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1. 发明申请

WO2010001395A2 DETECTION OF TRINITROTOLUENE 审中-公开
标题翻译：三氯硝基苯的检测
公开(公告)号：WO2010001395A2
公开(公告)日：2010-01-07
申请号：PCT/IL2009/000656
申请日：2009-06-30
申请人： YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM, LTD. , WILLNER, Itamar , TEL-VERED, Ran , RISKIN, Michael
发明人： WILLNER, Itamar , TEL-VERED, Ran , RISKIN, Michael
IPC分类号： G01N27/12 , G01N33/00 , G01N33/22
CPC分类号： G01N33/0057 , G01N2600/00 , Y10T436/173076
摘要： An ultrasensitive method for detecting analytes in a sample is provided. The method involves the use of a matrix of nanoparticles which are associated with recognition groups capable of undergoing interaction with the analyte.
摘要翻译：提供了一种用于检测样品中分析物的超灵敏方法。该方法涉及使用与能够与分析物相互作用的识别基团相关联的纳米颗粒的基质。

2. 发明申请

WO2008001376A3 DETECTION OF ANALYTES IN A MEDIUM 审中-公开
标题翻译：检测中值分析仪
公开(公告)号：WO2008001376A3
公开(公告)日：2008-04-10
申请号：PCT/IL2007000794
申请日：2007-06-28
申请人： YISSUM RES DEV CO , WILLNER ITAMAR , WEIZMANN YOSSI , BEISSENHIRTZ MORITZ K , CHEGLAKOV ZOYA
发明人： WILLNER ITAMAR , WEIZMANN YOSSI , BEISSENHIRTZ MORITZ K , CHEGLAKOV ZOYA
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6816 , C12Q1/6825 , C12Q2531/119 , C12Q2531/125 , C12Q2563/125
摘要： A nucleotide construct is provided that comprises a sequence A and a sequence B on a single nucleotide stretch, sequence B being on the 5' side of sequence A. Sequence A is complementary to sequence A'. Hybridization of sequence A' to the sequence A in the presence of a polymerase and nucleotides, yields synthesis of a complementary stretch of nucleic acids which comprises a sequence B' that is complementary to sequence B. Sequence B' being a reporting sequence that upon becoming freed from said construct after may be detected. This construct may be used for detection of analytes in a medium. The analyte may be a nucleotide sequence comprising sequence A', or a substrate that facilitates hybridization of sequence A' to A.
摘要翻译：提供了核苷酸构建体，其包含单序列A上的序列A和序列B，序列B位于序列A的5'侧。序列A与序列A'互补。在聚合酶和核苷酸存在下将序列A'与序列A的杂交产生核酸的互补序列的合成，其包含与序列B互补的序列B'。序列B'为成为后的报告序列可以检测到从所述构造中释放出来。该构建体可用于检测培养基中的分析物。分析物可以是包含序列A'或促进序列A'与A的杂交的底物的核苷酸序列。

3. 发明申请

WO2003096014A2 DETERMINATION OF AN ANALYTE IN A LIQUID MEDIUM 审中-公开
标题翻译：液体介质中分析物的测定
公开(公告)号：WO2003096014A2
公开(公告)日：2003-11-20
申请号：PCT/IL2003/000369
申请日：2003-05-06
申请人： YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM , WILLNER, Itamar , KATZ, Eugenii , WEIZMANN, Yossi , PATOLSKY, Fernando
发明人： WILLNER, Itamar , KATZ, Eugenii , WEIZMANN, Yossi , PATOLSKY, Fernando
IPC分类号： G01N33/53
CPC分类号： G01N33/54333 , C12Q1/6804 , C12Q1/6806 , C12Q1/6816 , C12Q2563/143 , C12Q2563/113 , C12Q2565/607 , C12Q2563/131 , C12Q2521/113
摘要： The present invention concerns a magneto-controlled method and system for the determination of an analyte in a liquid medium. The method and system of the invention are based on the use of functionalized magnetic particles, e.g. magnetic particles that carry a recognition agent, such that in the presence of the analyte and under appropriate conditions, a chemical reaction occurs yielding a reaction signal. The reaction signal may be an electric signal, a colorimetric signal, light emission or the formation of a precipitate. In accordance with the invention the reaction is significantly enhanced by inducing rapid vibrations or rotations of the magnetic particles on the barrier surface.
摘要翻译：本发明涉及用于确定液体介质中分析物的磁控方法和系统。本发明的方法和系统基于使用官能化的磁性颗粒，例如，携带识别剂的磁性颗粒，使得在分析物存在下和在合适的条件下发生化学反应，产生反应信号。反应信号可以是电信号，比色信号，发光或沉淀物的形成。根据本发明，通过诱导磁性颗粒在阻挡表面上的快速振动或旋转，反应显着增强。

