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1. 发明申请

WO2014153051A1 POLYMER DOT COMPOSITIONS AND RELATED METHODS 审中-公开
标题翻译：聚合物组合物及相关方法
公开(公告)号：WO2014153051A1
公开(公告)日：2014-09-25
申请号：PCT/US2014/028846
申请日：2014-03-14
申请人： UNIVERSITY OF WASHINGTON THROUGH ITS CENTER FOR COMMERCIALIZATION
发明人： CHIU, Daniel T. , SUN, Wei , YU, Jiangbo , WU, Changfeng , YE, Fangmao
IPC分类号： G01N33/53 , G01N33/566
CPC分类号： G01N33/54393 , C08G61/02 , C08G73/00 , C08G75/32 , C08G2261/11 , C08G2261/18 , C09B69/101 , C09B69/105 , C09B69/109 , C09K11/025 , C09K11/06 , G01N33/533 , G01N33/582 , G01N33/587 , G01N33/588 , G01N2650/00 , Y10T428/2982
摘要： Lyophilized chromophoric polymer dot compositions are provided. Also disclosed are methods of making and using the lyophilized compositions, methods of dispersing the lyophilized compositions in aqueous solutions and kits supplying the compositions.
摘要翻译：提供了冻干的发色聚合物点组合物。还公开了制备和使用冻干组合物的方法，将冻干组合物分散在水溶液中的方法和提供组合物的试剂盒。

2. 发明申请

WO2006044275A3 METHODS FOR ALTERING SURFACE CHARACTERISTICS OF MICROSPHERES 审中-公开
标题翻译：改善微球表面特性的方法
公开(公告)号：WO2006044275A3
公开(公告)日：2007-04-26
申请号：PCT/US2005036264
申请日：2005-10-11
申请人： LUMINEX CORP , LUGADE ANANDA G , HOFFACKER KURT D
发明人： LUGADE ANANDA G , HOFFACKER KURT D
IPC分类号： G01N33/543 , G01N33/546 , G01N33/58
CPC分类号： G01N21/645 , G01N33/54313 , G01N33/54353 , G01N33/54393 , G01N33/586 , G01N2021/6421 , G01N2650/00 , Y10T436/13
摘要： Various methods for forming dyed microspheres are provided. One method includes activating a chemical structure coupled to a dye using heat or light to form a reaction intermediate in the presence of a microsphere. The reaction intermediate covalently attaches to a polymer of the microsphere thereby coupling the dye to the polymer and forming the dyed microsphere. Additional methods are provided for forming a dyed microsphere coupled to a molecule. These methods include dyeing the microspheres as described above in addition to synthesizing the molecule on an outer surface of the dyed microspheres. A population of dyed microspheres is also provided. Each of the dyed microspheres of the population includes a dye attached to a polymer of each of the dyed microspheres by a chemical structure. A coefficient of variation in dye characteristics of the population of dyed microspheres attributable to the dye is less than about 10%.
摘要翻译：提供了形成染色微球的各种方法。一种方法包括使用热或光活化与染料偶联的化学结构，以在微球存在下形成反应中间体。反应中间体共价连接到微球的聚合物上，从而将染料偶联到聚合物上并形成染色的微球。提供用于形成耦合到分子的染色微球的其它方法。除了在染色的微球的外表面上合成分子之外，这些方法包括如上所述染色微球。还提供了一批染色微球。群体的每个染色的微球包括通过化学结构连接到每个染色微球的聚合物上的染料。由染料染色的微球体的染料特性的变异系数小于约10％。

