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1. 发明申请

WO2018053501A1 INSTRUMENT FOR PROCESSING CARTRIDGE FOR PERFORMING ASSAYS IN A CLOSED SAMPLE PREPARATION AND REACTION SYSTEM 审中-公开
标题翻译：在闭式样品制备和反应系统中加工用于进行测定的试剂盒的仪器
公开(公告)号：WO2018053501A1
公开(公告)日：2018-03-22
申请号：PCT/US2017/052248
申请日：2017-09-19
申请人： GENMARK DIAGNOSTICS, INC.
发明人： NGUYEN, Michael Thomas , FORD, Sean , HANSEN, Nikolas James
IPC分类号： G01N35/00
CPC分类号： G01N35/00732 , B01L3/502715 , B01L3/50273 , B01L3/502738 , B01L7/52 , B01L2200/04 , B01L2200/10 , B01L2300/123 , B01L2300/18 , B01L2300/1822 , B01L2300/1827 , B01L2400/0427 , B01L2400/0481 , B01L2400/0683 , G01N35/00029 , G01N35/00871 , G01N2035/00148 , G01N2035/00326 , G01N2035/00376 , G01N2035/00841 , G01N2035/00851 , G01N2035/0477
摘要： In one embodiment, a diagnostic system includes an instrument coupled to a client device and having at least one sample processing bay. The diagnostic system has a software architecture including instrument software (ISW) associated with the instrument. The ISW receives an assay definition file (ADF) that has a control file and an assay analysis module (AAM) file. The processing bay prepares and senses the sample according to parameters in the OPUS file and then generates sensor scan data. The diagnostic system then analyzes the sensor scan data and prepares a report according to the AAM file.
摘要翻译：在一个实施例中，诊断系统包括耦合到客户端设备并具有至少一个样品处理台的仪器。诊断系统具有软件架构，包括与仪器相关的仪器软件（ISW）。 ISW接收具有控制文件和化验分析模块（AAM）文件的化验定义文件（ADF）。处理托架根据OPUS文件中的参数准备并感测样本，然后生成传感器扫描数据。诊断系统然后分析传感器扫描数据并根据AAM文件准备报告。

2. 发明申请

WO2016077364A3 INSTRUMENT AND CARTRIDGE FOR PERFORMING ASSAYS IN A CLOSED SAMPLE PREPARATION AND REACTION SYSTEM 审中-公开
公开(公告)号：WO2016077364A3
公开(公告)日：2016-05-19
申请号：PCT/US2015/059978
申请日：2015-11-10
申请人： GENMARK DIAGNOSTICS, INC.
发明人： WRIGHT, David Walter , AIELLO, Dominic , KROEHL, Peter , KAYYEM, Jon Faiz , GRAY, Darren Scott , COREY, Scott , MURPHY, Brian , SCHNEIDER, Eric , FISH, Andrew , SRINIVASAN, Jay , MALTEZOS, George
IPC分类号： B01L3/00 , B01F7/16 , B01L7/00 , B01F7/00 , B01F13/00
摘要： In one embodiment, a multiplex fluid processing cartridge includes a sample well, a deformable fluid chamber, a mixing well with a mixer disposed therein, a lysis chamber including a lysis mixer, an electrowetting grid for microdroplet manipulation, and electrosensor arrays configured to detect analytes of interest. An instrument for processing the cartridge is configured to receive the cartridge and to selectively apply thermal energy, magnetic force, and electrical connections to one or more discrete locations on the cartridge and is further configured to compress the deformable chamber(s) in a specified sequence.

3. 发明申请

WO2019040769A1 ELECTROCHEMICAL DETECTION OF BACTERIAL AND/OR FUNGAL INFECTIONS 审中-公开
公开(公告)号：WO2019040769A1
公开(公告)日：2019-02-28
申请号：PCT/US2018/047781
申请日：2018-08-23
申请人： CLINICAL MICRO SENSORS, INC. (DBA GENMARK DIAGNOSTICS, INC.)
发明人： FREEMAN-COOK, Lisa Lynn , SHAW, Christine J. , MARTINEZ, Milena Iacobelli , AL-KHOURI, Anna Maria , BROWN, Bradley Adam , HARVEY, John Jay
IPC分类号： C12Q1/689 , C12Q1/6895
摘要： The present disclosure relates to methods and devices for amplifying a plurality of targets in a single PCR run while distinguishing between clinically relevant amplification and amplification from other sources such as from background contamination. The methods and devices further enable discrimination between gram-positive, gram-negative and fungal infections as wells as identify antimicrobial resistance genes. When applying the methods and devices of the invention, the species or genus of an infection(s), and genus of a fungal co-infection(s) or category of bacterial (gram-positive or negative) co-infection(s) are identified. Species identification of co-infections can also be achieved. Further, when applying the methods and devices of the invention, organisms which are likely to be contaminating organisms from a blood draw are identified.