4. 发明申请

WO0153792A3 A SYSTEM FOR DETECTING SUBSTANCES 审中-公开
标题翻译：一种用于检测物质的系统
公开(公告)号：WO0153792A3
公开(公告)日：2003-08-07
申请号：PCT/IL0100053
申请日：2001-01-18
申请人： GIVEN IMAGING LTD , MERON GAVRIEL , WILLNER ITAMAR , YISSUM RES DEV CO
发明人： MERON GAVRIEL , WILLNER ITAMAR
IPC分类号： A61B1/05 , A61B5/07 , G01N33/53
CPC分类号： A61B5/14546 , A61B1/041 , A61B1/05 , A61B5/07 , A61B5/073 , A61B5/14539
摘要： The present invention relates to a method and system for the in vivo determination of the presence and/or concentration of biological and/or chemical substances in body lumens. The system of the invention comprises a solid support, the support being inserted into a body lumen and having immobilized thereon at least one reactant capable of reacting with the substance resulting in an optical change; and a detecting unit, in communication with the support, capable of detecting a reaction resulting in an optical change between the reactant and the substance.
摘要翻译：本发明涉及一种用于体内测定体腔内生物和/或化学物质的存在和/或浓度的方法和系统。本发明的系统包括固体支持物，所述载体插入体腔中并且固定有至少一种能够与所述物质反应的反应物导致光学变化; 以及与支持体连通的检测单元，其能够检测导致反应物和物质之间的光学变化的反应。

5. 发明申请

WO2010001395A3 DETECTION OF TRINITROTOLUENE 审中-公开
标题翻译：三硝基甲苯的检测
公开(公告)号：WO2010001395A3
公开(公告)日：2010-06-10
申请号：PCT/IL2009000656
申请日：2009-06-30
申请人： YISSUM RES DEV CO , WILLNER ITAMAR , TEL-VERED RAN , RISKIN MICHAEL
发明人： WILLNER ITAMAR , TEL-VERED RAN , RISKIN MICHAEL
IPC分类号： G01N27/12 , G01N33/00 , G01N33/22
CPC分类号： G01N33/0057 , G01N2600/00 , Y10T436/173076
摘要： An ultrasensitive method for detecting analytes in a sample is provided. The method involves the use of a matrix of nanoparticles which are associated with recognition groups capable of undergoing interaction with the analyte.
摘要翻译：提供了一种用于检测样品中分析物的超灵敏方法。该方法涉及使用与能够与分析物相互作用的识别基团缔合的纳米颗粒基质。

