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    • 9. 发明申请
      WO1998025924A1 8-AZABICYCLO[3.2.1]OCTANE-, 8-AZABICYCLO[3.2.1]OCT-6-ENE-, 9-AZABICYCLO[3.3.1]NONANE-, 9-AZA-3-OXABICYCLO[3.3.1]NONANE- AND 9-AZA-3-THIABICYCLO[3.3.1]NONANE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS INSECTICIDES 审中-公开
    • 8-AZABICYCLO[3.2.1]OCTANE-, 8-AZABICYCLO[3.2.1]OCT-6-ENE-, 9-AZABICYCLO[3.3.1]NONANE-, 9-AZA-3-OXABICYCLO[3.3.1]NONANE- AND 9-AZA-3-THIABICYCLO[3.3.1]NONANE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS INSECTICIDES
    • 8-亚氨基双环[3.2.1]十八烷，8-亚氨基二环[3.2.1] OCT-6-ENE-，9-异亚氨基[3.3.1] NONANE-，9-亚氨基-3-氧代羰基[3.3.1] NONANE - 和9-氨基-3-噻唑啉[3.3.1] NONANE衍生物，其制备及其作为杀虫剂的用途
    • WO1998025924A1
    • 1998-06-18
    • PCT/GB1997003054
    • 1997-11-06
    • ZENECA LIMITED , URCH, Christopher, John , LEWIS, Terence , SUNLEY, Raymond, Leo , SALMON, Raymond , GODFREY, Christopher, Richard, Ayles , BRIGHTWELL, Christopher, Ian , HOTSON, Matthew, Brian
    • ZENECA LIMITED
    • C07D451/14
    • C07D451/02 , A01N43/90 , A01N47/16 , A01N47/18 , C07D451/04 , C07D451/06 , C07D451/14
    • A compound of formula (I) wherein A represents a bidentate group of the formula -CH2-X-CH2- (wherein X is methylene, sulfur or oxygen), X'C=CY or X'WC-CYZ (wherein X', W, Y and Z are independently hydrogen, hydroxy, acyloxy, alkoxy, alkylsilyloxy, cyano or halogen, or X' and W or Y and Z together with the carbon to which they are attached form a carbonyl group), provided that A is not CH2-CH2; Ar is an optionally substituted phenyl or 5- or 6-membered heterocyclic ring system containing from 1 to 3 heteroatoms individualy selected from nitrogen, oxygen and sulfur atoms, and at least one unsaturation (double bond) between adjacent atoms in the ring, said heterocyclic ring being optionally fused to a benzene ring, wherein the substituents, if present, are selected from halogen atoms, cyano, alkyl, alkenyl, alkynyl, alkoxy, haloalkyl, haloalkenyl, alkylthio and alkyl amino groups, any of which groups contain up to six carbon atoms; R is hydrogen or cyano or a group selected from alkyl, aryl, heteroaryl, aralkyl, heteroarylalkyl, alkenyl, aralkenyl, alkynyl, alkoxycarbonyl, alkanesulfonyl, arenesulfonyl, alkenyloxycarbonyl, aralkylocycarbonyl, aryloxycarbonyl, heterocyclylalkyl, carbamyl, dithiocarboxyl or X''R (where X'' represents oxygen or a group NR ), provided that when R is alkenyl, aralkenyl or alkynyl said group does not have an unsaturated carbon atom bonding directly to the ring nitrogen of