专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

WO2015065985A1 CHEMICAL REAGENTS FOR ATTACHING AFFINITY MOLECULES ON SURFACES 审中-公开
标题翻译：化学试剂，用于连接表面上的亲和力分子
公开(公告)号：WO2015065985A1
公开(公告)日：2015-05-07
申请号：PCT/US2014/062589
申请日：2014-10-28
申请人： ARIZONA BOARD OF REGENTS on behalf of ARIZONA STATE UNIVERSITY
发明人： ZHANG, Peiming , SENAPATI, Subhadip , MANNA, Saikat
IPC分类号： C07F7/10
CPC分类号： C07F7/1836 , C07C315/00 , C07C317/28 , C07F7/045 , C07F7/10 , C07F7/1876 , C07K5/126 , C12N15/115 , C12N2310/16 , C12N2310/351 , C12N2310/3517 , G01Q60/42 , G01Q70/18
摘要： Chemical linkage reagents, methods of making and method of using the same are provided. Chemical linkage reagents according to at least some of the embodiments of the present disclosure may be incorporated into or operatively-linked with affinity molecules for attachment to silicon oxide surfaces to, for example, measure interactions between an affinity molecule and its targeting biomolecules.
摘要翻译：提供了化学键合试剂，制备方法及其使用方法。根据本公开的至少一些实施方案的化学连接试剂可以并入或与活性连接的亲和分子连接到氧化硅表面以例如测量亲和分子与其靶向生物分子之间的相互作用。

2. 发明申请

WO2013065881A1 APPARATUS AND METHOD FOR DETERMINING SEQUENCES OF NUCLEIC ACIDS USING ATOMIC FORCE MICROSCOPE 审中-公开
标题翻译：使用原子力显微镜测定核酸序列的装置和方法
公开(公告)号：WO2013065881A1
公开(公告)日：2013-05-10
申请号：PCT/KR2011/008200
申请日：2011-10-31
申请人： LG ELECTRONICS INC. , SHIM, Bongchu , OH, Jeankun , KIM, Jitae , KIM, Dami , SHIN, Yong , CHO, Seongmoon
发明人： SHIM, Bongchu , OH, Jeankun , KIM, Jitae , KIM, Dami , SHIN, Yong , CHO, Seongmoon
IPC分类号： C12Q1/68 , C12Q1/48 , C12N15/11
CPC分类号： G01Q60/42 , C12Q1/6869 , C12Q2521/101 , C12Q2521/543 , C12Q2565/601
摘要： The present invention relates to an apparatus for determining sequences of nucleic acids using AFM (Atomic Force Microscope) capable of increasing a polymerization speed of a target nucleic acid molecule and enhancing accuracy of analysis through polymerization reaction, and a method using the apparatus, where the apparatus includes a polymerase attached to a tip of a cantilever for the AFM, and a substrate attached by a dNTP, and where the polymerase is moved on a substrate.
摘要翻译：本发明涉及使用能够提高靶核酸分子的聚合速度并提高通过聚合反应的分析精度的AFM（原子力显微镜）来确定核酸序列的装置，以及使用该装置的方法，其中装置包括连接到用于AFM的悬臂的尖端的聚合物和由dNTP附着的底物，并且聚合酶在基底上移动。

3. 发明申请

WO2011103049A3 METHOD FOR SCREENING RECEPTORS/LIGANDS INTERACTIONS 审中-公开
标题翻译：筛选受体/配体相互作用的方法
公开(公告)号：WO2011103049A3
公开(公告)日：2012-01-19
申请号：PCT/US2011024690
申请日：2011-02-14
申请人： IMMUNE DISEASE INST INC , SPRINGER TIMOTHY A , KIM JONGSEONG
发明人： SPRINGER TIMOTHY A , KIM JONGSEONG
IPC分类号： G01N33/68 , G01N33/53 , G01Q60/04
CPC分类号： G01Q60/42 , G01N33/542 , G01N2500/02
摘要： Embodiments of the invention herein relate to methods of studying binding interactions between two entities and methods for screening of modulators of such binding interactions, in particular, the protein-protein interaction observed in receptor-ligand interactions.
摘要翻译：本发明的实施方案涉及研究两个实体之间的结合相互作用的方法和用于筛选这种结合相互作用的调节剂的方法，特别是在受体 - 配体相互作用中观察到的蛋白质 - 蛋白质相互作用。

