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1. 发明申请

WO2011109216A3 NIR MATERIALS AND NANOMATERIALS FOR THERANOSTIC APPLICATIONS 审中-公开
标题翻译：近红外材料及其应用的纳米材料
公开(公告)号：WO2011109216A3
公开(公告)日：2012-01-12
申请号：PCT/US2011026044
申请日：2011-02-24
申请人： UNIV FLORIDA , BROWN SCOTT CHANG , GROBMYER STEPHEN R , SINGH AMIT KUMAR , MOUDGIL BRIJ M , SHARMA PARVESH
发明人： BROWN SCOTT CHANG , GROBMYER STEPHEN R , SINGH AMIT KUMAR , MOUDGIL BRIJ M , SHARMA PARVESH
IPC分类号： B82B1/00 , A61K49/00 , B82B3/00 , C09B57/00 , C09K11/06
CPC分类号： G01N33/54346 , A61K49/0032 , A61K49/0093 , C09B23/0041 , C09B23/0066 , C09B23/086 , C09B69/008 , G01N33/582
摘要： Novel fluorescent dye comprising metal oxide nanoparticles are prepared where the nanoparticles are as small as 3 ran or up to 7000 nm in diameter and where the dye is bound within the metal oxide matrix. In some embodiments the invention, novel dyes are covalently attached to the matrix and in other embodiments of the invention a dye is coordinate or ionic bound within the metal oxide matrix. A method for preparing the novel covalently bondable modified fluorescent dyes is presented. A method to prepare silica comprising nanoparticles that are 3 to 8 nm in diameter is presented. In some embodiments, the fluorescent dye comprising metal oxide nanoparticles are further decorated with functionality for use as multimodal in vitro or in vivo imaging agents. In other embodiments of the invention, the fluorescent dye comprising metal oxide nanoparticles provide therapeutic activity and incorporated therapeutic temperature monitoring.
摘要翻译：制备包含金属氧化物纳米颗粒的新型荧光染料，其中纳米颗粒直径小至3nm或高达7000nm，并且其中染料结合在金属氧化物基质内。在一些实施方案中，新颖的染料共价连接到基质上，在本发明的其它实施方案中，染料在金属氧化物基质内是配位或离子键合的。提出了一种制备新型共价键合修饰荧光染料的方法。提出了制备直径为3至8nm的纳米颗粒的制备二氧化硅的方法。在一些实施方案中，包含金属氧化物纳米颗粒的荧光染料进一步用功能性装饰用作多峰体外或体内成像剂。在本发明的其它实施方案中，包含金属氧化物纳米颗粒的荧光染料提供治疗活性并掺入治疗温度监测。

2. 发明申请

WO2013020040A3 RADIATED CANCER CELLS AS A VEHICLE FOR CANCER NANOTHERAPY 审中-公开
标题翻译：放射性癌细胞作为CANCER NANOTHERAPY的车辆
公开(公告)号：WO2013020040A3
公开(公告)日：2013-05-02
申请号：PCT/US2012049498
申请日：2012-08-03
申请人： UNIV FLORIDA , BROWN SCOTT CHANG , GROBMYER STEPHEN R , MOUDGIL BRIJ M , ZHOU GUANGYIN , HAHN MEGAN , SHARMA PARVESH
发明人： BROWN SCOTT CHANG , GROBMYER STEPHEN R , MOUDGIL BRIJ M , ZHOU GUANGYIN , HAHN MEGAN , SHARMA PARVESH
IPC分类号： A61K49/06 , A61K9/14 , A61K9/16 , A61K47/48 , A61K49/08 , A61P35/00
CPC分类号： A61K49/0097 , A61K9/5068 , A61K41/0057 , A61K47/6901 , A61K47/6923 , A61K47/6929 , A61K49/0032 , A61K49/0093
摘要： A non-proliferative autologous tumor cell (NATC) loaded with therapeutic agents and/or imaging agents, an agent loaded NATC, is formed where a tumor cell that is gamma-irradiated or chemically sterilized and non-proliferative is combined with one or more therapeutic and/or imaging agents. The agents comprise molecular constructs, nanoparticles, or micro particles. The agent loaded NATC are useful for treating and/or imaging primary and metastatic tumors.
摘要翻译：形成载有治疗剂和/或成像剂的非增殖性自体肿瘤细胞（NATC），其加载有载体的NATC，其中伽马辐射或化学灭菌和不增殖的肿瘤细胞与一种或多种治疗和/或成像剂。这些试剂包括分子构建体，纳米颗粒或微粒。加载NATC的药物可用于治疗和/或成像原发性和转移性肿瘤。