formula (I); R is hydrogen, cyano, hydroxy, alkyl, alkoxy, amino, nitro, isocyanato, acylamino, hydroxyalkyl, optionally substituted heteroaryl, alkoxyalkyl, haloalkyl, halohydroxyalkyl, aralkyloxyalkyl, acyloxyalkyl, amidoximido, sulfonyloxyalkyl, aminoalkyl, alkoxycarbonylamino, acylaminoalkyl, cyanoalkyl, imino, formyl, acyl or carboxylic acid or an ester or amide thereof, or alkenyl or alkynyl either of which is optionally substituted by halogen, alkoxy, cycloalkyl, optionally substituted aryl, optionally substituted heteroaryl or cyano; R and R are, independently, hydrogen, alkyl, aryl, heteroaryl, aralkyl, heteroarylalkyl, alkenyl, aralkenyl, alkynyl, heterocyclylalkyl, alkoxycarbonyl or carboxylic acyl; alkyl moieties of R, R and R comprise from 1 to 15 carbon atoms, and are optionally substituted with one or more substituents selected from, halogen, cyano, carboxyl, carboxylic acyl, carbamyl, alkoxycarbonyl, alkoxy, alkylenedioxy, hydroxy, nitro, amino, acylamino, imidate and phosphonato groups; aryl, heteroaryl, aralkyl, heteroarylalkyl, alkenyl, aralkenyl, alkynyl, alkoxycarbonyl, alkanesulfonyl, arenesulfonyl, alkanyloxycarbonyl, aralkyloxycarbonyl, aryloxycarbonyl, heterocyclylalkyl, carbamyl, dithiocarboxyl moieties of R, R and R comprise from 1 to 15 carbon atoms, and are optionally substituted with one or more substituents selected from, halogen, cyano, carboxyl, carboxylic acyl, carbamyl, alkoxycarbonyl, alkoxy, alkylenedioxy, hydroxy, nitro, haloalkyl, alkyl, amino, acylamino, imidate and phosphonato groups; or an acid addition salt, quaternary ammonium salt or N -oxide derived therefrom; an insecticidal, acaricidal or nematicidal composition comprising a compound of formula (I) and a suitable carrier or diluent therefor; a method of combating and controlling insect, acarine or nematode pests at a locus which comprises treating the pests or the locus of the pests with an effective amount of a compound of formula (I) or a composition as hereinbefore described.
    • 式（I）的化合物，其中A表示式-CH 2 -X-CH 2 - （其中X是亚甲基，硫或氧），X'C = CY或X'WC-CYZ（其中X'， W，Y和Z独立地是氢，羟基，酰氧基，烷氧基，烷基甲硅烷氧基，氰基或卤素，或X'和W或Y和Z与它们所连接的碳一起形成羰基），条件是A不是 CH2-CH2; Ar是任选取代的苯基或含有1至3个选自氮，氧和硫原子的杂原子的5或6元杂环系，以及环中相邻原子之间的至少一个不饱和键（双键），所述杂环 任选地与苯环稠合，其中取代基（如果存在的话）选自卤素原子，氰基，烷基，烯基，炔基，烷氧基，卤代烷基，卤代烯基，烷硫基和烷基氨基，其中任何一个基团含有最多六个 碳原子 R是氢或氰基或选自烷基，芳基，杂芳基，芳烷基，杂芳基烷基，烯基，芳烯基，炔基，烷氧基羰基，链烷磺酰基，芳烃磺酰基，烯氧基羰基，芳烷基羰基，芳氧基羰基，杂环基烷基，氨基甲酰基，二硫代羧基或X'R （其中X“表示氧或基团NR 4），条件是当R是烯基时，所述基团不具有与式（I）的环氮直接键合的不饱和碳原子; R 1是氢，氰基，羟基，烷基，烷氧基，氨基，硝基，异氰酸根合，酰氨基，羟烷基，任选取代的杂芳基，烷氧基烷基，卤代烷基，卤代羟烷基，芳烷氧基烷基，酰氧基烷基，酰氨基亚氨基，磺酰氧基烷基，氨基烷基，烷氧基羰基氨基，酰基氨基烷基， 酰基或羧酸或其酯或酰胺，或任选被卤素，烷氧基，环烷基，任选取代的芳基，任选取代的杂芳基或氰基取代的链烯基或炔基; R 3和R 4独立地是氢，烷基，芳基，杂芳基，芳烷基，杂芳基烷基，烯基，芳烯基，炔基，杂环基烷基，烷氧基羰基或羧基酰基。 