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1. 发明申请

WO2012019121A3 MULTIPLEXED SUPRAMOLECULAR ASSEMBLIES FOR NON-VIRAL DELIVERY OF GENETIC MATERIAL 审中-公开
标题翻译：用于非法传播遗传材料的多功能分子组装
公开(公告)号：WO2012019121A3
公开(公告)日：2013-05-02
申请号：PCT/US2011046791
申请日：2011-08-05
申请人： UNIV ILLINOIS , CHENG JIANJUN , GABRIELSON NATHAN , LICHEN YIN
发明人： CHENG JIANJUN , GABRIELSON NATHAN , LICHEN YIN
IPC分类号： A61K48/00
CPC分类号： A61K48/0025 , A61K9/1075 , A61K9/5123 , A61K31/7088 , A61K47/18 , A61K47/183 , A61K48/00 , A61K48/0033 , A61K48/0041 , C12N15/87
摘要： The invention provides a composition comprising two or more of a) genetic material; b) a condensing agent; c) a membrane destabilizing agent; d) a targeting/stabilizing agent, and optionally e) an ionic cross-linking agent. The components of the composition can self-assemble to form particles via electrostatic and/or lipophilic interactions. Methods of making and using the composition are also provided. The compositions can be used, for example, to transfer genetic material to cells in vitro or in vivo.
摘要翻译：本发明提供了包含以下两种或多种的组合物：a）遗传物质; b）冷凝剂; c）膜去稳定剂; d）靶向/稳定剂，以及任选的e）离子交联剂。组合物的组分可以通过静电和/或亲油相互作用自组装形成颗粒。还提供了制备和使用组合物的方法。组合物可用于例如体外或体内将遗传物质转移至细胞。

2. 发明申请

WO2012075147A2 STABLE HELICAL IONIC POLYPEPTIDES 审中-公开
标题翻译：稳定的螺旋离子多肽
公开(公告)号：WO2012075147A2
公开(公告)日：2012-06-07
申请号：PCT/US2011062656
申请日：2011-11-30
申请人： UNIV ILLINOIS , CHENG JIANJUN , LU HUA
发明人： CHENG JIANJUN , LU HUA
IPC分类号： A61K47/48
CPC分类号： C08G69/48 , A01N43/36 , A61K31/785 , A61K47/34 , A61K47/595 , C07K14/001 , C08G63/08 , C08G63/68 , C08G69/08 , C08G69/10 , C08G69/22 , C08L77/02 , C08L77/04
摘要： The invention provides polymers comprising Formula 1 wherein monomer is a repeating unit comprising 2, 3, 4, 5, 6 or 7 carbon atoms and the monomers are linked together through amide or ester bonds; n is about 6 to about 1000; and Linker is an optionally substituted carbon chain that is optionally interrupted by moieties such as oxygen, nitrogen, sulfur, phosphorus, or silicon. Charge is a moiety having a positive or negative charge on a heteroatom, such as nitrogen, oxygen, phosphorus, or sulfur; where the Linker separates the monomer and the Charge by at least six linear atoms. The invention also provides methods of preparing the polymers and the copolymers and methods of using the polymers and copolymers, for example, as drug delivery systems, as membrane penetrating peptides, and as therapeutic agents.
摘要翻译：本发明提供了包含式1的聚合物，其中单体是包含2,3,4,5,6或7个碳原子的重复单元，并且所述单体通过酰胺键或酯键连接在一起; n为约6至约1000; 并且接头是任选取代的碳链，其任选被诸如氧，氮，硫，磷或硅等部分中断。电荷是在杂原子上具有正电荷或负电荷的部分，例如氮，氧，磷或硫; 接头将单体和电荷分开至少六个线性原子。本发明还提供了制备聚合物和共聚物的方法以及使用该聚合物和共聚物的方法，例如作为药物递送系统，作为穿膜肽和作为治疗剂。

