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1. 发明申请

WO2011021183A3 ALIGNED NANOARRAY AND METHOD FOR FABRICATING THE SAME 审中-公开
标题翻译：对准的纳米级及其制备方法
公开(公告)号：WO2011021183A3
公开(公告)日：2011-06-03
申请号：PCT/IL2010000649
申请日：2010-08-11
申请人： UNIV RAMOT , PATOLSKY FERNANDO , DUCOBNI TAMIR , PEVZNER ALEXANDER , ENGEL YONI , ELNATHAN ROEY , BEN-ISHAI MOSHIT
发明人： PATOLSKY FERNANDO , DUCOBNI TAMIR , PEVZNER ALEXANDER , ENGEL YONI , ELNATHAN ROEY , BEN-ISHAI MOSHIT
IPC分类号： B82Y40/00 , B82Y10/00 , H01L29/06
CPC分类号： H01L29/0665 , B82Y10/00 , B82Y30/00 , B82Y40/00 , H01L21/67092 , H01L29/0673 , Y10T29/49155 , Y10T428/24355
摘要： An elongated nanostructure is formed on a planar surface of a substrate such that the nanostructure is oriented generally perpendicularly to the surface. The nanostructure is then felled onto the surface such that it is oriented generally parallel to the surface.
摘要翻译：在衬底的平坦表面上形成细长的纳米结构，使得纳米结构大致垂直于表面定向。然后将纳米结构挤压到表面上，使得其大致平行于表面定向。

2. 发明申请

WO2011021183A8 ALIGNED NANOARRAY AND METHOD FOR FABRICATING THE SAME 审中-公开
标题翻译：对准的纳米阵列及其制造方法
公开(公告)号：WO2011021183A8
公开(公告)日：2011-07-21
申请号：PCT/IL2010000649
申请日：2010-08-11
申请人： UNIV RAMOT , PATOLSKY FERNANDO , DUCOBNI TAMIR , PEVZNER ALEXANDER , ENGEL YONI , ELNATHAN ROEY , BEN-ISHAI MOSHIT
发明人： PATOLSKY FERNANDO , DUCOBNI TAMIR , PEVZNER ALEXANDER , ENGEL YONI , ELNATHAN ROEY , BEN-ISHAI MOSHIT
IPC分类号： B82Y40/00 , B82Y10/00 , H01L29/06
CPC分类号： H01L29/0665 , B82Y10/00 , B82Y30/00 , B82Y40/00 , H01L21/67092 , H01L29/0673 , Y10T29/49155 , Y10T428/24355
摘要： An elongated nanostructure is formed on a planar surface of a substrate such that the nanostructure is oriented generally perpendicularly to the surface. The nanostructure is then felled onto the surface such that it is oriented generally parallel to the surface.
摘要翻译：细长纳米结构形成在基底的平坦表面上，使得纳米结构大致垂直于表面定向。纳米结构然后被倒在表面上，使得其大致平行于表面取向。

3. 发明申请

WO2010052704A3 TUBULAR NANOSTRUCTURES, PROCESSES OF PREPARING SAME AND DEVICES MADE THEREFROM 审中-公开
标题翻译：管状纳米结构，其制备方法及其制备方法
公开(公告)号：WO2010052704A3
公开(公告)日：2010-09-02
申请号：PCT/IL2009001030
申请日：2009-11-04
申请人： UNIV RAMOT , BEN-ISHAI MOSHIT , PATOLSKY FERNANDO
发明人： BEN-ISHAI MOSHIT , PATOLSKY FERNANDO
IPC分类号： C30B25/02 , C30B29/06 , C30B29/08 , C30B29/60 , C30B33/10
CPC分类号： B82Y30/00 , B82Y10/00 , C30B25/02 , C30B29/06 , C30B29/08 , C30B29/602 , C30B33/10 , H01L29/0665 , H01L29/0673 , H01L29/068 , H01L29/775
摘要： Method of producing single-walled and multi-walled, single-crystalline, tubular nanostructures, made of an inorganic substance (e.g., silicon), and single-walled and multi-walled, single-crystalline, tubular nanostructures produced thereby, are disclosed. Also disclosed are devices into which the nanostructures are integrated. The methods described herein are used to reproducibly and controllably producing single-crystalline nanostructures with well-defined shape, diameter and/or interwall distance, chemical composition and morphology, using sacrificial layers (such as Germanium).
摘要翻译：公开了制备由无机物质（例如硅）制成的单壁和多壁单晶管状纳米结构体的方法，以及由此制备的单壁和多壁，单晶管状纳米结构体。还公开了纳米结构集成到其中的装置。本文描述的方法用于使用牺牲层（例如锗）可重复地和可控地产生具有良好限定的形状，直径和/或间壁距离，化学组成和形态的单晶纳米结构。

