专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

WO2007056134A3 RESORBABLE PHENOLIC POLYMERS 审中-公开
标题翻译：可分离的酚醛聚合物
公开(公告)号：WO2007056134A3
公开(公告)日：2009-04-23
申请号：PCT/US2006042944
申请日：2006-11-03
申请人： TYRX PHARMA INC , MOSES ARIKHA , PULAPURA SATISH , SCHWARTZ ARTHUR , GE QING , SHATOVA IRENE
发明人： MOSES ARIKHA , PULAPURA SATISH , SCHWARTZ ARTHUR , GE QING , SHATOVA IRENE
IPC分类号： C08G73/00 , A61M31/00 , C07C233/65 , C08F220/44 , C08G65/40 , C08G69/08
CPC分类号： C08G69/48 , C07C235/34 , C07C235/52 , C08G63/6856 , C08G64/12 , C08G73/028
摘要： The invention provides biocompatible resorbable polymers, comprising monomer units having formula (I), formula (II), formula (III) or formula (IV). The polymers degrade over time when implanted in the body, and are useful as components of implantable medical devices.
摘要翻译：本发明提供具有式（I），式（II），式（III）或式（IV））的单体单元的生物相容性可再吸收聚合物。当植入体内时，聚合物随时间降解，并且可用作可植入医疗装置的组件。

2. 发明申请

WO2008121816A2 BIODEGRADABLE, POLYMER COVERINGS FOR BREAST IMPLANTS 审中-公开
标题翻译：用于乳房植入物的可生物降解的聚合物覆盖物
公开(公告)号：WO2008121816A2
公开(公告)日：2008-10-09
申请号：PCT/US2008058652
申请日：2008-03-28
申请人： TYRX PHARMA INC , MOSES ARIKHA , PULAPURA SATISH , GE QING , NETHULA SARITA , RAJARAM ARCHANA
发明人： MOSES ARIKHA , PULAPURA SATISH , GE QING , NETHULA SARITA , RAJARAM ARCHANA
IPC分类号： A61F2/12 , A61K31/496 , A61K31/65
CPC分类号： A61F2/12 , A61K31/167 , A61K31/381 , A61K31/404 , A61K31/41 , A61K31/445 , A61K31/47 , A61K31/496 , A61K31/545 , A61K31/65 , A61K31/7036 , A61K31/7048 , A61K38/13 , B29C41/14 , A61K2300/00
摘要： A biodegradable, flexible covering for a breast implant is provided which comprises one or more biodegradable polymer layers dimensioned and shaped to cover at least a portion of the breast implant. The implant can be inserted into an opening of the covering immediately prior to surgery, but alternate configurations and times of insertion are contemplated as well as open or sheet type devices. The coverings can optionally contain one or more drugs for delivery at the surgical site, particularly for treating or preventing infection, pain, inflammation, capsular contracture, scarring or other complications associated with breast augmentation or breast reconstruction.
摘要翻译：提供了用于乳房植入物的可生物降解的柔性覆盖物，其包括一个或多个可生物降解的聚合物层，所述聚合物层的尺寸和形状被设计为覆盖乳房植入物的至少一部分。可以在手术之前立即将植入物插入覆盖物的开口中，但是可以考虑插入的替代构造和时间以及开放式或片式装置。覆盖物可以任选地含有一种或多种用于在手术部位递送的药物，特别是用于治疗或预防与隆胸或乳房再造相关的感染，疼痛，炎症，荚膜挛缩，瘢痕形成或其他并发症。

3. 发明申请

WO2012027566A2 NOVEL MEDICAL DEVICE COATINGS 审中-公开
标题翻译：新型医疗器械涂料
公开(公告)号：WO2012027566A2
公开(公告)日：2012-03-01
申请号：PCT/US2011049140
申请日：2011-08-25
申请人： TYRX INC , PULAPURA SATISH , GE QING
发明人： PULAPURA SATISH , GE QING
CPC分类号： A61L31/10 , A61K31/155 , A61K31/496 , A61K31/65 , A61K33/38 , A61L31/16 , A61L2300/204 , A61L2300/216 , A61L2300/404 , A61L2300/606 , A61L2420/06 , C09D5/14 , C09D171/02 , Y10T428/265 , Y10T428/31678 , C08L71/02 , C08L67/02
摘要： The present invention relates to coatings comprising polyethylene glycol and at least one polyphenolic polymer. In particular, the polyphenolic polymer could be selected from the group consisting of tyrosine-derived polyarylates, linear polyesteramides, dihydroxybenzoate polymers, and resorcinol-derived polymers. The coating of the present invention may also include a drug, such as an antibiotic. The coatings of the present invention are suitable for use as coatings for medical devices, such as orthopedic pins or stents.
摘要翻译：本发明涉及包含聚乙二醇和至少一种多酚聚合物的涂料。特别地，多酚聚合物可以选自酪氨酸衍生的多芳基化合物，线性聚酯酰胺，二羟基苯甲酸酯聚合物和间苯二酚衍生的聚合物。本发明的涂层还可以包括药物，例如抗生素。本发明的涂层适合用作医疗装置如矫形针或支架的涂层。

