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1. 发明申请

WO2007115208A3 SHAPE MEMORY POLYMER MEDICAL DEVICES 审中-公开
标题翻译：形状记忆聚合物医疗器械
公开(公告)号：WO2007115208A3
公开(公告)日：2007-11-22
申请号：PCT/US2007065691
申请日：2007-03-30
申请人： UNIV COLORADO , SHANDAS ROBIN , YAKACKI CHRISTOPHER M , GALL KENNETH , ECKSTEIN ALEX E , LYONS MICHAEL , NAIR DEVATHA P
发明人： SHANDAS ROBIN , YAKACKI CHRISTOPHER M , GALL KENNETH , ECKSTEIN ALEX E , LYONS MICHAEL , NAIR DEVATHA P
IPC分类号： A61B17/00 , A61F2/92 , A61M29/00
CPC分类号： A61B17/12022 , A61B17/12099 , A61B17/12159 , A61B17/12163 , A61B17/1219 , A61B2017/00526 , A61B2017/00867 , A61F2/844 , A61F2/88 , A61F2/91 , A61F2/92 , A61F2220/0016 , A61L31/048 , A61L31/14 , A61L2400/16 , C08L33/04
摘要： Medical devices for in vivo medical applications are disclosed. The medical devices are constructed of shape memory polymer (SMP) materials capable of assuming a memory shape at physiological temperatures. These medical devices may be used in surgical procedures and in both vascular and non-vascular applications. These SMP medical devices have a post-implantation memory shape that is substantially identical to or slightly larger than the insertion site to adapt to vessel growth or size changes. SMP medical devices may be formed as stents or occlusion devices (i.e., plugs) having a number of different structural features. The SMP medical devices may be formed from a first monomer and a second cross-linking monomer, wherein the weight percentages of the first and second monomers are selected by performing an iterative function to reach a predetermined glass transition temperature (T g ) and a predetermined rubbery modulus to optimize post-implantation memory shape properties of the devices.
摘要翻译：公开了用于体内医疗应用的医疗装置。医疗器械由能够在生理温度下呈现记忆形状的形状记忆聚合物（SMP）材料构成。这些医疗装置可用于外科手术和血管和非血管应用。这些SMP医疗装置具有植入后记忆形状，其基本上与插入位点相同或略大，以适应血管生长或尺寸变化。 SMP医疗装置可以形成为具有多个不同结构特征的支架或闭塞装置（即，塞子）。 SMP医疗装置可以由第一单体和第二交联单体形成，其中第一和第二单体的重量百分比通过执行迭代函数来选择，以达到预定的玻璃化转变温度（T < / SUB>）和预定的橡胶模量以优化装置的植入后记忆形状特性。

2. 发明申请

WO2007115208A9 SHAPE MEMORY POLYMER MEDICAL DEVICES 审中-公开
标题翻译：形状记忆聚合物医疗器械
公开(公告)号：WO2007115208A9
公开(公告)日：2008-11-13
申请号：PCT/US2007065691
申请日：2007-03-30
申请人： UNIV COLORADO , SHANDAS ROBIN , YAKACKI CHRISTOPHER M , GALL KENNETH , ECKSTEIN ALEX E , LYONS MICHAEL , NAIR DEVATHA P
发明人： SHANDAS ROBIN , YAKACKI CHRISTOPHER M , GALL KENNETH , ECKSTEIN ALEX E , LYONS MICHAEL , NAIR DEVATHA P
IPC分类号： A61B17/00 , A61F2/92 , A61M29/00
CPC分类号： A61B17/12022 , A61B17/12099 , A61B17/12159 , A61B17/12163 , A61B17/1219 , A61B2017/00526 , A61B2017/00867 , A61F2/844 , A61F2/88 , A61F2/91 , A61F2/92 , A61F2220/0016 , A61L31/048 , A61L31/14 , A61L2400/16 , C08L33/04
摘要： Medical devices for in vivo medical applications are disclosed. The medical devices are constructed of shape memory polymer (SMP) materials capable of assuming a memory shape at physiological temperatures. These medical devices may be used in surgical procedures and in both vascular and non-vascular applications. These SMP medical devices have a post-implantation memory shape that is substantially identical to or slightly larger than the insertion site to adapt to vessel growth or size changes. SMP medical devices may be formed as stents or occlusion devices (i.e., plugs) having a number of different structural features. The SMP medical devices may be formed from a first monomer and a second cross-linking monomer, wherein the weight percentages of the first and second monomers are selected by performing an iterative function to reach a predetermined glass transition temperature (T g ) and a predetermined rubbery modulus to optimize post-implantation memory shape properties of the devices.
摘要翻译：公开了用于体内医疗应用的医疗装置。医疗器械由能够在生理温度下呈现记忆形状的形状记忆聚合物（SMP）材料构成。这些医疗装置可用于外科手术和血管和非血管应用。这些SMP医疗装置具有植入后记忆形状，其基本上与插入位点相同或略大，以适应血管生长或尺寸变化。 SMP医疗装置可以形成为具有多个不同结构特征的支架或闭塞装置（即，塞子）。 SMP医疗装置可以由第一单体和第二交联单体形成，其中第一和第二单体的重量百分比通过执行迭代函数来选择，以达到预定的玻璃化转变温度（T < / SUB>）和预定的橡胶模量以优化装置的植入后记忆形状特性。

