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1. 发明申请

WO00061256A1 METHOD AND APPARATUS FOR PRODUCING PLATELET RICH PLASMA AND/OR PLATELET CONCENTRATE 审中-公开
标题翻译：用于生产富勒斯等离子体和/或电解质浓缩物的方法和装置
公开(公告)号：WO00061256A1
公开(公告)日：2000-10-19
申请号：PCT/US2000/008718
申请日：2000-04-11
IPC分类号： G01N33/48 , A61K35/14 , A61M1/02 , A61M1/36 , B01D21/26 , B04B5/02 , B04B5/04 , G01N33/49
CPC分类号： A61M1/0209 , A61M1/029 , A61M1/3693 , A61M2202/0415 , A61M2202/0427 , B01D21/262 , B01D2221/10 , B04B5/0421 , A61M2202/0092
摘要： Platelet rich plasma and/or platelet concentrate is prepared by placing whole blood in a first chamber (6) of a sterile processing disposable having two chambers (6, 8). The processing disposable is subjected to a first centrifugation to separate red blood cells (36), and the resulting platelet rich plasma supernatant (38) is decanted to the second chamber (8). The processing disposable is subjected to a second centrifugation to concentrate platelets. A volume of the platelet poor plasma supernatant in the second chamber (8) is removed, and the platelets are re-suspended in the remaining plasma. The second chamber (8) may contain anticoagulant (34) to preclude aggregation of the platelets.
摘要翻译：通过将全血放置在具有两个腔室（6,8）的无菌处理一次性的第一腔室（6）中来制备富血小板血浆和/或血小板浓缩物。对一次性处理进行第一次离心以分离红细胞（36），并将所得的富含血小板的血浆上清液（38）倾析到第二腔室（8）。对一次性处理进行第二次离心以浓缩血小板。除去第二腔室（8）中血小板不良血浆上清液的体积，并将血小板重新悬浮在剩余的血浆中。第二室（8）可以含有抗凝血剂（34）以排除血小板聚集。

2. 发明申请

WO99002215A1 TREATMENT OF INFLAMMATORY DISORDERS OF THE BOWEL AND URINARY BLADDER 审中-公开
标题翻译：治疗BOWEL和URIARY BLADDER的炎症性疾病
公开(公告)号：WO99002215A1
公开(公告)日：1999-01-21
申请号：PCT/US1998/014118
申请日：1998-07-08
IPC分类号： A61K31/37 , A61M1/36 , A61M37/00
CPC分类号： A61K31/37 , A61M1/3681 , A61M1/3683 , A61M2202/0439 , A61M2205/051 , A61M2202/0092
摘要： A method of treating inflammatory disorders of the bowel and inflammatory disorders of the urinary bladder is disclosed. A method of modulating the function of monocytes is also disclosed. The method involves the treatment of a patient's blood with a photoactivatable compound followed by ultraviolet light-activation of the photoactivatable compound. The blood treated as such is returned to the patient in a process known as extracorporeal photopheresis.
摘要翻译：公开了一种治疗肠道炎症性疾病和膀胱炎症性疾病的方法。还公开了调节单核细胞功能的方法。该方法涉及用可光活化化合物治疗患者的血液，然后紫外线激活可光活化化合物。如此处理的血液以称为体外光泳术的方法返回给患者。