4. 发明申请

WO2016077333A1 DOUBLE IDENTIFICATION FOR SAMPLE TRACKING ON A DIAGNOSTIC DEVICE 审中-公开
标题翻译：用于诊断设备上的样本跟踪的双重标识
公开(公告)号：WO2016077333A1
公开(公告)日：2016-05-19
申请号：PCT/US2015/059938
申请日：2015-11-10
申请人： GENMARK DIAGNOSTICS, INC.
发明人： TIEMAN, Brad Frederick , COREY, Scott
IPC分类号： G01N35/00
CPC分类号： B01L3/502 , B01L3/54 , B01L3/545 , B01L2200/026 , B01L2300/021 , B01L2300/022 , B01L2300/042 , B01L2300/087 , B01L2400/0481 , G01N35/00732 , G01N2035/00742 , G01N2035/00752 , G01N2035/00762 , G01N2035/00772 , G01N2035/00782 , G01N2035/00801 , G01N2035/00811 , G01N2035/00831 , G01N2035/00851
摘要： A sample-containing device configured to be placed into a sample processing instrument for performing a process on a sample contained in the device includes redundant identification features, such as machine-readable tags. A first machine-readable information tag is read before the device is placed in the instrument, and a second machine-readable information tag is read after the device is in the instrument. Information read from the two tags is compared to determine if there is proper correspondence between the information read from the tags to ensure that the correct sample processing device was placed in the instrument.
摘要翻译：被配置为放置在用于对包含在该设备中的样品进行处理的样品处理仪器中的样品含有装置包括冗余识别特征，诸如机器可读标签。在将设备放置在仪器中之前，先读取第一个机器可读信息标签，并在设备进入仪器后读取第二机器可读信息标签。比较从两个标签读取的信息，以确定从标签读取的信息之间是否存在正确的对应关系，以确保将正确的样品处理装置放置在仪器中。

5. 发明申请

WO2014150905A3 SYSTEMS, METHODS, AND APPARATUS FOR MANIPULATING DEFORMABLE FLUID VESSELS 审中-公开
标题翻译：用于操纵可变形流体容器的系统，方法和设备
公开(公告)号：WO2014150905A3
公开(公告)日：2014-09-25
申请号：PCT/US2014/024499
申请日：2014-03-12
申请人： GENMARK DIAGNOSTICS, INC.
发明人： WRIGHT, David, Walter , AIELLO, Dominic , CLARK, Robert
IPC分类号： B01L3/00
摘要： An apparatus for processing a fluid module, including a collapsible vessel supported on a planar substrate, comprises a first actuator component configured to be movable in a first direction is generally parallel to the plane of the substrate, a second actuator component configured to be movable in a second direction having a component that is normal to the plane of the substrate, and a motion conversion mechanism coupling the first actuator component with the second actuator component and configured to convert movement of the first actuator component in the first direction into movement of the second actuator component in the second direction. A fluid container comprises a first vessel, a second vessel connected or connectable to the first vessel, and a sealing partition preventing fluid flow from the second vessel. The container further includes a spherical opening element initially supported within the second vessel by the sealing partition and configured to be contacted with the sealing partition to open the sealing partition and permit fluid flow from the second vessel. An apparatus configured for displacing fluid from a fluid container comprises first and second actuators configured to be movable together until the first actuator compresses a first part of the fluid container and then moveable independently until the second actuator compresses a second part of the fluid container. Fluid containers comprise a first vessel, a second vessel, and a sealing partition preventing fluid flow from the second vessel and further include piercing means for piercing the sealing partition to permit fluid flow from the second vessel. A fluid container comprises a vessel configured to be collapsed to displace fluid from the vessel, a housing surrounding at least a portion of the vessel, and a floating compression plate movably disposed within the housing and configured to permit an external actuator to press the compression plate into the vessel to collapse the vessel and displace the fluid contents therefrom.
摘要翻译：一种用于处理流体模块的装置，所述流体模块包括支撑在平面基底上的可伸缩容器，所述装置包括被构造成可沿第一方向移动的第一致动器部件，其大致平行于所述基底的平面，第二致动器部件，所述第二致动器部件被构造成可沿具有垂直于所述衬底的所述平面的分量的第二方向运动;以及运动转换机构，其将所述第一致动器部件与所述第二致动器部件联接并且被配置为将所述第一致动器部件的运动进入第二致动器部件沿第二方向的运动的第一方向。流体容器包括第一容器，连接或可连接到第一容器的第二容器，以及防止流体从第二容器流动的密封隔板。该容器还包括球形开口元件，该球形开口元件最初由密封隔板支撑在第二容器内并配置成与密封隔板接触以打开密封隔板并允许流体从第二容器流动。构造成用于从流体容器中排出流体的装置包括第一致动器和第二致动器，第一致动器和第二致动器构造成一起移动直到第一致动器压缩流体容器的第一部分，然后独立地移动直到第二致动器压缩流体容器的第二部分。流体容器包括第一容器，第二容器和防止流体从第二容器流动的密封隔板，并且还包括用于刺穿密封隔板以允许流体从第二容器流动的刺穿装置。一种流体容器，包括：容器，其被配置为被压扁以从容器移置流体;外壳，其围绕容器的至少一部分;以及浮动压缩板，其可移动地设置在外壳内并且被配置为允许外部致动器按压压缩板进入容器以使容器塌陷并从中排出流体内容物。

