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1. 发明申请

WO2013101902A2 CHROMOPHORIC POLYMER DOTS WITH NARROW-BAND EMISSION 审中-公开
标题翻译：具有窄带辐射的色谱聚合物
公开(公告)号：WO2013101902A2
公开(公告)日：2013-07-04
申请号：PCT/US2012/071767
申请日：2012-12-27
申请人： UNIVERSITY OF WASHINGTON, THROUGH ITS CENTER FOR COMMERCIALIZATION , CHIU, Daniel, T. , WU, Changfeng , RONG, Yu , ZHANG, Yong , WU, Yi-Che , CHAN, Yang-Hsiang , ZHANG, Xuanjun , YU, Jiangbo , SUN, Wei
发明人： CHIU, Daniel, T. , WU, Changfeng , RONG, Yu , ZHANG, Yong , WU, Yi-Che , CHAN, Yang-Hsiang , ZHANG, Xuanjun , YU, Jiangbo , SUN, Wei
IPC分类号： A61K49/00 , G01N21/64
CPC分类号： C08G75/32 , A61K49/0019 , A61K49/0067 , B82Y30/00 , B82Y40/00 , C08G79/00 , C09B69/105 , G01N33/582 , G01N33/587 , G01N2021/6439 , H01L51/0034 , H01L51/0036 , H01L51/0039 , H01L51/0043 , H01L51/5012
摘要： Polymers, monomers, chromophoric polymer dots and related methods are provided. Highly fluorescent chromophoric polymer dots with narrow-band emissions are provided. Methods for synthesizing the chromophoric polymers, preparation methods for forming the chromophoric polymer dots, and biological applications using the unique properties of narrow-band emissions are also provided.
摘要翻译：提供聚合物，单体，发色聚合物点和相关方法。提供了具有窄带辐射的高度荧光发色聚合物点。还提供了合成发色聚合物的方法，形成发色聚合物点的制备方法和使用窄带发射的独特性质的生物应用。

2. 发明申请

WO2012054525A2 CHROMOPHORIC POLYMER DOTS 审中-公开
标题翻译：色谱聚合物
公开(公告)号：WO2012054525A2
公开(公告)日：2012-04-26
申请号：PCT/US2011/056768
申请日：2011-10-18
申请人： UNIVERSITY OF WASHINGTON CENTER FOR COMMERCIALIZATION , CHIU, Daniel T. , WU, Changfeng , ZHANG, Xuanjun , YU, Jiangbo , YE, Fangmao
发明人： CHIU, Daniel T. , WU, Changfeng , ZHANG, Xuanjun , YU, Jiangbo , YE, Fangmao
IPC分类号： B82B1/00 , B82B3/00 , B82Y40/00
CPC分类号： G01N33/588 , B82Y15/00 , B82Y30/00 , B82Y40/00 , C08G61/126 , C08G2261/12 , C08G2261/1426 , C08G2261/228 , C08G2261/3142 , C08G2261/3246 , C08G2261/522 , C08G2261/54 , C08G2261/72 , C08G2261/94 , C08J3/11 , C08J2327/22 , C09K11/025 , C09K11/06 , C09K2211/1425 , H01L51/0039
摘要： The present invention provides, among other aspects, stabilized chromophoric nanoparticles. In certain embodiments, the chromophoric nanoparticles provided herein are rationally functionalized with a pre-determined number of functional groups. In certain embodiments, the stable chromophoric nanoparticles provided herein are modified with a low density of functional groups. In yet other embodiments, the chromophoric nanoparticles provided herein are conjugated to one or more molecules. Also provided herein are methods for making rationally functionalized chromophoric nanoparticles.
摘要翻译：本发明尤其提供了稳定的发色纳米颗粒。在某些实施方案中，本文提供的发色纳米颗粒用预定数量的官能团合理地官能化。在某些实施方案中，本文提供的稳定发色纳米粒子用低密度官能团修饰。在其它实施方案中，本文提供的发色纳米颗粒与一个或多个分子缀合。本文还提供了用于制备合理官能化的发色纳米颗粒的方法。

3. 发明申请

WO2015006714A1 FLUORINATED POLYMER DOTS 审中-公开
标题翻译：氟化聚合物
公开(公告)号：WO2015006714A1
公开(公告)日：2015-01-15
申请号：PCT/US2014/046387
申请日：2014-07-11
申请人： UNIVERSITY OF WASHINGTON THROUGH ITS CENTER FOR COMMERCIALIZATION
发明人： CHIU, Daniel , ZHANG, Yong , YU, Jiangbo , RONG, Yu
IPC分类号： G01N21/64 , B82Y20/00 , B82Y15/00
CPC分类号： G01N33/582 , B82Y15/00 , B82Y20/00 , C08G75/32 , Y10S977/773 , Y10S977/92
摘要： This disclosure provides semiconducting polymer dots (Pdots) for use in a wide variety of applications. In particular, this disclosure provides Pdots that are halogenated, including fluormated Pdots. This disclosure also provides methods for synthesizing Pdots and methods for using Pdots, such as for biological imaging.
摘要翻译：本公开提供用于各种应用的半导体聚合物点（Pdots）。特别地，本公开提供被卤化的Pd，包括发光的Pd。本公开还提供了用于合成Pdots的方法和用于使用Pdots的方法，例如用于生物成像。