3. 发明申请

WO2011109214A3 NEAR-IR INDOCYANINE GREEN DOPED MULTIMODAL SILICA NANOPARTICLES AND METHODS FOR MAKING THE SAME 审中-公开
标题翻译：近红外吲哚啉绿色多糖多元二氧化硅纳米颗粒及其制备方法
公开(公告)号：WO2011109214A3
公开(公告)日：2012-02-02
申请号：PCT/US2011026038
申请日：2011-02-24
申请人： UNIV FLORIDA , SHARMA PARVESH , BROWN SCOTT CHANG , BENGTSSON NICLAS , WALTER GLENN A , IWAKUMA NOBUTAKA , SCOTT EDWARD W , GROBMYER STEPHEN R , SANTRA SWADESHMUKUL , MOUDGIL BRIJ M
发明人： SHARMA PARVESH , BROWN SCOTT CHANG , BENGTSSON NICLAS , WALTER GLENN A , IWAKUMA NOBUTAKA , SCOTT EDWARD W , GROBMYER STEPHEN R , SANTRA SWADESHMUKUL , MOUDGIL BRIJ M
IPC分类号： C09K11/02 , A61K49/10 , G01N33/52
CPC分类号： A61N5/062 , A61K49/001 , B82Y5/00 , B82Y15/00 , C09K11/02 , C09K11/06 , G01N21/6486
摘要： The subject invention provides novel fluorescent core-shell nanoparticles comprising an encapsulated fluorescent core comprising an ionically bound fluorescent dye and a metal oxide shell. In one exemplary embodiment of the invention a core containing indocyanine green (ICG) with a silica shell that displays excellent photostability for generation of a near infrared fluorescence signal. The fluorescent core-shell nanoparticle can be further modified to act as an MRI, x-ray, or PAT contrast agent. The ICG nanoparticles can also be used as photodynamic therapeutic agent. Other embodiments of the invention directed to methods of making the novel core-shell nanoparticles and to the use of the core-shell nanoparticles for in vitro or in vivo imaging.
摘要翻译：本发明提供了新颖的荧光核 - 壳纳米颗粒，其包含包含离子键的荧光染料和金属氧化物壳的包封的荧光核心。在本发明的一个示例性实施方案中，含有具有二氧化硅壳的吲哚菁绿（ICG）的核心，其显示出用于产生近红外荧光信号的优异的光稳定性。荧光核 - 壳纳米颗粒可进一步修饰为MRI，X射线或PAT造影剂。 ICG纳米颗粒也可以用作光动力治疗剂。本发明的其它实施方案涉及制备新型核 - 壳纳米颗粒的方法以及使用核 - 壳纳米颗粒进行体外或体内成像。