3. 发明申请

WO2013049068A8 METHOD FOR FUNCTIONALIZING A POROUS MEMBRANE COVERING OF AN OPTICAL SENSOR TO FACILITATE COUPLING OF AN ANTITHROMBOGENIC AGENT 审中-公开
标题翻译：用于功能化光学传感器的多孔膜覆盖以促进抗原性代谢物联合的方法
公开(公告)号：WO2013049068A8
公开(公告)日：2013-06-20
申请号：PCT/US2012057127
申请日：2012-09-25
申请人： GLUMETRICS INC
发明人： SURI JEFF T , PATTERSON ERIC
IPC分类号： A61K9/00 , A61L33/00 , B05D3/00
CPC分类号： G01N33/66 , A61L33/0023 , B05D3/142 , G01N33/54393 , G01N2400/40 , G01N2650/00 , Y10T436/144444
摘要： Methods of covalently attaching heparin to a membrane comprising plasma treating the membrane to produce an amino-functionalized membrane; and reacting the amino-functionalized membrane with heparin under conditions in which heparin becomes covalently attached to the amino-functionalized membrane, wherein said heparin is indirectly attached via a spacer to said amino-functionalized membrane and/or said heparin is attached from a single site in said heparin to a single site on said amino- functionalized membrane or to said spacer. Also disclosed are analyte sensors.
摘要翻译：将肝素共价连接到包含等离子体处理膜以产生氨基官能化膜的膜的方法; 并且在肝素共价连接到氨基官能化膜的条件下使氨基官能化的膜与肝素反应，其中所述肝素通过间隔物间接连接到所述氨基官能化膜和/或所述肝素从单个位点在所述肝素中至所述氨基官能化膜上的单个位点或所述间隔物。还公开了分析物传感器。

4. 发明申请

WO2004043588A2 PRODUCTION OF POLYMERIC MICROARRAYS 审中-公开
标题翻译：聚合物微阵列的生产
公开(公告)号：WO2004043588A2
公开(公告)日：2004-05-27
申请号：PCT/US2003/024564
申请日：2003-08-06
申请人： MASSACHUSETTS INSTITUTE OF TECHNOLOGY , ANDERSON, Daniel, G. , LANGER, Robert, S.
发明人： ANDERSON, Daniel, G. , LANGER, Robert, S.
IPC分类号： B01J19/00
CPC分类号： B82Y30/00 , B01J19/0046 , B01J2219/00378 , B01J2219/00387 , B01J2219/00497 , B01J2219/00527 , B01J2219/00585 , B01J2219/00596 , B01J2219/00605 , B01J2219/0061 , B01J2219/00612 , B01J2219/00626 , B01J2219/00628 , B01J2219/0063 , B01J2219/00637 , B01J2219/00641 , B01J2219/00659 , B01J2219/00675 , B01J2219/00691 , B01J2219/00707 , B01J2219/00711 , B01J2219/00716 , B01J2219/00722 , B01J2219/00725 , B01J2219/00736 , B01J2219/00743 , C40B40/06 , C40B40/10 , C40B40/14 , C40B50/14 , C40B60/14 , G01N2650/00
摘要： A method of preparing a microarray of polymer elements (6). The method includes providing a substrate surface (4), providing a plurality of individual monomers in a liquid phase, depositing said monomers as a plurality of discrete monomer elements on the substrate surface (4), and exposing the plurality of discrete monomer elements to initiating conditions to form polymer elements (6). A portion of the discrete monomer elements may include more than one type of monomer.
摘要翻译：制备聚合物元件微阵列（6）的方法。该方法包括提供衬底表面（4），提供液相中的多个单体单体，将所述单体作为多个离散单体元素沉积在衬底表面（4）上，并且暴露多个离散单体元素以引发条件以形成聚合物元件（6）。一部分离散单体元素可以包括多于一种类型的单体。

5. 发明申请

WO99054729A2 IMMOBILIZED SUBSTRATE, SEPARATION GELS PRODUCED THEREWITH AND METHOD FOR DETECTING ENZYMATIC ACTIVITY AFTER ELECTROPHORETIC PROTEIN SEPARATION 审中-公开
标题翻译：固定化SUBSTRATES使后作电泳分离蛋白分离用于检测酶活性凝胶和方法
公开(公告)号：WO99054729A2
公开(公告)日：1999-10-28
申请号：PCT/EP1999/002688
申请日：1999-04-21
IPC分类号： G01N27/447 , C07K17/06 , C12Q20060101 , C12Q1/00 , C12Q1/48 , G01N21/64 , G01N27/62 , G01N30/90 , G01N33/483 , G01N33/52 , G01N33/53 , G01N33/543 , G01N33/561
CPC分类号： G01N33/561 , C12Q1/00 , G01N30/90 , G01N2650/00
摘要： The invention relates to a method for fixing substrate molecules in gel matrices. Said method is characterized in that a substrate is covalently linked to a monomeric or oligomeric structural unit of a gel and the resulting product is polymerized. The invention also relates to gels produced using said method.
摘要翻译：本发明涉及一种方法，用于在凝胶基质，其特征在于，一个相关联共价连接至聚合的凝胶的单体或低聚的建筑砌块，并且将所得产物的底物，并且可以通过这种方法的凝胶来制备固定的底物分子。

