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1. 发明申请

WO2010011204A1 PLACENTAL BLOOD EXTRACTOR 审中-公开
标题翻译：普通血液提取物
公开(公告)号：WO2010011204A1
公开(公告)日：2010-01-28
申请号：PCT/US2008/009018
申请日：2008-07-25
申请人： HORVAT, Branimir, L. , HORVAT, Nevenka
发明人： HORVAT, Branimir, L. , HORVAT, Nevenka
IPC分类号： A61M1/02
CPC分类号： A61B5/150755 , A61B5/150038 , A61B5/150045 , A61B5/150221 , A61B5/150229 , A61B5/150366 , A61M1/02 , A61M1/025 , A61M2202/0462
摘要： A placental blood extractor consisting of an outside box having a plurality of plastic bags mounted within the top and bottom sections of the box and having an opening in the bottom section, a sterile bag having a central closure on a first side and a leader for an umbilical cord on a second side for holding a placenta mounted between the top and bottom plastic bags and a collector of blood system attached to the opening in the bottom, the collector of blood system consists of a pump, a manometer, a computer and a vibrator for gentle shaking of the colector of blood system.
摘要翻译：一种胎盘血液提取器，其由外部箱体组成，所述外部箱体具有安装在所述箱体的顶部和底部部分内的多个塑料袋，并且在所述底部部分中具有开口，具有在第一侧上的中心封闭物的无菌袋和用于用于保持安装在顶部和底部塑料袋之间的胎盘和连接到底部开口处的血液系统收集器的第二侧上的脐带，血液系统的收集器由泵，压力计，计算机和振动器轻轻摇动血液系统的凝聚器。

2. 发明申请

WO2004012798A1 SYSTEMS AND METHODS FOR THAWING, MIXING, AND PROCESSING BIOPHARMACEUTICAL MATERIALS 审中-公开
标题翻译：用于治疗，混合和加工生物材料的系统和方法
公开(公告)号：WO2004012798A1
公开(公告)日：2004-02-12
申请号：PCT/US2003/024260
申请日：2003-08-05
申请人： INTEGRATED BIOSYSTEMS, INC. , WISNIEWSKI, Richard
发明人： WISNIEWSKI, Richard
IPC分类号： A61M5/44
CPC分类号： B62B3/08 , A61M1/025 , A61M1/0254 , A61M5/445 , A61M2205/366 , A61M2205/368 , A61M2205/3686 , A61M2209/084
摘要： The present invention provides a system for thawing, mixing and processing a biopharmaceutical material, which includes a moveable platform and a container for holding the biopharmaceutical material. The container is operably mounted on the platform to allow the container to be skewed relative to the platform. Further, the container may be tilted relative to the platform.
摘要翻译：本发明提供了用于解冻，混合和加工生物药物材料的系统，其包括可移动平台和用于保持生物药物材料的容器。容器可操作地安装在平台上以允许容器相对于平台倾斜。此外，容器可以相对于平台倾斜。

3. 发明申请

WO2002078544A2 IN-VIVO BLOOD STORAGE SYSTEM 审中-公开
标题翻译：血管内储存系统
公开(公告)号：WO2002078544A2
公开(公告)日：2002-10-10
申请号：PCT/US2002/004378
申请日：2002-02-14
申请人： RHEOLOGICS, INC. , KENSEY, Kenneth , HOGENAUER, William, N.
发明人： KENSEY, Kenneth , HOGENAUER, William, N.
IPC分类号： A61B5/145
CPC分类号： A61M1/025 , A61M1/0254 , G01N11/04
摘要： A method and apparatus for testing the efficacy of agents (e.g., new drugs, old drugs, biologically-active agents, etc.) by removing a predetermined amount of blood from a living being and placing this predetermined amount of blood in continuous motion in a temperature-controlled environment and then removing samples from the continuously-moving predetermined amount of blood. The drug, or drugs, or agents under test can then be administered to the removed samples, instead of into the living being, thereby avoiding subjecting the living being to any risk of any adverse reaction while utilizing blood samples that simulate the circulating blood of the living being.
摘要翻译：一种用于通过从活体中除去预定量的血液并将该预定量的血液连续运动放置在试管中来测试药剂（例如新药，老药，生物活性剂等）的功效的方法和装置温度控制环境，然后从连续移动的预定量的血液中取出样品。然后可以将药物或药物或被试药物施用于去除的样品，而不是进入生物体，从而避免使生物受到任何不良反应的风险，同时利用模拟循环血液的血液样品生活在