4. 发明申请

WO2006115847A3 COATED ENDOPROSTHESES 审中-公开
标题翻译：包衣内含物
公开(公告)号：WO2006115847A3
公开(公告)日：2007-10-04
申请号：PCT/US2006014150
申请日：2006-04-13
申请人： BOSTON SCIENT SCIMED INC , UNIV CONNECTICUT , SAHATJIAN RONALD A , TAN FRANCISCA , MATHER PATRICK T , LIU CHANGDENG , GE QING
发明人： SAHATJIAN RONALD A , TAN FRANCISCA , MATHER PATRICK T , LIU CHANGDENG , GE QING
IPC分类号： A61L31/10 , A61F2/00 , A61F2/06
CPC分类号： A61L31/10 , A61F2250/0067 , A61L31/022 , A61L31/04 , A61L31/16 , A61L2300/402 , Y10T428/24926 , C08L75/04 , C08L83/04
摘要： Endoprostheses are disclosed.
摘要翻译：公布内裤假体。

5. 发明申请

WO2006110688A9 RNAI THERAPEUTIC FOR RESPIRATORY VIRUS INFECTION 审中-公开
标题翻译： RNAI治疗呼吸道病毒感染
公开(公告)号：WO2006110688A9
公开(公告)日：2007-03-15
申请号：PCT/US2006013374
申请日：2006-04-07
申请人： NASTECH PHARM CO , GE QING , KUMAR MUKESH , MCSWIGGEN JAMES ANTHONY
发明人： GE QING , KUMAR MUKESH , MCSWIGGEN JAMES ANTHONY
IPC分类号： C12N15/113
CPC分类号： C12N15/1131 , C12N2310/111 , C12N2310/14 , C12N2310/321 , C12N2310/53 , C12N2310/3521
摘要： Disclosed herein is a double stranded siRNA molecule that inhibits production of a respiratory virus, wherein each strand of said siRNA molecule is about 15 to about 50 nucleotides, and wherein one strand of said siRNA molecule comprises a nucleic acid sequence identical to a conserved site, or a variant thereof, within the nucleic acid sequence of the respiratory virus, and uses thereof.
摘要翻译：本文公开了抑制呼吸病毒生产的双链siRNA分子，其中所述siRNA分子的每条链约为15至约50个核苷酸，并且其中所述siRNA分子的一条链包含与保守位点相同的核酸序列，或其变体，以及其用途。

6. 发明申请

WO2010045384A3 SHORT HAIRPIN RNAS FOR INHIBITION OF GENE EXPRESSION 审中-公开
标题翻译：短发HAIRPIN RNAS用于抑制基因表达
公开(公告)号：WO2010045384A3
公开(公告)日：2010-06-10
申请号：PCT/US2009060712
申请日：2009-10-14
申请人： SOMAGENICS INC , GE QING , JOHNSTON BRIAN H , KAZAKOV SERGEI A , ILVES HEINI , DALLAS ANNE
发明人： GE QING , JOHNSTON BRIAN H , KAZAKOV SERGEI A , ILVES HEINI , DALLAS ANNE
IPC分类号： C07H21/04
CPC分类号： C12N15/111 , C12N15/1131 , C12N2310/14 , C12N2310/531 , C12N2310/533
摘要： Methods, compositions, and kits that include small hairpin RNA (shRNA) useful for inhibition of gene expression, such as viral-mediated gene expression, are described.
摘要翻译：描述了包括用于抑制基因表达的小发夹RNA（shRNA）的方法，组合物和试剂盒，例如病毒介导的基因表达。