6. 发明申请

WO2005073405A3 CATALYTIC POLYNUCLEOTIDE AND ITS USE FOR DETERMINATION OF ANALYTES 审中-公开
标题翻译：催化多核苷酸及其用于测定分析物的用途
公开(公告)号：WO2005073405A3
公开(公告)日：2006-02-16
申请号：PCT/IL2005000097
申请日：2005-01-27
申请人： YISSUM RES DEV CO , WILLNER ITAMAR , XIAO YI , PAVLOV VALERI , GILL RON , NIAZOV TAMARA
发明人： WILLNER ITAMAR , XIAO YI , PAVLOV VALERI , GILL RON , NIAZOV TAMARA
IPC分类号： C12Q1/68 , C12N15/115
CPC分类号： C12N15/115 , C12Q1/6813 , C12Q1/683 , C12Q2521/543 , C12Q2521/331
摘要： A method for the determination of an analyte in a sample, the method comprising: (a) providing a catalytic polynucleotide; (b) contacting the catalytic polynucleotide with the sample so that the catalytic polynucleotide may bind to the analyte; (c) providing assay conditions such that the catalytic polynucleotide produces an optically detectable signal in the presence of the analyte; and (d) detecting the signal, thereby determining the presence of the analyte in the sample. One application of the method is for the detection of telomerase in a biological sample.
摘要翻译：一种用于测定样品中分析物的方法，所述方法包括：（a）提供催化多核苷酸; （b）使催化多核苷酸与样品接触，使得催化多核苷酸可以结合分析物; （c）提供测定条件，使得催化多核苷酸在分析物存在下产生可光学检测的信号; 和（d）检测信号，从而确定样品中分析物的存在。该方法的一个应用是用于检测生物样品中的端粒酶。

7. 发明申请

WO0220838A3 METHOD AND SYSTEM FOR DETECTING NUCLEIC ACIDS 审中-公开
标题翻译：检测核酸的方法和系统
公开(公告)号：WO0220838A3
公开(公告)日：2003-10-23
申请号：PCT/IL0100808
申请日：2001-08-29
申请人： YISSUM RES DEV CO , PATOLSKY FERNANDO , LICHTENSTEIN AMIR , WILLNER ITAMAR , WEIZMANN YOSSI
发明人： PATOLSKY FERNANDO , LICHTENSTEIN AMIR , WILLNER ITAMAR , WEIZMANN YOSSI
IPC分类号： G01N33/53 , C12M1/00 , C12N15/09 , C12Q1/26 , C12Q1/28 , C12Q1/32 , C12Q1/42 , C12Q1/68 , C40B40/06 , G01N5/02 , G01N27/327 , G01N27/416 , G01N27/42 , G01N27/48 , G01N37/00 , B01J19/00
CPC分类号： C12Q1/6816 , B01J2219/00529 , B01J2219/00585 , B01J2219/00596 , B01J2219/00605 , B01J2219/0061 , B01J2219/00612 , B01J2219/00653 , B01J2219/00659 , B01J2219/00713 , B01J2219/00722 , C12Q1/6825 , C12Q1/6834 , C40B40/06
摘要： A method for the detection of a target nucleic acid in a sample containing a mixture of nucleic acids. The method comprises (a) providing a solid surface; (b) attaching to the solid surface an oligonucleotide probe complementary to a segment of the target nucleic acid; (c) contacting the surface with the sample, thereby allowing the probe to bind the target nucleic acid; (d) incubating the bound target nucleic acid with the 4 nucleotide types and a replication biocatalyst thereby forming a multi-stranded nucleic acid assembly, wherein at least one of the nucleotide types is bound by a label; and (e) detecting the label on the multi-stranded nucleic acid assembly, thereby detecting the target nucleic acid. Also disclosed are a system for identifying a target nucleic acid sequence in a sample and a kit for use in the method.
摘要翻译：用于检测含有核酸混合物的样品中的靶核酸的方法。该方法包括（a）提供固体表面; （b）将与靶核酸片段互补的寡核苷酸探针附着于固体表面; （c）使表面与样品接触，从而使探针结合目标核酸; （d）用4核苷酸类型孵育结合的靶核酸和复制生物催化剂，从而形成多链核酸组装体，其中至少一个核苷酸类型被标记结合; 和（e）检测多链核酸组合物上的标记，从而检测靶核酸。还公开了用于鉴定样品中的靶核酸序列的系统和用于该方法的试剂盒。

8. 发明申请

WO2002056650A3 FORMING A CONDUCOR CIRCUIT ON A SUBSTRATE 审中-公开
公开(公告)号：WO2002056650A3
公开(公告)日：2002-07-18
申请号：PCT/IB2002/000009
申请日：2002-01-07
申请人： YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM , SHIPWAY, Andrew, N. , WILLNER, Itamar
发明人： SHIPWAY, Andrew, N. , WILLNER, Itamar
IPC分类号： C23C18/16
摘要： Disclosed is a process for forming a conductor pattern on a face of a substrate, which is typically sorbing and porous, such as paper or cloth. The method comprises forming on the surface an exposed pattern of colloid particles, corresponding to the conductor pattern to be formed. The colloid particles suitable for use according to the invention are those that are capable of catalyzing electroless deposition of copper, silver, gold, and the like. After the exposed pattern of colloid particles is formed, precipitation of a metal substance on said face is caused, to form said conductor pattern.