4. 发明申请

WO0072902A9 ENHANCED THAWING OF BIOPHARMACEUTICAL SOLUTIONS USING OSCILLATORY MOTION 审中-公开
标题翻译：使用振荡运动增强生物医学解决方案
公开(公告)号：WO0072902A9
公开(公告)日：2002-07-04
申请号：PCT/US0014783
申请日：2000-05-26
申请人： INTEGRATED BIOSYSTEMS
发明人： WISNIEWSKI RICHARD
IPC分类号： A61J3/00 , A61K9/08 , A61M1/02 , A61M5/44 , B01F11/00 , B01F11/04 , B01F15/00 , B01F15/06 , B01J6/00 , B06B1/00
CPC分类号： A61M1/025 , A61M1/0254 , A61M5/445 , B01F11/0022 , B01F11/0025 , B01F11/0082 , B01F11/0094 , B01F11/04 , B01F15/00915 , B01F15/065 , B01F2015/062
摘要： Disclosed are methods for thawing frozen biopharmaceutical solutions including providing a container that contains a biopharmaceutical solution, at least a portion of the biopharmaceutical solution being frozen, providing an oscillatory driver coupled to the biopharmaceutical solution; providing a heat flux into the biopharmaceutical solution; and inducing oscillatory motion of the biopharmaceutical solution via oscillatory motion of the oscillatory driver to accelerate thawing, compared to motionless thawing, of the portion of the biopharmaceutical solution that is frozen. Also disclosed are devices for thawing frozen biopharmaceutical solutions.
摘要翻译：公开了用于解冻冷冻生物药物溶液的方法，包括提供包含生物药物溶液的容器，至少部分生物药物溶液被冷冻，提供耦合到生物药物溶液的振荡驱动器; 向生物药物溶液提供热通量; 并且通过所述振荡驱动器的振荡运动来诱导所述生物药物溶液的振荡运动，以相对于被冻结的所述生物药物溶液的部分的静态解冻来加速解冻。还公开了用于解冻冷冻生物药物溶液的装置。

5. 发明申请

WO01083002A2 WHOLE BLOOD SEPARATOR APPARATUS AND METHOD OF USE 审中-公开
标题翻译：全血分离装置及其使用方法
公开(公告)号：WO01083002A2
公开(公告)日：2001-11-08
申请号：PCT/US2001/014354
申请日：2001-05-03
IPC分类号： A61M1/02 , A61M1/36 , A61M1/00
CPC分类号： A61M1/3633 , A61M1/0218 , A61M1/025 , A61M1/0277 , A61M1/029 , A61M1/3618 , A61M1/362 , A61M1/3636 , A61M1/3693 , A61M2202/0439 , B03C1/01 , B03C1/0332 , B03C1/288 , B03C2201/18 , B03C2201/26 , A61M2202/0057
摘要： An apparatus for separating a selected cell population from blood or a blood component includes a container, a plurality of particles having a reactant that binds to a selected cell population and a separating device for separating the selected cell population from the blood or blood component. The particles have a density that allows gravity settling of the particles through the blood or blood component. The separating device can include a device for compressing the container, a magnet or a filter, for example. The apparatus can also include a mixing device for mixing the particles with the blood or blood component. The reactant bound to the particles can include an antibody or antibody fragment, such as lectin or a lectin fragment.
摘要翻译：用于从血液或血液成分分离所选择的细胞群的装置包括容器，具有结合所选细胞群的反应物的多个颗粒和用于将所选择的细胞群与血液或血液成分分离的分离装置。颗粒具有允许颗粒通过血液或血液成分的重力沉降的密度。分离装置可以包括例如用于压缩容器，磁体或过滤器的装置。该装置还可以包括用于将颗粒与血液或血液成分混合的混合装置。与颗粒结合的反应物可以包括抗体或抗体片段，例如凝集素或凝集素片段。

