专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

WO2008033848A3 SELF-ASSEMBLED COMBINATORIAL ENCODING NANOARRAYS FOR MULTIPLEXED BIOSENSING 审中-公开
标题翻译：自组装的纳米阵列组合式纳米阵列用于多重生物分子识别
公开(公告)号：WO2008033848A3
公开(公告)日：2008-12-18
申请号：PCT/US2007078174
申请日：2007-09-11
申请人： UNIV ARIZONA , YAN HAO , LIN CHENXIANG , KATILIUS EVALDAS , LIU YAN
发明人： YAN HAO , LIN CHENXIANG , KATILIUS EVALDAS , LIU YAN
IPC分类号： G01N33/53 , C12Q1/70
CPC分类号： C12N15/10 , B01J2219/00527 , B01J2219/00576 , B01J2219/00585 , B01J2219/00596 , B01J2219/00599 , B01J2219/00605 , B01J2219/00626 , B01J2219/00659 , B01J2219/00677 , B01J2219/00709 , B01J2219/00722 , B82Y30/00 , C40B50/14 , C40B50/16
摘要： The present invention provides combinatorial encoding nucleic acid tiling arrays and methods for their use and synthesis.
摘要翻译：本发明提供了组合编码核酸拼接阵列及其使用和合成方法。

2. 发明申请

WO2008033804A3 QUANTUM DOT BARCODE STRUCTURES AND USES THEREOF 审中-公开
标题翻译：量子块结构及其用途
公开(公告)号：WO2008033804A3
公开(公告)日：2008-06-05
申请号：PCT/US2007078114
申请日：2007-09-11
申请人： UNIV ARIZONA , YAN HAO , WANG QIANGBIN , LIU YAN
发明人： YAN HAO , WANG QIANGBIN , LIU YAN
IPC分类号： H01L21/311
CPC分类号： C09C1/24 , A61K9/14 , B82Y10/00 , B82Y15/00 , C01P2004/03 , C01P2004/04 , C01P2006/42 , G01N33/54366 , G01N33/588 , H01L29/127 , Y10T428/2991
摘要： The present invention provides novel barcode microstructures and methods for making and using the microstructures for molecular recognition, and/or delivery of therapeutic, diagnostic, contrast, and imaging agents.
摘要翻译：本发明提供了用于制备和使用用于分子识别和/或递送治疗，诊断，对比和成像剂的微结构的新型条形码微结构和方法。

3. 发明申请

WO2010132725A3 CYCLIN DEPENDENT KINASE INHIBITORS AND METHODS OF USE 审中-公开
标题翻译： CYCLIN依赖性激酶抑制剂及其使用方法
公开(公告)号：WO2010132725A3
公开(公告)日：2011-03-31
申请号：PCT/US2010034816
申请日：2010-05-13
申请人： UNIV NORTH CAROLINA , SHARPLESS NORMAN E , ROBERTS PATRICK J , WONG KWOK , LIU YAN , JOHNSON SOREN
发明人： SHARPLESS NORMAN E , ROBERTS PATRICK J , WONG KWOK , LIU YAN , JOHNSON SOREN
IPC分类号： A61K38/18 , A61K38/17 , A61K38/20 , A61P1/00 , A61P37/00 , A61P37/08
CPC分类号： A61K31/519 , A61K38/1816 , A61K45/06 , A61K2300/00
摘要： The presently disclosed subject matter relates to methods and compositions for protecting healthy cells from damage due to DNA damaging agents. In particular, the presently disclosed subject matter relates to the protective action of selective cyclin dependent kinase 4/6 (CDK4/6) inhibitors administered to subjects that have been exposed to or that are at risk of exposure to DNA damage.
摘要翻译：目前公开的主题涉及用于保护健康细胞免受DNA损伤剂损伤的方法和组合物。特别地，目前公开的主题涉及对暴露于或处于暴露于DNA损伤的风险的受试者施用的选择性细胞周期蛋白依赖性激酶4/6（CDK4 / 6）抑制剂的保护作用。