6. 发明申请

WO2016077341A3 INSTRUMENT AND CARTRIDGE FOR PERFORMING ASSAYS IN A CLOSED SAMPLE PREPARATION AND REACTION SYSTEM EMPLOYING ELECTROWETTING FLUID MANIPULATION 审中-公开
标题翻译：用于在使用电解液流体操作的封闭样品制备和反应系统中进行测定的仪器和盒
公开(公告)号：WO2016077341A3
公开(公告)日：2017-06-08
申请号：PCT/US2015059947
申请日：2015-11-10
申请人： GENMARK DIAGNOSTICS INC , ADVANCED LIQUID LOGIC INC
发明人： KAYYEM JON FAIZ , FORD SEAN , PAMULA VAMSEE K , SRINIVASAN VIJAY , COREY SCOTT , MURPHY BRIAN , WRIGHT DAVID WALTER , AIELLO DOMINIC
IPC分类号： B01L3/00
CPC分类号： B01L3/502 , B01L3/502792 , B01L3/52 , B01L7/525 , B01L2200/04 , B01L2200/0647 , B01L2200/10 , B01L2200/16 , B01L2300/021 , B01L2300/04 , B01L2300/06 , B01L2300/0636 , B01L2300/0672 , B01L2300/0681 , B01L2300/0816 , B01L2300/0867 , B01L2300/0874 , B01L2300/123 , B01L2300/1822 , B01L2400/0427 , B01L2400/043 , B01L2400/0481 , B01L2400/0487 , B01L2400/0683
摘要： In one embodiment, a multiplex fluid processing cartridge includes a sample well, a deformable fluid chamber, a mixing well with a mixer disposed therein, a lysis chamber including a lysis mixer, an electrowetting grid for microdroplet manipulation, and electrosensor arrays configured to detect analytes of interest. An instrument for processing the cartridge is configured to receive the cartridge and to selectively apply thermal energy, magnetic force, and electrical connections to one or more discrete locations on the cartridge and is further configured to compress the deformable chamber(s) in a specified sequence.
摘要翻译：在一个实施例中，多路复用流体处理盒包括样品井，可变形流体室，其中设置有混合器的混合井，包括裂解混合器的裂解室，用于微滴处理的电润湿网格，以及被配置为检测分析物的电传感器阵列出于兴趣。用于处理药筒的器械被配置为接收药筒并且选择性地将热能，磁力和电连接施加到药筒上的一个或多个离散位置，并且还被配置为以特定顺序压缩可变形腔室。