3. 发明申请

WO0143756A3 REGENERATIVE ADJUVANT 审中-公开
标题翻译：再生工具
公开(公告)号：WO0143756A3
公开(公告)日：2002-03-28
申请号：PCT/EP0012803
申请日：2000-12-15
申请人： CURASAN AG , UHR GUENTER
发明人： UHR GUENTER
IPC分类号： A61K35/16 , A61M1/02 , A61M1/36 , A61P17/02 , A61P19/08 , A61K33/06 , A61K33/42 , B01L3/14
CPC分类号： A61K35/16 , A61M1/0272 , A61M1/3693 , A61M2202/0415 , A61M2202/0092
摘要： The invention relates to a regenerative adjuvant to be used in skin and bone defects of living beings and to a method that can be carried out in any doctor's practice without the need for a specialized laboratory. The invention further relates to a kit used with this regenerative adjuvant that can be easily handled. The inventive regenerative adjuvant for skin and bone defects comprises thrombocyte-rich plasma (platelet-rich plasma) and calcium phosphates. An inventive method comprises the following steps: drawing up blood into a container, fixing said container in a centrifuge, carrying out the first centrifugation step, removing the container from the centrifuge and the radially inner fraction from the container and transferring it to a second container, fixing said container in the centrifuge, carrying out the second centrifugation step at a substantially higher speed, removing the container from the centrifuge, removing a part of the radially inner fraction from the second container, mixing the radially outer fraction with the rest of the radially inner fraction in the second tube to give PRP plasma and mixing the content of the second container with a bone replacement agent.
摘要翻译：本发明涉及一种在皮肤和骨缺陷动物以及其可以在每一个医疗实践进行无需特别的实验室的方法的再生助剂，根据也容易处理的试剂盒将被用于此目的是要被形成的。用于皮肤和骨缺损的本发明的再生佐剂具有富含血小板的血浆（富含血小板血浆）和磷酸钙。根据本发明的方法具有以下步骤：在容器中升高血，夹持件放入离心机，进行第一离心步骤，去除从离心机容器并从容器径向内部分和在第二容器输送，夹紧其进入离心机，执行第二离心分离步骤以基本上更高的速度去除所述容器从离心机中，去除从第二容器径向内部分的一部分上，与所述径向内部部分的在该第二管中的剩余部分混合的径向外部分，以PRP等离子体和混合所述第二容器的内容这与骨替代物。

4. 发明申请

WO1992007656A2 SYSTEM AND METHOD FOR PROCESSING BIOLOGICAL FLUIDS 审中-公开
标题翻译：用于处理生物流体的系统和方法
公开(公告)号：WO1992007656A2
公开(公告)日：1992-05-14
申请号：PCT/US1991008316
申请日：1991-11-06
申请人： PALL CORPORATION
发明人： PALL CORPORATION , PALL, David, B. , GSELL, Thomas, C. , MATKOVICH, Vlado, I. , BORMANN, Thomas
IPC分类号： B01L03/14
CPC分类号： A61J1/10 , A61M1/0209 , A61M1/0218 , A61M1/0227 , A61M1/0231 , A61M1/029 , A61M1/3472 , A61M1/3633 , A61M1/3646 , A61M1/3652 , A61M1/3693 , A61M2202/0413 , A61M2202/0415 , A61M2202/0427 , A61M2202/0429 , A61M2202/0439 , A61M2206/12 , B01D61/14 , B01D61/145 , B01D61/147 , B01D61/16 , B01D63/087 , B01D2311/04 , B04B2005/0435 , A61M2202/0092 , A61M2202/0042 , A61M2202/0035 , A61M2202/005 , B01D2311/2649
摘要： A system for collecting and processing donated blood comprises a first porous medium interposed between a blood collection bag (11) and a satellite bag (18) and a second porous medium (13) interposed between the blood collection bag and another satellite bag (41). The porous media are leucocyte depletion media. The system may also include one or more of the following: a red cell barrier medium, a separation medium, a gas inlet, and a gas outlet. The system can be used to centrifuge whole blood into one or more components, and includes a means for protecting the system during centrifugation.

5. 发明申请

WO0174159A3 SYSTEMS AND METHODS FOR COLLECTING PLASMA THAT IS FREE OR VIRTUALLY FREE OF CELLULAR BLOOD SPECIES 审中-公开
标题翻译：收集等离子体的系统和方法是免费的或虚拟的免费细胞血液物种
公开(公告)号：WO0174159A3
公开(公告)日：2002-02-28
申请号：PCT/US0109866
申请日：2001-03-27
申请人： BAXTER INT
发明人： BLOM AGNETA A , MATHIAS JEAN-MARIE , MESPREUVE LUC , PAYRAT JEAN-MARC , VANDENDAUL DANIEL
IPC分类号： A61L2/04 , A61M1/02 , A61M1/36 , G01N33/49 , A61M37/00 , A61B19/00
CPC分类号： A61L2/04 , A61M1/0222 , A61M1/0227 , A61M1/0231 , A61M1/3633 , A61M1/3636 , A61M2202/0429 , A61M2205/60 , G01N33/491 , A61M2202/0092
摘要： Systems and methods treat plasma by separating targeted blood cell species such as red blood cells and platelets from the plasma by filtration through hydrophilic polyvinylidene fluoride (PVDF) membranes.
摘要翻译：系统和方法通过用亲水聚偏二氟乙烯（PVDF）膜过滤，从等离子体中分离目标血液细胞物质如红细胞和血小板来治疗血浆。

