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1. 发明申请

WO03008539A2 NON-ALLOYING CORE SHELL NANOPARTICLES 审中-公开
标题翻译：非合金核壳纳米粒子
公开(公告)号：WO03008539A2
公开(公告)日：2003-01-30
申请号：PCT/US0216382
申请日：2002-05-22
申请人： UNIV NORTHWESTERN , MIRKIN CHAD A , CAO YUN-WEI , JIN RONGCHAO
发明人： MIRKIN CHAD A , CAO YUN-WEI , JIN RONGCHAO
IPC分类号： G01N33/553 , B22F1/00 , B22F1/02 , B22F3/26 , B22F7/04 , B22F9/24 , B82B1/00 , C07H21/02 , C07H21/04 , C12M1/34 , C12N20060101 , C12N15/09 , C12Q1/68 , G01N21/27 , G01N21/33 , G01N33/53 , G01N33/543 , G01N33/566 , G01N33/58 , H01F3/02 , C12N
CPC分类号： B22F1/0062 , A61K47/6923 , B22F1/0059 , B22F1/025 , B22F9/24 , B22F2998/00 , B82Y5/00 , B82Y10/00 , B82Y15/00 , B82Y25/00 , B82Y30/00 , C01B19/007 , C01G7/00 , C01G11/02 , C01G49/08 , C01P2002/82 , C01P2004/04 , C01P2004/64 , C01P2004/84 , C01P2006/42 , C12Q1/6813 , C12Q1/6816 , C12Q1/6834 , G01N33/543 , G01N33/5434 , G01N33/54393 , G01N33/553 , G01N33/588 , H01F1/0054 , H01L29/127 , Y10S977/704 , Y10S977/722 , Y10S977/773 , Y10S977/81 , Y10T428/12014 , C12Q2563/155 , B22F1/0018
摘要： The present invention relates composite core/shell nanoparticles and a two-step method for their preparation. The present invention further relates to biomolecule-core/shell nanoparticle conjugates and methods for their preparation. The invention also relates to methods of detection of biomolecules comprising the biomolecule-core/shell nanoparticle conjugates.
摘要翻译：本发明涉及复合核/壳纳米颗粒和两步法的制备方法。本发明还涉及生物分子 - 核/壳纳米颗粒缀合物及其制备方法。本发明还涉及检测包含生物分子 - 核/壳纳米颗粒共轭物的生物分子的方法。

2. 发明申请

WO03095973A2 NANOPARTICLE PROBES WITH RAMAN SPECTROSCOPIC FINGERPRINTS FOR ANALYTE DETECTION 审中-公开
标题翻译：用于分析物检测的拉曼光谱指纹图谱的纳米颗粒探针
公开(公告)号：WO03095973A2
公开(公告)日：2003-11-20
申请号：PCT/US0314100
申请日：2003-05-07
申请人： UNIV NORTHWESTERN , MIRKIN CHAD , CAO YUN-WEI , JIN RONGCHAO
发明人： MIRKIN CHAD , CAO YUN-WEI , JIN RONGCHAO
IPC分类号： G01N21/65 , C12M1/00 , C12N15/09 , C12Q1/02 , C12Q1/68 , G01N33/53 , G01N33/543 , G01N33/553 , G01N33/566 , G01N33/58 , G01N
CPC分类号： G01N33/587 , C12Q1/6816 , G01N33/54373 , G01N33/583 , C12Q2565/632 , C12Q2565/519 , C12Q2537/125
摘要： The invention encompasses reagents comprising particles with at least one Raman dye and a specific binding members bound thereto and methods of using such reagents. The invention also encompasses reagents of a specific binding member and two or more different Raman dyes and methods for using such reagents. New types of particle probes having a specific binding member bound thereto are described. These reagents are used in a novel detection strategy that utilizes the catalytic properties of the Au nanoparticles to generate a silver coating that can behave as a surface-enhanced Raman scattering (SERS) promoter for the dye-labeled particles that have been captured by target and an underlying chip in microarray format. The strategy provides the high sensitivity and high selectivity attributes of grey-scale scanometric detection but provides a route to multiplexing and ratioing capabilities since a very large number of probes can be designed based upon the concept of using a Raman tag as a spectroscopic fingerprint in detection. These spectra are used as fingerprints to differentiate oligonucleotide or other targets in one solution. This method has been used to distinguish six dissimilar DNA targets with six Raman labeled nanoparticle probes, and also two RNA targets with single nucleotide polymorphisms (SNPs).
摘要翻译：本发明包括含有至少一种拉曼染料和与其结合的特异性结合成员的颗粒的试剂和使用这些试剂的方法。本发明还包括特异性结合成员和两种或更多种不同拉曼染料的试剂和使用这些试剂的方法。描述具有与其结合的特异性结合成员的新型粒子探针。这些试剂用于一种新的检测策略，其利用Au纳米粒子的催化性能产生可以作为被目标捕获的染料标记的颗粒的表面增强拉曼散射（SERS）启动子的银涂层，微芯片格式的底层芯片。该策略提供了灰度扫描测量检测的高灵敏度和高选择性属性，但是提供了多路复用和比较能力的途径，因为可以基于在检测中使用拉曼标签作为光谱指纹的概念来设计非常大量的探针。这些光谱用作指纹以在一种溶液中区分寡核苷酸或其他靶标。该方法已被用于区分六个不同的DNA靶标与六个拉曼标记的纳米粒子探针，以及两个具有单核苷酸多态性（SNPs）的RNA靶标。

3. 发明申请

WO0225745A2 SEMICONDUCTOR NANOCRYSTALLINE MATERIALS AND THEIR USES 审中-公开
标题翻译：半导体纳米材料及其用途
公开(公告)号：WO0225745A2
公开(公告)日：2002-03-28
申请号：PCT/IL0100828
申请日：2001-09-03
申请人： YISSUM RES DEV CO , BANIN URI , CAO YUN WEI
发明人： BANIN URI , CAO YUN-WEI
IPC分类号： H01S5/30 , H01L33/00 , H01S5/32 , H01S5/34 , H01S5/343 , H01S5/347 , H01S5/50
CPC分类号： H01L33/08 , B82Y20/00 , H01L33/30 , H01S5/3214 , H01S5/3401 , H01S5/341 , H01S5/3412 , H01S5/3432 , H01S5/347
摘要： The invention relates to new semiconductor composite nanocrystal materials having desirable luminescent properties, specifically high quantum yields and good photochemical stability with specific, desirable emittance wavelengths, preferably in the near infrared. The invention further relates to various applications in optical, electrical, electro-optical and laser devices, particularly in the field of telecommunication, of these new semiconductor composite nanocrystal materials.
摘要翻译：本发明涉及新型半导体复合纳米晶体材料，其具有期望的发光性质，特别是高量子产率和优异的光化学稳定性以及特定的理想发射波长，优选在近红外波长。本发明进一步涉及在这些新型半导体复合纳米晶体材料的光学，电学，电光学和激光器件，尤其是电信领域中的各种应用。

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