6. 发明申请

WO1996040399A1 BLOOD PROCESSING SYSTEMS CONTROLLED BY APPARENT HEMATOCRIT 审中-公开
标题翻译：由实验室控制的血液加工系统
公开(公告)号：WO1996040399A1
公开(公告)日：1996-12-19
申请号：PCT/US1996007714
申请日：1996-05-22
申请人： BAXTER INTERNATIONAL INC.
发明人： BAXTER INTERNATIONAL INC. , BROWN, Richard, I.
IPC分类号： B01D17/038
CPC分类号： A61M1/3696 , A61M1/0209 , A61M1/0218 , A61M1/025 , A61M1/30 , A61M1/302 , A61M1/303 , A61M1/308 , A61M1/3603 , A61M1/3624 , A61M1/3672 , A61M1/3693 , A61M1/385 , A61M2202/0415 , A61M2202/0427 , A61M2205/331 , A61M2205/3344 , A61M2205/3351 , A61M2205/3355 , A61M2205/3393 , B01D17/0217 , B01D21/2405 , B01D21/245 , B01D21/26 , B01D21/262 , B01D21/34 , B01D2221/10 , B04B5/0442 , B04B7/08 , B04B13/00 , A61M2202/0071 , A61M2202/0092
摘要： Blood processing systems separate whole blood (WB) into red blood cells (RBC) and a plasma constituent (PRP) within a rotating centrifugal separation device (12). The systems convey whole blood into the separation device (12) through an inlet pump (P2) operable at a prescribed rate. The systems remove plasma constituent (PRP) from the separation device (12) through an outlet pump (P4) operable at a prescribed rate. The systems derive a value representing an apparent hematocrit of whole blood entering the separation device (12) which is used by a controller (18) to control the systems.
摘要翻译：血液处理系统将全血（WB）分离成旋转离心分离装置（12）内的红细胞（RBC）和等离子体成分（PRP）。系统通过可以规定速率操作的入口泵（P2）将全血输送到分离装置（12）中。系统通过可以规定速率操作的出口泵（P4）从分离装置（12）中除去等离子体成分（PRP）。系统导出代表进入分离装置（12）的全血的明显血细胞比容的值，由控制器（18）用来控制系统。