4. 发明申请

WO2010029550A3 NOVEL NANOSTRUCTURES AND PROCESS OF PREPARING SAME 审中-公开
标题翻译：新型纳米结构及其制备方法
公开(公告)号：WO2010029550A3
公开(公告)日：2010-06-10
申请号：PCT/IL2009000887
申请日：2009-09-10
申请人： UNIV RAMOT , PATOLSKY FERNANDO , ELNATHAN ROEY , KANTAEV RAISA
发明人： PATOLSKY FERNANDO , ELNATHAN ROEY , KANTAEV RAISA
IPC分类号： C25D1/00 , B28B7/16 , B28B21/76 , C25F3/02
CPC分类号： C25D1/006 , B01J2219/005 , B01J2219/00504 , B01J2219/00547 , B82Y15/00 , B82Y30/00 , C25D5/10 , C25D5/18 , C25D11/04 , C25D13/04 , Y10T29/49826 , Y10T428/10 , Y10T428/12493 , Y10T428/12528 , Y10T428/12542 , Y10T428/12556 , Y10T428/12826 , Y10T428/12868 , Y10T428/12889 , Y10T428/2913 , Y10T428/298
摘要： A process of preparing a plurality of nanostructures, each being composed of at least one target material is disclosed. The process comprises sequentially electrodepositing a first material and the at least one target material into pores of a porous membrane having a nanometric pore diameter, to thereby obtain within the pores nanometric rods, each of the nanometric rods having a plurality of segments where any two adjacent segments are made of different materials. The process further comprises and etching the membrane and the first material, thereby obtaining the nanostructures.
摘要翻译：公开了一种制备多个纳米结构的方法，每个纳米结构由至少一种目标材料组成。该方法包括将第一材料和至少一种靶材料依次电沉积在具有纳米孔径的多孔膜的孔中，从而在孔内纳米棒中获得，每个纳米棒具有多个段，其中任何两个相邻片段由不同的材料制成。该方法还包括并蚀刻膜和第一材料，从而获得纳米结构。

5. 发明申请

WO2012077110A2 METHODS AND KITS FOR DETECTION OF DRUGS 审中-公开
标题翻译：检测药物的方法和试剂盒
公开(公告)号：WO2012077110A2
公开(公告)日：2012-06-14
申请号：PCT/IL2011050041
申请日：2011-12-06
申请人： UNIV RAMOT , PATOLSKY FERNANDO , IOFFE MICHAEL
发明人： PATOLSKY FERNANDO , IOFFE MICHAEL
IPC分类号： G01N33/14
CPC分类号： G01N33/14 , G01N21/00 , G01N21/49 , G01N21/51 , G01N21/59 , G01N21/5907 , G01N33/143 , G01N33/146
摘要： The present invention discloses a method for determining the presence of a drug or drug mixture in a liquid medium such as a beverage.
摘要翻译：本发明公开了用于确定液体介质如饮料中药物或药物混合物的存在的方法。

