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1. 发明申请

WO2013016689A3 MODULATING GANTRY ROTATION SPEED AND IMAGE ACQUISITION IN RESPIRATORY CORRELATED (4D) CONE BEAM CT IMAGES 审中-公开
标题翻译：呼吸相关（4D）CONE BEAM CT图像中的调制旋转速度和图像采集
公开(公告)号：WO2013016689A3
公开(公告)日：2013-04-25
申请号：PCT/US2012048693
申请日：2012-07-27
申请人： UNIV LELAND STANFORD JUNIOR , UNIV SYDNEY , KEALL PAUL J , O'BRIEN RICKY , COOPER BENJAMIN , LU JUN , WILLAMSON JEFFREY F
发明人： KEALL PAUL J , O'BRIEN RICKY , COOPER BENJAMIN , LU JUN , WILLAMSON JEFFREY F
IPC分类号： A61B6/03
CPC分类号： A61B6/541 , A61B6/4085 , A61B6/486 , A61B6/5205 , A61B6/5264 , A61B6/583 , A61N2005/1061
摘要： A method of optimizing 4D cone beam computed tomography (4DCBCT) imaging is provided that includes using a scanner to generate projections of a target, where the projections are used to form a cone beam computed tomography (CBCT) scan of the target, where the CBCT includes a 3D image of the target, and using an appropriately programmed computer to control rotation speed of a gantry and projection acquisition of the CBCT in real-time according to a measured patient respiratory signal, where the real-time acquisition of the CBCT forms an optimized 4DCBCT image set.
摘要翻译：提供了优化4D锥形束计算机断层摄影（4DCBCT）成像的方法，其包括使用扫描仪来产生靶的投影，其中所述突起用于形成靶的锥束计算机断层摄影（CBCT）扫描，其中CBCT 包括目标的3D图像，并且使用适当编程的计算机根据所测量的患者呼吸信号实时地控制台架的转速和CBCT的投影采集，其中CBCT的实时采集形成优化的4DCBCT图像集。

2. 发明申请

WO2011053783A3 AX213 AND AX132 PCSK9 ANTAGONISTS AND VARIANTS 审中-公开
标题翻译： AX213和AX132 PCSK9 ANTAGONISTS和变量
公开(公告)号：WO2011053783A3
公开(公告)日：2011-07-28
申请号：PCT/US2010054714
申请日：2010-10-29
申请人： MERCK SHARP & DOHME , LUO PETER PEIZHI , NI YAN , WANG KEVIN CAILI , HSIEH MARK , WANG XINWEI , DONG FENG , GOLOSOV ANDREI , WANG WEIRONG , LI YAN , ZHONG PINGYU , PETERSON LAURENCE B , CUBBON ROSE , SHARMA SUJATA , CONDRA JON , LU JUN , PARTHASARATHY GOPALAKRISHNAN , SOISSON STEPHEN , BYRNE NOEL
发明人： LUO PETER PEIZHI , NI YAN , WANG KEVIN CAILI , HSIEH MARK , WANG XINWEI , DONG FENG , GOLOSOV ANDREI , WANG WEIRONG , LI YAN , ZHONG PINGYU , PETERSON LAURENCE B , CUBBON ROSE , SHARMA SUJATA , CONDRA JON , LU JUN , PARTHASARATHY GOPALAKRISHNAN , SOISSON STEPHEN , BYRNE NOEL
IPC分类号： A61K39/395 , C07K16/00
CPC分类号： C07K16/40 , C07K2299/00 , C07K2317/21 , C07K2317/52 , C07K2317/55 , C07K2317/76 , C07K2317/94 , C07K2319/00
摘要： Antagonists of human proprotein convertase subtilisin-kexin type 9 ("PCSK9") are disclosed. The disclosed antagonists are effective in the inhibition of PCSK9 function and, accordingly, present desirable antagonists for use in the treatment of conditions associated with PCSK9 activity. The present invention also discloses nucleic acid encoding said antagonists, vectors, host cells, and compositions comprising the antagonists. Methods of making PCSK9-specific antagonists as well as methods of using the antagonists for inhibiting or antagonizing PCSK9 function are also disclosed and form important additional aspects of the present disclosure.
摘要翻译：公开了人前体蛋白转化酶枯草杆菌蛋白酶-Kexin 9型（“PCSK9”）的拮抗剂。所公开的拮抗剂在抑制PCSK9功能方面是有效的，因此，呈现用于治疗与PCSK9活性相关的病症的所需拮抗剂。本发明还公开了编码所述拮抗剂，载体，宿主细胞和包含拮抗剂的组合物的核酸。还公开了制备PCSK9特异性拮抗剂的方法以及使用拮抗剂抑制或拮抗PCSK9功能的方法，并且形成了本公开的重要的附加方面。

