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1. 发明申请

WO1998028306A1 PROCESS FOR THE PREPARATION OF AN ORGANOZINC REAGENT 审中-公开
标题翻译：制备有机原料试剂的方法
公开(公告)号：WO1998028306A1
公开(公告)日：1998-07-02
申请号：PCT/GB1997003443
申请日：1997-12-15
申请人： ZENECA LIMITED , BLACKER, Andrew, John , FIELDEN, Jan, Michael
发明人： ZENECA LIMITED
IPC分类号： C07F03/06
CPC分类号： C07D213/30 , C07B53/00 , C07B2200/07 , C07C29/40 , C07F3/06 , C07C33/22 , C07C33/46 , C07C33/20
摘要： A process for the preparation of an aromatic organozinc compound is provided. The process comprises reacting a zinc chloride, bromide or iodide and an organometallic compoud of another metal comprising an aromatic moiety, producing a reaction product comprising an organozinc compound and a halide salt of the other metal. The reaction product is then contacted with a liquid hydrocarbon, in which the organozinc compound is soluble and the halide salt of the other metal is of low solubility. The halide salt of the other metal is separated from the hydrocarbon, and the organozinc compound can be recovered from the hydrocarbon. Organozinc compounds produced by this process can be employed to generate chiral centres in suitable substrates.
摘要翻译：提供了一种制备芳香族有机锌化合物的方法。该方法包括使氯化锌，溴化物或碘化物与包含芳族部分的另一种金属的有机金属化合物反应，产生包含有机锌化合物和另一种金属的卤化物盐的反应产物。然后使反应产物与液态烃接触，其中有机锌化合物是可溶的，另一种金属的卤化物盐的溶解度低。另一种金属的卤化物盐与烃分离，有机锌化合物可以从烃中回收。通过该方法制备的有机锌化合物可用于在合适的底物中产生手性中心。

2. 发明申请

WO1992008703A1 PROCESS FOR THE PREPARATION OF PYRIMIDINE COMPOUNDS 审中-公开
标题翻译：制备吡嗪化合物的方法
公开(公告)号：WO1992008703A1
公开(公告)日：1992-05-29
申请号：PCT/GB1991001989
申请日：1991-11-12
申请人： IMPERIAL CHEMICAL INDUSTRIES PLC , JONES, John, David , DeBOOS, Gareth, Andrew , WILKINSON, Paul , COX, Brian, Geoffrey , FIELDEN, Jan, Michael
发明人： IMPERIAL CHEMICAL INDUSTRIES PLC
IPC分类号： C07D239/34
CPC分类号： C07D239/34 , C07D307/83 , C07D311/12
摘要： A process for preparing agrochemical intermediates of formula (I), wherein W is (CH3O)2CH.CHCO2CH3 or CH3O.CH=CCO2CH3; Z is a halogen atom; and R , R , R and R are independently hydrogen, halogen, C1-4 alkyl, C1-4 alkoxy, acetoxy or acyl; the process comprising the steps of: (a) reacting a compound of formula (II), wherein X, R , R , R and R are as defined above, with a compound of formula ROCH3, wherein R is a metal; and, (b) reacting the product of (a) with a compound of formula (III), wherein Z and Z are halogen atoms. A process for the preparation of compounds of formula (II) and compounds of formula (II) themselves. A process for obtaining, in substantially pure form, a compound of formula (II) and compounds of formula (II) themselves. A process for obtaining, in substantially pure form, a compound of formula (II) wherein R , R and R are all hydrogen.
摘要翻译：一种制备式（I）的农药中间体的方法，其中W是（CH 3 O）2 CH.CHCO 2 CH 3或CH 3 O.CH = CCO 2 CH 3; Z 1是卤原子; R 1，R 2，R 3和R 4独立地是氢，卤素，C 1-4烷基，C 1-4烷氧基，乙酰氧基或酰基; 该方法包括以下步骤：（a）将其中X，R 1，R 2，R 3和R 4如上定义的式（II）化合物与式式ROCH 3，其中R是金属; 和（b）使（a）的产物与式（III）化合物反应，其中Z 1和Z 2均为卤素原子。制备式（II）化合物和式（II）化合物本身的方法。以基本上纯的形式获得式（II）化合物和式（II）化合物本身的方法。以基本上纯的形式获得其中R 1，R 2，R 3和R 4均为氢的式（II）化合物的方法。

3. 发明申请

WO2003035604A1 PROCESS FOR THE PREPARATION OF ARYL HYDRAZONE AND ARYL HYDRAZINE 审中-公开
标题翻译：制备ARYL HYDRAZONE和ARYL HYDRAZINE的方法
公开(公告)号：WO2003035604A1
公开(公告)日：2003-05-01
申请号：PCT/GB2002/004459
申请日：2002-10-02
申请人： SYNGENTA LIMITED , ATHERTON, John, Heathcote , BLACKER, Andrew, John , FIELDEN, Jan, Michael , JACKSON, David, Anthony , DODMAN, David
发明人： ATHERTON, John, Heathcote , BLACKER, Andrew, John , FIELDEN, Jan, Michael , JACKSON, David, Anthony , DODMAN, David
IPC分类号： C07C251/86
CPC分类号： C07C249/16 , C07C251/86
摘要： A process for the preparation of a compound of formula (I): wherein Ar represents an optionally substituted aromatic carbocycle or heterocycle, and R 1 and R 2 independently represent hydrogen, C 1-10 alkyl, C(O)C 1-10 alkyl or optionally substituted aryl provided that R 1 and R 2 are not both hydrogen which process comprises reacting together a compound of formula (II): Ar-X, wherein Ar is as defined in relation to formula (I) and X represents a leaving group with a compound of formula (III): wherein R 1 and R 2 are as defined in relation to formula (I) under aqueous conditions in the presence of a Pd (II) salt, a ligand and a Group I or Group II metal hydroxide base at a pH greater than 7. Compounds of formula (I) may be hydrolysed to the corresponding hydrazine.
摘要翻译：制备式（I）化合物的方法：其中Ar表示任选取代的芳族碳环或杂环，R 1和R 2独立地表示氢，C 1-10烷基，C（O）C 1-10烷基或任选取代的芳基，条件是R 1和R 2不是氢，该方法包括使式（II）化合物：Ar-X（其中Ar如关于式（I）所定义）与X 代表具有式（III）化合物的离去基团：其中R 1和R 2如在式（I）中所定义，在水溶液条件下，在Pd（II）盐，配体和在大于7的pH下的第I族或II族金属氢氧化物碱。式（I）化合物可以被水解成相应的肼。

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