disposed within the housing. The signal/stimulation generator may be disposed within the housing and configured to deliver test stimulation to a nerve tissue of the patient via the implantable lead. The EMG signal processor may be disposed within the housing and configured to record a stimulation-induced EMG motor response for each test stimulation via the at least one EMG sensing electrode. The graphical user interface at least partially comprises the external surface of the housing and has a touch screen display for direct user interaction or for use with a keyboard, mouse, or the like.
摘要翻译：综合肌电图（EMG）和信号/刺激生成临床医生编程器可以与患者中的可植入临时或永久性引线耦合，并且至少一个EMG感测电极微创地定位在皮肤表面或患者体内。通常，综合临床医生编程器可以包括便携式外壳，信号/刺激发生器和EMG信号处理器以及图形用户界面。壳体具有外表面并且包围至少部分地设置在壳体内的电路。信号/刺激发生器可以设置在壳体内并且被配置为经由可植入引线将测试刺激递送到患者的神经组织。 EMG信号处理器可以被布置在壳体内并且被配置为经由至少一个EMG感测电极记录针对每个测试刺激的刺激引起的EMG电动机响应。图形用户界面至少部分地包括外壳的外表面，并且具有用于直接用户交互或用于键盘，鼠标等的触摸屏显示器。

9. 发明申请

WO2016025913A1 ELECTROMYOGRAPHIC LEAD POSITIONING AND STIMULATION TITRATION IN A NERVE STIMULATION SYSTEM FOR TREATMENT OF OVERACTIVE BLADDER 审中-公开
标题翻译：用于治疗过敏性刮板的神经刺激系统中的电子引导定位和刺激ER度
公开(公告)号：WO2016025913A1
公开(公告)日：2016-02-18
申请号：PCT/US2015/045408
申请日：2015-08-14
申请人： AXONICS MODULATION TECHNOLOGIES, INC. , SCHROEDER, Dennis
发明人： SCHROEDER, Dennis , GUANGQIANG, Jiang , WOOCK, John , SCHMID, Eric
IPC分类号： A61N1/04 , A61N1/05 , A61N1/36
CPC分类号： A61N1/36185 , A61N1/0504 , A61N1/0551 , A61N1/36007 , A61N1/36017 , A61N1/3606 , A61N1/36107 , A61N1/36125 , A61N1/36135 , A61N1/36146 , A61N1/36157 , A61N1/37241 , A61N1/37247
摘要： The present invention provides improved methods for positioning of an implantable lead in a patient with an integrated EMG and stimulation clinician programmer. The integrated clinician programmer is coupled to the implantable lead, wherein the implantable lead comprises at least four electrodes, and to at least one EMG sensing electrode minimally invasively positioned on a skin surface or within the patient. The method comprises delivering a test stimulation at a stimulation amplitude level from the integrated clinician programmer to a nerve tissue of the patient with a principal electrode of the implantable lead. Test stimulations are delivered at a same stimulation amplitude level for a same period of time sequentially to each of the four electrodes of the implantable lead. A stimulation-induced EMG motor response is recorded with the integrated clinician programmer for each test stimulation on each electrode of the implantable lead via the at least one pair of EMG sensing electrodes so as to facilitate initial positioning of the implantable lead at a target stimulation region
摘要翻译：本发明提供了一种用于使用集成的EMG和刺激临床医师编程器将可植入引线定位在患者体内的改进方法。集成的临床医生编程器耦合到可植入引线，其中可植入引线包括至少四个电极，以及至少一个EMG感测电极，其最微小地入侵地定位在皮肤表面或患者体内。该方法包括以刺激振幅水平从集成的临床医师编程器将可测量刺激递送到具有可植入引线的主电极的患者的神经组织。测试刺激在相同的刺激振幅水平下相继地递送到可植入引线的四个电极中的每个电极上。通过所述至少一对EMG感测电极，利用集成的临床医生编程器记录刺激诱导的EMG运动反应，用于对可植入引线的每个电极上的每个测试刺激，以便于将可植入引线初始定位在目标刺激区域

10. 发明申请

WO2016025912A1 SYSTEMS AND METHODS FOR NEUROSTIMULATION ELECTRODE CONFIGURATIONS BASED ON NEURAL LOCALIZATION 审中-公开
标题翻译：基于神经局部化神经网络电极配置的系统和方法
公开(公告)号：WO2016025912A1
公开(公告)日：2016-02-18
申请号：PCT/US2015/045404
申请日：2015-08-14
申请人： AXONICS MODULATION TECHNOLOGIES, INC. , SCHROEDER, Dennis
发明人： SCHROEDER, Dennis , GUANGQIANG, Jiang , WOOCK, John , SCHMID, Eric
IPC分类号： A61N1/04 , A61N1/05 , A61N1/36
CPC分类号： A61N1/36007 , A61B5/0482 , A61B5/0488 , A61B5/0492 , A61B5/4893 , A61N1/0551 , A61N1/36132 , A61N1/36135 , A61N1/36164 , A61N1/36185 , A61N1/37247 , A61N1/37264
摘要： Methods and systems for obtaining and analyzing electromyography responses of electrodes of an implanted neurostimulation lead for use neurostimulation programming are provided herein. System setups for neural localization and/or programming include a clinician programmer coupleable with a temporary or permanent lead implantable in a patient and at least one pair of EMG sensing electrodes minimally invasively positioned on a skin surface or within the patient. The clinician programmer is configured to determine a plurality of recommended electrode configurations based on thresholds and EMG responses of the plurality of electrodes and rank the electrode configuration according to pre-determined criteria. The clinician programmer further includes graphical user interface on which the plurality of recommended electrode configurations are displayed for modification and/or selection by a clinician in programming an IPG or EPG coupled with the lead to apply a neurostimulation treatment according to the selected electrode configuration.
摘要翻译：本文提供了用于获得和分析用于使用神经刺激程序的植入神经刺激导联的电极的肌电描记反应的方法和系统。用于神经定位和/或编程的系统设置包括可与可植入患者的临时或永久导联的至少一对EMG感测电极耦合的临床医生编程器，以及最少侵入性地位于皮肤表面或患者体内的EMG感测电极。临床医生编程器被配置为基于多个电极的阈值和EMG响应来确定多个推荐的电极配置，并根据预先确定的标准对电极配置进行排序。临床医生编程器还包括图形用户界面，在该界面上显示多个推荐的电极配置，用于修改和/或选择临床医生编程与引线耦合的IPG或EPG，以根据所选择的电极配置进行神经刺激治疗。

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