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1. 发明申请

WO2016077341A2 INSTRUMENT AND CARTRIDGE FOR PERFORMING ASSAYS IN A CLOSED SAMPLE PREPARATION AND REACTION SYSTEM EMPLOYING ELECTROWETTING FLUID MANIPULATION 审中-公开
标题翻译：用于在封闭的样品制备和反应系统中进行测定的仪器和盒子使用电镀液体操作
公开(公告)号：WO2016077341A2
公开(公告)日：2016-05-19
申请号：PCT/US2015/059947
申请日：2015-11-10
申请人： GENMARK DIAGNOSTICS, INC. , ADVANCED LIQUID LOGIC, INC.
发明人： KAYYEM, Jon Faiz , FORD, Sean , PAMULA, Vamsee K. , SRINIVASAN, Vijay , COREY, Scott , MURPHY, Brian , WRIGHT, David Walter , AIELLO, Dominic
IPC分类号： B01L3/00
CPC分类号： B01L3/502 , B01L3/502792 , B01L3/52 , B01L7/525 , B01L2200/04 , B01L2200/0647 , B01L2200/10 , B01L2200/16 , B01L2300/021 , B01L2300/04 , B01L2300/06 , B01L2300/0636 , B01L2300/0672 , B01L2300/0681 , B01L2300/0816 , B01L2300/0867 , B01L2300/0874 , B01L2300/123 , B01L2300/1822 , B01L2400/0427 , B01L2400/043 , B01L2400/0481 , B01L2400/0487 , B01L2400/0683
摘要： In one embodiment, a multiplex fluid processing cartridge includes a sample well, a deformable fluid chamber, a mixing well with a mixer disposed therein, a lysis chamber including a lysis mixer, an electrowetting grid for microdroplet manipulation, and electrosensor arrays configured to detect analytes of interest. An instrument for processing the cartridge is configured to receive the cartridge and to selectively apply thermal energy, magnetic force, and electrical connections to one or more discrete locations on the cartridge and is further configured to compress the deformable chamber(s) in a specified sequence.
摘要翻译：在一个实施例中，多重流体处理盒包括样品阱，可变形流体室，与其中设置的混合器的混合井，包含裂解混合器的裂解室，用于微滴操作的电润湿栅格和被配置为检测分析物的电传感器阵列出于兴趣。用于处理盒的装置被配置为接收盒并且选择性地将热能，磁力和电连接施加到盒上的一个或多个离散位置，并且还被配置成以指定的顺序压缩可变形室。

2. 发明申请

WO2016077364A3 INSTRUMENT AND CARTRIDGE FOR PERFORMING ASSAYS IN A CLOSED SAMPLE PREPARATION AND REACTION SYSTEM 审中-公开
公开(公告)号：WO2016077364A3
公开(公告)日：2016-05-19
申请号：PCT/US2015/059978
申请日：2015-11-10
申请人： GENMARK DIAGNOSTICS, INC.
发明人： WRIGHT, David Walter , AIELLO, Dominic , KROEHL, Peter , KAYYEM, Jon Faiz , GRAY, Darren Scott , COREY, Scott , MURPHY, Brian , SCHNEIDER, Eric , FISH, Andrew , SRINIVASAN, Jay , MALTEZOS, George
IPC分类号： B01L3/00 , B01F7/16 , B01L7/00 , B01F7/00 , B01F13/00
摘要： In one embodiment, a multiplex fluid processing cartridge includes a sample well, a deformable fluid chamber, a mixing well with a mixer disposed therein, a lysis chamber including a lysis mixer, an electrowetting grid for microdroplet manipulation, and electrosensor arrays configured to detect analytes of interest. An instrument for processing the cartridge is configured to receive the cartridge and to selectively apply thermal energy, magnetic force, and electrical connections to one or more discrete locations on the cartridge and is further configured to compress the deformable chamber(s) in a specified sequence.

3. 发明申请

WO2014150905A3 SYSTEMS, METHODS, AND APPARATUS FOR MANIPULATING DEFORMABLE FLUID VESSELS 审中-公开
标题翻译：用于操纵可变形流体容器的系统，方法和设备
公开(公告)号：WO2014150905A3
公开(公告)日：2014-09-25
申请号：PCT/US2014/024499
申请日：2014-03-12
申请人： GENMARK DIAGNOSTICS, INC.
发明人： WRIGHT, David, Walter , AIELLO, Dominic , CLARK, Robert
IPC分类号： B01L3/00
摘要： An apparatus for processing a fluid module, including a collapsible vessel supported on a planar substrate, comprises a first actuator component configured to be movable in a first direction is generally parallel to the plane of the substrate, a second actuator component configured to be movable in a second direction having a component that is normal to the plane of the substrate, and a motion conversion mechanism coupling the first actuator component with the second actuator component and configured to convert movement of the first actuator component in the first direction into movement of the second actuator component in the second direction. A fluid container comprises a first vessel, a second vessel connected or connectable to the first vessel, and a sealing partition preventing fluid flow from the second vessel. The container further includes a spherical opening element initially supported within the second vessel by the sealing partition and configured to be contacted with the sealing partition to open the sealing partition and permit fluid flow from the second vessel. An apparatus configured for displacing fluid from a fluid container comprises first and second actuators configured to be movable together until the first actuator compresses a first part of the fluid container and then moveable independently until the second actuator compresses a second part of the fluid container. Fluid containers comprise a first vessel, a second vessel, and a sealing partition preventing fluid flow from the second vessel and further include piercing means for piercing the sealing partition to permit fluid flow from the second vessel. A fluid container comprises a vessel configured to be collapsed to displace fluid from the vessel, a housing surrounding at least a portion of the vessel, and a floating compression plate movably disposed within the housing and configured to permit an external actuator to press the compression plate into the vessel to collapse the vessel and displace the fluid contents therefrom.
摘要翻译：一种用于处理流体模块的装置，所述流体模块包括支撑在平面基底上的可伸缩容器，所述装置包括被构造成可沿第一方向移动的第一致动器部件，其大致平行于所述基底的平面，第二致动器部件，所述第二致动器部件被构造成可沿具有垂直于所述衬底的所述平面的分量的第二方向运动;以及运动转换机构，其将所述第一致动器部件与所述第二致动器部件联接并且被配置为将所述第一致动器部件的运动进入第二致动器部件沿第二方向的运动的第一方向。流体容器包括第一容器，连接或可连接到第一容器的第二容器，以及防止流体从第二容器流动的密封隔板。该容器还包括球形开口元件，该球形开口元件最初由密封隔板支撑在第二容器内并配置成与密封隔板接触以打开密封隔板并允许流体从第二容器流动。构造成用于从流体容器中排出流体的装置包括第一致动器和第二致动器，第一致动器和第二致动器构造成一起移动直到第一致动器压缩流体容器的第一部分，然后独立地移动直到第二致动器压缩流体容器的第二部分。流体容器包括第一容器，第二容器和防止流体从第二容器流动的密封隔板，并且还包括用于刺穿密封隔板以允许流体从第二容器流动的刺穿装置。一种流体容器，包括：容器，其被配置为被压扁以从容器移置流体;外壳，其围绕容器的至少一部分;以及浮动压缩板，其可移动地设置在外壳内并且被配置为允许外部致动器按压压缩板进入容器以使容器塌陷并从中排出流体内容物。

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