3. 发明申请

WO2011079279A3 NANOCONJUGATES AND NANOCONJUGATE FORMULATIONS 审中-公开
标题翻译：纳米复合物和纳米复合物配方
公开(公告)号：WO2011079279A3
公开(公告)日：2011-12-01
申请号：PCT/US2010062030
申请日：2010-12-23
申请人： UNIV ILLINOIS , CHENG JIANJUN , TONG RONG
发明人： CHENG JIANJUN , TONG RONG
IPC分类号： A61K47/48 , A61K9/20 , A61K9/24 , A61K31/7028 , A61K47/30 , A61K47/42
CPC分类号： A61K9/1658 , A61K9/0019 , A61K9/5169 , A61K47/593 , A61K47/60 , A61K47/6935
摘要： The invention provides a drug-polymer nanoconjugate that includes a drug covalently bonded to a polymer. The nanoconjugate can include a block copolymer coating and/or an albumin coating. The drug of the drug-polymer nanoconjugate can be one or more of a variety of therapeutic agents linked to the polymer through ether or thioether linkages formed from hydroxyl or thiol groups of the drug. The albumin coating can substantially or completely retard or prevent aggregation of the nanoconjugates in solid form or in solution. The invention further provides compositions that include a plurality of drug-polymer nanoconjugates, as well as methods for using the drug-polymer nanoconjugates, such as in therapeutic or diagnostic applications.
摘要翻译：本发明提供了包含与聚合物共价键合的药物的药物 - 聚合物纳米缀合物。纳米缀合物可以包括嵌段共聚物涂层和/或白蛋白涂层。药物 - 聚合物纳米缀合物的药物可以是通过由药物的羟基或巯基形成的醚或硫醚键与聚合物连接的多种治疗剂中的一种或多种。白蛋白涂层可以基本上或完全延缓或防止固体形式或溶液中纳米缀合物的聚集。本发明进一步提供了包含多种药物 - 聚合物纳米缀合物的组合物，以及使用药物 - 聚合物纳米缀合物的方法，例如在治疗或诊断应用中。

4. 发明申请

WO2012075087A3 SILICA NANOPARTICLE AGENT CONJUGATES 审中-公开
标题翻译：二氧化硅纳米颗粒剂共轭物
公开(公告)号：WO2012075087A3
公开(公告)日：2012-12-13
申请号：PCT/US2011062548
申请日：2011-11-30
申请人： UNIV ILLINOIS , CHENG JIANJUN , TANG LI
发明人： CHENG JIANJUN , TANG LI
IPC分类号： G01N33/00
CPC分类号： A61K47/48861 , A61K9/0019 , A61K9/12 , A61K9/2054 , A61K9/4858 , A61K47/6923 , A61K49/0032 , A61K49/0041 , A61K49/0093 , B82B1/008 , B82Y5/00 , Y10S977/773 , Y10T428/2982
摘要： The invention provide a silica nanoparticle comprising a non-porous matrix of silicon-oxygen bonds, wherein the matrix comprises organic agents conjugated to silicon or oxygen atoms in the matrix, the organic agents are conjugated to the matrix through linker L groups, wherein the linker L comprises, for example, an ester, urea, thiourea, or thio ether group, and wherein the diameter of the nanoparticle is about 15 nm to about 200 nm. The invention also provides novel methods of making and using the silica nanoparticles described herein.
摘要翻译：本发明提供了包含硅 - 氧键非多孔基质的二氧化硅纳米粒子，其中基质包含与基质中的硅或氧原子共轭的有机试剂，有机试剂通过连接基L基团缀合至基质，其中连接基团 L包含例如酯，脲，硫脲或硫醚基团，并且其中纳米颗粒的直径为约15nm至约200nm。本发明还提供制造和使用本文所述的二氧化硅纳米粒子的新方法。

5. 发明申请

WO2006105367A2 MAGNETICALLY-LABELED MICROPARTICLES FOR ORAL DRUG DELIVERY 审中-公开
标题翻译：用于口服药物递送的磁性标记微量元素
公开(公告)号：WO2006105367A2
公开(公告)日：2006-10-05
申请号：PCT/US2006011832
申请日：2006-03-30
申请人： MASSACHUSETTS INST TECHNOLOGY , CHENG JIANJUN , FAROKHZAD OMID C , TEPLY BENJAMIN , LANGER ROBERT S
发明人： CHENG JIANJUN , FAROKHZAD OMID C , TEPLY BENJAMIN , LANGER ROBERT S
IPC分类号： A61K9/14
CPC分类号： A61K9/5094
摘要： A pharmaceutically active agent is associated with a magnetic particle and formulated for oral administration. An externally imposed magnetic field retains the magnetic particle in the intestines, increasing the amount of the pharmaceutically active agent that passes from the intestines into the bloodstream.
摘要翻译：药物活性剂与磁性颗粒结合并配制用于口服给药。外部施加的磁场将磁性颗粒保留在肠中，增加从肠流入血流的药物活性剂的量。

