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    • 9. 发明申请
    • OSMOTIC DEVICES HAVING VAPOR-PERMEABLE COATINGS
    • 具有蒸气渗透性涂料的操作装置
    • WO1995003033A1
    • 1995-02-02
    • PCT/IB1994000114
    • 1994-05-19
    • PFIZER INC.CUSSLER, Edward, L.HERBIG, Scott, M.SMITH, Kelly, L.VAN EIKEREN, Paul
    • PFIZER INC.
    • A61K09/00
    • C07C205/11A61K9/0004C07C205/19C07C205/26C07C215/14C07C323/25C08G18/384C08G59/50C08G59/504C08G63/6856C09D163/00G03F7/0045G03F7/039G03F7/164C08L75/04
    • An osmotic device that, following the imbibement of water vapor, provides for the controlled release of a beneficial agent to an aqueous environment. The device comprises a hydrophilic formulation including a beneficial agent, and if needed, an osmagent, surrounded by a wall. The wall is formed at least in part of a semipermeable hydrophobic membrane having an average pore size between about 0.1 mu m and 30 mu m. The pores are substantially filled with a gas phase. The hydrophobic membrane is permeable to water in the vapor phase and the hydrophobic membrane is impermeable to an aqueous medium at a pressure less than about 100 Pa. The beneficial agent is released, for example, by osmotic pumping or osmotic bursting upon imbibement of sufficient water vapor into the device core. These devices minimize incompatibilities between the beneficial agent and ions (such as hydrogen or hydroxyl) or other dissolved or suspended materials in the aqueous medium, since contact between the beneficial agent and the aqueous medium does not occur until after the beneficial agent is released. This results from the semipermeable membrane's selective permeability for water vapor. In addition, the high water fluxes attendant with these vapor-permeable membranes facilitate the delivery of beneficial agents having low solubilities, and the delivery of high dosages of beneficial agents.
    • 在水蒸汽吸收之后,渗透装置提供将有益剂控制释放到水性环境中。 该装置包括亲水性制剂,其包括有益剂,并且如果需要,包含被壁围绕的渗透剂。 所述壁至少部分形成有平均孔径在约0.1μm至30μm之间的半透性疏水膜。 孔基本上充满气相。 疏水膜在气相中是透水的,并且疏水膜在低于约100Pa的压力下对水介质是不可渗透的。有益剂例如通过渗透泵送或渗透的足够的水渗透渗出来释放 蒸汽进入设备核心。 这些装置使有益剂和离子(例如氢或羟基)或水性介质中的其它溶解或悬浮的材料之间的不兼容性最小化,因为有益剂和水性介质之间的接触直到有益剂被释放才会发生。 这是由半透膜对水蒸汽的选择性渗透性产生的。 此外,伴随这些透气膜的高水通量促进了具有低溶解度的有益试剂的递送和高剂量的有益试剂的输送。