4. 发明申请

WO2009032752A3 MULTIMODAL NANOPARTICLES FOR NON-INVASIVE BIO-IMAGING 审中-公开
标题翻译：用于非侵入性生物成像的多模式纳米颗粒
公开(公告)号：WO2009032752A3
公开(公告)日：2009-04-30
申请号：PCT/US2008074630
申请日：2008-08-28
申请人： UNIV FLORIDA , SHARMA PARVESH , MOUDGIL BRIJ M , WALTER GLENN A , GROBMYER STEPHEN R , SANTRA SWADESHMUKUL , JIANG HUABEI , BROWN SCOTT CHANG , SCOTT EDWARD W , ZHANG QIZHI , BENGTSSON NICLAS
发明人： SHARMA PARVESH , MOUDGIL BRIJ M , WALTER GLENN A , GROBMYER STEPHEN R , SANTRA SWADESHMUKUL , JIANG HUABEI , BROWN SCOTT CHANG , SCOTT EDWARD W , ZHANG QIZHI , BENGTSSON NICLAS
IPC分类号： A61K49/00 , A61B5/055
CPC分类号： A61K49/222 , A61B5/0035 , A61B5/0059 , A61B5/0095 , A61B5/055 , A61B6/00 , A61K41/0052 , A61K49/0002 , A61K49/0093 , A61K49/0423 , A61K49/1806 , A61K49/1881 , A61M31/005 , A61N5/10 , B82Y5/00
摘要： Multimodal nanoparticles are nanoparticles containing contrast agents for PAT and one or more of luminescence imaging, x-ray imaging, and/or MRI. The multimodal nanoparticles can have a dielectric core comprising an oxide with a metal coating on the core. The particles can be metal speckled. The multimodal nanoparticles can be used for therapeutic purposes such as ablation of tumors or by neutron capture in addition to use as contrast agents for imaging.
摘要翻译：多模态纳米粒子是含有用于PAT和用于发光成像，X射线成像和/或MRI中的一种或多种的造影剂的纳米粒子。多模态纳米粒子可以具有包含氧化物的电介质核，在核上具有金属涂层。颗粒可以是金属斑点。多峰纳米颗粒除了用作造影剂用于成像外，还可以用于治疗目的，例如肿瘤消融或通过中子俘获。

5. 发明申请

WO2009100011A2 TARGETED CELLULAR SELECTIVITY OF SURFACE ACTIVE MOLECULES 审中-公开
标题翻译：表面活性分子的靶向细胞选择性
公开(公告)号：WO2009100011A2
公开(公告)日：2009-08-13
申请号：PCT/US2009032851
申请日：2009-02-02
申请人： UNIV FLORIDA , MOUDGIL BRIJ M , VARSHNEY MANOJ , GROBMYER STEPHEN R
发明人： MOUDGIL BRIJ M , VARSHNEY MANOJ , GROBMYER STEPHEN R
IPC分类号： A61K31/765 , A61K49/06 , A61P35/00
CPC分类号： A61K49/0017 , A61K31/765 , A61K47/543 , A61K47/60
摘要： A method for the treatment of cancer involves delivering a surface active agent to an organism, where the surface active agent selectively partitions to and kills cancer cells as opposed to healthy cells. The surface active agent can be an ionic or a non-ionic surfactant with a HLB of less than 29 or a mixture of surface active agents with a HLB of less than 40, where the hydrophobic portion is a lesser fraction of the surface active agent than the hydrophilic portion. A fluorescence method of detecting and locating cancer cells in an organism involves delivering a surface active agent, where the surface active agent includes a fluorescence moiety that upon selective partitioning of the surface active agent to the cancer cells and irradiation by a radiation source to excite the fluorescence moiety, a fluorescence emission is observed permitting the detection and location of the cancerous tissue by local volumes of relatively high intensity emission.
摘要翻译：用于治疗癌症的方法包括将表面活性剂递送至生物体，其中表面活性剂选择性分配并杀死癌细胞而非健康细胞。表面活性剂可以是HLB小于29的离子或非离子表面活性剂或HLB小于40的表面活性剂的混合物，其中疏水部分是表面活性剂的较少部分亲水部分。检测和定位生物体中的癌细胞的荧光方法涉及递送表面活性剂，其中表面活性剂包括荧光部分，所述荧光部分在表面活性剂选择性分配到癌细胞上并通过辐射源辐射以激发荧光部分，观察到荧光发射，允许通过相对高强度发射的局部体积检测和定位癌组织。