6. 发明申请

WO2004022099A3 CYCLODEXTRIN-BASED POLYMERS FOR DELIVERING THE THERAPEUTIC AGENTS COVALENTLY BOUND THERETO 审中-公开
标题翻译：用于递送治疗药物的CYCLODEXTRIN-based聚合物
公开(公告)号：WO2004022099A3
公开(公告)日：2004-10-28
申请号：PCT/US0327588
申请日：2003-09-04
申请人： INSERT THERAPEUTICS INC , CHENG JIANJUN , DAVIS MARK E , KHIN KAY T
发明人： CHENG JIANJUN , DAVIS MARK E , KHIN KAY T
IPC分类号： A61K31/724 , A61K47/48 , A61P35/00 , C08G63/48 , C08G63/91 , A61K47/40
CPC分类号： C08G69/44 , A61K31/337 , A61K31/7048 , A61K47/48176 , A61K47/48192 , A61K47/482 , A61K47/48215 , A61K47/4823 , A61K47/48338 , A61K47/48969 , A61K47/58 , A61K47/59 , A61K47/60 , A61K47/61 , A61K47/6951 , B82Y5/00 , C08B30/00 , C08B31/00 , C08B37/0012 , C08F220/28 , C08F220/58 , C08F222/22 , C08F2220/282 , C08G81/02 , G06F19/3456 , G06Q50/22 , Y02A90/22 , Y02A90/26
摘要： The present invention relates to novel compositions of therapeutic cyclodextrin containing polymeric compounds designed as a carrier for small molecule therapeutics delivery and pharmaceutical compositions thereof. In particular, the therapeutic/bioactive agents are covalently bound to the cyclodextrin-containing polymers. These cyclodextrin-containing polymers improve drug stability and solubility, and reduce toxicity of the small molecule therapeutic when used in vivo. Furthermore, by selecting from a variety of linker groups and targeting ligands the polymers present methods for controlled delivery of the therapeutic agents. The invention also relates to methods of treating subjects with the therapeutic compositions described herein. The invention further relates to methods for conducting pharmaceutical business comprising manufacturing, licensing, or distribution kits containing or relating to the polymeric compounds described herein.
摘要翻译：本发明涉及设计为小分子治疗剂递送载体的治疗性环糊精含有聚合物的组合物及其药物组合物。特别地，治疗/生物活性剂与含环糊精的聚合物共价结合。这些含环糊精的聚合物改善药物稳定性和溶解性，并且在体内使用时降低小分子治疗剂的毒性。此外，通过从各种接头基团和靶向配体中选择，聚合物呈现用于治疗剂的受控递送的方法。本发明还涉及用本文所述的治疗组合物治疗受试者的方法。本发明还涉及用于进行药物业务的方法，包括制造，许可或分发试剂盒，其包含或涉及本文所述的聚合物。

7. 发明申请

WO2007001448A3 COATED CONTROLLED RELEASE POLYMER PARTICLES AS EFFICIENT ORAL DELIVERY VEHICLES FOR BIOPHARMACEUTICALS 审中-公开
标题翻译：作为有效的口服输送车辆的涂层控制释放聚合物颗粒
公开(公告)号：WO2007001448A3
公开(公告)日：2009-04-23
申请号：PCT/US2005040100
申请日：2005-11-04
申请人： MASSACHUSETTS INST TECHNOLOGY , JON SANGYONG , FAROKHAZD OMID C , LANGER ROBERT S , CHENG JIANJUN
发明人： JON SANGYONG , FAROKHAZD OMID C , LANGER ROBERT S , CHENG JIANJUN
IPC分类号： A61K9/14 , A61K9/16 , A61K31/70
CPC分类号： A61K9/5138 , A61K9/0043 , A61K9/0065 , A61K9/5036 , A61K9/5153 , A61K9/5192 , A61K38/28
摘要： A composition for delivering an active agent to a patient. The composition includes a polymer core encapsulating the active agent and a mucoadhesive coating disposed about the core. The polymer may include covalently linked poly(ethylene glycol) chains, and the mucoadhesive coating may be selected to facilitate transfer of the particle through the intestinal mucosa. A molecular weight and cross-link density of the polymer may be selected such that the polymer core will decompose in a predetermined time interval. The fraction of the dose of the drug entering the system at circulation during the predetermined time interval may be between about 0.25% and about 25%. The composition may be formulated as a plurality of nanoparticles or microparticles that are combined with a pharmaceutically acceptable carrier to produce an edible or inhalable drug product.
摘要翻译：用于将活性剂递送至患者的组合物。该组合物包括包封活性剂的聚合物芯和围绕该芯设置的粘膜粘附性涂层。聚合物可以包括共价连接的聚（乙二醇）链，并且可以选择粘膜粘附性涂层以促进颗粒通过肠粘膜的转移。可以选择聚合物的分子量和交联密度，使得聚合物芯将以预定的时间间隔分解。在预定时间间隔期间进入系统的药物剂量的分数可以在约0.25％至约25％之间。组合物可以配制成与药学上可接受的载体组合以产生可食用或可吸入药物的多个纳米颗粒或微粒。