3. 发明申请

WO2004030621A3 METHOD OF TREATING CANCER USING ADENOSINE AND ITS ANALOGS 审中-公开
标题翻译：使用腺嘌呤及其类似物治疗癌症的方法
公开(公告)号：WO2004030621A3
公开(公告)日：2004-12-09
申请号：PCT/US0330701
申请日：2003-09-30
申请人： UNIV BOSTON , RAVID KATYA , LU JUN
发明人： RAVID KATYA , LU JUN
IPC分类号： A61K31/7076 , A61K31/70
CPC分类号： A61K31/137 , A61K31/56 , A61K31/7076
摘要： The present invention provides methods of treating individuals having malignancies associated with estrogen receptor activity comprising administering to an individual affected with said malignancy, an effective amount of adenosine analog in a pharmaceutical carrier to downregulate or diminish estrogen receptors in the cells. The invention further provides methods of identifying novel adenosine analogues capable of treating malignant cells expressing estrogen receptors. The invention also provides kits comprising adenosine analogs for downregulating estrogen receptors in cells and kits for screening for novel adenosine analogs capable of downregulating estrogen receptors. Further, the invention provides uses of adenosine analogs in downregulation of estrogen receptors, cell growth and cell cycle, as well as pharmaceutical compositions comprising adenosine analogs effective in suppressing cellular growth, cell cycle or downregulating estrogen receptors.
摘要翻译：本发明提供了治疗患有与雌激素受体活性相关的恶性肿瘤的个体的方法，其中包括对受到所述恶性肿瘤影响的个体施用有效量的药物载体中的腺苷类似物以下调或减少细胞中的雌激素受体。本发明还提供鉴定能够治疗表达雌激素受体的恶性细胞的新型腺苷类似物的方法。本发明还提供了包含用于下调细胞中雌激素受体的腺苷类似物的试剂盒和用于筛选能够下调雌激素受体的新型腺苷类似物的试剂盒。此外，本发明提供了腺苷类似物在下调雌激素受体，细胞生长和细胞周期中的用途，以及包含有效抑制细胞生长，细胞周期或下调雌激素受体的腺苷类似物的药物组合物的用途。

4. 发明申请

WO2010017551A3 METHOD FOR MIR-125A IN PROMOTING HEMATOPOIETIC STEM CELL SELF RENEWAL AND EXPANSION 审中-公开
标题翻译： MIR-125A在促进HEMATOPOIETIC干细胞自我更新和扩张的方法
公开(公告)号：WO2010017551A3
公开(公告)日：2010-06-10
申请号：PCT/US2009053290
申请日：2009-08-10
申请人： GEN HOSPITAL CORP , MASSACHUSETTS INST TECHNOLOGY , SCADDEN DAVID , GUO SHANGQIN , LU JUN
发明人： SCADDEN DAVID , GUO SHANGQIN , LU JUN
IPC分类号： C12N5/02 , C12N5/071 , C12N5/0789 , C12N15/113 , C12N15/63
CPC分类号： C12N15/113 , C12N5/0647 , C12N2310/14 , C12N2310/141 , C12N2501/65
摘要： Embodiments of the invention relate to methods and compositions for the expansion of hematopoietic stem cell (HSC) self renewal. The microRNA-125a is a master control of HSC self-renewal. Increased expression of mir-125a increased HSC self-renewal by 6-30 folds. Increased expression of mir-125a can be used to expand HSC ex vivo and in vivo.
摘要翻译：本发明的实施方案涉及用于扩增造血干细胞（HSC）自我更新的方法和组合物。 microRNA-125a是HSC自我更新的主要控制。 mir-125a的表达增加使HSC自我更新增加6-30倍。 mir-125a的增加的表达可用于离体和体内扩增HSC。