9. 发明申请

WO2009156999A1 PHOTOCHEMICAL ELECTRODE, CONSTRUCTION AND USES THEREOF 审中-公开
标题翻译：光电化学电极，其结构及其用途
公开(公告)号：WO2009156999A1
公开(公告)日：2009-12-30
申请号：PCT/IL2009/000641
申请日：2009-06-28
申请人： YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM, LTD. , WILLNER, Itamar , TEL-VERED, Ran , BEKIR YILDIZ, Huseyin
发明人： WILLNER, Itamar , TEL-VERED, Ran , BEKIR YILDIZ, Huseyin
IPC分类号： H01L51/46
CPC分类号： H01L51/426 , B82Y30/00 , C01G7/00 , C01G11/00 , C01P2004/62 , C01P2004/64 , C01P2006/40 , C09K11/565 , Y02E10/549
摘要： The invention provides an electrode comprising a conductive surface connected to a matrix; said matrix comprising a plurality of semiconductor nanoparticles and noble metal nanoparticles, substantially each of which is connected to another nanoparticle of said plurality of nanoparticles by at least one matrix connecting group and at least a portion of said plurality of nanoparticles of said matrix is each connected to said conductive surface by at least one surface connecting group. The invention further provides photovoltaic cells and devices comprising electrode of the invention.
摘要翻译：本发明提供了一种电极，其包括连接到基体的导电表面; 所述基质包括多个半导体纳米颗粒和贵金属纳米颗粒，其基本上每个都通过至少一个基质连接基团连接到所述多个纳米颗粒的另一纳米颗粒，并且所述基质的所述多个纳米颗粒的至少一部分各自连接通过至少一个表面连接基团连接到所述导电表面。本发明还提供了包含本发明电极的光伏电池和器件。

10. 发明申请

WO2003019170A1 SELF-POWERED BIOSENSOR 审中-公开
标题翻译：自动生物传感器
公开(公告)号：WO2003019170A1
公开(公告)日：2003-03-06
申请号：PCT/IL2002/000660
申请日：2002-08-12
申请人： YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM , WILLNER, Itamar , KATZ, Evgeny
发明人： WILLNER, Itamar , KATZ, Evgeny
IPC分类号： G01N27/327
CPC分类号： H01M8/16 , C12Q1/004 , Y02E60/527
摘要： The present invention provides a system for the determination of an analyte in a liquid medium. The system comprises a self-powered biosensor and a detector for measuring an electrical signal generated by said biosensor while the analyte is being oxidized or reduced, the biosensor comprising a pair of electrodes, one of the electrodes being an anode and the other a cathode, both of which carry redox enzymes on their surface. An enzyme carried on one of the electrodes can catalyze an oxidation or reduction reaction in which the analyte is oxidized or reduced, respectively, and the other of said pair of electrodes carries on its surface enzymes that can catalyze a reaction in which the oxidizer or the reducer are reduced or oxidized, respectively, in the presence of the analyte.
摘要翻译：本发明提供了一种用于确定液体介质中的分析物的系统。该系统包括自供电的生物传感器和用于在分析物被氧化或还原时测量由所述生物传感器产生的电信号的检测器，所述生物传感器包括一对电极，一个电极是阳极，另一个是阴极，两者都在其表面携带氧化还原酶。携带在其中一个电极上的酶可以催化氧化或还原反应，其中分析物分别被氧化或还原，并且所述一对电极中的另一个在其表面上承载可以催化反应的酶，其中氧化剂或还原剂分别在分析物存在下还原或氧化。

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