3. 发明申请

WO2008051254A8 A POLYMER FORMULATION A METHOD OF DETERMINING A POLYMER FORMULATION AND A METHOD OF DETERMINING A POLYMER FABRICATION 审中-公开
标题翻译：聚合物配方确定聚合物配方的方法和确定聚合物制造方法
公开(公告)号：WO2008051254A8
公开(公告)日：2009-02-26
申请号：PCT/US2006060297
申请日：2006-10-27
申请人： UNIV COLORADO , YAKACKI CHRISTOPHER M , GALL KENNETH , SHANDAS ROBIN
发明人： YAKACKI CHRISTOPHER M , GALL KENNETH , SHANDAS ROBIN
IPC分类号： A61F2/02
CPC分类号： A61L27/50 , A61L31/14 , A61L2400/16
摘要： The thermomechanical response of shape memory polymer (SMP) materials can be controlled to predict and optimize shape-memory properties. Polymer systems may be designed and optimized to a high degree of tailorability that is capable of adapting and responding to patients needs for biomedical applications such as stenting or orthopedic fixation.
摘要翻译：可以控制形状记忆聚合物（SMP）材料的热机械响应来预测和优化形状记忆特性。聚合物系统可以被设计和优化，以便能够适应和响应患者生物医学应用如支架置入或矫形固定的需要的高度的定制性。

4. 发明申请

WO2006108114A3 A GRAFT FIXATION DEVICE AND METHOD 审中-公开
标题翻译： GRAFT固定装置和方法
公开(公告)号：WO2006108114A3
公开(公告)日：2007-03-15
申请号：PCT/US2006012934
申请日：2006-04-03
申请人： UNIV COLORADO , GALL KENNETH , TYBER JEFFREY ALAN , YAKACKI CHRISTOPHER M , BARTZ REED
发明人： GALL KENNETH , TYBER JEFFREY ALAN , YAKACKI CHRISTOPHER M , BARTZ REED
IPC分类号： A61F2/44
CPC分类号： A61L27/16 , A61B17/0401 , A61B2017/00871 , A61B2017/0448 , A61F2/0811 , A61F2002/0835 , A61F2002/0858 , A61F2002/0864 , A61F2002/0882 , A61F2002/0888 , A61F2210/0014 , A61L27/50 , A61L2400/16 , A61L2430/02
摘要： In one aspect a device is disclosed for use as a bone implant comprising, a body having a pre-implantation shape and a post-implantation shape different from the pre-implantation shape. The body is configured to change from the pre-implantation shape to the post-implantation shape in response to the body being activated. The body is configured to be inserted in a bone recess while the body is in the pre-implantation shape. In another aspect a method is disclosed comprising inserting a cable member into a recess in a bone, inserting a retention device into the recess, the retention device containing a shape memory material, and activating the shape memory material.
摘要翻译：在一个方面，公开了一种用作骨植入物的装置，其包括具有植入前形状和与植入前形状不同的植入后形状的身体。身体构造成响应于身体被激活而从植入前形状改变为植入后形状。身体构造成当身体处于预植入形状时插入骨凹槽中。在另一方面，公开了一种方法，包括将电缆构件插入骨中的凹部中，将保持装置插入凹部中，保持装置包含形状记忆材料，以及激活形状记忆材料。