4. 发明申请

WO2014058903A3 METAL-CONTAINING SEMICONDUCTING POLYMER DOTS 审中-公开
公开(公告)号：WO2014058903A3
公开(公告)日：2014-04-17
申请号：PCT/US2013/063917
申请日：2013-10-08
申请人： UNIVERSITY OF WASHINGTON THROUGH ITS CENTER FOR COMMERCIALIZATION
发明人： CHIU, Daniel T. , SUN, Wei , YU, Jiangbo , WU, Changfeng
IPC分类号： G01N21/64 , G01N21/76 , B82B1/00
摘要： The present disclosure provides metal-containing (MC) semiconducting (SC) Pdots (MC-SC-Pdots) with beneficial functionalities in both cellular imaging and manipulation, among other applications. The Pdots comprise at least one nanoparticle comprising at least one metal, and a semiconducting polymer associated with the nanoparticle.

5. 发明申请

WO2014153051A1 POLYMER DOT COMPOSITIONS AND RELATED METHODS 审中-公开
标题翻译：聚合物组合物及相关方法
公开(公告)号：WO2014153051A1
公开(公告)日：2014-09-25
申请号：PCT/US2014/028846
申请日：2014-03-14
申请人： UNIVERSITY OF WASHINGTON THROUGH ITS CENTER FOR COMMERCIALIZATION
发明人： CHIU, Daniel T. , SUN, Wei , YU, Jiangbo , WU, Changfeng , YE, Fangmao
IPC分类号： G01N33/53 , G01N33/566
CPC分类号： G01N33/54393 , C08G61/02 , C08G73/00 , C08G75/32 , C08G2261/11 , C08G2261/18 , C09B69/101 , C09B69/105 , C09B69/109 , C09K11/025 , C09K11/06 , G01N33/533 , G01N33/582 , G01N33/587 , G01N33/588 , G01N2650/00 , Y10T428/2982
摘要： Lyophilized chromophoric polymer dot compositions are provided. Also disclosed are methods of making and using the lyophilized compositions, methods of dispersing the lyophilized compositions in aqueous solutions and kits supplying the compositions.
摘要翻译：提供了冻干的发色聚合物点组合物。还公开了制备和使用冻干组合物的方法，将冻干组合物分散在水溶液中的方法和提供组合物的试剂盒。

6. 发明申请

WO2015081126A1 ENCODED CHROMOPHORIC POLYMER PARTICLES 审中-公开
标题翻译：编码的色谱聚合物颗粒
公开(公告)号：WO2015081126A1
公开(公告)日：2015-06-04
申请号：PCT/US2014/067471
申请日：2014-11-25
申请人： UNIVERSITY OF WASHINGTON THROUGH ITS CENTER FOR COMMERCIALIZATION
发明人： CHIU, Daniel, T. , WU, Changfeng , YU, Jiangbo
IPC分类号： C09K11/06 , G01N21/63
CPC分类号： G01N33/58 , C09B23/0066 , C09B23/04 , C09B57/007 , C09B69/109 , C09K11/02 , C09K11/06 , C09K2211/1007 , C09K2211/1011 , C09K2211/1044 , C09K2211/1416 , C09K2211/182 , G01N21/6408 , G01N21/6428 , G01N33/582 , G01N33/587 , G01N33/588 , G01N2021/6417 , G01N2021/6439 , G01N2021/6441 , G01N2201/12
摘要： The present disclosure provides encoded chromophoric polymer particles that are capable of, for example, optical and/or biomolecular encoding of analytes. The present disclosure also provides suspensions comprising a plurality of encoded chromophoric polymer particles. The present disclosure also provides methods of using the encoded chromophoric polymer particles and systems for performing multiplex analysis with encoded chromophoric polymer particles.
摘要翻译：本公开提供了能够例如分析物的光学和/或生物分子编码的经编码的发色聚合物颗粒。本公开还提供了包含多个编码的发色聚合物颗粒的悬浮液。本公开还提供了使用经编码的发色聚合物颗粒和系统用编码的发色聚合物颗粒进行多重分析的方法。