7. 发明申请

WO2006047683B1 ANTISENSE ANTIVIRAL COMPOUND AND METHOD FOR TREATING INFLUENZA VIRAL INFECTION 审中-公开
标题翻译：抗真菌化合物和治疗流感病毒感染的方法
公开(公告)号：WO2006047683B1
公开(公告)日：2006-11-09
申请号：PCT/US2005038780
申请日：2005-10-26
申请人： AVI BIOPHARMA INC , STEIN DAVID A , GE QING , CHEN JIANZHU , IVERSEN PATRICK L
发明人： STEIN DAVID A , GE QING , CHEN JIANZHU , IVERSEN PATRICK L
IPC分类号： C07H21/04 , C12N15/113
CPC分类号： C12N15/1131 , C12N2310/3145 , C12N2310/3233 , C12N2310/3513
摘要： The invention provides antisense antiviral compounds and methods of their use and production in inhibition of growth of viruses of the Orthomyxoviridae family and in the treatment of a viral infection. The compounds are particularly useful in the treatment of influenza virus infection in a mammal. The antisense antiviral compounds are substantially uncharged morpholino oligonucleotides having 1) a nuclease resistant backbone, 2) 12-40 nucleotide bases, and 3) a targeting sequence of at least 12 bases in length that hybridizes to a target region selected from the following: a) the 5' or 3' terminal 25 bases of the negative sense viral RNA segment of Influenzavirus A, Influenzavirus B and Influenzavirus C; b) the terminal 25 bases of the 3' terminus of the positive sense cRNA and; and c) the 50 bases surrounding the AUG start codon of an influenza viral mRNA.
摘要翻译：本发明提供反义抗病毒化合物及其在抑制正粘病毒科的病毒生长和用于病毒感染治疗中的用途和生产方法。该化合物特别可用于治疗哺乳动物的流感病毒感染。反义抗病毒化合物是基本上不带电荷的吗啉代寡核苷酸，其具有1）核酸酶抗性主链，2）12-40个核苷酸碱基，和3）长度为至少12个碱基的靶向序列与选自以下的靶区域杂交：）流感病毒A，流感病毒B和流感病毒C的负义病毒RNA片段的5'或3'末端25个碱基; b）正义cRNA的3'末端的末端25个碱基; 和c）围绕流感病毒mRNA的AUG起始密码子的50个碱基。

8. 发明申请

WO2004029213A3 COMPOSITIONS AND METHODS FOR DELIVERY OF SHORT INTERFERING RNA AND SHORT HAIRPIN RNA 审中-公开
标题翻译：用于递送短干扰RNA和短发夹RNA的组合物和方法
公开(公告)号：WO2004029213A3
公开(公告)日：2004-09-16
申请号：PCT/US0330508
申请日：2003-09-29
申请人： MASSACHUSETTS INST TECHNOLOGY , CHEN JIANZHU , EISEN HERMAN N , GE QING
发明人： CHEN JIANZHU , EISEN HERMAN N , GE QING
IPC分类号： A61K38/00 , A61K48/00 , C12N15/11 , C12N15/113 , C12N15/09 , C12N15/63
CPC分类号： C12N15/1131 , A61K9/5146 , A61K9/5153 , A61K38/00 , C12N15/111 , C12N2310/111 , C12N2310/14 , C12N2310/53 , C12N2320/32 , C12N2799/021
摘要： The present invention provides compositions comprising an RNAi-inducing entity any of a variety of different delivery agents. Preferred RNAi-inducing agents include siRNA, shRNA, and RNAi-inducing vectors. Preferred delivery agents include cationic polymers, modified cationic polymers, lipids, and surfactants suitable for introduction into the lung. The invention further provides methods of inhibiting expression of a target 10 transcript in a mammal and methods of treating or preventing a disease or condition in a mammal by administration of the compositions.
摘要翻译：本发明提供了包含RNAi诱导实体的组合物，所述组合物包含多种不同递送剂中的任一种。优选的RNAi诱导剂包括siRNA，shRNA和RNAi诱导载体。优选的递送剂包括阳离子聚合物，改性阳离子聚合物，脂质和适用于引入肺中的表面活性剂。本发明进一步提供了抑制哺乳动物中靶转录物表达的方法以及通过施用组合物治疗或预防哺乳动物的疾病或病症的方法。