6. 发明申请

WO2009026423A2 NANOMOTORS BASED ON CARBON NANOTUBES AS THRUSTERS 审中-公开
标题翻译：基于碳纳米管的纳米电极作为透镜
公开(公告)号：WO2009026423A2
公开(公告)日：2009-02-26
申请号：PCT/US2008073835
申请日：2008-08-21
申请人： UNIV FLORIDA , KRISHNA VIJAY , MOUDGIL BRIJ M , KOOPMAN BEN L , BROWN SCOTT CHANG
发明人： KRISHNA VIJAY , MOUDGIL BRIJ M , KOOPMAN BEN L , BROWN SCOTT CHANG
IPC分类号： B82B1/00
CPC分类号： B81B3/0029 , B01L3/50273
摘要： A nanomotor propulsion system includes a nanoparticle load attached to at least one carbon nanotube and a source of electromagnetic radiation. When electromagnetic radiation is provided with sufficient intensity, combustion of the carbon nanotube provides thrust to move the nanoparticle load. The electromagnetic radiation source can be a laser. The carbon nanotubes can be single, double, multiwall or any combination thereof and can contain or be decorated with at least one combustion initiator.
摘要翻译：纳米电动推进系统包括附着到至少一个碳纳米管和电磁辐射源的纳米颗粒负载。当以足够的强度提供电磁辐射时，碳纳米管的燃烧提供推动以移动纳米颗粒负载。电磁辐射源可以是激光。碳纳米管可以是单层，双层，多壁或其任何组合，并且可以含有或用至少一种燃烧引发剂进行装饰。

7. 发明申请

WO2011127285A3 FUNCTIONALIZED FULLERENES AS A BIOMASS STIMULANT AND A LIFE EXTENSION AGENT 审中-公开
标题翻译：作为生物传感器和生命延伸剂的功能丰富的富勒烯
公开(公告)号：WO2011127285A3
公开(公告)日：2012-02-23
申请号：PCT/US2011031581
申请日：2011-04-07
申请人： UNIV FLORIDA , GAO JIE , KRISHNA VIJAY , BAI WEI , KOOPMAN BENJAMIN L , MOUDGIL BRIJ M , INDEGLIA PAUL ANTHONY , FOLTA KEVIN MICHAEL , GEORGIEVA ANGELINA TSENOVA
发明人： GAO JIE , KRISHNA VIJAY , BAI WEI , KOOPMAN BENJAMIN L , MOUDGIL BRIJ M , INDEGLIA PAUL ANTHONY , FOLTA KEVIN MICHAEL , GEORGIEVA ANGELINA TSENOVA
IPC分类号： C12N1/38 , C12N1/12 , C12N1/14
CPC分类号： C12N1/38 , B82Y5/00 , C12N1/12 , C12N1/14
摘要： Methods of stimulating an increase in biomass by stimulating the growth, lifespan and/or reproduction of organisms such as fungi, algae, plants, and other aquatic organisms are provided by applying an effective amount of functionalized fullerenes. For example, polyhydroxy fullerenes are effective at low levels of promoting the increase in biomass.
摘要翻译：通过施用有效量的官能化富勒烯来提供刺激生物体如真菌，藻类，植物和其它水生生物的生长，寿命和/或繁殖来刺激生物量增加的方法。例如，多羟基富勒烯在促进生物量增加的低水平方面是有效的。

8. 发明申请

WO2004077019A3 CAPILLARY RISE TECHNIQUE FOR THE ASSESSMENT OF THE WETTABILITY OF PARTICULATE SURFACES 审中-公开
标题翻译：用于评估颗粒表面湿度的毛细增加技术
公开(公告)号：WO2004077019A3
公开(公告)日：2005-03-17
申请号：PCT/US2004005646
申请日：2004-02-25
申请人： UNIV FLORIDA , MOUDGIL BRIJ M , BROWN SCOTT C , OLIVEIRA ROBERTO C
发明人： MOUDGIL BRIJ M , BROWN SCOTT C , OLIVEIRA ROBERTO C
IPC分类号： G01B9/10 , G01N20060101 , G01N13/00 , G01N13/02 , H01L21/66
CPC分类号： G01N13/02
摘要： A method and system for determining the wettability of particulate surfaces. In particular, the method for determining the wettability of particulate surfaces includes the steps of inserting a test device having the particulate surface (130) into a test liquid (140) to form a liquid meniscus; measuring the liquid meniscus to generate a liquid meniscus measurement; and calculating the wettability of the particulate surface using the liquid meniscus measurement. The system for determining the wettability of particulate surface includes a test device having the particulate surface (130), a test liquid (140), and a measurement device (110, 120, 150).
摘要翻译：用于确定颗粒表面的润湿性的方法和系统。特别地，用于确定颗粒表面的润湿性的方法包括将具有颗粒表面（130）的测试装置插入测试液体（140）中以形成液体弯液面的步骤; 测量液体弯液面以产生液体弯液面测量; 并使用液体弯液面测量计算颗粒表面的润湿性。用于确定颗粒表面的润湿性的系统包括具有颗粒表面（130），测试液体（140）和测量装置（110,120,150）的测试装置。