4. 发明申请

WO2011141602A1 MODIFICACIÓN DE PUNTAS DE MICROSCOPÍA DE FUERZAS ATÓMICAS MEDIANTE DEPÓSITO DE NANOPARTÍCULAS CON UNA FUENTE DE AGREGADOS 审中-公开
标题翻译：通过用聚集源沉积纳米颗粒来改变原子力显微镜
公开(公告)号：WO2011141602A1
公开(公告)日：2011-11-17
申请号：PCT/ES2011/070319
申请日：2011-05-04
申请人： CONSEJO SUPERIOR DE INVESTIGACIONES CIENTÍFICAS (CSIC) , ROMÁN GARCÍA, Elisa Leonor , MARTÍNEZ ORELLANA, Lidia , DÍAZ LAGOS, Mercedes , HUTTEL, Yves
发明人： ROMÁN GARCÍA, Elisa Leonor , MARTÍNEZ ORELLANA, Lidia , DÍAZ LAGOS, Mercedes , HUTTEL, Yves
IPC分类号： G01Q60/42 , B82Y15/00 , B82B3/00
CPC分类号： G01Q60/38 , B82Y15/00 , B82Y35/00 , C23C14/22 , G01Q60/42 , G01Q60/56
摘要： La presente invención se refiere a un procedimiento para recubrir puntas de AFM (Atomic Forcé Microscopy, microscopio de fuerzas atómicas) mediante el depósito de un material en forma de nanopartículas con una fuente de agregados.
摘要翻译：本发明涉及通过用聚集源沉积纳米颗粒形式的材料来覆盖原子力显微镜（AFM）尖端的方法。

5. 发明申请

WO2011103049A2 METHOD FOR SCREENING RECEPTORS/LIGANDS INTERACTIONS 审中-公开
标题翻译：筛选受体/配体相互作用的方法
公开(公告)号：WO2011103049A2
公开(公告)日：2011-08-25
申请号：PCT/US2011/024690
申请日：2011-02-14
申请人： IMMUNE DISEASE INSTITUTE, INC. , SPRINGER, Timothy, A. , KIM, Jongseong
发明人： SPRINGER, Timothy, A. , KIM, Jongseong
IPC分类号： G01N33/68 , G01N33/53 , G01Q60/04
CPC分类号： G01Q60/42 , G01N33/542 , G01N2500/02
摘要： Embodiments of the invention herein relate to methods of studying binding interactions between two entities and methods for screening of modulators of such binding interactions, in particular, the protein-protein interaction observed in receptor-ligand interactions.
摘要翻译：本发明的实施方案涉及研究两个实体之间的结合相互作用的方法和用于筛选这种结合相互作用的调节剂的方法，特别是在受体 - 配体相互作用中观察到的蛋白质 - 蛋白质相互作用。

6. 发明申请

WO2010112440A1 APPARATUS AND METHOD FOR THE FUNCTIONALISATION OF AFM TIPS 审中-公开
标题翻译： AFM提示功能的设备和方法
公开(公告)号：WO2010112440A1
公开(公告)日：2010-10-07
申请号：PCT/EP2010/054056
申请日：2010-03-29
申请人： CENTRO DE INVESTIGACIÓN COOPERATIVA EN BIOMATERIALES (CIC biomaGUNE) , MARTINES, Elena , GARCÍA MARTÍN, Isabel , PENADÉS ULLATE, Soledad
发明人： MARTINES, Elena , GARCÍA MARTÍN, Isabel , PENADÉS ULLATE, Soledad
IPC分类号： G01Q60/42
CPC分类号： G01Q60/42
摘要： The present invention includes an apparatus that holds the probes to a solid support throughout the passages of the functionalisation process, thus avoiding user-dependent breakage or damage of the fragile AFM cantilevers. The apparatus allows the tips of the AFM probes to be placed face-down, which avoids the deposition of contaminants on their functional side. The device also allows functionalising the tips with small liquid volumes and cleaning. The present invention includes a functionalisation process preventing non-specific adsorption of molecules on the tip.
摘要翻译：本发明包括一种在功能化过程的整个通道中将探针保持在固体支持物上的装置，从而避免用户依赖的破坏或破坏脆弱的AFM悬臂。该设备允许AFM探针的顶端面朝下放置，这避免了污染物在其功能侧的沉积。该装置还允许使用小液体体积和清洁功能使尖端功能化。本发明包括阻止分子在尖端上的非特异性吸附的官能化过程。