R 3，R 3和R 4的烷基部分含有1至15个碳原子，并且任选地被一个或多个选自卤素，氰基，羧基，羧酰基，氨基甲酰基，烷氧基羰基，烷氧基，亚烷基二氧基 ，羟基，硝基，氨基，酰氨基，亚氨基和膦酸基; 芳基，杂芳基，芳烷基，杂芳基烷基，烯基，芳烯基，炔基，烷氧基羰基，烷磺酰基，芳烃磺酰基，烷氧基羰基，芳烷氧基羰基，芳氧基羰基，杂环基烷基，氨基甲酰基，R 3，R 3和R 4的二硫代羧基部分包含1至15个碳 任选被一个或多个选自卤素，氰基，羧基，羧基酰基，氨基甲酰基，烷氧基羰基，烷氧基，亚烷基二氧基，羟基，硝基，卤代烷基，烷基，氨基，酰氨基，亚氨酸酯基和膦酸基的取代基取代。 或由其衍生的酸加成盐，季铵盐或N，N-氧化物; 杀虫杀螨或杀线虫组合物，其包含式（I）化合物及其合适的载体或稀释剂; 一种防治昆虫，螨虫或线虫害虫的方法，包括用有效量的式（I）化合物或上述组合物处理害虫或害虫的场所。
    • 基本信息 添加关注 加入工作空间 PDF全文 PDF下载 全文下载 相似专利 双屏查看 权利要求书 说明书全文 Global Dossier Espacenet 法律信息 同族专利 专利引用
    • 10. 发明申请
      WO1998024065A1 3D IMAGING FROM 2D SCANS 审中-公开
    • 3D IMAGING FROM 2D SCANS
    • 从2D扫描3D成像
    • WO1998024065A1
    • 1998-06-04
    • PCT/GB1997003250
    • 1997-11-27
    • ZENECA LIMITED
    • ZENECA LIMITED , ALLOTT, Christopher, Paul , BARRY, Christopher, David , ARUNDEL, Philip, Anthony , JOHN, Nigel, William , MELLOR, Paul, Maxwell
    • G06T17/00
    • G01S7/52087 , A61B8/483 , G01S15/8993 , G01S15/8995 , G06T17/00
    • There is disclosed a method and apparatus for reconstructing in 3D an image of an object scanned in 2D a plurality of times to produce a plurality of 2D image data slices at different angles of inclination. The slices are recorded and stored on a recording medium e.g. video tape, whereon the slices are recorded in succession together with at least one datum which identifies the image data slices as corresponding to at least one changing physical parameter such as positioning, ECG, and/or respiration cycle. The 2D image data slices are processed to create a 3D grid of points containing data values based on at least part of an object being scanned, with the image data values being inserted at the grid points as a result of processing the 2D image data slices in dependence upon said at least one datum. Preferably the scanning is carried out by feehand ultrasound scanning, and can be employed for the non-invasive determination of a condition inside a mammalian body.
    • 公开了一种用于在3D中重构在2D中多次扫描的对象的图像以产生不同倾斜角度的多个2D图像数据切片的方法和装置。 将切片记录并存储在记录介质上，例如 视频磁带，其中片与连续记录的至少一个数据一起记录，所述至少一个数据标识与至少一个改变的物理参数（例如定位，ECG和/或呼吸循环）相对应的图像数据切片。 处理2D图像数据切片以创建基于被扫描对象的至少一部分的包含数据值的点的3D网格，其中图像数据值作为处理2D图像数据切片的结果插入网格点 依赖于所述至少一个基准。 优选地，扫描通过手动超声扫描进行，并且可以用于非侵入式确定哺乳动物体内的状况。
    • 基本信息 添加关注 加入工作空间 PDF全文 PDF下载 全文下载 相似专利 双屏查看 权利要求书 说明书全文 Global Dossier Espacenet 法律信息 同族专利 专利引用
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