6. 发明申请

WO99053975A1 METHOD FOR PRODUCING A THROMBOCYTE PREPARATION 审中-公开
标题翻译：用于生产制备血小板
公开(公告)号：WO99053975A1
公开(公告)日：1999-10-28
申请号：PCT/EP1999/001119
申请日：1999-02-20
IPC分类号： A61M1/02
CPC分类号： A61M1/0209 , A61M1/0218 , A61M1/029 , A61M2202/0427 , A61M2202/0439 , A61M2205/331 , A61M2202/0042 , A61M2202/0092 , A61M2202/0057
摘要： The invention relates to a method for producing a thrombocyte preparation (27) that is low in leucocytes and erythrocytes from a thrombocyte concentrate (26) containing leucocytes and a residual proportion of erythrocytes. The thrombocyte concentrate (26) is initially centrifuged. The thrombocyte concentrate is subsequently filtered using a leucocyte depletion filter (21), beginning with the centrifugal supernatant. The proportion of erythocytes in the thrombocyte concentrate (26) to be filtered is monitored (16) before passing through to the leucocyte depletion filter (21). The entire filter process is terminated when a specific proportion of erythrocytes is obtained.
摘要翻译：在用于生产由血小板浓缩物（26），白细胞和红细胞贫血小板制剂（27）的方法，其包含白细胞和红细胞的剩余组分，血小板浓缩液（26）被第一离心。此后，血小板浓缩物开始通过白细胞滤器离心上清液（21）被过滤。在此之前在比例红细胞的白细胞去除过滤器（21）监测待过滤的血小板浓缩液（26）（16），并且结束时整个过滤过程的某一红细胞部分。

7. 发明申请

WO1994001193A1 AUTOMATED SYSTEM AND METHOD FOR PROCESSING BIOLOGICAL FLUID 审中-公开
标题翻译：自动化系统和处理生物流体的方法
公开(公告)号：WO1994001193A1
公开(公告)日：1994-01-20
申请号：PCT/US1993006547
申请日：1993-07-13
申请人： PALL CORPORATION , KRASNOFF, Eric, J. , BORMANN, Thomas, J. , GSELL, Thomas, C. , PASCALE, Frank, R. , MATKOVICH, Vlado, I.
发明人： PALL CORPORATION
IPC分类号： B01D21/30
CPC分类号： B01D63/08 , A61M1/02 , A61M1/0218 , A61M1/0227 , A61M1/025 , A61M1/029 , A61M1/3646 , A61M1/3652 , A61M1/3693 , A61M1/3698 , A61M5/1486 , A61M2202/0413 , A61M2202/0415 , A61M2202/0427 , A61M2202/0429 , A61M2202/0439 , B01D61/145 , B01D61/16 , B01D61/20 , B01D61/22 , B01D65/08 , B01D2321/2066 , B01D2321/2083 , A61M2202/0092 , A61M2202/0042 , A61M2202/0035 , A61M2202/005
摘要： An automated system for processing biological fluid includes a pressure differential generator (51); a biological fluid processing assembly (10), and an automated control arrangement (50) coupled to at least one of the pressure differential generator and the biological fluid processing assembly (10). The automated system may include at least one porous medium in a housing to form a filter assembly, such as a red cell barrier filter assembly (12), a leukocyte depletion filter assembly (13, 17) and a red cell barrier leukocyte depletion filter assembly.
摘要翻译：用于处理生物流体的自动化系统包括压差发生器（51）; 生物流体处理组件（10）和耦合到所述压力差发生器和所述生物流体处理组件（10）中的至少一个的自动化控制装置（50）。自动化系统可以包括壳体中的至少一个多孔介质以形成过滤器组件，例如红细胞屏障过滤器组件（12），白细胞消耗过滤器组件（13,17）和红细胞屏障白细胞消耗过滤器组件。