4. 发明申请

WO2013116709A1 COMPUTERIZED IMAGE RECONSTRUCTION METHOD AND APPARATUS 审中-公开
标题翻译：计算机图像重构方法和装置
公开(公告)号：WO2013116709A1
公开(公告)日：2013-08-08
申请号：PCT/US2013024423
申请日：2013-02-01
申请人： RES FOUNDATION OF STATES UNIVERSITY OF NEW YORK , LIANG ZHENGRONG , MA JIANHUA , LIU YAN
发明人： LIANG ZHENGRONG , MA JIANHUA , LIU YAN
IPC分类号： A61B6/03 , G06F19/00 , G06T7/00
CPC分类号： G06T11/005 , A61B6/032 , G06T11/006 , G06T2207/10081 , G06T2207/10124 , G06T2207/30096 , G06T2211/424
摘要： Provided herein is a computerized image reconstruction apparatus and method that includes recording projection path information and energy loss information of a plurality of particles traversing an object being imaged and determining an estimated image of the object based on the projection path information and the energy loss information sampled into a projection format. The estimated image includes an active volume defined by an enclosure border. Cost function minimization uses an Adaptive-weighted Total Variation cost function, a Penalized Weighted Least-Squares cost function, or an Alpha-Divergence cost function to update the estimated image. An iterative updating algorithm corresponding to the cost function updates the estimated image and produces a final image based on the estimated image according to a predetermined threshold.
摘要翻译：本文提供了一种计算机图像重建装置和方法，其包括记录穿过正在成像的对象的多个粒子的投影路径信息和能量损失信息，并且基于投影路径信息和采样的能量损失信息来确定对象的估计图像成为投影格式。估计的图像包括由外壳边界定义的活动卷。成本函数最小化使用自适应加权总变差成本函数，惩罚加权最小二乘法成本函数或Alpha-Divergence代价函数来更新估计图像。对应于成本函数的迭代更新算法更新估计图像，并根据预定阈值基于估计图像产生最终图像。

5. 发明申请

WO2008141282A3 MATERIALS AND METHODS FOR FOXP3 TUMOR SUPPRESSION 审中-公开
标题翻译： FOXP3肿瘤抑制的材料与方法
公开(公告)号：WO2008141282A3
公开(公告)日：2009-04-02
申请号：PCT/US2008063419
申请日：2008-05-12
申请人： UNIV MICHIGAN , UNIV OHIO STATE RES FOUND , LIU YAN , ZHENG PAN , CHANG XING , WANG LIZHONG , LIU RUNHUA , WANG YIN , LIU YANG , ZUO TAO
发明人： LIU YAN , ZHENG PAN , CHANG XING , WANG LIZHONG , LIU RUNHUA , WANG YIN , LIU YANG , ZUO TAO
IPC分类号： A61P35/00 , A61K38/17 , A61K48/00 , G01N33/50
CPC分类号： G01N33/57415 , A61K31/7088 , A61K38/1709 , A61K45/06 , G01N33/57434 , A61K2300/00
摘要： Provided herein are methods of treating a cancer in a subject comprising administering a F0XP3 protein, a nucleic acid encoding a F0XP3 protein, or an inducing compound which induces FOXP3 protein expression. Methods of altering a phenotype of a cancer cell or tumor cell, methods of inhibiting growth of such cells, and methods of inducing apoptosis of these cells are also provided herein. These methods comprise contacting the cell with a F0XP3 protein, a nucleic acid encoding a F0XP3 protein, or an inducing compound which induces F0XP3 protein expression. Further provided herein are diagnostic methods, comprising comparing the expression or structure of a F0XP3 protein or F0XP3 gene in a test sample to that of a normal or prior sample. A method of screeing a test compound for anti-cancer activity comprising administering to cells the test compound and measuring F0XP3 protein or F0XP3 gene expression is moreover provided herein.
摘要翻译：本文提供了治疗受试者中的癌症的方法，包括施用F0XP3蛋白，编码F0XP3蛋白的核酸或诱导FOXP3蛋白表达的诱导化合物。本文还提供了改变癌细胞或肿瘤细胞表型的方法，抑制细胞生长的方法和诱导细胞凋亡的方法。这些方法包括使细胞与F0XP3蛋白，编码F0XP3蛋白的核酸或诱导F0XP3蛋白表达的诱导化合物接触。本文进一步提供了诊断方法，其包括将测试样品中F0XP3蛋白或F0XP3基因的表达或结构与正常或先前样品的表达或结构进行比较。本发明提供了一种筛选测试化合物用于抗癌活性的方法，其包括向细胞施用测试化合物并测量F0XP3蛋白或F0XP3基因表达。