6. 发明申请

WO0220838A3 METHOD AND SYSTEM FOR DETECTING NUCLEIC ACIDS 审中-公开
标题翻译：检测核酸的方法和系统
公开(公告)号：WO0220838A3
公开(公告)日：2003-10-23
申请号：PCT/IL0100808
申请日：2001-08-29
申请人： YISSUM RES DEV CO , PATOLSKY FERNANDO , LICHTENSTEIN AMIR , WILLNER ITAMAR , WEIZMANN YOSSI
发明人： PATOLSKY FERNANDO , LICHTENSTEIN AMIR , WILLNER ITAMAR , WEIZMANN YOSSI
IPC分类号： G01N33/53 , C12M1/00 , C12N15/09 , C12Q1/26 , C12Q1/28 , C12Q1/32 , C12Q1/42 , C12Q1/68 , C40B40/06 , G01N5/02 , G01N27/327 , G01N27/416 , G01N27/42 , G01N27/48 , G01N37/00 , B01J19/00
CPC分类号： C12Q1/6816 , B01J2219/00529 , B01J2219/00585 , B01J2219/00596 , B01J2219/00605 , B01J2219/0061 , B01J2219/00612 , B01J2219/00653 , B01J2219/00659 , B01J2219/00713 , B01J2219/00722 , C12Q1/6825 , C12Q1/6834 , C40B40/06
摘要： A method for the detection of a target nucleic acid in a sample containing a mixture of nucleic acids. The method comprises (a) providing a solid surface; (b) attaching to the solid surface an oligonucleotide probe complementary to a segment of the target nucleic acid; (c) contacting the surface with the sample, thereby allowing the probe to bind the target nucleic acid; (d) incubating the bound target nucleic acid with the 4 nucleotide types and a replication biocatalyst thereby forming a multi-stranded nucleic acid assembly, wherein at least one of the nucleotide types is bound by a label; and (e) detecting the label on the multi-stranded nucleic acid assembly, thereby detecting the target nucleic acid. Also disclosed are a system for identifying a target nucleic acid sequence in a sample and a kit for use in the method.
摘要翻译：用于检测含有核酸混合物的样品中的靶核酸的方法。该方法包括（a）提供固体表面; （b）将与靶核酸片段互补的寡核苷酸探针附着于固体表面; （c）使表面与样品接触，从而使探针结合目标核酸; （d）用4核苷酸类型孵育结合的靶核酸和复制生物催化剂，从而形成多链核酸组装体，其中至少一个核苷酸类型被标记结合; 和（e）检测多链核酸组合物上的标记，从而检测靶核酸。还公开了用于鉴定样品中的靶核酸序列的系统和用于该方法的试剂盒。

7. 发明申请

WO0231191A3 DENDRITICALLY AMPLIFIED DETECTION METHOD 审中-公开
标题翻译：分辨放大检测方法
公开(公告)号：WO0231191A3
公开(公告)日：2003-09-12
申请号：PCT/IL0100886
申请日：2001-09-24
申请人： YISSUM RES DEV CO , WILLNER ITAMAR , PATOLSKY FERNANDO
发明人： WILLNER ITAMAR , PATOLSKY FERNANDO
IPC分类号： G01N33/53 , B82B1/00 , B82B3/00 , C12M1/00 , C12N15/09 , C12Q1/68 , G01N21/78 , G01N33/483 , G01N33/543 , G01N33/551 , G01N33/566 , G01N37/00 , H01L51/00 , H01L51/30
CPC分类号： B82Y10/00 , C12Q1/682 , C12Q1/6825 , H01L51/0093
摘要： A method and system for the detection of a target nucleic acid in a sample solution. The target nucleic acid comprises a first and a second end sequence, one of the end sequences being a 5' end sequence and the other end sequence being a 3' end sequence. The method comprises: (a) attaching to a solid surface a first oligonucleotide probe, at least a portion of which is complementary to the first end sequence of the target nucleic acid; (b) contacting the solid surface with the sample solution, thereby allowing the first probe to bind the target nucleic acid; (c) providing a second semiconductor nanoparticle to which has been attached a second oligonucleotide probe, at least a portion of which is complementary to the second end sequence of the target nucleic acid; (d) contacting the solid surface of step (b) with the second nanoparticle, thereby allowing the second probe to bind the bound target nucleic acid; (e) providing a first semiconductor nanoparticle to which has been attached the first oligonucleotide probe and pre-incubating the first nanoparticle with the target nucleic acid, thereby allowing the first probe to bind the target nucleic acid; (f) contacting the solid surface of step (d) with the pre-incubated first nanoparticle, thereby allowing the target nucleic acid bound to the first probe to bind the second probe on the second nanoparticle; and (g) detecting the presence of the nanoparticles on the solid surface, thereby detecting the target nucleic acid.
摘要翻译：用于检测样品溶液中靶核酸的方法和系统。靶核酸包含第一和第二末端序列，末端序列之一是5'末端序列，另一个末端序列是3'末端序列。该方法包括：（a）将第一寡核苷酸探针与固体表面连接，第一寡核苷酸探针的至少一部分与靶核酸的第一末端序列互补; （b）使固体表面与样品溶液接触，从而使第一探针结合目标核酸; （c）提供第二个半导体纳米颗粒，其上连接有第二寡核苷酸探针，其中至少一部分与靶核酸的第二末端序列互补; （d）使步骤（b）的固体表面与第二纳米颗粒接触，从而允许第二探针结合结合的靶核酸; （e）提供第一半导体纳米颗粒，已经将第一寡核苷酸探针连接到其上并将第一纳米颗粒与靶核酸预孵育，从而允许第一探针结合靶核酸; （f）使步骤（d）的固体表面与预培养的第一纳米颗粒接触，由此使与第一探针结合的靶核酸结合第二纳米颗粒上的第二探针; 和（g）检测固体表面上纳米颗粒的存在，由此检测靶核酸。