7. 发明申请

WO2011057295A2 FUNCTIONALIZED CHROMOPHORIC POLYMER DOTS AND BIOCONJUGATES THEREOF 审中-公开
标题翻译：功能化的色谱聚合物及其生物活性剂
公开(公告)号：WO2011057295A2
公开(公告)日：2011-05-12
申请号：PCT/US2010/056079
申请日：2010-11-09
申请人： UNIVERSITY OF WASHINGTON CENTER FOR COMMERCIALIZATION , CLEMSON UNIVERSITY , CHIU, Daniel, T. , WU, Changfeng , MCNEILL, Jason , YU, Jiangbo
发明人： CHIU, Daniel, T. , WU, Changfeng , MCNEILL, Jason , YU, Jiangbo
IPC分类号： C09K11/02 , C09K11/06 , G01N21/76 , G01N21/64 , G03C1/00
CPC分类号： G01N33/587 , C09K11/06 , G01N33/582
摘要： The present invention provides, among other aspects, functionalized chromophoric polymer dots comprising a hydrophobic core and a hydrophilic cap, and bioconjugates thereof. Also provided are improved methods for preparing functionalized chromophoric polymer dots. Methods for in vivo imaging and molecular labeling are also disclosed.
摘要翻译：除其他方面之外，本发明提供了包含疏水性核心和亲水性帽子的官能化发色聚合物点及其生物缀合物。还提供了用于制备官能化发色聚合物点的改进方法。还公开了体内成像和分子标记的方法。

8. 发明申请

WO2017210841A1 NANOPARTICLE TRANSDUCER SENSORS AND METHODS OF USE THEREOF 审中-公开
标题翻译：纳米颗粒传感器传感器及其使用方法
公开(公告)号：WO2017210841A1
公开(公告)日：2017-12-14
申请号：PCT/CN2016/084986
申请日：2016-06-06
申请人： UNIVERSITY OF WASHINGTON , LAMPROGEN, INC. , WU, Changfeng
发明人： WU, Changfeng , CHIU, Daniel , YU, Jiangbo , SUN, Kai
IPC分类号： G01N33/58 , B82Y30/00
摘要： Nanoparticle transducers and methods of use thereof for the detection of analyte concentrations in a fluid are provided. Nanoparticle transducers can comprise a nanoparticle, such as a Pdot, coupled to an enzyme that catalyzes a reaction with the analyte. The nanoparticle transducers further comprise chromophores that emit fluorescence that varies as a function of the concentration of one of the elements of the reaction. The nanoparticle transducer thus changes fluorescence as the analyte concentration changes, transforming analyte concentration values into fluorescence intensities. The measurement of these intensities provides a measurement of the analyte concentration. The nanoparticle transducers are biocompatible, allowing for use in vivo, for the monitoring of analyte blood concentrations such as blood glucose concentrations.
摘要翻译：提供纳米粒子换能器及其用于检测流体中分析物浓度的使用方法。纳米颗粒换能器可以包含与催化与分析物反应的酶偶联的纳米颗粒，例如P点。纳米颗粒换能器还包含发射荧光的发色团，所述荧光根据反应的元素之一的浓度而变化。纳米颗粒换能器因此在分析物浓度改变时改变荧光，将分析物浓度值转化为荧光强度。这些强度的测量提供了分析物浓度的测量。纳米粒子换能器是生物相容的，允许在体内使用，用于监测分析物血浓度，例如血糖浓度。

9. 发明申请

WO2010031485A1 MATERIALIEN FÜR ORGANISCHE ELEKTROLUMINESZENZVORRICHTUNGEN 审中-公开
标题翻译：材料有机场致发光
公开(公告)号：WO2010031485A1
公开(公告)日：2010-03-25
申请号：PCT/EP2009/006149
申请日：2009-08-25
申请人： MERCK PATENT GMBH , YERSIN, Hartmut , MONKOWIUS, Uwe , CZERWIENIEC, Rafal , YU, Jiangbo
发明人： YERSIN, Hartmut , MONKOWIUS, Uwe , CZERWIENIEC, Rafal , YU, Jiangbo
IPC分类号： H01L51/30
CPC分类号： H01L51/0091 , C07F5/02 , C07F9/5045 , C09B57/10 , C09K11/06 , C09K2211/1044 , C09K2211/1085 , C09K2211/188 , H01L51/0037 , H01L51/008 , H01L51/0094 , H01L51/5012 , H01L2251/5384 , Y02E10/549 , Y10S428/917
摘要： Die Erfindung betrifft einkernige neutrale Kupfer(l)-Komplexe mit einem bidentaten Liganden, der über Stickstoff bindet und zwei Phosphan- oder Arsanliganden, deren Verwendung zur Herstellung elektronischer Bauelemente sowie elektronische Vorrichtungen enthaltend diese Komplexe.
摘要翻译：本发明涉及单核中性铜（I）与结合的氮和两个膦或Arsanliganden，其用于生产电子元件以及含有这些配合物的电子设备使用的二齿配位体配合物。

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