6. 发明申请

WO2007028135A3 IMIDAZOPYRIDINE COMPOUNDS 审中-公开
标题翻译：咪唑并吡啶化合物
公开(公告)号：WO2007028135A3
公开(公告)日：2007-11-01
申请号：PCT/US2006034441
申请日：2006-09-01
申请人： TAKEDA PHARMACEUTICAL , TAKEDA SAN DIEGO INC , IWATA HIDEHISA , KOHARA YASUHISA , CAO SHELDON X , GUNTUPALLI PRASUNA , GWALTNEY STEPHEN L , HOSFIELD DAVID J , LIU YAN , STAFFORD JEFFREY A , THROOP BEVERLY
发明人： IWATA HIDEHISA , KOHARA YASUHISA , CAO SHELDON X , GUNTUPALLI PRASUNA , GWALTNEY STEPHEN L , HOSFIELD DAVID J , LIU YAN , STAFFORD JEFFREY A , THROOP BEVERLY
IPC分类号： C07D471/04 , A61K31/437 , A61P5/48
CPC分类号： A61K31/437 , A61K9/2018 , A61K9/4858 , C07D471/02 , C07D471/04 , C12N9/1205 , C12Y207/01001
摘要： Compounds, pharmaceutical compositions, kits and methods are provided for use with glucokinase that comprise a compound selected from the group consisting of formula (I) wherein the variables are as defined herein.
摘要翻译：提供与葡糖激酶一起使用的化合物，药物组合物，试剂盒和方法，所述葡糖激酶包含选自式（I）的化合物，其中变量如本文所定义。

7. 发明申请

WO2004024302A8 ELECTROLYTIC ELUENT GENERATOR AND METHOD OF USE 审中-公开
标题翻译：电解液发生器及其使用方法
公开(公告)号：WO2004024302A8
公开(公告)日：2004-07-08
申请号：PCT/US0328511
申请日：2003-09-09
申请人： DIONEX CORP , LIU YAN , AVDALOVIC NEBOJSA
发明人： LIU YAN , AVDALOVIC NEBOJSA
IPC分类号： G01N30/26 , B01D15/16 , B01D61/44 , B01D61/48 , B01D69/02 , B01D69/14 , G01N30/02 , G01N30/34 , G01N30/64 , G01N30/88 , G01N30/96 , B01J41/06 , C02F1/469 , C25B1/14 , C25B1/22
CPC分类号： B01D69/02 , B01D15/16 , B01D15/166 , B01D61/44 , B01D61/48 , B01D69/141 , G01N30/34 , G01N30/96 , G01N2030/965 , Y10T436/25
摘要： An acid or base is generated in an aqueous solution by the steps of: (a) providing a source of first ions (40) adjacent an aqueous liquid in a first acid or base generation zone (50), separated by a first barrier (46) (e.g., anion exchange membrane) substantially preventing liquid flow and transporting ions only of the same charge as said first ions, (b) providing a source of second ions of opposite charge (40) adjacent an aqueous liquid in a second acid or base generation zone (48), separated by a second barrier (44) transporting ions only of the same charge as the second ions, and (c) transporting ions across the first barrier by applying an electrical potential (52, 54) through said first and second zones and a base-containing aqueous solution in the other one which may be combined to form a salt (62). Also electrolytic apparatus for performing the above method. The product solutions can be used as an element for a chromato graphic separation medium (70). The element can be regenerated in order to reuse the ions by means of a membrane suppressor (74).
摘要翻译：通过以下步骤在水溶液中产生酸或碱：（a）在第一酸或碱产生区（50）中提供邻近水性液体的第一离子源（40），由第一阻挡层（46 ）（例如阴离子交换膜）基本上防止液体流动并仅传输与所述第一离子相同的电荷的离子，（b）在第二酸或碱中提供与水性液体相邻的相反电荷的第二离子源（40）由第二势垒（44）隔开，所述第二势垒（44）仅传输与第二离子相同的电荷的离子，和（c）通过施加电势（52,54）通过所述第一离子和/ 第二区和另一个中的含碱的水溶液，其可以组合形成盐（62）。还有用于执行上述方法的电解装置。产品溶液可用作色谱分离介质（70）的元素。可以再生该元件以便通过膜抑制器重新使用离子（74）。

