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    • 10. 发明申请
    • REMOTE MAGNETICALLY INDUCED TREATMENT OF CANCER
    • 远程磁性诱导治疗癌症
    • WO2005065282A3
    • 2006-01-05
    • PCT/US2004043459
    • 2004-12-23
    • UNIV CALIFORNIAJIN SUNGHOPISANIC THOMAS
    • JIN SUNGHOPISANIC THOMAS
    • A61K41/00A61K47/48A61N2/02A61N2/06A61B5/055A61N2/00G01N33/544G01N33/551G03G19/00
    • A61N2/06A61K41/0028A61K41/0052A61K47/6923A61K47/6929A61N2/02
    • This invention describes unique treatment methods and innovative articles that can be placed in a human or animal body to enable controlled destruction of diseased tissue. The methods include destruction of diseased cells and tissues by magnetically controlled motion and an externally controllable drug delivery process with a capability to start and stop the drug delivery at any time, for any duration. This invention provides two approaches to diseased cell destruction, (1) magneto-mechanical disturbance of cell structure (e.g. cancer cells) for cell lysis and (2) magnetically activated drug release at local regions (e.g. tumors) from a magnetic-particle-containing drug reservoir. The invention also provides combinations of both the above treatments for dual therapy. It further combines one or both of the treatments with magnetic hyperthermia for multifunctional cell destruction therapy. The approaches can be combined with magnetic MRI for monitoring the accuracy of placement as well as for following up the cancer destruction progress and appropriate reprogramming of the magneto-mechanical therapy and remote-controlled drug release.
    • 本发明描述了可以放置在人体或动物体内的独特的治疗方法和创新的制品,以实现病变组织的受控破坏。 所述方法包括通过磁力控制的运动破坏患病细胞和组织,以及外部可控的药物递送过程,其能够在任何时间内随时开始和停止药物递送。 本发明提供了两种病变细胞破坏的方法,(1)用于细胞裂解的细胞结构(例如癌细胞)的磁机械扰动和(2)来自含磁粉的局部区域(例如肿瘤)的磁性活化药物释放 药库 本发明还提供了用于双重治疗的上述两种治疗的组合。 它进一步结合了一种或两种治疗与磁疗热疗用于多功能细胞破坏治疗。 这些方法可以与磁性MRI结合,用于监测放置的准确性,以及跟踪癌症破坏进展和磁力机械治疗和远程控制药物释放的适当重新编程。