8. 发明申请

WO1993017774A1 FILTER AND METHOD FOR OBTAINING PLATELETS 审中-公开
标题翻译：用于获取板的过滤器和方法
公开(公告)号：WO1993017774A1
公开(公告)日：1993-09-16
申请号：PCT/US1993002010
申请日：1993-03-03
申请人： PALL CORPORATION
发明人： PALL CORPORATION , PALL, David, P. , GSELL, Thomas, C.
IPC分类号： B01D21/26
CPC分类号： A61M1/029 , A61J1/10 , A61M1/0209 , A61M1/0218 , A61M1/0227 , A61M1/0231 , A61M1/3633 , A61M1/3646 , A61M1/3652 , A61M1/3693 , A61M2202/0413 , A61M2202/0415 , A61M2202/0427 , A61M2202/0429 , A61M2202/0439 , A61M2206/12 , B01D39/1623 , B01D61/147 , B01D61/16 , B01D63/087 , A61M2202/005 , A61M2202/0092 , A61M2202/0042 , A61M2202/0071 , A61M2202/0035 , A61M2202/0057
摘要： A method is provided for processing donated blood, particularly a platelet-containing solution such as platelet-containing plasma, involving separating blood into a red cell containing sediment layer and a supernatant layer, and passing the supernatant layer through a filter until the filter is blocked, thereby leaving platelets to be harvested. The preferred filter comprises a housing (1) having an inlet (2) and an outlet (3) defining a liquid flow path between the inlet (2) and the outlet (3) and a porous medium (4) having a plurality of zones of progressively increasing density positioned inside the housing (1) across the liquid flow path.
摘要翻译：提供了一种用于处理捐赠血液，特别是含血小板的溶液如含血小板的血浆的方法，包括将血液分离成含有沉积物层和上清液层的红细胞，并将上清液层通过过滤器直至过滤器被堵塞，从而使血小板被收获。优选的过滤器包括具有入口（2）和限定入口（2）和出口（3）之间的液体流动通道的出口（3）的壳体（1）和具有多个区域的多孔介质逐渐增加位于壳体（1）内部的液体流动通道的密度。

9. 发明申请

WO01074159A2 SYSTEMS AND METHODS FOR COLLECTING PLASMA THAT IS FREE OR VIRTUALLY FREE OF CELLULAR BLOOD SPECIES 审中-公开
标题翻译：收集等离子体的系统和方法是免费的或虚拟的免费细胞血液物种
公开(公告)号：WO01074159A2
公开(公告)日：2001-10-11
申请号：PCT/US2001/009866
申请日：2001-03-27
IPC分类号： A61L2/04 , A61M1/02 , A61M1/36 , G01N33/49 , A01N
CPC分类号： A61L2/04 , A61M1/0222 , A61M1/0227 , A61M1/0231 , A61M1/3633 , A61M1/3636 , A61M2202/0429 , A61M2205/60 , G01N33/491 , A61M2202/0092
摘要： Systems and methods treat plasma by separating targeted blood cell species such as red blood cells and platelets from the plasma by filtration through hydrophilic polyvinylidene fluoride (PVDF) membranes.
摘要翻译：系统和方法通过用亲水聚偏二氟乙烯（PVDF）膜过滤，从等离子体中分离目标血液细胞物质如红细胞和血小板来治疗血浆。

10. 发明申请

WO99059493A1 CONFINED AIR TUBE AND METHODS FOR HANDLING AIR IN CLOSED BLOOD PROCESSING SYSTEMS 审中-公开
标题翻译：限制空气管和在封闭式血液处理系统中处理空气的方法
公开(公告)号：WO99059493A1
公开(公告)日：1999-11-25
申请号：PCT/US1999/010535
申请日：1999-05-12
IPC分类号： A61L2/04 , A61M1/02 , A61B19/00 , A61L2/00
CPC分类号： A61M1/0209 , A61L2/04 , A61M1/0218 , A61M1/0231 , A61M2202/0429 , A61M2205/60 , A61M2202/0092
摘要： A confined air tube (44) is intended to be placed into an in-line communication with the transfer tubing (36) of a blood processing system (30). The confined air tube provides an incremental volume of air, which keeps the transfer tubing from collapsing, and sticking together during heat sterilization. After sterilization, the confined air tube accommodates conveyance of a blood component into an associated downstream transfer container (34). The confined air tube can also receive air vented from the transfer container, so that the blood component can undergo further processing or be stored in an air-depleted environment within the transfer container.
摘要翻译：封闭空气管（44）旨在与血液处理系统（30）的输送管（36）成直线连通。密闭空气管提供增加的空气体积，保持输送管不会塌陷，并在加热灭菌期间粘在一起。灭菌后，密闭空气管容纳血液成分输送到相关联的下游转运容器（34）中。受限制的空气管还可以接收从转移容器排出的空气，使得血液成分可以进一步处理或存储在转移容器内的空气贫乏的环境中。

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