8. 发明申请

WO2008051316A2 NANOSENSORS AND RELATED TECHNOLOGIES 审中-公开
标题翻译：纳米传感器和相关技术
公开(公告)号：WO2008051316A2
公开(公告)日：2008-05-02
申请号：PCT/US2007013700
申请日：2007-06-11
申请人： HARVARD COLLEGE , LIEBER CHARLES M , FANG YING , PATOLSKY FERNANDO
发明人： LIEBER CHARLES M , FANG YING , PATOLSKY FERNANDO
IPC分类号： C12Q1/68
CPC分类号： G01N33/551 , B82Y10/00 , C12Q1/6825 , C12Q2600/156 , G01N27/4145 , G01N27/4146 , G01N33/553 , H01L51/0049 , H01L51/0093 , C12Q2563/155
摘要： The present invention generally relates to nanotechnology and sub-microelectronic circuitry, as well as associated methods and devices, for example, nanoscale wire devices and methods for use in determining nucleic acids or other analytes suspected to be present in a sample (for example, their presence and/or dynamical information), e.g., at the single molecule level. For example, a nanoscale wire device can be used in some cases to detect single base mismatches within a nucleic acid (e.g., by determining association and/or dissociation rates). In one aspect, dynamical information such as a binding constant, an association rate, and/or a dissociation rate, can be determined between a nucleic acid or other analyte, and a binding partner immobilized relative to a nanoscale wire. In some cases, the nanoscale wire includes a first portion comprising a metal-semiconductor compound, and a second portion that does not include a metal-semiconductor compound. The binding partner, in some embodiments, is immobilized relative to at least the second portion of the nanoscale wire, and the size of the second portion of the nanoscale wire may be minimized and/or controlled in some instances. Articles and devices of size greater than the nanoscale are also included in certain embodiments. Still other aspects of the invention include assays, sensors, kits, and/or other devices that include such nanoscale wires, methods of making and/or using such nanoscale wires, or the like.
摘要翻译：本发明一般涉及纳米技术和亚微电子电路以及相关的方法和装置，例如纳米级线装置和用于确定疑似存在于样品中的核酸或其他分析物的方法（例如它们的存在和/或动态信息），例如在单分子水平。例如，在一些情况下可以使用纳米级线装置来检测核酸内的单碱基错配（例如通过确定缔合和/或解离速率）。在一个方面，可以在核酸或其他分析物与相对于纳米线固定的结合配偶体之间确定动力学信息，例如结合常数，结合速率和/或解离速率。在一些情况下，纳米级线包括包含金属半导体化合物的第一部分和不包含金属半导体化合物的第二部分。在一些实施方案中，结合配偶体相对于纳米线的至少第二部分固定，并且在一些情况下纳米线的第二部分的尺寸可以被最小化和/或控制。尺寸大于纳米级的制品和器件也包括在某些实施方案中。本发明的其他方面包括分析，传感器，套件和/或包括这种纳米线的其他装置，制造和/或使用这种纳米线的方法等。