5. 发明申请

WO2006012452A8 A PROGRAMMABLE PARTICLE SCATTERER FOR RADIATION THERAPY BEAM FORMATION 审中-公开
标题翻译：用于辐射治疗波束形成的可编程粒子散射器
公开(公告)号：WO2006012452A8
公开(公告)日：2007-03-08
申请号：PCT/US2005025942
申请日：2005-07-21
申请人： STILL RIVER SYSTEMS INC , SLISKI ALAN , GALL KENNETH
发明人： SLISKI ALAN , GALL KENNETH
IPC分类号： A61N5/10
CPC分类号： A61N5/1077 , A61N2005/1087 , A61N2005/1095 , G21K1/08 , G21K5/04 , H05H7/00
摘要： Interposing a programmable path length of one or more materials into a particle beam modulates scattering angle and beam range in a predetermined manner to create a predetermined spread out Bragg peak at a predetermined range. Materials can be "low Z" and "high Z" materials that include fluids. A charged particle beam scatterer/range modulator can comprise a fluid reservoir having opposing walls in a particle beam path and a drive to adjust the distance between the walls of the fluid reservoir under control by a programmable controller. A "high Z" and, independently, a "low Z" reservoir, arranged in series, can be used. When used for radiation treatment, the beam can be monitored by measuring beam intensity, and the programmable controller can adjust the distance between the opposing walls of the "high Z" reservoir and, independently, the distance between the opposing walls of the "low Z" reservoir according to a predetermined relationship to integral beam intensity. Beam scattering and modulation can be done continuously and dynamically during a treatment in order to deposit dose in a target volume in a predetermined three dimensional distribution.
摘要翻译：将一个或多个材料的可编程路径长度插入到粒子束中，以预定方式调制散射角和波束范围，以在预定范围产生预定的扩展布拉格峰。材料可以是包括流体的“低Z”和“高Z”材料。带电粒子束散射体/范围调制器可以包括在粒子束路径中具有相对壁的流体储存器，以及通过可编程控制器来控制流体储存器的壁之间的距离的驱动器。可以使用串联布置的“高Z”和独立地“低Z”储存器。当用于辐射处理时，可以通过测量光束强度来监视光束，并且可编程控制器可以调节“高Z”储存器的相对壁之间的距离，并且独立地调节“低Z”储存器的相对壁之间的距离 “储层按照与整体光束强度的预定关系。光束散射和调制可以在处理期间连续且动态地进行，以便以预定的三维分布将剂量沉积在目标体积中。

6. 发明申请

WO2007061937A2 CHARGED PARTICLE RADIATION THERAPY 审中-公开
标题翻译：带电粒子辐射治疗
公开(公告)号：WO2007061937A2
公开(公告)日：2007-05-31
申请号：PCT/US2006044853
申请日：2006-11-17
申请人： STILL RIVER SYSTEMS INC , GALL KENNETH
发明人： GALL KENNETH
IPC分类号： A61N5/00
CPC分类号： A61N5/1081 , A61N5/10 , A61N2005/1087 , H05H7/04 , H05H13/02 , H05H13/04 , H05H2007/043
摘要： Among other things, an accelerator is mounted on a gantry to enable the accelerator to move through a range of positions around a patient on a patient support. The accelerator is configured to produce a proton or ion beam having an energy level sufficient to reach any arbitrary target in the patient from positions within the range. The proton or ion beam passes essentially directly from the accelerator to the patient. In some examples, the synchrocyclotron has a superconducting electromagnetic structure that generates a field strength of at least 6 Tesla, produces a beam of particles having an energy level of at least 150 MeV, has a volume no larger than 4.5 cubic meters, and has a weight less than 30 Tons.
摘要翻译：其中，加速器安装在机架上以使加速器能够移动通过患者支架上患者周围的一系列位置。加速器被配置成产生具有足以从该范围内的位置到达患者中的任意目标的能量水平的质子或离子束。质子或离子束基本上直接从加速器传递给患者。在一些示例中，同步回旋加速器具有超导电磁结构，其产生至少6特斯拉的场强，产生具有至少150MeV的能量水平的粒子束，具有不大于4.5立方米的体积，并且具有重量小于30吨。