6. 发明申请

WO2014127111A1 PEPTOIDS THAT BIND SPECIFIC ANTIGENS 审中-公开
标题翻译： PEPTOIDS绑定特异性抗原
公开(公告)号：WO2014127111A1
公开(公告)日：2014-08-21
申请号：PCT/US2014/016222
申请日：2014-02-13
申请人： THE SCRIPPS RESEARCH INSTITUTE
发明人： KODADEK, Thomas , RAVEENDRA, Bindu , WU, Hao , BACCALA, Roberto , THEOFILOPOULOS, Argyrios
IPC分类号： C40B40/10 , C40B30/04
CPC分类号： G01N33/564 , C07K7/06 , G01N33/6845 , G01N2500/04 , G01N2650/00 , G01N2800/16 , G01N2800/285
摘要： Combinatorial libraries were generated providing a vast number of diverse peptoid ligands. From these libraries, ligands were identified which specifically bind molecules associated with autoimmune diseases, such as antibodies specific to aquaporin-4 (AQP4), binding of which to AQP4 causes the autoimmune disease, Neuoromyelitis Optica. Methods of generating peptoid libraries and for diagnosing Neuromyelitis Optica are also provided.
摘要翻译：产生组合文库，提供大量不同的拟肽配体。从这些文库中，鉴定了与自身免疫疾病相关的分子特异性结合的配体，例如水通道蛋白-4特异性抗体（AQP4），其与AQP4的结合导致自身免疫疾病，神经脊髓炎眼科。还提供了产生拟肽文库和用于诊断神经性脊髓炎Optica的方法。

7. 发明申请

WO2004043588A3 PRODUCTION OF POLYMERIC MICROARRAYS 审中-公开
标题翻译：聚合微生物的生产
公开(公告)号：WO2004043588A3
公开(公告)日：2004-08-19
申请号：PCT/US0324564
申请日：2003-08-06
申请人： MASSACHUSETTS INST TECHNOLOGY , ANDERSON DANIEL G , LANGER ROBERT S
发明人： ANDERSON DANIEL G , LANGER ROBERT S
IPC分类号： B01J19/00 , C40B40/06 , C40B40/10 , C40B40/14 , C40B50/14 , C40B60/14
CPC分类号： B82Y30/00 , B01J19/0046 , B01J2219/00378 , B01J2219/00387 , B01J2219/00497 , B01J2219/00527 , B01J2219/00585 , B01J2219/00596 , B01J2219/00605 , B01J2219/0061 , B01J2219/00612 , B01J2219/00626 , B01J2219/00628 , B01J2219/0063 , B01J2219/00637 , B01J2219/00641 , B01J2219/00659 , B01J2219/00675 , B01J2219/00691 , B01J2219/00707 , B01J2219/00711 , B01J2219/00716 , B01J2219/00722 , B01J2219/00725 , B01J2219/00736 , B01J2219/00743 , C40B40/06 , C40B40/10 , C40B40/14 , C40B50/14 , C40B60/14 , G01N2650/00
摘要： A method of preparing a microarray of polymer elements (6). The method includes providing a substrate surface (4), providing a plurality of individual monomers in a liquid phase, depositing said monomers as a plurality of discrete monomer elements on the substrate surface (4), and exposing the plurality of discrete monomer elements to initiating conditions to form polymer elements (6). A portion of the discrete monomer elements may include more than one type of monomer.
摘要翻译：制备聚合物元件（6）的微阵列的方法。该方法包括提供衬底表面（4），在液相中提供多个单独的单体，在衬底表面（4）上沉积作为多个离散单体元素的所述单体，以及将多个离散的单体元件暴露于起始形成聚合物元素的条件（6）。离散单体元件的一部分可以包括多于一种类型的单体。