7. 发明申请

WO2016077341A2 INSTRUMENT AND CARTRIDGE FOR PERFORMING ASSAYS IN A CLOSED SAMPLE PREPARATION AND REACTION SYSTEM EMPLOYING ELECTROWETTING FLUID MANIPULATION 审中-公开
标题翻译：用于在封闭的样品制备和反应系统中进行测定的仪器和盒子使用电镀液体操作
公开(公告)号：WO2016077341A2
公开(公告)日：2016-05-19
申请号：PCT/US2015/059947
申请日：2015-11-10
申请人： GENMARK DIAGNOSTICS, INC. , ADVANCED LIQUID LOGIC, INC.
发明人： KAYYEM, Jon Faiz , FORD, Sean , PAMULA, Vamsee K. , SRINIVASAN, Vijay , COREY, Scott , MURPHY, Brian , WRIGHT, David Walter , AIELLO, Dominic
IPC分类号： B01L3/00
CPC分类号： B01L3/502 , B01L3/502792 , B01L3/52 , B01L7/525 , B01L2200/04 , B01L2200/0647 , B01L2200/10 , B01L2200/16 , B01L2300/021 , B01L2300/04 , B01L2300/06 , B01L2300/0636 , B01L2300/0672 , B01L2300/0681 , B01L2300/0816 , B01L2300/0867 , B01L2300/0874 , B01L2300/123 , B01L2300/1822 , B01L2400/0427 , B01L2400/043 , B01L2400/0481 , B01L2400/0487 , B01L2400/0683
摘要： In one embodiment, a multiplex fluid processing cartridge includes a sample well, a deformable fluid chamber, a mixing well with a mixer disposed therein, a lysis chamber including a lysis mixer, an electrowetting grid for microdroplet manipulation, and electrosensor arrays configured to detect analytes of interest. An instrument for processing the cartridge is configured to receive the cartridge and to selectively apply thermal energy, magnetic force, and electrical connections to one or more discrete locations on the cartridge and is further configured to compress the deformable chamber(s) in a specified sequence.
摘要翻译：在一个实施例中，多重流体处理盒包括样品阱，可变形流体室，与其中设置的混合器的混合井，包含裂解混合器的裂解室，用于微滴操作的电润湿栅格和被配置为检测分析物的电传感器阵列出于兴趣。用于处理盒的装置被配置为接收盒并且选择性地将热能，磁力和电连接施加到盒上的一个或多个离散位置，并且还被配置成以指定的顺序压缩可变形室。

8. 发明申请

WO2014066704A1 INTEGRATED MULTIPLEX TARGET ANALYSIS 审中-公开
标题翻译：综合多目标分析
公开(公告)号：WO2014066704A1
公开(公告)日：2014-05-01
申请号：PCT/US2013/066717
申请日：2013-10-24
申请人： GENMARK DIAGNOSTICS, INC.
发明人： KAYYEM, Jon, Faiz , SRINIVASAN, Jay
IPC分类号： G01N13/02 , G01N27/26 , G01N33/00 , C12Q1/68 , C12M1/34 , B01L3/00 , F16H21/00 , F16H25/00 , B65D81/32
CPC分类号： C12Q1/6825 , B01L3/502715 , B01L3/502738 , B01L3/502784 , B01L3/523 , B01L7/52 , B01L9/527 , B01L2200/025 , B01L2200/10 , B01L2200/16 , B01L2300/021 , B01L2300/0672 , B01L2300/0816 , B01L2300/0867 , B01L2300/1822 , B01L2300/1827 , B01L2400/0427 , B01L2400/0481 , B01L2400/0683
摘要： A biochip cartridge comprising: a) a bottom substrate comprising a printed circuit board (PCB) comprising: i) an electrowetting grid of electrodes forming a droplet pathway; ii) an array of detection electrodes accessible to said droplet pathway, each comprising a self-assembled monolayer and a capture probe; iii) a plurality of interconnections from said electrowetting grid and said detection electrodes; and b) a top plate comprising a conductive surface parallel to said bottom substrate and mated thereto to form a reaction chamber. Furthermore, a method of detecting target nucleic acids, an apparatus for processing fluid, and a fluid container are also disclosed. The method of detecting target nucleic acids include adding binding buffer and capture beads to the sample, eluting the target nucleic acids from the beads and amplifying them to form amplicans, adding signalling probes to the amplicons to form hybridization complexes, and binding the hybridization complexes to capture probes to form and detect assay complexes. The apparatus for processing a fluid comprises a collapsible vessel including a first actuator, a second actuator which are coupled through a motion conversion mechanism. The first described fluid container comprises a first vessel, a second vessel, a sealing partition, and an opening device to open the sealing partition. The second described fluid container comprises a collapsible vessel surrounded by a housing and means to apply an external pressure to displace fluid from the vessel.
摘要翻译：一种生物芯片盒，包括：a）包括印刷电路板（PCB）的底部基板，包括：i）形成液滴通道的电极的电润湿网格; ii）可由所述液滴通道接近的检测电极阵列，每个包括自组装单层和捕获探针; iii）来自所述电润湿网格和所述检测电极的多个互连; 以及b）顶板，其包括平行于所述底部基板的导电表面并与之配合以形成反应室。此外，还公开了检测靶核酸的方法，用于处理流体的装置和流体容器。检测靶核酸的方法包括向样品中加入结合缓冲液和捕获珠，从珠中洗脱靶核酸并扩增其形成扩增子，向扩增子加入信号探针以形成杂交复合物，并将杂交复合物结合到捕获探针以形成和检测测定复合物。用于处理流体的装置包括可折叠容器，其包括第一致动器，通过运动转换机构联接的第二致动器。第一种描述的流体容器包括第一容器，第二容器，密封隔板和用于打开密封隔板的打开装置。第二种描述的流体容器包括由壳体包围的可折叠容器和用于施加外部压力以从容器移置流体的装置。