8. 发明申请

WO2008105773A2 SYSTEM FOR TARGETED DELIVERY OF THERAPEUTIC AGENTS 审中-公开
标题翻译：用于治疗药物的定向递送系统
公开(公告)号：WO2008105773A2
公开(公告)日：2008-09-04
申请号：PCT/US2007007927
申请日：2007-03-30
申请人： MASSACHUSETTS INST TECHNOLOGY , BRIGHAM & WOMENS HOSPITAL , FAROKHZAD OMID C , CHENG JIANJUN , TEPLEY BENJAMIN A , LANGER ROBERT S , ZALE STEPHEN E
发明人： FAROKHZAD OMID C , CHENG JIANJUN , TEPLEY BENJAMIN A , LANGER ROBERT S , ZALE STEPHEN E
IPC分类号： A61K9/14
CPC分类号： A61K47/4813 , A61K9/5031 , A61K9/5153 , A61K9/5192 , A61K31/337 , A61K47/482 , A61K47/48215 , A61K47/549 , A61K47/555 , A61K47/593 , A61K47/60 , A61K47/6935 , A61K47/6937 , A61K51/0417 , A61K51/0491 , A61K51/0495 , A61K51/065
摘要： The present invention provides a drug delivery system for targeted delivery of therapeutic agent-containing particles to tissues, cells, and intracellular compartments. The invention provides targeted particles comprising a particle, one or more targeting moieties, and one or more therapeutic agents to be delivered and pharmaceutical compositions comprising inventive targeted particles. The present invention provides methods of designing, manufacturing, and using inventive targeted particles and pharmaceutical compositions thereof.
摘要翻译：本发明提供了用于将组合物，细胞和细胞内区室靶向递送含治疗剂的颗粒的药物递送系统。本发明提供了包含颗粒，一种或多种靶向部分和一种或多种待递送治疗剂和包含本发明靶向颗粒的药物组合物的靶向颗粒。本发明提供了设计，制造和使用本发明的靶向颗粒及其药物组合物的方法。

9. 发明申请

WO2013173834A3 TRIGGER-RESPONSIVE CHAIN-SHATTERING POLYMERS 审中-公开
标题翻译：触发链式剪切聚合物
公开(公告)号：WO2013173834A3
公开(公告)日：2014-01-09
申请号：PCT/US2013041859
申请日：2013-05-20
申请人： UNIV ILLINOIS
发明人： CHENG JIANJUN , ZHANG YANFENG
IPC分类号： C08G65/00 , A61K47/34
CPC分类号： C08G18/384 , A61K9/19 , A61K9/5146 , A61K31/4375 , A61K47/34 , C08G18/73 , C08G65/34 , C08G71/04 , C08G2650/12
摘要： Disclosed are polymers containing a backbone comprising alternating N-protected hydroxymethylaniline units ("spacer") and linker units.
摘要翻译：公开了含有主链的聚合物，其包含交替的N-保护的羟甲基苯胺单元（“间隔”）和连接体单元。

10. 发明申请

WO2014169264A3 NANOPARTICLE MEDIATED DELIVERY OF SIRNA 审中-公开
标题翻译： SIRNA的纳米介质传递
公开(公告)号：WO2014169264A3
公开(公告)日：2015-11-12
申请号：PCT/US2014033888
申请日：2014-04-11
申请人： UNIV ILLINOIS
发明人： CHENG JIANJUN , YIN LICHEN
IPC分类号： A61K48/00
CPC分类号： C12N15/1136 , A61K9/5115 , C12N15/111 , C12N2310/14 , C12N2320/32
摘要： The invention provides multifunctional supramolecular self-assembled nanoparticles (SSNPs) comprising a set of rationally designed components that collectively facilitate efficient intestinal absorption of siRNA. The nanoparticles can induce potent TNF-α silencing in macrophages. Single gavage of SSNPs in mice depleted systemic TNF-α production at an siRNA dose as low as 50 μg/kg, and protected the mice from lipopolysaccharide-induced hepatic injury.
摘要翻译：本发明提供了多功能超分子自组装纳米颗粒（SSNP），其包含一组合理设计的组分，其共同促进siRNA的有效肠吸收。纳米颗粒可诱导巨噬细胞中有效的TNF-α沉默。小鼠SSNPs的单次管饲减少了siRNA剂量低至50μg/ kg的全身TNF-α产生，并保护小鼠免受脂多糖诱导的肝损伤。

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