5. 发明申请

WO2007079625A8 AN ULTRAFINE GRAIN STEEL SHEET PRODUCED BY CONTINUOUS CASTING AND ROLLING A MEDIUM-THIN SLAB AND ITS MANUFACTURE PROCESS 审中-公开
标题翻译：连续铸造生产的超细晶粒钢板，轧制中厚板及其制造工艺
公开(公告)号：WO2007079625A8
公开(公告)日：2008-08-07
申请号：PCT/CN2006001097
申请日：2006-05-25
申请人： ANGANG STEEL CO LTD , SUN JIANLUN , ZHANG WANSHAN , GUANG JU , YANG XU , CHEN XIN , SUN QUN , WANG KEQIANG , LIU LIQUN , ZHAI YONGBIN , FU GUOLI , LU JUN , YANG MINGKAI
发明人： SUN JIANLUN , ZHANG WANSHAN , GUANG JU , YANG XU , CHEN XIN , SUN QUN , WANG KEQIANG , LIU LIQUN , ZHAI YONGBIN , FU GUOLI , LU JUN , YANG MINGKAI
IPC分类号： C22C38/04 , B21B1/26 , B21B1/46 , C21D8/02
CPC分类号： B21B3/02 , C21D8/0215 , C21D8/0226 , C21D8/0415 , C21D8/0426 , C21D9/48 , C21D2211/005 , C22C38/02 , C22C38/04
摘要： An ultrafine grain steel sheet produced by continuous casting and rolling a medium-thin slab and its manufacture process. The composition of the steel is (in wt%): C 0.12-0.18%, Si 0.15-0.35%, Mn 0.65-1.20%, P=0.02%, S=0.015%, balance Fe and impurities. The manufacture process includes: hot loading the cast ingot directly at a temperature above 800°C, heating to 1100-1280°C; rough rolling the slab to 30-60mm; finish rolling in multi-passes with large accumulated deformation with an inlet temperature of 920-1050°C and an outlet temperature of 750-850°C, in which the average deformation rate of the steel sheet between finish rolling mills is 1-10/s; laminar cooling at a rate of 10-45°C/s, reeling at 400-620°C. The hot-continuous-rolling steel sheet is 2-18mm in thickness, and have an average grain size of 3-7µm, yield strength up to above 400MPa, tensile strength of 510-580MPa, and elongation beyond 26%.
摘要翻译：通过连续铸造和轧制中薄板坯制造的超细晶粒钢板及其制造方法。钢的组成为（重量％）：C 0.12-0.18％，Si 0.15-0.35％，Mn 0.65-1.20％，P = 0.02％，S = 0.015％，余量为Fe和杂质。制造工艺包括：将铸锭直接在800℃以上的温度下加热，加热至1100-1280℃; 将板坯粗轧至30-60mm; 入口温度为920-1050℃，出口温度为750-850℃的大型积聚变形的多道次精轧，其中精轧机间钢板的平均变形率为1-10 / S; 以10-45℃/ s的速率层流冷却，在400-620℃下卷取。热轧连续轧制钢板的厚度为2-18mm，平均粒径为3-7μm，屈服强度高达400MPa，拉伸强度为510-580MPa，伸长率超过26％。

6. 发明申请

WO2006053050A3 SYSTEM AND METHOD FOR PERFORMING AUXILIARY STORAGE OPERATIONS 审中-公开
标题翻译：执行辅助存储操作的系统和方法
公开(公告)号：WO2006053050A3
公开(公告)日：2007-04-19
申请号：PCT/US2005040606
申请日：2005-11-08
申请人： COMMVAULT SYSTEMS INC , AMARENDRAN PRASAD , VIJAYAN RETNAMMA MANOJ KUMAR , PRAHLAD ANAND , GOKHALE PARAG , LU JUN
发明人： AMARENDRAN PRASAD , VIJAYAN RETNAMMA MANOJ KUMAR , PRAHLAD ANAND , GOKHALE PARAG , LU JUN
IPC分类号： G06F12/00
CPC分类号： G06F3/0649 , G06F3/0619 , G06F3/0685 , G06F11/1456 , G06F11/1458
摘要： Systems and methods for protecting data in a tiered storage system are provided. The storage system comprises a management server, a media management component connected to the management server, a plurality of storage media connected to the media management component, and a data source connected to the media management component. Source data is copied from a source to a buffer to produce intermediate data. The intermediate data is copied to both a first and second medium to produce a primary and auxiliary copy, respectively. An auxiliary copy may be made from another auxiliary copy. An auxiliary copy may also be made from a primary copy right before the primary copy is pruned.
摘要翻译：提供了用于保护分层存储系统中的数据的系统和方法。存储系统包括管理服务器，连接到管理服务器的媒体管理组件，连接到媒体管理组件的多个存储媒体以及连接到媒体管理组件的数据源。源数据从源复制到缓冲区以产生中间数据。中间数据被复制到第一和第二介质以分别产生主副本。辅助副本可以由另一副辅助副本制作。辅助副本也可以在主副本修剪之前从主副本进行。