7. 发明申请

WO1994008687A1 ENHANCED YIELD PLATELET COLLECTION SYSTEMS AND METHODS 审中-公开
标题翻译：增强型电子收集系统和方法
公开(公告)号：WO1994008687A1
公开(公告)日：1994-04-28
申请号：PCT/US1993002852
申请日：1993-03-23
申请人： BAXTER INTERNATIONAL INC.
发明人： BAXTER INTERNATIONAL INC. , BROWN, Richard, I.
IPC分类号： B01D21/26
CPC分类号： B04B13/00 , A61M1/0209 , A61M1/025 , A61M1/029 , A61M1/30 , A61M1/302 , A61M1/303 , A61M1/308 , A61M1/3603 , A61M1/3624 , A61M1/3693 , A61M1/3696 , A61M2202/0427 , A61M2205/331 , A61M2205/3344 , A61M2205/3351 , A61M2205/3355 , A61M2205/3393 , B01D17/0217 , B01D21/0003 , B01D21/2405 , B01D21/245 , B01D21/2488 , B01D21/26 , B01D21/262 , B01D21/32 , B01D21/34 , B01D2221/10 , B04B5/0442 , B04B7/08 , B04B2005/045 , A61M2202/0071
摘要： Systems and methods for separating a suspension of plasma and platelets from whole blood rotate a chamber (58) about an axis (62) to create within the chamber (58) a low-G zone radially close to the axis (62) and a high-G zone (66) spaced radially further from the axis (62) than the low-G zone (64). The systems and methods introduce whole blood into an inlet region (68) of the chamber (58) to initiate separation of red blood cells toward the high-G zone (66) of the inlet region (68). This creates a strong flow of plasma that moves radially toward the low-G zone (64) of the inlet region (68) and elutes platelets into suspension with it. The systems and methods direct the radial flow of plasma and eluted platelets within the inlet region (68) to a port (72) in the inlet region (68) for transport out of the chamber (58).
摘要翻译：用于从全血分离血浆和血小板的悬浮液的系统和方法围绕轴线（62）旋转腔室（58），以在腔室（58）内产生径向靠近轴线（62）的低G区域，并且高 -G区（66）比所述低G区（64）径向地远离所述轴线（62）。系统和方法将全血引入腔室（58）的入口区域（68），以引发红细胞朝向入口区域（68）的高G区域（66）的分离。这产生强烈的等离子流，其径向地朝向入口区域（68）的低G区（64）移动，并将血小板与其一起洗脱成悬浮液。系统和方法将入口区域（68）内的等离子体和洗脱的血小板的径向流引导到入口区域（68）中的端口（72），以便输送出室（58）。

8. 发明申请

WO2014138566A3 BLOOD BAG COMPRISING REMOVABLE HEAT TRANSFER MEMBER AND SYSTEM FOR PROVIDING WRIST-ACTION MOTION DURING FREEZING OR THAWING 审中-公开
标题翻译：血液袋包括可移动热传递部件和系统，用于在冷冻或治疗期间提供手腕运动
公开(公告)号：WO2014138566A3
公开(公告)日：2015-01-08
申请号：PCT/US2014021690
申请日：2014-03-07
申请人： CRYOMEDIC TECHNOLOGIES LLC
发明人： WALTER WILLIAM , WALKER JIMMY
IPC分类号： A01N1/02 , A61M1/02
CPC分类号： A01N1/0268 , A01N1/0242 , A01N1/0263 , A01N1/0284 , A61J1/10 , A61J1/1487 , A61J2200/42 , A61J2200/44 , A61M1/025 , A61M1/0272 , A61M1/0281 , A61M1/36
摘要： One aspect of the present disclosure relates to a bag (10) for storing platelets or contaminated blood previously withdrawn from a subject. The bag comprises a flexible, closed container (12) and at least one removable heat transfer member (24). The container includes an inlet (14) adapted for fluid-tight connection to a tube member (16). A further aspect of the disclosure relates to a system for freezing or thawing platelets or contaminated blood, which comprises an agitator drive; a linkage arm operably connected to the agitator drive, the linkage arm configured to translate a rotary motion generated by the agitator drive to an angular reciprocation motion; a reciprocating arm operably connected to the linkage arm; and a container configured to hold the blood and being operably connected to a distal end of the reciprocating arm. Operation of the system provides a wrist-action motion to the container and thereby minimizes the amount of red blood cell (RBC) and platelet lysis caused by freezing or thawing.
摘要翻译：本公开的一个方面涉及一种用于存储先前从受试者撤回的血小板或污染的血液的袋（10）。该袋包括柔性封闭容器（12）和至少一个可拆卸传热构件（24）。容器包括适于与管构件（16）流体密封连接的入口（14）。本公开的另一方面涉及用于冷冻或解冻血小板或污染血液的系统，其包括搅拌器驱动; 连杆臂可操作地连接到搅拌器驱动器，所述连杆臂构造成将由搅拌器驱动产生的旋转运动转换成角度往复运动; 可操作地连接到所述连杆臂的往复臂; 以及构造成保持血液并且可操作地连接到往复臂的远端的容器。该系统的操作为容器提供了手腕动作，从而使红细胞（RBC）的量和冻结或解冻引起的血小板裂解最小化。