9. 发明申请

WO2008027078A2 NANOBIOELECTRONICS 审中-公开
公开(公告)号：WO2008027078A2
公开(公告)日：2008-03-06
申请号：PCT/US2007006545
申请日：2007-03-15
申请人： HARVARD COLLEGE , PATOLSKY FERNANDO , TIMKO BRIAN P , YU GUIHUA , LIEBER CHARLES M
发明人： PATOLSKY FERNANDO , TIMKO BRIAN P , YU GUIHUA , LIEBER CHARLES M
CPC分类号： G01N33/5058 , B82Y10/00 , H01L29/0665 , H01L29/0673 , H01L29/1606
摘要： The present invention generally relates to nanobioelectronics and, in some cases, to circuits comprising nanoelectronic elements, such as nanotubes and/or nanowires, and biological components, such as neurons. In one aspect, cells, such as neurons, are positioned in electrical communication with one or more nanoscale wires. The nanoscale wires may be used to stimulate the cells, and/or determine an electrical condition of the cells. More than one nanoscale wire may be positioned in electrical communication with the cell, for example, in distinct regions of the cell. However, the nanoscale wires may be positioned such that they are relatively close together, for example, spaced apart by no more than about 200 nm. The nanoscale wires may be disposed on a substrate, for example, between electrodes, and the cells may be adhered to the substrate, for example, using cell adhesion factors such as polylysine. Also provided in other aspects of the invention are methods for making and using such devices, kits for using the same, and the like.
摘要翻译：本发明一般涉及纳米生物电子学，并且在一些情况下涉及包含纳米电子元件（例如纳米管和/或纳米线）和生物组分（例如神经元）的电路。在一个方面，诸如神经元的细胞被定位成与一个或多个纳米级导线电连通。纳米级线可用于刺激细胞，和/或确定细胞的电状况。例如，在电池的不同区域中，可以放置多于一根的纳米级电线与电池电连通。然而，纳米级线材可以定位成使得它们相对靠近在一起，例如间隔不超过约200nm。纳米级线可以设置在例如电极之间的基板上，并且例如可以使用细胞粘附因子例如聚赖氨酸将细胞粘附到基板。在本发明的其他方面也提供了制造和使用这种装置的方法，使用它们的试剂盒等。

10. 发明申请

WO2014111944A8 SYSTEMS AND METHODS FOR IDENTIFYING EXPLOSIVES 审中-公开
标题翻译：用于识别爆炸物的系统和方法
公开(公告)号：WO2014111944A8
公开(公告)日：2014-08-28
申请号：PCT/IL2014050070
申请日：2014-01-20
申请人： UNIV RAMOT , TRACENSE SYSTEMS LTD
发明人： PATOLSKY FERNANDO , SHACHAM RONEN , LICHTENSTEIN AMIR , HAVIVI EHUD , HAHAMY EHUD
IPC分类号： G01N33/22 , G01N27/414 , H01L29/772
CPC分类号： G01N27/4146 , C40B30/02 , G01N33/0031 , G01N33/0057
摘要： A method and a system for identifying an explosive in a sample are disclosed. The method comprises receiving an explosive fingerprint defined by a set of kinetic parameters, describing a plurality of interactions between the explosive and each of a respective plurality of functional moieties. The method further comprises using a data processor for accessing a database of explosive fingerprints, and searching the database for a database fingerprint matching the received fingerprint. The system comprises a plurality of sensing devices, each comprising semiconductor nanostructures (e.g. Si nanowires) having attached thereto a functional moiety selected to interact with a nitro-containing and/or peroxide-containing explosive sample.
摘要翻译：公开了一种用于识别样品中的炸药的方法和系统。该方法包括接收由一组动力学参数定义的炸药指纹，描述炸药与相应的多个功能部分中的每一个之间的多个相互作用。该方法还包括使用数据处理器来访问爆炸指纹的数据库，并且在数据库中搜索与所接收的指纹匹配的数据库指纹。该系统包括多个感测装置，每个感测装置均包含半导体纳米结构（例如Si纳米线），其中附着有选择与含硝基和/或含过氧化物的爆炸性样品相互作用的功能部分。

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