7. 发明申请

WO2007061937A9 CHARGED PARTICLE RADIATION THERAPY 审中-公开
标题翻译：充电颗粒辐射治疗
公开(公告)号：WO2007061937A9
公开(公告)日：2007-08-16
申请号：PCT/US2006044853
申请日：2006-11-17
申请人： STILL RIVER SYSTEMS INC , GALL KENNETH
发明人： GALL KENNETH
IPC分类号： A61N5/00
CPC分类号： A61N5/1081 , A61N5/10 , A61N2005/1087 , H05H7/04 , H05H13/02 , H05H13/04 , H05H2007/043
摘要： Among other things, an accelerator is mounted on a gantry to enable the accelerator to move through a range of positions around a patient on a patient support. The accelerator is configured to produce a proton or ion beam having an energy level sufficient to reach any arbitrary target in the patient from positions within the range. The proton or ion beam passes essentially directly from the accelerator to the patient. In some examples, the synchrocyclotron has a superconducting electromagnetic structure that generates a field strength of at least 6 Tesla, produces a beam of particles having an energy level of at least 150 MeV, has a volume no larger than 4.5 cubic meters, and has a weight less than 30 Tons.
摘要翻译：除此之外，加速器安装在台架上以使加速器能够移动通过病人支架周围的患者位置的范围。加速器被配置为产生具有足以从该范围内的位置到达患者任何任意目标的能级的质子或离子束。质子或离子束基本上直接从加速器传递到患者身上。在一些示例中，同步回旋加速器具有产生至少6特斯拉的场强的超导电磁结构，产生具有至少150MeV的能级的颗粒束，具有不大于4.5立方米的体积，并具有重量小于30吨。

8. 发明申请

WO2006012467A2 A PROGRAMMABLE RADIO FREQUENCY WAVEFORM GENERATOR FOR A SYNCHROCYCLOTRON 审中-公开
标题翻译：可编程无线电频率波形发生器
公开(公告)号：WO2006012467A2
公开(公告)日：2006-02-02
申请号：PCT/US2005025965
申请日：2005-07-21
申请人： STILL RIVER SYSTEMS INC , SLISKI ALAN , GALL KENNETH
发明人： SLISKI ALAN , GALL KENNETH
CPC分类号： H05H13/02
摘要： A synchrocyclotron comprises a resonant circuit that includes electrodes having a gap therebetween across the magnetic field. An oscillating voltage input, having a variable amplitude and frequency determined by a programmable digital waveform generator generates an oscillating electric field across the gap. The synchrocyclotron can include a variable capacitor in circuit with the electrodes to vary the resonant frequency. The synchrocyclotron can further include an injection electrode and an extraction electrode having voltages controlled by the programmable digital waveform generator. The synchrocyclotron can further include a beam monitor. The synchrocyclotron can detect resonant conditions in the resonant circuit by measuring the voltage and/or current in the resonant circuit, driven by the input voltage, and adjust the capacitance of the variable capacitor or the frequency of the input voltage to maintain the resonant conditions. The programmable waveform generator can adjust at least one of the oscillating voltage input, the voltage on the injection electrode and the voltage on the extraction electrode according to beam intensity and in response to changes in resonant conditions.
摘要翻译：同步回旋加速器包括谐振电路，其包括在磁场之间具有间隙的电极。具有由可编程数字波形发生器确定的可变幅度和频率的振荡电压输入产生跨越间隙的振荡电场。同步回旋加速器可以包括与电极电路中的可变电容器以改变谐振频率。同步回旋加速器还可以包括具有由可编程数字波形发生器控制的电压的注入电极和引出电极。同步回旋加速器还可以包括光束监视器。同步回旋加速器可以通过测量由输入电压驱动的谐振电路中的电压和/或电流来检测谐振电路中的谐振条件，并调整可变电容器的电容或输入电压的频率以保持谐振条件。可编程波形发生器可以根据光束强度和响应谐振条件的变化来调节振荡电压输入，注入电极上的电压和引出电极上的电压中的至少一个。

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