9. 发明申请

WO2014181158A1 MIXING SYSTEM FOR MIXING BIOLOGICAL SPECIMENS WITH ADDITIVES 审中-公开
标题翻译：用于混合生物样品与添加剂的混合系统
公开(公告)号：WO2014181158A1
公开(公告)日：2014-11-13
申请号：PCT/IB2013/058403
申请日：2013-09-09
申请人： BIOSAFE S.A.
发明人： CAMISANI, Julien Pierre , WARIDEL, Olivier
IPC分类号： B01F11/00 , B01F15/06 , A61M1/02
CPC分类号： A61J1/2003 , A01N1/0242 , A61J1/10 , A61J1/165 , A61M1/025 , A61M2205/36 , B01F5/0602 , B01F11/0065 , B01F15/0085 , B01F15/065 , B01F2015/062 , B01F2215/0037
摘要： A device for mixing biological specimens contained in flexible storage bags (104) at controlled temperature, comprising a support (105) for supporting a storage bag containing a biological specimen to be mixed; means for imparting a displacement to a specimen in a storage bag on the support to mix the specimen; and temperature control means for maintaining the specimens at a controlled temperature during mixing. The means for imparting displacement to a specimen comprises at least one inflatable/deflatable bag (102, 103) (air bag) that when inflated contacts the surface of a part of a storage bag to progressively squeeze the storage bag and displace the contained specimen into another part of the storage bag.
摘要翻译：一种用于混合在受控温度下容纳在柔性储存袋（104）中的生物样品的装置，包括用于支撑包含要混合的生物样本的储存袋的支撑件（105）用于对所述支撑体上的储存袋中的样本施加位移以混合所述样本的装置; 以及用于在混合期间将样品保持在受控温度的温度控制装置。用于赋予样品置换的装置包括至少一个充气/可放气的袋（102,103）（气袋），当充气接触存储袋的一部分的表面时，逐渐挤压储存袋并将所容纳的样品置于储物袋的另一部分。

10. 发明申请

WO2003090795A1 APPARATUS AND METHOD FOR IRRADIATING AND MIXING FLUIDS IN CONTAINERS 审中-公开
标题翻译：装置和容器中混合流体的方法
公开(公告)号：WO2003090795A1
公开(公告)日：2003-11-06
申请号：PCT/US2003/013278
申请日：2003-04-28
申请人： GAMBRO, INC.
发明人： HLAVINKA, Dennis, J. , MARTINEZ, Michael, A.
IPC分类号： A61L2/08
CPC分类号： B01F5/0682 , A61L2/0011 , A61L2/0088 , A61L2/08 , A61L2/084 , A61L2/10 , A61L2202/22 , A61M1/025 , A61M1/0277 , A61M1/3683 , B01F5/0683 , B01F5/0688 , B01F9/0014 , B01F11/0065 , B01F13/0001 , B01F13/001
摘要： A mixing system, apparatus and/or method. Pathogen reduction of and/or mixing storage solutions into blood or blood components are useful purposes for these. Squeezing or clapping devices may be used to activate the mixing process, as may rotational devices or laterally movable, rotational and/or orbital devices. Constriction elements may also be used to create useful vortex mixing actions. Photoradiation may be provided while the components continue to be mixed together for pathogen reduction of blood or blood components.
摘要翻译：混合系统，装置和/或方法。病原体减少和/或将储存溶液混合到血液或血液成分中是有用的。压缩或拍打装置可以用于激活混合过程，如旋转装置或横向可移动，旋转和/或轨道装置。收缩元件也可用于产生有用的涡流混合动作。可以提供光引发剂，同时组分继续混合在一起用于血液或血液成分的病原体减少。

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