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    • 4. 发明申请
    • ARTICLES COMPRISING LARGE-SURFACE-AREA BIO-COMPATIBLE MATERIALS AND METHODS FOR MAKING AND USING THEM
    • 包含大面积生物相容材料的文章及其制作和使用方法
    • WO2008066965A3
    • 2008-12-11
    • PCT/US2007071947
    • 2007-06-22
    • UNIV CALIFORNIAJIN SUNGHOOH SEUNGHAN
    • JIN SUNGHOOH SEUNGHAN
    • A61K9/00
    • A61L27/306A61L27/10A61L27/14A61L27/16A61L27/18A61L27/30A61L27/3839A61L27/54A61L2300/252A61L2300/254A61L2300/256A61L2300/258A61L2300/406A61L2300/414A61L2300/43A61L2300/624A61L2400/12A61L2400/18C23C28/32C23C28/345C23C30/00C25D7/006C25D11/02
    • The present invention provides articles of manufacture comprising biocompatible nanostructures comprising significantly increased surface area for, e.g., organ, tissue and/or cell growth, e.g., for bone, tooth, kidney or liver growth, and uses thereof, e.g., for in vitro testing of drugs, chemicals or toxins, or as in vivo implants, including their use in making and using artificial tissues and organs, and related, diagnostic, screening, research and development and therapeutic uses, e.g., as drug delivery devices. The present invention provides biocompatible nanostructures with significantly increased surface area, such as with nanotube and nanopore array on the surface of metallic, ceramic, or polymer materials for enhanced cell and bone growth, for in vitro andin vivo testing, cleansing reaction, implants and therapeutics. The present invention provides optically transparent or translucent cell-culturing substrates. The present invention provides biocompatible and cell-growth-enhancing culture substrates comprising elastically compliant protruding nanostructure substrates coated with Ti, TiO2 or related metal and metal oxide films.
    • 本发明提供包含生物相容性纳米结构的制品,其包括显着增加例如器官,组织和/或细胞生长的表面积,例如用于骨,牙齿,肾脏或肝脏生长,及其用途,例如用于体外测试 药物,化学物质或毒素,或作为体内植入物,包括其在制备和使用人造组织和器官中的用途以及相关的,诊断,筛选,研究和开发以及治疗用途,例如作为药物递送装置。 本发明提供具有显着增加的表面积的生物相容性纳米结构,例如在用于体外和体内测试,清洁反应,植入物和治疗剂的金属,陶瓷或聚合物材料的表面上的纳米管和纳米孔阵列用于增强的细胞和骨生长 。 本发明提供光学透明或半透明的细胞培养基质。 本发明提供生物相容性和细胞生长增强培养基质,其包含用Ti,TiO 2或相关金属和金属氧化物膜涂覆的弹性柔顺突出的纳米结构基底。