7. 发明申请

WO2009109809A3 ATOMIC FORCE MICROSCOPE AS AN ANALYZING TOOL FOR BIOCHIP 审中-公开
标题翻译：原子力显微镜作为生物技术分析工具
公开(公告)号：WO2009109809A3
公开(公告)日：2009-11-05
申请号：PCT/IB2008003959
申请日：2008-06-16
申请人： POSTECH ACAD IND FOUND , POSCO , PARK JOON WON , HONG BONG JIN , KWON SUNG HONG
发明人： PARK JOON WON , HONG BONG JIN , KWON SUNG HONG
IPC分类号： C12Q1/68 , G01N33/48
CPC分类号： G01N33/6845 , G01Q60/42
摘要： The present application discloses a method for detecting a presence of target ligand in a fluid medium which includes the steps of: (i) contacting the fluid medium with a solid substrate that includes an array of dendrons on its surface, wherein each of the dendron includes a central atom, a probe that is attached to the central atom optionally through a linker, and a base portion attached to the central atom and having a plurality of termini that are attached to the surface of the solid support; and (ii) determining the presence of a probe-target ligand complex by measuring binding force between the bound ligand and detection molecule tethered to the tip of an atomic force microscope ('AFM'), which detection molecule has affinity for the ligand, wherein measurement of an increase in force between the probe-target ligand complex and the detection molecule by AFM indicates the presence of the probe-target ligand complex.
摘要翻译：本申请公开了一种用于检测流体介质中目标配体存在的方法，其包括以下步骤：（i）使流体介质与其表面上包含一系列树突的固体基质接触，其中每个树枝包括中心原子，任选地通过连接体连接到中心原子上的探针和连接到中心原子上并具有连接到固体载体的表面上的多个末端的基部; 和（ii）通过测量结合的配体和拴在原子力显微镜（“AFM”）的末端的检测分子之间的结合力来确定探针 - 靶配体复合物的存在，该检测分子对配体具有亲和性，其中通过AFM测量探针 - 靶配体复合物和检测分子之间的力的增加表明探针 - 靶配体复合物的存在。

8. 发明申请

WO2007140497A8 VIRUS-NANOARRAY 审中-公开
标题翻译：病毒纳米阵列
公开(公告)号：WO2007140497A8
公开(公告)日：2008-02-14
申请号：PCT/AT2007000264
申请日：2007-06-01
申请人： UNIV LINZ , KIENBERGER FERRY , ARTELSMAIER HELGA , RANKL CHRISTIAN , TINAZLI ALI , TAMPE ROBERT , BLAAS DIETER , HINTERDORFER PETER
发明人： KIENBERGER FERRY , ARTELSMAIER HELGA , RANKL CHRISTIAN , TINAZLI ALI , TAMPE ROBERT , BLAAS DIETER , HINTERDORFER PETER
IPC分类号： G01N33/543 , B01J19/00 , G01N33/569 , G01N33/68 , G01Q60/42
CPC分类号： G01N33/6845 , B01J19/0046 , B01J2219/00436 , B01J2219/00527 , B01J2219/00596 , B01J2219/00605 , B01J2219/00612 , B01J2219/00617 , B01J2219/0063 , B01J2219/00637 , B01J2219/00659 , B01J2219/00677 , B01J2219/00725 , B01J2219/0074 , G01N33/56988 , G01Q60/42
摘要： The present invention provides a nanoarray of viral ligands immobilized in a pattern of spots each of a diameter size of less than 1000 nm, and wherein the spots are provided embedded in a layer of antiadsorptive proteins which encompasses the area between the spots, as well as a method for its manufacture and specific analytical use for an AFM measurement.
摘要翻译：本发明提供了固定在直径大小小于1000nm的斑点图案中的病毒配体的纳米阵列，并且其中斑点被提供嵌入在包含斑点之间的区域的抗吸收蛋白层中，以及其制造方法和AFM测量的具体分析用途。