9. 发明申请

WO2005085443A3 RNAI-BASED THERAPEUTICS FOR ALLERGIC RHINITIS AND ASTHMA 审中-公开
标题翻译：基于RNAI的过敏性胃炎和哮喘的治疗方法
公开(公告)号：WO2005085443A3
公开(公告)日：2006-03-16
申请号：PCT/US2005006445
申请日：2005-03-01
申请人： MASSACHUSETTS INST TECHNOLOGY , CHEN JIANZHU , EISEN HERMAN N , GE QING
发明人： CHEN JIANZHU , EISEN HERMAN N , GE QING
IPC分类号： A61K31/713 , A61P11/00 , A61P11/06 , C12N15/11 , C12N15/113
CPC分类号： C12N15/113 , C12N15/111 , C12N15/1137 , C12N15/1138 , C12N2310/111 , C12N2310/14 , C12N2310/53 , C12N2320/32
摘要： The present invention provides compositions comprising one or more RNAi agents (e.g., siRNAs, shRNAs, or RNAi vectors) for the treatment of conditions and diseases mediated by (e.g., featuring IgE-mediated hypersensitivity), as well as systems for identifying RNAi agents effective for this purpose. The compositions are suitable for the treatment of allergic rhinitis and/or asthma. In certain embodiments of the invention the RNAi agent is targeted to a transcript that encodes a protein selected from the group consisisting of the FCeRIa chain, the FCeRIß chain, c-Kit, Lyn, Syk, ICOS, OX40L, CD40, CD80, CD86, RelA, RelB, 4-1BB ligand, TLR1, TLR2, TLR3,TLR4, TLR5, TLR6, TLR7, TLR8, TLR9, CD83, SLAM, common ? chain, and COX-2. In addition, the invention provides RNAi agent/delivery agent compositions and methods of use. In certain embodiments of the invention compositions comprising an RNAi agent are delivered by the respiratory route.
摘要翻译：本发明提供包含用于治疗由（例如，特征为IgE介导的超敏反应）介导的病症和疾病的一种或多种RNAi试剂（例如siRNA，shRNA或RNAi载体）的组合物，以及用于鉴定有效的RNAi试剂的系统以此目的。该组合物适用于治疗过敏性鼻炎和/或哮喘。在本发明的某些实施方案中，RNAi试剂靶向编码选自FCeRIa链，FCeRIβ链，c-Kit，Lyn，Syk，ICOS，OX40L，CD40，CD80，CD86， RelA，RelB，4-1BB配体，TLR1，TLR2，TLR3，TLR4，TLR5，TLR6，TLR7，TLR8，TLR9，CD83，SLAM，链和COX-2。此外，本发明提供RNAi剂/递送剂组合物和使用方法。在本发明的某些实施方案中，包含RNAi试剂的组合物通过呼吸途径递送。

10. 发明申请

WO2004028471A3 INFLUENZA THERAPEUTIC 审中-公开
标题翻译：流感治疗
公开(公告)号：WO2004028471A3
公开(公告)日：2006-03-09
申请号：PCT/US0330502
申请日：2003-09-29
申请人： MASSACHUSETTS INST TECHNOLOGY , CHEN JIANZHU , EISEN HERMAN N , GE QING
发明人： CHEN JIANZHU , EISEN HERMAN N , GE QING
IPC分类号： A61K38/00 , A61K48/00 , C12N15/11 , C12N15/113 , C07H21/04 , A61K35/00 , C12Q1/70
CPC分类号： C12N15/1131 , A61K9/5146 , A61K9/5153 , A61K38/00 , C12N15/111 , C12N2310/111 , C12N2310/14 , C12N2310/53 , C12N2320/32 , C12N2799/021
摘要： The present invention provides methods and compositions for inhibiting influenza infection and/or replication based on the phenomenon of RNA interference (RNAi) well as systems for identifying effective siRNAs and shRNAs for inhibiting influenza virus and systems for studying influenza virus infective mechanisms. The invention also provides methods and compositions for inhibiting infection, pathogenicity and/or replication of other infectious agents, particularly those that infect cells that are directly accessible from outside the body, e.g., skin cells or mucosal cells. In addition, the invention provides compositions comprising an RNAi-inducing entity, e.g., an siRNA, shRNA, or RNAi-inducing vector targeted to an influenza virus transcript and any of a variety of delivery agents. The invention further includes methods of use of the compositions for treatment of influenza.
摘要翻译：本发明提供了用于基于RNA干扰（RNAi）现象抑制流感感染和/或复制的方法和组合物以及用于鉴定用于抑制流感病毒的有效siRNA和shRNA以及用于研究流感病毒感染机制的系统的系统。本发明还提供用于抑制感染，致病性和/或其他感染因子的复制的方法和组合物，特别是感染可以从身体外部直接接近的细胞的感染，例如皮肤细胞或粘膜细胞的方法和组合物。此外，本发明提供了包含RNAi诱导实体的组合物，例如靶向流感病毒转录物的siRNA，shRNA或RNAi诱导载体和各种递送试剂中的任一种。本发明还包括使用该组合物治疗流感的方法。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式