8. 发明申请

WO9954729A3 IMMOBILIZED SUBSTRATE, SEPARATION GELS AND METHOD FOR DETECTING ENZYMATIC ACTIVITY 审中-公开
标题翻译：固定化底物，检测酶活性的分离胶和方法
公开(公告)号：WO9954729A3
公开(公告)日：2000-02-17
申请号：PCT/EP9902688
申请日：1999-04-21
申请人： BIOTECHNOLOG FORSCHUNG GMBH , FRANK RONALD , TEGGE WERNER
发明人： FRANK RONALD , TEGGE WERNER
IPC分类号： G01N27/447 , C07K17/06 , C12Q20060101 , C12Q1/00 , C12Q1/48 , G01N21/64 , G01N27/62 , G01N30/90 , G01N33/483 , G01N33/52 , G01N33/53 , G01N33/543 , G01N33/561 , G01N30/48
CPC分类号： G01N33/561 , C12Q1/00 , G01N30/90 , G01N2650/00
摘要： The invention relates to a method for fixing substrate molecules in gel matrices. Said method is characterized in that a substrate is covalently linked to a monomeric or oligomeric structural unit of a gel and the resulting product is polymerized. The invention also relates to gels produced using said method.
摘要翻译：本发明涉及一种方法，用于在凝胶基质，其特征在于，一个相关联共价连接至聚合的凝胶的单体或低聚的建筑砌块，并且将所得产物的底物，并且可以通过这种方法的凝胶来制备固定的底物分子。

9. 发明申请

WO2015171786A1 CATIONIC POLYMER SYSTEMS FOR SELECTIVE BACTERIAL CAPTURE 审中-公开
标题翻译：用于选择性细菌捕获的阳离子聚合物体系
公开(公告)号：WO2015171786A1
公开(公告)日：2015-11-12
申请号：PCT/US2015/029498
申请日：2015-05-06
申请人： THE JOHNS HOPKINS UNIVERSITY
发明人： O'BRIEN-COON, Devin , SINHA, Anjana , MANABE, Yuka , LAMICCHANE, Gyanu , NEIRA, Hector , MAO, Hai-Quan , MISTRY, Hiren , CHOPRA, Anmol , JIANG, Xuesong
IPC分类号： C12M1/12 , C12M1/34 , C12Q1/02 , C12Q1/24
CPC分类号： C12Q1/04 , C12Q1/18 , C12Q1/24 , G01N33/5014 , G01N2333/35 , G01N2500/10 , G01N2650/00
摘要： A device and methods of use thereof for isolating one or more microorganisms from a biological sample, the device comprising a polymeric surface having one or more cationic polymers covalently grafted thereto, wherein the one or more cationic polymers have a selective affinity for the one or more microorganisms.
摘要翻译：一种用于从生物样品中分离一种或多种微生物的装置及其使用方法，所述装置包括具有共价接枝到其上的一种或多种阳离子聚合物的聚合物表面，其中所述一种或多种阳离子聚合物对所述一种或多种具有选择性亲和性微生物。

10. 发明申请

WO2013049068A1 METHOD FOR FUNCTIONALIZING A POROUS MEMBRANE COVERING OF AN OPTICAL SENSOR TO FACILITATE COUPLING OF AN ANTITHROM-BOGENIC AGENT 审中-公开
标题翻译：用于功能化光学传感器的多孔膜覆盖以方便抗原性生物剂偶联的方法
公开(公告)号：WO2013049068A1
公开(公告)日：2013-04-04
申请号：PCT/US2012/057127
申请日：2012-09-25
申请人： GLUMETRICS, INC.
发明人： SURI, Jeff, T. , PATTERSON, Eric
IPC分类号： A61K9/00 , A61L33/00 , B05D3/00
CPC分类号： G01N33/66 , A61L33/0023 , B05D3/142 , G01N33/54393 , G01N2400/40 , G01N2650/00 , Y10T436/144444
摘要： Methods of covalently attaching heparin to a membrane comprising plasma treating the membrane to produce an amino-functionalized membrane; and reacting the amino-functionalized membrane with heparin under conditions in which heparin becomes covalently attached to the amino-functionalized membrane, wherein said heparin is indirectly attached via a spacer to said amino-functionalized membrane and/or said heparin is attached from a single site in said heparin to a single site on said amino- functionalized membrane or to said spacer. Also disclosed are analyte sensors.
摘要翻译：将肝素共价连接到包含等离子体处理膜以产生氨基官能化膜的膜的方法; 并且在肝素共价连接到氨基官能化膜的条件下使氨基官能化的膜与肝素反应，其中所述肝素通过间隔物间接连接到所述氨基官能化膜和/或所述肝素从单个位点在所述肝素中至所述氨基官能化膜上的单个位点或所述间隔物。还公开了分析物传感器。

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