9. 发明申请

WO2007065802A1 Y-SHAPED CARBON NANOTUBES AS AFM PROBE FOR ANALYZING SUBSTRATES WITH ANGLED TOPOGRAPHY 审中-公开
标题翻译： Y型碳纳米管作为AFM探针，用于分析具有光滑地理位置的基底
公开(公告)号：WO2007065802A1
公开(公告)日：2007-06-14
申请号：PCT/EP2006/068835
申请日：2006-11-23
申请人： INTERNATIONAL BUSINESS MACHINES CORPORATION , IBM UNITED KINGDOM LIMITED , BOYE, Carol, Ann , FURUKAWA, Toshiharu , HAKEY, Mark, Charles , HOLMES, Steven, John , HORAK, David, Vaclav , KOBURGER III, Charles, William
发明人： BOYE, Carol, Ann , FURUKAWA, Toshiharu , HAKEY, Mark, Charles , HOLMES, Steven, John , HORAK, David, Vaclav , KOBURGER III, Charles, William
IPC分类号： G01N13/16 , G12B21/08 , G12B21/02
CPC分类号： G01Q60/42 , G01Q70/12
摘要： A Y-shaped carbon nanotube atomic force microscope probe tip and methods comprise a shaft portion; a pair of angled arms extending from a same end of the shaft portion, wherein the shaft portion and the pair of angled arms comprise a chemically modified carbon nanotube, and wherein the chemically modified carbon nanotube is modified with any of an amine, carboxyl, fluorine, and metallic component. Preferably, each of the pair of angled arms comprises a length of at least 200nm and a diameter between 10 and 200nm. Moreover, the chemically modified carbon nanotube is preferably adapted to allow differentiation between substrate materials to be probed. Additionally, the chemically modified carbon nanotube is preferably adapted to allow fluorine gas to flow through the chemically modified carbon nanotube onto a substrate to be characterized. Furthermore, the chemically modified carbon nanotube is preferably adapted to chemically react with a substrate surface to be characterized.
摘要翻译： Y型碳纳米管原子力显微镜探针头和方法包括轴部分; 一对成角度的臂，其从所述轴部的同一端延伸，其中所述轴部和所述一对成角度的臂包括化学改性的碳纳米管，并且其中所述化学改性的碳纳米管用胺，羧基，氟，和金属成分。优选地，一对成角度的臂中的每一个包括至少200nm的长度和10和200nm之间的直径。此外，化学改性的碳纳米管优选适于允许待探测的基底材料之间的分化。此外，化学改性的碳纳米管优选适于使氟气通过化学改性的碳纳米管流动到待表征的基底上。此外，化学改性的碳纳米管优选适于与要表征的基材表面发生化学反应。

10. 发明申请

WO2007046819A2 BIOMARKER SENSORS AND METHOD FOR MULTI-COLOR IMAGING AND PROCESSING OF SINGLE-MOLECULE LIFE SIGNATURES 审中-公开
标题翻译：生物标记传感器和多色成像和单分子生命信号处理方法
公开(公告)号：WO2007046819A2
公开(公告)日：2007-04-26
申请号：PCT/US2005/041954
申请日：2005-11-15
申请人： CALIFORNIA INSTITUE OF TECHNOLOGY , WADE, Lawarence, A. , COLLIER, Charles, Patrick
发明人： WADE, Lawarence, A. , COLLIER, Charles, Patrick
IPC分类号： C12Q1/68 , C12M1/34 , C12M3/00
CPC分类号： G01Q60/42 , G01Q80/00
摘要： A device comprising an array of active regions for use in reacting one or more species in at least two of the active regions in a sequential process, e.g., sequential reactions. The device has a transparent substrate member, which has a surface region. The device has a silane material overlying the surface region. The device has a first active region formed overlying a first portion of the silane material. In a specific embodiment, the first active region has a first dimension of less than 1 micron in size and has one or more first molecules capable of binding to the first portion of the silane material. In a specific embodiment, the device has a second active region formed overlying a second portion of the silane material. The second active region has a second dimension of less than 1 micron in size and has one or more second molecules capable of binding to the second portion of the active region. In a specific embodiment, the device has a spatial distance separating the first active region and the second active region. In a preferred embodiment, the spatial distance is characterized by a dimension of 1 micron and less. The device has a fluid material in contact with the first active region, the second active region, and the spatial distance according to a specific embodiment. The device also has a reactant species within the fluid material. The reactant species is capable of spatially moving from the first active region to the second active region over the spatial distance of 1 micron and less within a time of less than 10 microseconds.
摘要翻译：一种包含活性区域阵列的装置，其用于在顺序过程（例如顺序反应）中使至少两个活性区域中的一种或多种物质反应。该装置具有透明基板部件，该基板部件具有表面区域。该装置具有覆盖表面区域的硅烷材料。该装置具有覆盖硅烷材料的第一部分的第一有源区。在具体实施方案中，第一有源区具有尺寸小于1微米的第一尺寸，并具有一个或多个能够结合硅烷材料的第一部分的第一分子。在具体实施方案中，该装置具有覆盖硅烷材料的第二部分的第二有源区。第二有源区具有尺寸小于1微米的第二维度，并且具有一个或多个能够结合活性区的第二部分的第二分子。在具体实施例中，该装置具有分隔第一有源区和第二有源区的空间距离。在优选实施例中，空间距离的特征在于1微米和更小的尺寸。根据具体实施例，该装置具有与第一有源区域，第二有源区域和空间距离接触的流体材料。该装置还在流体材料内具有反应物种类。反应物种能够在小于10微秒的时间内在空间距离为1微米以下的空间距离上从第一有源区域移动到第二有源区域。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式