7. 发明申请

WO2009151952A3 THIN FILM PHOTOVOLTAIC MODULE 审中-公开
标题翻译：薄膜光伏模块
公开(公告)号：WO2009151952A3
公开(公告)日：2010-10-07
申请号：PCT/US2009045226
申请日：2009-05-27
申请人： SOLUTIA INC , KORAN FRANCOIS ANDRE , LU JUN , HALDEMAN STEVEN VINCENT
发明人： KORAN FRANCOIS ANDRE , LU JUN , HALDEMAN STEVEN VINCENT
IPC分类号： B32B17/10 , H01L31/048
CPC分类号： B32B17/10761 , B32B17/10688 , B32B2457/12 , H01L31/0445 , H01L31/0481 , Y02E10/50
摘要： The present invention provides a thin film photovoltaic device comprising a poly(vinyl butyral) layer that provides excellent adhesion, resistivity, sealing, processability, and durability to the device.
摘要翻译：本发明提供一种包含聚（乙烯醇缩丁醛）层的薄膜光伏器件，其提供优异的粘合性，电阻率，密封性，加工性和对器件的耐久性。

8. 发明申请

WO2007102994A3 SYSTEMS AND METHODS FOR HYDROGEN STORAGE AND GENERATION FROM WATER USING LITHIUM BASED MATERIALS 审中-公开
标题翻译：氢氧储存和使用基于锂的材料从水中产生的系统和方法
公开(公告)号：WO2007102994A3
公开(公告)日：2008-07-31
申请号：PCT/US2007004592
申请日：2007-02-22
申请人： UNIV UTAH RES FOUND , FANG ZHIGANG ZAK , LU JUN , SOHN HONG YONG
发明人： FANG ZHIGANG ZAK , LU JUN , SOHN HONG YONG
IPC分类号： C01B6/04 , H01M8/04
CPC分类号： C01B3/065 , C01B3/0026 , C01B6/04 , C01D15/02 , C01F5/04 , C22B5/04 , C22B26/12 , Y02E60/327 , Y02E60/362
摘要： A process for forming lithium hydride for use in storing and producing hydrogen is presented. The process includes reacting lithium oxide with water to form a regenerated lithium hydroxide and reacting the regenerated lithium hydroxide with magnesium to form magnesium oxide and a regenerated lithium hydride. The magnesium oxide can be regenerated to form magnesium. The process can further include reacting lithium hydride to form hydrogen and lithium oxide. Such hydrogen production can include reaction between lithium hydride and lithium hydroxide, and/or reaction between lithium hydride and water.
摘要翻译：提出了一种形成用于储存和生产氢的氢化锂的方法。该方法包括使氧化锂与水反应以形成再生的氢氧化锂，并使再生的氢氧化锂与镁反应形成氧化镁和再生的氢化锂。氧化镁可再生以形成镁。该方法还可以包括使氢化锂反应形成氢和氧化锂。这种氢气生成可以包括氢化锂和氢氧化锂之间的反应，和/或氢化锂与水之间的反应。