9. 发明申请

WO2009089161A2 OPTICAL LUMINESCENCE OF FUNCTIONALIZED FULLERENES IN AN OXYGEN FREE ENVIRONMENT 审中-公开
标题翻译：无氧环境下功能化富勒烯的光学发光
公开(公告)号：WO2009089161A2
公开(公告)日：2009-07-16
申请号：PCT/US2009030120
申请日：2009-01-05
申请人： UNIV FLORIDA RES FOUNDATIONS I , KRISHNA VIJAY , MOUDGIL BRIJ M , KOOPMAN BEN L
发明人： KRISHNA VIJAY , MOUDGIL BRIJ M , KOOPMAN BEN L
IPC分类号： C09K11/06
CPC分类号： C09K11/06 , C09K2211/1011 , C09K2211/1416 , G01N2021/6432
摘要： Functionalized fullerenes, when excited at any of a broad range of wavelengths in an oxygen free environment, undergo luminescence. The oxygen sensitive luminescence of functionalized fullerenes is used for numerous applications including oxygen detection; irradiation induced healing of polymeric materials; and phosphors for optical location and display applications. The degradation of the functionalized fullerenes allows for the detection of oxygen by diminished luminescence when the fullerenes are exposed to an irradiation source, such as a laser beam, in the presence of oxygen. The luminescence from a portion of a surface of a material with functionalized fullerenes allows for the location of the surface containing a functionalized fullerene target in the absence of oxygen or to heat the object in the area irradiated that is exposed to oxygen. The localized heating can be used to repair defects to a material containing the functionalized fullerenes. Materials containing functionalized fullerenes can be used as phosphors in display applications.
摘要翻译：官能化的富勒烯在无氧环境中在宽范围的任何波长激发时都会发光。官能化富勒烯的氧敏感发光被用于许多应用，包括氧气检测; 照射诱导聚合材料的愈合; 和用于光学定位和显示应用的磷光体。官能化富勒烯的降解允许当富勒烯在氧气存在下暴露于照射源如激光束时通过减少发光来检测氧。来自具有官能化富勒烯的材料表面的一部分的发光允许在没有氧气的情况下含有官能化富勒烯靶材的表面的位置，或者允许加热暴露于氧气的经辐射区域中的物体。局部加热可用于修复含有官能化富勒烯的材料的缺陷。含有官能化富勒烯的材料可以用作显示器应用中的荧光粉。

10. 发明申请

WO2006102600A3 MATERIALS AND METHODS FOR IDENTIFYING BIOINTERACTIVE NANOSTRUCTURES AND/OR NANOPARTICLES 审中-公开
标题翻译：用于鉴定生物活性纳米结构和/或纳米颗粒的材料和方法
公开(公告)号：WO2006102600A3
公开(公告)日：2006-12-07
申请号：PCT/US2006010828
申请日：2006-03-23
申请人： UNIV FLORIDA , BROWN SCOTT C , MOUDGIL BRIJ M , RABINOVICH YAKOV I , ANTONY VEENA B , KAMAL MOHAMMED A
发明人： BROWN SCOTT C , MOUDGIL BRIJ M , RABINOVICH YAKOV I , ANTONY VEENA B , KAMAL MOHAMMED A
IPC分类号： G01B5/00 , G01B5/28 , G01N33/50 , G01Q10/00 , G01Q60/24 , G01Q60/42
CPC分类号： G01N33/54373 , G01Q60/42
摘要： Disclosed herein are surface force microscope probes comprising living cells adhered thereto, as well as methods of making same. Also disclosed is a system for high throughput screening of nanostructures having biological relevance through use of surface force microscope probes comprising living cells. Further disclosed are methods of screening for biointeractive nanostructures.
摘要翻译：本文公开了包含粘附于其上的活细胞的表面力显微镜探针，以及制造它们的方法。还公开了用于通过使用包含活细胞的表面力显微镜探针对具有生物相关性的纳米结构进行高通量筛选的系统。进一步公开了筛选生物相互作用纳米结构的方法。

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