8. 发明申请

WO2006105127A8 HYDROXYSTEROID DEHYDROGENASE INHIBITORS 审中-公开
标题翻译：羟肟酸脱氢酶抑制剂
公开(公告)号：WO2006105127A8
公开(公告)日：2017-02-09
申请号：PCT/US2006011347
申请日：2006-03-28
申请人： TAKEDA SAN DIEGO INC , AERTGEERTS KATHLEEN , BRENNAN NANCY K , CAO SHELDON X , CHANG EDCON , KIRYANOV ANDRE A , LIU YAN
发明人： AERTGEERTS KATHLEEN , BRENNAN NANCY K , CAO SHELDON X , CHANG EDCON , KIRYANOV ANDRE A , LIU YAN
IPC分类号： C07D295/22 , C07D211/96 , C07D213/71 , C07D215/36 , C07D217/22 , C07D217/24 , C07D231/18 , C07D233/84 , C07D261/10 , C07D261/20 , C07D265/36 , C07D271/12 , C07D277/62 , C07D285/16 , C07D307/87
CPC分类号： C07D241/38 , C07D207/48 , C07D209/08 , C07D211/18 , C07D211/22 , C07D211/34 , C07D211/38 , C07D211/54 , C07D211/58 , C07D211/62 , C07D211/76 , C07D211/96 , C07D213/70 , C07D213/74 , C07D215/04 , C07D215/42 , C07D215/58 , C07D217/02 , C07D217/06 , C07D217/08 , C07D217/22 , C07D217/24 , C07D231/18 , C07D231/56 , C07D233/42 , C07D235/26 , C07D239/14 , C07D241/08 , C07D241/50 , C07D261/10 , C07D265/36 , C07D271/12 , C07D277/56 , C07D277/58 , C07D277/62 , C07D279/16 , C07D285/14 , C07D285/16 , C07D295/26 , C07D307/68 , C07D307/79 , C07D333/62 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/12 , C07D409/12 , C07D413/04 , C07D471/08 , C07D487/04 , C07D487/08 , C07D491/10 , C07D513/04
摘要： Compounds, pharmaceutical compositions, kits and methods are provided for use with hydroxysteroid dehydrogenases that comprise a compound selected from the group consisting of: formula (I), wherein the variables are as defined herein.
摘要翻译：提供化合物，药物组合物，试剂盒和方法用于含有选自以下的化合物的羟基类固醇脱氢酶：式（I），其中变量如本文所定义。

9. 发明申请

WO2009042711A4 POLO-LIKE KINASE INHIBITORS 审中-公开
标题翻译： POLO-like激素抑制剂
公开(公告)号：WO2009042711A4
公开(公告)日：2009-06-04
申请号：PCT/US2008077558
申请日：2008-09-24
申请人： TAKEDA PHARMACEUTICAL , CAO SHELDON X , FEHER VICTORIA , ICHIKAWA TAKASHI , JONES BENJAMIN , KALDOR STEPHEN W , KIRYANOV ANDRE A , LIU YAN , MCBRIDE CHRISTOPHER , NATALA SRINIVASA REDDY , NIE ZHE , STAFFORD JEFFREY A , LAM BETTY
发明人： CAO SHELDON X , FEHER VICTORIA , ICHIKAWA TAKASHI , JONES BENJAMIN , KALDOR STEPHEN W , KIRYANOV ANDRE A , LIU YAN , MCBRIDE CHRISTOPHER , NATALA SRINIVASA REDDY , NIE ZHE , STAFFORD JEFFREY A , LAM BETTY
IPC分类号： A61K31/4545 , A61P11/00 , A61P37/08 , C07D487/04 , C07D487/14
CPC分类号： C07D487/04 , C07D487/14 , C07D519/00
摘要： Compounds of the following formula are provided for use with kinases: (I) wherein the variables are as defined herein. Also provided are pharmaceutical compositions, kits and articles of manufacture comprising such compounds; methods and intermediates useful for making the compounds; and methods of using said compounds.
摘要翻译：提供下式的化合物用于激酶：（I），其中变量如本文所定义。还提供了包含这些化合物的药物组合物，试剂盒和制品; 用于制备化合物的方法和中间体; 以及使用所述化合物的方法。

10. 发明申请

WO2007098198A3 MODULATION OF BONE FORMATION 审中-公开
标题翻译：骨形成调节
公开(公告)号：WO2007098198A3
公开(公告)日：2008-03-13
申请号：PCT/US2007004510
申请日：2007-02-16
申请人： WYETH CORP , BILLIARD JULIA , LIU YAN
发明人： BILLIARD JULIA , LIU YAN
IPC分类号： C07K14/47 , A61P19/08 , C12Q1/48
CPC分类号： C07K14/47 , A61K38/00 , C12Q1/485 , G01N2500/04 , G01N2800/108
摘要： This invention relates to modulating Ror activity (e.g., Ror2 protein activity) and/or 14-3-3 ß to affect bone formation or resorption. The invention further relates to compositions and methods for the screening, diagnosis and development of therapies for bone-related disorders such as osteoporosis and bone fracture. Antibodies and antibody fragments directed to Ror2 protein are particularly useful in causing dimerization of Ror2 proteins, thereby leading to the activation of Ror2.
摘要翻译：本发明涉及调节Ror活性（例如，Ror2蛋白活性）和/或14-3-3β以影响骨形成或吸收。本发明还涉及用于骨相关疾病如骨质疏松症和骨折的治疗的筛选，诊断和开发的组合物和方法。针对Ror2蛋白的抗体和抗体片段特别可用于引起Ror2蛋白的二聚化，从而导致Ror2的激活。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式