9. 发明申请

WO2007137255A2 BACTERIAL THIOREDOXIN REDUCTASE INHIBITORS AND METHODS FOR USE THEREOF 审中-公开
标题翻译：细菌三氧化二氮还原酶抑制剂及其使用方法
公开(公告)号：WO2007137255A2
公开(公告)日：2007-11-29
申请号：PCT/US2007069455
申请日：2007-05-22
申请人： THIOREDOXIN SYSTEMS AB , THYOGEN PHARMACEUTICALS INC , HOLMGREN ARNE , LU JUN , VLAMIS-GARDIKAS ALEXIOS , ZHAO RONG , KANDASAMY K , ENGMAN LARS , ENGSTRAND LARS , HOFFNER SVEN
发明人： HOLMGREN ARNE , LU JUN , VLAMIS-GARDIKAS ALEXIOS , ZHAO RONG , KANDASAMY K , ENGMAN LARS , ENGSTRAND LARS , HOFFNER SVEN
IPC分类号： A61K31/41
CPC分类号： C07D421/04 , A61K31/381 , A61K31/41 , C07D293/12
摘要： The mechanism of action of Ebselen differentiates between bacterial and mammalian thioredoxin reductase (TrxR). It displays fast oxidation of mammalian Trx and via the NADPH-TrxR catalyzed turnover of ebselen selenol with hydrogen peroxide, and therefore are mammalian antioxidants. Ebselen, and its diselenide, are strong competitive inhibitors of E.coli TrxR with K i of 0.14 µM and 0.46 µM, respectively. E.coli mutants lacking glutathione reductase or glutathione were much more sensitive to inhibition by ebselen. Since either glutaredoxin or thioredoxin systems are electron donors to ribonucleotide reductase, ebselen targets primarily glutathione and glutaredoxin-negative bacteria, a class which includes major pathogens. Ebselen, and similar compounds are therefore useful as antibacterial agents, even for multiresistant strains. Two major pathogenic bacteria, which previously had not been known to be sensitive to ebselen, Mycobacterium tuberculosis (tuberculosis) and Helicobacter pylori (stomach ulcer and cancer), were shown to be excellent targets. Helicobacter
摘要翻译： Ebselen的作用机制区分细菌和哺乳动物硫氧还蛋白还原酶（TrxR）。它显示哺乳动物Trx的快速氧化，并且通过NADPH-TrxR催化依次硒硒酚与过氧化氢的周转，因此是哺乳动物抗氧化剂。依布硒及其二硒化物是分别具有0.14μM和0.46μM的KI大肠杆菌TrxR的强竞争性抑制剂。缺乏谷胱甘肽还原酶或谷胱甘肽的大肠杆菌突变体对依贝硒的抑制更敏感。由于谷氧还蛋白或硫氧还蛋白系统是核糖核苷酸还原酶的电子供体，依普硒靶主要是谷胱甘肽和谷氧还蛋白阴性细菌，一类包括主要病原体。因此，依布硒林和类似化合物可用作抗菌剂，即使对于多抗性菌株也是有用的。以前不知道对ebselen，结核分枝杆菌（结核分枝杆菌）和幽门螺杆菌（胃溃疡和癌症）敏感的两种主要致病菌被证明是优异的靶标。幽门螺杆菌

10. 发明申请

WO2008057340A3 LIGHT METAL BASED MATERIAL SYSTEM FOR HYDROGEN STORAGE 审中-公开
标题翻译：基于轻金属的氢储存材料系统
公开(公告)号：WO2008057340A3
公开(公告)日：2009-04-02
申请号：PCT/US2007022926
申请日：2007-10-29
申请人： UNIV UTAH RES FOUND , ZAK-FANG ZHIGANG , LU JUN , SOHN HONG YONG
发明人： ZAK-FANG ZHIGANG , LU JUN , SOHN HONG YONG
IPC分类号： C01B21/00
CPC分类号： C01B3/0031 , C01B21/0602 , C01P2002/52 , C01P2002/72 , C01P2002/88 , F17C11/005 , Y02E60/321 , Y02E60/327
摘要： The invention provides methods, compositions, and systems for a reversible hydrogen storage material. The hydrogen storage material contains a lithium-magnesium compound, having LiMgN in a dehydrogenated state and a hydrogenated lithium magnesium product in a hydrogenated state, where the hydrogenated and dehydrogenated states are reversible. The lithium-magnesium compound is formed by reacting MgH2 and LiNH2 in a substantially inert atmosphere in amounts sufficient to obtain a hydrogen adsorption of at least 3 wt%, and in many cases up to about 8.1 wt%.
摘要翻译：本发明提供了用于可逆储氢材料的方法，组合物和系统。储氢材料含有脱氢状态的LiMgN和处于氢化状态的氢化锂镁产物的氢化和脱氢状态是可逆的锂 - 镁化合物。锂 - 镁化合物通过在基本惰性气氛中使MgH 2和LiNH 2反应，其量足以获得至少3重量％的氢吸附量，并且在许多情况下高达约8.1重量％。

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