9. 发明申请

WO2020072763A1 SYSTEMS AND METHODS FOR ASSESSING ELECTRICAL CONNECTIVITY BETWEEN ELEMENTS OF ASSAY DEVICES 审中-公开
公开(公告)号：WO2020072763A1
公开(公告)日：2020-04-09
申请号：PCT/US2019/054478
申请日：2019-10-03
申请人： GENMARK DIAGNOSTICS, INC.
发明人： TAYLOR, Roger Harry
IPC分类号： G01R31/04
摘要： Disclosed are devices, systems and methods for assessing the integrity of electrical connections between elements of interfacing electronic devices. In some aspects, a system includes an analysis device having electronics that interface with an assay cartridge inserted into the analysis device, wherein the analysis device is configured to conduct a preflight test in which impedance values for each circuit between the assay cartridge and analysis device are rearranged and assessed to determine the electrical connection integrity of the assay cartridge to the analysis device prior to implementing the assay.

10. 发明申请

WO2015050872A1 MODULE WITH COLLAPSIBLE FLUID CHAMBER AND ONBOARD FLUID CHAMBER COMPRESSION ELEMENT 审中-公开
标题翻译：具有可拆卸流体室和板载流体室压缩元件的模块
公开(公告)号：WO2015050872A1
公开(公告)日：2015-04-09
申请号：PCT/US2014/058322
申请日：2014-09-30
申请人： GENMARK DIAGNOSTICS, INC.
发明人： WRIGHT, David, Walter
IPC分类号： B01L3/00 , B65D81/32
CPC分类号： B01L3/505 , B01L3/502 , B01L3/52 , B01L2200/0621 , B01L2300/0816 , B01L2300/087 , B01L2300/12 , B01L2300/123 , B01L2300/126 , B01L2400/0481 , B65D81/3238
摘要： A module for processing fluids includes one or more collapsible fluid chambers supported on a substrate, a compression element supported on the substrate and configured to be movable with respect to the one or more chambers, and an actuating element coupled to the compression element and configured to effect movement of the compression element relative to the one or more fluid chambers to collapse each fluid chamber by compressing the fluid chamber between the compression element and the substrate as the compression element moves over the fluid chamber. A method for motivating a fluid out of a fluid chamber comprises the steps of providing a module that includes one or more collapsible fluid chambers supported on a substrate, a compression element supported on the substrate and configured to be movable with respect to the one or more chambers, and an actuating element coupled to the compression element and configured to effect movement of the compression element relative to the one or more fluid chambers and moving the actuator element to move the compression element across at least a portion of t substrate and compress the fluid chamber, thereby motivating the fluid out of the fluid chamber.
摘要翻译：用于处理流体的模块包括支撑在基板上的一个或多个可折叠流体室，支撑在基板上并被配置为可相对于一个或多个室移动的压缩元件，以及联接到压缩元件的致动元件，当压缩元件在流体室上移动时，压缩元件相对于一个或多个流体室的运动，以使每个流体室压缩，以压缩压缩元件和衬底之间的流体室。一种用于将流体从流体室中激励的方法包括以下步骤：提供模块，该模块包括支撑在基板上的一个或多个可折叠流体室，支撑在基板上的压缩元件，并被配置为可相对于一个或多个腔室和联接到压缩元件并被配置为实现压缩元件相对于一个或多个流体室的移动的致动元件并且移动致动器元件以使压缩元件跨过t基底的至少一部分并压缩流体从而激励流体离开流体室。

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